Percavirus (taxid:548688)



Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embeded in the lipid envelope.


Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.


Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' nontranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.




Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

The viral interleukin-10 homolog down-regulates the expression of the TAP1 gene (transporter associated with antigen processing), thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.

Apoptosis modulation

The EHV-2 v-FLIP protein (ORF E8) inhibits TNFRSF1A, TNFRSF6, TNFRSF10 and TNFRSF12 induced apoptosis.

Cell-cycle modulation

The UL24 protein induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Splicing inhibition

Modulates the viral and host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to website)

75 entries grouped by strain

74 entries

Equine herpesvirus 2 (strain 86/87) (EHV-2) reference strain

SCAF_EHV2 Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) [Cleaved into: Assemblin ...
GB_EHV2 Envelope glycoprotein B (gB)
VCLAP_EHV2 CARD domain-containing protein E10
DPOL_EHV2 DNA polymerase catalytic subunit (EC
GM_EHV2 Envelope glycoprotein M (gM)
KITH_EHV2 Thymidine kinase (EC
GH_EHV2 Envelope glycoprotein H (gH)
AN_EHV2 Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)
CEP3_EHV2 Cytoplasmic envelopment protein 3
GN_EHV2 Envelope glycoprotein N
PRIM_EHV2 DNA primase (EC 2.7.7.-)
RIR2_EHV2 Ribonucleoside-diphosphate reductase small subunit (EC (Ribonucleotide reductase small ...
RIR1_EHV2 Ribonucleoside-diphosphate reductase large subunit (R1) (EC (Ribonucleotide reductase ...
LTP_EHV2 Large tegument protein deneddylase (EC (EC 3.4.22.-)
TYSY_EHV2 Thymidylate synthase (TS) (TSase) (EC
UNG_EHV2 Uracil-DNA glycosylase (UDG) (EC (UNG)
IL10H_EHV2 Viral interleukin-10 homolog (vIL-10)
VGE3_EHV2 SUSHI domain-containing protein E3
DNBI_EHV2 Major DNA-binding protein
TRM1_EHV2 Tripartite terminase subunit 1
VGE6_EHV2 G-protein coupled receptor E6
CVC2_EHV2 Capsid vertex component 2
MCP_EHV2 Major capsid protein (MCP)
TRX2_EHV2 Triplex capsid protein 2
VG28_EHV2 Uncharacterized gene 28 protein
TRM3_EHV2 Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)
CVC1_EHV2 Capsid vertex component 1
CEP2_EHV2 Cytoplasmic envelopment protein 2
VG36_EHV2 Probable inactive protein kinase 38
HEPA_EHV2 DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)
CEP1_EHV2 Cytoplasmic envelopment protein 1
PORTL_EHV2 Portal protein
HELI_EHV2 DNA replication helicase (EC 3.6.4.-)
GL_EHV2 Envelope glycoprotein L (gL)
BRLF1_EHV2 Putative transcription activator BRLF1 homolog
VG51_EHV2 Putative C-type lectin protein 51
DUT_EHV2 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC (dUTP pyrophosphatase)
TEG7_EHV2 Tegument protein UL51 homolog
VG59_EHV2 DNA polymerase processivity factor
TRX1_EHV2 Triplex capsid protein 1
ITP_EHV2 Inner tegument protein
SCP_EHV2 Small capsomere-interacting protein
NEC2_EHV2 Nuclear egress protein 2
TRM2_EHV2 Tripartite terminase subunit 2
UL32_EHV2 Packaging protein UL32 homolog
NEC1_EHV2 Nuclear egress protein 1
VG74_EHV2 G-protein coupled receptor 74
CFLA_EHV2 Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)
VGE9_EHV2 Uncharacterized gene E9 protein
VGE1_EHV2 G-protein coupled receptor E1
VGE2_EHV2 Uncharacterized gene E2 protein
VP03_EHV2 Probable membrane antigen 3 (Tegument protein)
VGE4_EHV2 Uncharacterized gene E4 protein
VG10_EHV2 Uncharacterized gene 10 protein
VG11_EHV2 Uncharacterized gene 11 protein
VG12_EHV2 Protein E6A
VG13_EHV2 Protein E6C
UL79_EHV2 Gene 18 protein
UL24_EHV2 Protein UL24 homolog
VG23_EHV2 Uncharacterized gene 23 protein
UL87_EHV2 Gene 24 protein
VG27_EHV2 Uncharacterized gene 27 protein
UL91_EHV2 Uncharacterized gene 30 protein
UL92_EHV2 Gene 31 protein
UL95_EHV2 Gene 34 protein
UL96_EHV2 Gene 35 protein
VG45_EHV2 Uncharacterized gene 45 protein
VG48_EHV2 Tegument protein G48
VG49_EHV2 Uncharacterized gene 49 protein
VG52_EHV2 Gene 52 protein
IE63_EHV2 Immediate-early phosphoprotein 57
VG58_EHV2 Gene 58 protein
UL49_EHV2 Uncharacterized gene 66 protein
VG75_EHV2 Probable membrane antigen 75 (Tegument protein)

1 entry

Equine herpesvirus 2 (strain T400/3) (EHV-2)

IL10H_EHV2T Viral interleukin-10 homolog (vIL-10)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Equid gammaherpesvirus 2 taxid:12657

Protein ModelArchive
CARD-like apoptotic protein (V-CARMEN) ma-jd-viral-66273
Capsid triplex subunit 1 ma-jd-viral-09163
Capsid triplex subunit 2 ma-jd-viral-04773
Cytoplasmic envelopment protein 3 ma-jd-viral-62510
DNA packaging protein UL33 ma-jd-viral-51038
DNA packaging terminase subunit 1 ma-jd-viral-06537
Deoxyuridine triphosphatase (EC ma-jd-viral-12806
E1 ma-jd-viral-18377
E1 ma-jd-viral-18425
E6 (Membrane protein BILF1) ma-jd-viral-18458
Envelope glycoprotein 48 ma-jd-viral-44546
Nuclear egress lamina protein ma-jd-viral-10275
ORF74 ma-jd-viral-18347
Protein E2 ma-jd-viral-43927
Protein G49 ma-jd-viral-04966
Protein UL79 ma-jd-viral-54779
Protein UL91 ma-jd-viral-52792
Thymidylate synthase (EC ma-jd-viral-08301
ribonucleoside-diphosphate reductase (EC ma-jd-viral-05506

Equid gammaherpesvirus 5 taxid:10371

Protein ModelArchive
Apoptosis regulator BALF1 ma-jd-viral-06297
Apoptosis regulator E10 ma-jd-viral-35252
Apoptosis regulator E8 ma-jd-viral-16381
Capsid portal protein ma-jd-viral-59284
Capsid scaffold protein ma-jd-viral-52942
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12473
Capsid triplex subunit 1 ma-jd-viral-09160
Capsid triplex subunit 2 ma-jd-viral-04758
Cytoplasmic envelopment protein 3 ma-jd-viral-62509
DNA packaging protein UL33 ma-jd-viral-51039
DNA packaging tegument protein UL17 ma-jd-viral-02080
DNA packaging tegument protein UL25 ma-jd-viral-01793
DNA packaging terminase subunit 1 ma-jd-viral-06542
DNA packaging terminase subunit 2 ma-jd-viral-61471
DNA polymerase processivity subunit ma-jd-viral-21485
Deoxyribonuclease ma-jd-viral-08480
Deoxyuridine triphosphatase (EC ma-jd-viral-12796
Envelope glycoprotein 150 ma-jd-viral-29971
Envelope glycoprotein 350 ma-jd-viral-29398
Envelope glycoprotein 42 ma-jd-viral-16439
Envelope glycoprotein 48 ma-jd-viral-44545
Envelope glycoprotein B ma-jd-viral-31229
Envelope glycoprotein H ma-jd-viral-16885
Envelope glycoprotein L ma-jd-viral-03919
Envelope glycoprotein M ma-jd-viral-37867
Envelope glycoprotein N ma-jd-viral-38369
Envelope protein UL43 ma-jd-viral-02354
Helicase-primase helicase subunit ma-jd-viral-37566
Helicase-primase primase subunit ma-jd-viral-33325
Helicase-primase subunit ma-jd-viral-17366
Membrane protein BILF1 ma-jd-viral-18457
Membrane protein E1 ma-jd-viral-18419
Membrane protein E11 ma-jd-viral-24349
Membrane protein E3 ma-jd-viral-48409
Membrane protein E9 ma-jd-viral-47362
Membrane protein G74 ma-jd-viral-18349
Multifunctional expression regulator ma-jd-viral-15589
Nuclear antigen LANA-1 ma-jd-viral-62618
Nuclear egress lamina protein ma-jd-viral-10270
Nuclear egress membrane protein ma-jd-viral-12373
Nuclear protein UL24 ma-jd-viral-12133
Packaging protein UL32 ma-jd-viral-40961
Protein E2 ma-jd-viral-43928
Protein E5A ma-jd-viral-39619
Protein E6A ma-jd-viral-44446
Protein E6B ma-jd-viral-46471
Protein G10 ma-jd-viral-12719
Protein G49 ma-jd-viral-04975
Protein Rta ma-jd-viral-00118
Protein UL49 ma-jd-viral-21385
Protein UL79 ma-jd-viral-54803
Protein UL87 ma-jd-viral-50962
Protein UL91 ma-jd-viral-52802
Protein UL92 ma-jd-viral-51384
Protein UL95 ma-jd-viral-36735
Ribonucleoside-diphosphate reductase large subunit (R1) (EC (Ribonucleotide reductase large... ma-jd-viral-14344
Small capsomere-interacting protein ma-jd-viral-60237
Tegument protein G45 ma-jd-viral-62378
Tegument protein G48 ma-jd-viral-14048
Tegument protein UL14 ma-jd-viral-14650
Tegument protein UL16 ma-jd-viral-02693
Tegument protein UL37 ma-jd-viral-14865
Tegument protein UL51 ma-jd-viral-37455
Tegument protein UL7 ma-jd-viral-14118
Tegument protein UL88 ma-jd-viral-10996
Tegument serine/threonine protein kinase (EC ma-jd-viral-24748
Thymidine kinase (EC ma-jd-viral-05862
Thymidylate synthase (EC ma-jd-viral-08304
Uracil-DNA glycosylase (EC ma-jd-viral-07766
Viral interleukin-10 homolog ma-jd-viral-13427
Virion protein G11 ma-jd-viral-12708
Virion protein G52 ma-jd-viral-07463
ribonucleoside-diphosphate reductase (EC ma-jd-viral-05513

Equine herpesvirus 2 (strain 86/87) taxid:82831

Protein ModelArchive
CARD domain-containing protein E10 ma-jd-viral-66273
Capsid scaffold protein ma-jd-viral-52946
Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) ma-jd-viral-12510
Capsid vertex component 1 ma-jd-viral-02087
Capsid vertex component 2 ma-jd-viral-01755
Cytoplasmic envelopment protein 1 ma-jd-viral-14107
Cytoplasmic envelopment protein 2 ma-jd-viral-02689
Cytoplasmic envelopment protein 3 ma-jd-viral-62510
DNA helicase/primase complex-associated protein (HEPA) (Primase-associated... ma-jd-viral-17365
DNA polymerase processivity factor ma-jd-viral-21492
DNA primase (EC 2.7.7.-) ma-jd-viral-33307
DNA replication helicase (EC 3.6.4.-) ma-jd-viral-37586
Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC (dUTP... ma-jd-viral-12806
Envelope glycoprotein B (gB) ma-jd-viral-31243
Envelope glycoprotein H (gH) ma-jd-viral-16881
Envelope glycoprotein L (gL) ma-jd-viral-03920
Envelope glycoprotein M (gM) ma-jd-viral-37857
Envelope glycoprotein N ma-jd-viral-38377
G-protein coupled receptor 74 ma-jd-viral-18347
G-protein coupled receptor E1 ma-jd-viral-18377
G-protein coupled receptor E1 ma-jd-viral-18425
G-protein coupled receptor E6 ma-jd-viral-18458
Gene 18 protein ma-jd-viral-54779
Gene 24 protein ma-jd-viral-50953
Gene 31 protein ma-jd-viral-51376
Gene 34 protein ma-jd-viral-36742
Gene 35 protein ma-jd-viral-14649
Gene 52 protein ma-jd-viral-07461
Gene 58 protein ma-jd-viral-02352
Immediate-early phosphoprotein 57 ma-jd-viral-15590
Inner tegument protein ma-jd-viral-14859
Nuclear antigen LANA-1 ma-jd-viral-62619
Nuclear egress protein 1 ma-jd-viral-10275
Nuclear egress protein 2 ma-jd-viral-12371
Packaging protein UL32 homolog ma-jd-viral-40970
Portal protein ma-jd-viral-59293
Probable inactive protein kinase 38 ma-jd-viral-24757
Protein E5A ma-jd-viral-39618
Protein E6A ma-jd-viral-55474
Protein E6C ma-jd-viral-35828
Protein UL24 homolog ma-jd-viral-12130
Putative C-type lectin protein 51 ma-jd-viral-16441
Putative transcription activator BRLF1 homolog ma-jd-viral-00121
Ribonucleoside-diphosphate reductase large subunit (R1) (EC (Ribonucleotide reductase large... ma-jd-viral-14319
Ribonucleoside-diphosphate reductase small subunit (EC (Ribonucleotide reductase small... ma-jd-viral-05506
SUSHI domain-containing protein E3 ma-jd-viral-32137
Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-) ma-jd-viral-08470
Small capsomere-interacting protein ma-jd-viral-13439
Tegument protein G48 ma-jd-viral-14047
Tegument protein UL51 homolog ma-jd-viral-37465
Thymidine kinase (EC ma-jd-viral-05863
Thymidylate synthase (TS) (TSase) (EC ma-jd-viral-08301
Tripartite terminase subunit 1 ma-jd-viral-61478
Tripartite terminase subunit 2 ma-jd-viral-51038
Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit) ma-jd-viral-06537
Triplex capsid protein 1 ma-jd-viral-09163
Triplex capsid protein 2 ma-jd-viral-04773
Uncharacterized gene 10 protein ma-jd-viral-12718
Uncharacterized gene 11 protein ma-jd-viral-12700
Uncharacterized gene 23 protein ma-jd-viral-11004
Uncharacterized gene 27 protein ma-jd-viral-44546
Uncharacterized gene 28 protein ma-jd-viral-29973
Uncharacterized gene 30 protein ma-jd-viral-52792
Uncharacterized gene 45 protein ma-jd-viral-62377
Uncharacterized gene 49 protein ma-jd-viral-04966
Uncharacterized gene 66 protein ma-jd-viral-21381
Uncharacterized gene E2 protein ma-jd-viral-43927
Uncharacterized gene E4 protein ma-jd-viral-06293
Uncharacterized gene E9 protein ma-jd-viral-53450
Uracil-DNA glycosylase (UDG) (EC (UNG) ma-jd-viral-07738
Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein)... ma-jd-viral-16379
Viral interleukin-10 homolog (vIL-10) ma-jd-viral-13428

Equine herpesvirus 2 (strain T400/3) taxid:82832

Protein ModelArchive
Viral interleukin-10 homolog (vIL-10) ma-jd-viral-13428

Felis catus gammaherpesvirus 1 taxid:1452540

Protein ModelArchive
Capsid scaffolding protein (Protease precursor) (pPR) ma-jd-viral-12519
Cytoplasmic envelopment protein 3 ma-jd-viral-36425
DNA polymerase (EC ma-jd-viral-17263
F1 ma-jd-viral-47574
F10 ma-jd-viral-16871
F11 ma-jd-viral-64713
F12 ma-jd-viral-06300
F13 ma-jd-viral-44766
F14 ma-jd-viral-53091
F15 ma-jd-viral-16821
F16 ma-jd-viral-29396
F17 ma-jd-viral-39614
F19 ma-jd-viral-34259
F2 ma-jd-viral-59199
F20 ma-jd-viral-43206
F21 ma-jd-viral-62820
F22 ma-jd-viral-62255
F23 ma-jd-viral-64838
F24 ma-jd-viral-30466
F25 ma-jd-viral-33002
F26 ma-jd-viral-39905
F3 ma-jd-viral-63250
F4 ma-jd-viral-30006
F5 ma-jd-viral-64886
F6 ma-jd-viral-57147
F7 ma-jd-viral-16380
F8 ma-jd-viral-49538
F9 ma-jd-viral-50163
ORF10 ma-jd-viral-12717
ORF17.5 ma-jd-viral-52949
ORF18 ma-jd-viral-54769
ORF19 ma-jd-viral-01778
ORF20 ma-jd-viral-12117
ORF21 ma-jd-viral-05860
ORF22 ma-jd-viral-16878
ORF24 ma-jd-viral-50967
ORF26 ma-jd-viral-04759
ORF27 ma-jd-viral-21097
ORF29 ma-jd-viral-06511
ORF30 ma-jd-viral-52804
ORF31 ma-jd-viral-51383
ORF32 ma-jd-viral-02085
ORF33 ma-jd-viral-02695
ORF34 ma-jd-viral-36741
ORF35 ma-jd-viral-14639
ORF36 ma-jd-viral-24755
ORF37 ma-jd-viral-08495
ORF39 ma-jd-viral-37862
ORF40 ma-jd-viral-17363
ORF42 ma-jd-viral-14111
ORF43 ma-jd-viral-59265
ORF44 ma-jd-viral-37540
ORF45 ma-jd-viral-54373
ORF46 ma-jd-viral-07761
ORF47 ma-jd-viral-03926
ORF48 ma-jd-viral-14049
ORF49 ma-jd-viral-04982
ORF50 ma-jd-viral-00120
ORF51 ma-jd-viral-16440
ORF52 ma-jd-viral-07465
ORF53 ma-jd-viral-38374
ORF54 ma-jd-viral-12812
ORF55 ma-jd-viral-37463
ORF56 ma-jd-viral-33328
ORF57 ma-jd-viral-15546
ORF58 ma-jd-viral-02367
ORF59 ma-jd-viral-21486
ORF62 ma-jd-viral-09161
ORF63 ma-jd-viral-14858
ORF66 ma-jd-viral-21380
ORF67 ma-jd-viral-12370
ORF67A ma-jd-viral-51030
ORF69 ma-jd-viral-10279
ORF7 ma-jd-viral-61500
ORF73 ma-jd-viral-60142
ORF74 ma-jd-viral-18351
ORF8 ma-jd-viral-31244
Packaging protein UL32 ma-jd-viral-40972
Ribonucleoside-diphosphate reductase (EC ma-jd-viral-14335
Small capsomere-interacting protein ma-jd-viral-13451
ribonucleoside-diphosphate reductase (EC ma-jd-viral-05550
thymidylate synthase (EC ma-jd-viral-08314