Atadenovirus (taxid:100953)



Non-enveloped capsid with a pseudo T=25 icosahedral symmetry. The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.


Monopartite, linear double-stranded DNA of 30 kb encoding about 30 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.


Transcription is nuclear, in two phases; early (replication), late (virion assembly). All genes are transcribed by host RNA pol II. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.




  1. Attachment of the viral fiber glycoproteins to host receptors mediates endocytosis of the virus into the host cell and fiber shedding.
  2. Disruption of the endosome by lytic protein VI releases the viral capsid in the cytosol.
  3. Viral penetration into host nucleus.
  4. Transcription of early genes (E genes) by host RNA pol II, replication of the DNA genome by DNA strand displacement in the nucleus.
  5. Transcription of late genes (L genes) by host RNA pol II, mostly encoding for structural proteins.
  6. Assembly of new virions in the nucleus.
  7. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

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33 entries grouped by strain

28 entries

Snake adenovirus serotype 1 (SnAdV-1) reference strain

CAP6_ADES1 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
PKG1_ADES1 Packaging protein 1 (Packaging protein IVa2)
TERM_ADES1 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
CAP3_ADES1 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
SHUT_ADES1 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
CAP8_ADES1 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
DNB2_ADES1 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
PRO_ADES1 Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
CAPSH_ADES1 Hexon protein (CP-H) (Protein II)
NP_ADES1 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
DPOL_ADES1 DNA polymerase (EC
LH3_ADES1 Hexon-interlacing protein LH3
PKG3_ADES1 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
CAPSP_ADES1 Penton protein (CP-P) (Penton base protein) (Protein III)
SPIKE_ADES1 Fiber protein (SPIKE) (Protein IV)
L2MU_ADES1 Late L2 mu core protein (Protein X) (pX) (pMu)
P32K_ADES1 Structural protein p32K
LH1_ADES1 Protein LH1
LH2_ADES1 Protein LH2
33K_ADES1 Putative protein 33K
22K_ADES1 Putative protein 22K
UXP_ADES1 Probable U-exon protein
E43_ADES1 Protein E4.3
E42_ADES1 Protein E4.2
E41_ADES1 Protein E4.1
ORF1_ADES1 Protein ORF1
RH1_ADES1 Protein RH1
105R_ADES1 Protein 105R

3 entries

Ovine adenovirus D serotype 7 (isolate OAV287) (OAdV-7) (Ovine adenovirus 7) reference strain

PRO_ADEO7 Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
P32K_ADEO7 Structural protein p32K
LH3_ADEO7 Hexon-interlacing protein LH3

1 entry

Bovine adenovirus 4 (BAdV-4) reference strain

PRO_ADEB4 Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

1 entry

Bovine adenovirus 7 (BAdV-7)

PRO_ADEB7 Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Bovine adenovirus 4 taxid:70333

Protein ModelArchive
100K protein ma-jd-viral-56520
22K ma-jd-viral-63744
33K protein ma-jd-viral-06978
34K-2 ma-jd-viral-38160
52K protein ma-jd-viral-08600
DBP ma-jd-viral-53379
E1B 55K ma-jd-viral-09425
E4.1 ma-jd-viral-14153
E4.2 ma-jd-viral-05118
E4.3 ma-jd-viral-38158
Fiber ma-jd-viral-32340
Hexon protein (CP-H) (Protein II) ma-jd-viral-50745
III ma-jd-viral-40862
LH1 ma-jd-viral-29873
LH2 ma-jd-viral-31703
PIIIa ma-jd-viral-49418
PIIIa ma-jd-viral-49438
PTP ma-jd-viral-56602
PVI ma-jd-viral-29677
PVII ma-jd-viral-58780
PX ma-jd-viral-55670
Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) ma-jd-viral-65521
Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase)... ma-jd-viral-14002
Protein IVa2 ma-jd-viral-10685
RH0 ma-jd-viral-47522
RH1 ma-jd-viral-47521
RH1 ma-jd-viral-57295
RH2 ma-jd-viral-31853
RH2 ma-jd-viral-47519
RH4 ma-jd-viral-47525
RH5 ma-jd-viral-48725
RH6 ma-jd-viral-47523
U-exon ma-jd-viral-40063
URF1 ma-jd-viral-39258
p32K ma-jd-viral-21615

Bovine adenovirus 6 taxid:111167

Protein ModelArchive
100K ma-jd-viral-56536
22K ma-jd-viral-63745
33K ma-jd-viral-06974
52K ma-jd-viral-08595
DBP ma-jd-viral-53416
E4.1 ma-jd-viral-14152
E4.2 ma-jd-viral-05115
E4.3 ma-jd-viral-38161
Fiber ma-jd-viral-32342
Hexon protein (CP-H) (Protein II) ma-jd-viral-50761
IVa2 ma-jd-viral-10647
LH1 ma-jd-viral-29874
LH2 ma-jd-viral-31702
LH3 ma-jd-viral-09427
ORF1 ma-jd-viral-53261
ORF2 ma-jd-viral-47030
PIIIa ma-jd-viral-49434
PTP ma-jd-viral-56624
PVI ma-jd-viral-29666
PVII ma-jd-viral-58779
PX ma-jd-viral-55671
Penton base ma-jd-viral-40909
Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) ma-jd-viral-65519
Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase)... ma-jd-viral-13993
RH4 ma-jd-viral-47518
RH5 ma-jd-viral-48724
RH6 ma-jd-viral-47524
U exon ma-jd-viral-40061
p32K ma-jd-viral-21613

Lizard adenovirus 2 taxid:874272

Protein ModelArchive
100K ma-jd-viral-56521
22K ma-jd-viral-64769
33K ma-jd-viral-06977
52K ma-jd-viral-08598
DBP ma-jd-viral-53411
DNA polymerase (EC ma-jd-viral-44323
E4.1 ma-jd-viral-14155
E4.2 ma-jd-viral-05119
E4.3 ma-jd-viral-38159
Fiber 1 ma-jd-viral-44633
Fiber 2 ma-jd-viral-64398
Hexon protein (CP-H) (Protein II) ma-jd-viral-50768
PIIIa ma-jd-viral-49450
PTP ma-jd-viral-56615
PVI ma-jd-viral-29670
PVII ma-jd-viral-58774
PX ma-jd-viral-61739
Penton protein (CP-P) (Penton base protein) (Protein III) ma-jd-viral-40897
Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) ma-jd-viral-65512
Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase)... ma-jd-viral-14000
Protein 105R ma-jd-viral-49123
Protein IVa2 ma-jd-viral-10641
Protein LH1 ma-jd-viral-45128
Protein LH2 ma-jd-viral-31704
Protein LH3 ma-jd-viral-09424
Protein ORF1 ma-jd-viral-53748
Protein ORF2 ma-jd-viral-58356
Protein ORF3 ma-jd-viral-50299
Protein ORF4 ma-jd-viral-43765
Protein ORF5 ma-jd-viral-29335
Protein ORF6 ma-jd-viral-50307
Protein RH ma-jd-viral-30014
U-exon ma-jd-viral-40064
p32K ma-jd-viral-21612

Psittacine adenovirus 3 taxid:1580497

Protein ModelArchive
100K ma-jd-viral-56525
33K ma-jd-viral-06976
52K ma-jd-viral-08596
DNA polymerase (EC ma-jd-viral-44318
DNA-binding protein ma-jd-viral-53384
E1B small T-antigen ma-jd-viral-31400
E4.1 protein ma-jd-viral-59489
E4.2 protein ma-jd-viral-05117
E4.3 protein ma-jd-viral-42495
Fiber ma-jd-viral-45131
Fiber-2 ma-jd-viral-32559
Hexon protein (CP-H) (Protein II) ma-jd-viral-50767
IIIa ma-jd-viral-49445
IVa2 ma-jd-viral-10648
PVI ma-jd-viral-29676
PVII ma-jd-viral-58778
PVIII ma-jd-viral-65498
PX ma-jd-viral-54408
Penton protein (CP-P) (Penton base protein) (Protein III) ma-jd-viral-40894
Protease (EC (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase)... ma-jd-viral-13962
Terminal protein ma-jd-viral-56638
U-exon ma-jd-viral-40060
Uncharacterized protein ma-jd-viral-12616
Uncharacterized protein ma-jd-viral-12617
Uncharacterized protein ma-jd-viral-30404
Uncharacterized protein ma-jd-viral-37449
Uncharacterized protein ma-jd-viral-64699
Uncharacterized protein ma-jd-viral-56189
p32K ma-jd-viral-34902