Atadenovirus

VIRION

Non-enveloped capsid with a pseudo T=25 icosahedral symmetry. The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.

GENOME

Non-segmented, linear double-stranded DNA of 30 kb encoding about 30 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly). All genes are transcribed by host RNA pol II. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.

REPLICATION

NUCLEUS

  1. Attachment of the viral fiber glycoproteins to host receptors mediates endocytosis of the virus into the host cell and fiber shedding.
  2. Disruption of the endosome by lytic protein VI releases the viral capsid in the cytosol.
  3. Viral penetration into host nucleus.
  4. Transcription of early genes (E genes) by host RNA pol II, replication of the DNA genome by DNA strand displacement in the nucleus.
  5. Transcription of late genes (L genes) by host RNA pol II, mostly encoding for structural proteins.
  6. Assembly of new virions in the nucleus.
  7. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

33 entries grouped by strain (browse by keywords)

28 entries

Snake adenovirus serotype 1 (SnAdV-1) reference strain

Select_allDeselect_all
SHUT_ADES1 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
UXP_ADES1 Probable U-exon protein
TERM_ADES1 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
CAP8_ADES1 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
105R_ADES1 Protein 105R
33K_ADES1 Putative protein 33K
CAPSP_ADES1 Penton protein (CP-P) (Penton base protein) (Protein III)
ORF1_ADES1 Protein ORF1
CAP6_ADES1 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
LH2_ADES1 Protein LH2
PKG3_ADES1 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
P32K_ADES1 Structural protein p32K
PRO_ADES1 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
E41_ADES1 Protein E4.1
RH1_ADES1 Protein RH1
SPIKE_ADES1 Fiber protein (SPIKE) (Protein IV)
PKG1_ADES1 Packaging protein 1 (Packaging protein IVa2)
CAP3_ADES1 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
LH3_ADES1 Hexon-interlacing protein LH3
NP_ADES1 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
LH1_ADES1 Protein LH1
DNB2_ADES1 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
L2MU_ADES1 Late L2 mu core protein (Protein X) (pX) (pMu)
E42_ADES1 Protein E4.2
DPOL_ADES1 DNA polymerase (EC 2.7.7.7)
E43_ADES1 Protein E4.3
22K_ADES1 Putative protein 22K
CAPSH_ADES1 Hexon protein (CP-H) (Protein II)

3 entries

Ovine adenovirus D serotype 7 (isolate OAV287) (OAdV-7) (Ovine adenovirus 7) reference strain

Select_allDeselect_all
P32K_ADEO7 Structural protein p32K
PRO_ADEO7 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
LH3_ADEO7 Hexon-interlacing protein LH3

1 entry

Bovine adenovirus 4 (BAdV-4) reference strain

PRO_ADEB4 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

1 entry

Bovine adenovirus 7 (BAdV-7)

PRO_ADEB7 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)