Non-enveloped capsid with a pseudo T=25 icosahedral symmetry. The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.


Non-segmented, linear double-stranded DNA of 30 kb encoding about 30 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.


Transcription is nuclear, in two phases; early (replication), late (virion assembly). All genes are transcribed by host RNA pol II. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.



  1. Attachment of the viral fiber glycoproteins to host receptors mediates endocytosis of the virus into the host cell and fiber shedding.
  2. Disruption of the endosome by lytic protein VI releases the viral capsid in the cytosol.
  3. Viral penetration into host nucleus.
  4. Transcription of early genes (E genes) by host RNA pol II, replication of the DNA genome by DNA strand displacement in the nucleus.
  5. Transcription of late genes (L genes) by host RNA pol II, mostly encoding for structural proteins.
  6. Assembly of new virions in the nucleus.
  7. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

33 entries grouped by strain (browse by keywords)

28 entries

Snake adenovirus serotype 1 (SnAdV-1) reference strain

SPIKE_ADES1 Fiber protein (SPIKE) (Protein IV)
TERM_ADES1 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
ORF1_ADES1 Protein ORF1
SHUT_ADES1 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
LH2_ADES1 Protein LH2
PRO_ADES1 Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
RH1_ADES1 Protein RH1
33K_ADES1 Putative protein 33K
CAP8_ADES1 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CAP6_ADES1 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP3_ADES1 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAPSP_ADES1 Penton protein (CP-P) (Penton base protein) (Protein III)
DPOL_ADES1 DNA polymerase (EC
22K_ADES1 Putative protein 22K
E42_ADES1 Protein E4.2
DNB2_ADES1 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
105R_ADES1 Protein 105R
E41_ADES1 Protein E4.1
E43_ADES1 Protein E4.3
LH1_ADES1 Protein LH1
L2MU_ADES1 Late L2 mu core protein (Protein X) (pX) (pMu)
PKG3_ADES1 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
LH3_ADES1 Hexon-interlacing protein LH3
NP_ADES1 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
UXP_ADES1 Probable U-exon protein
P32K_ADES1 Structural protein p32K
PKG1_ADES1 Packaging protein 1 (Packaging protein IVa2)
CAPSH_ADES1 Hexon protein (CP-H) (Protein II)

3 entries

Ovine adenovirus D serotype 7 (isolate OAV287) (OAdV-7) (Ovine adenovirus 7) reference strain

PRO_ADEO7 Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
P32K_ADEO7 Structural protein p32K
LH3_ADEO7 Hexon-interlacing protein LH3

1 entry

Bovine adenovirus 4 (BAdV-4) reference strain

PRO_ADEB4 Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

1 entry

Bovine adenovirus 7 (BAdV-7)

PRO_ADEB7 Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)