Bracoviriform (taxid:2946836)

(formerly named Bracovirus)
Viriform: endogenous mobile genetic element that fulfill functions for the encoding host.

VIRION

image

Enveloped, prolate ellipsoid form (ichnoviriform) and cylindrical (bracoviriform). Depending on the species, a virion contains one or several nucleocapsids.

GENOME

Segmented, circular supercoiled dsDNAs ranging from 2.0-31kb. Each virion contains multiple copies of the genome.

GENE EXPRESSION

REPLICATION

NUCLEAR

a) replicative: occurs in the calyx cells of the ovary.

  1. Excision and circularization of viral DNA in the ovary cells.
  2. Viral DNA synthesis.
  3. Appearance of viral envelopes and nucleocapsids in the nucleus.
  4. Mature virions are released into the lumen of the oviduct probably by lysis (brachoviriform) or budding through the cell membrane (ichnoviriform).

b) vegetative: occurs in all non-reproductive cells.

The viral genome is transmitted in proviral linear form integrated in the wasp's chromosomes. The virus DNA is replicated, just like any other part of the wasp's genome.

Host-virus interaction

Apoptosis modulation

PTP-H2 triggers mitochondrial membrane depolarization and caspase-dependent apoptosis suggesting that apoptosis is induced through a mitochondria-dependent death pathway.

NF-kappa-B modulation

Polydnavirus Ank proteins bind NF-kappa-B homodimers and inhibit processing of relish/NF-kappa-B p110 subunit .

Innate immune response inhibition

Microplitis demolitor cracovirus PTP-H2 and PTP-H3 are functional tyrosine phosphatases whose expression inhibit phagocytosis . Another protein, Glc1.8 is also involved in suppression of the insect cellular immune response .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

52 entries grouped by strain

52 entries

Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

Select_allDeselect_all
EG10_MDBVW Protease inhibitor Egf1.0
GL18A_MDBVW Mucin-like protein Glc1.8a
PTPH2_MDBVW Tyrosine phosphatase H2 (PTP-H2) (EC 3.1.3.48)
GL18B_MDBVW Mucin-like protein Glc1.8b (Glc1.8b)
EG15B_MDBVW Protease inhibitor Egf1.5b
EG15A_MDBVW Protease inhibitor Egf1.5a
IKBI1_MDBVW I-Kappa-B like protein I1
PTPN3_MDBVW Tyrosine phosphatase-like protein N3 (PTP-N3)
IKBN3_MDBVW I-Kappa-B like protein N3
IKBN2_MDBVW I-kappa-B like protein N2
PTPN2_MDBVW Tyrosine phosphatase-like protein N2 (PTP-N2)
PTPN1_MDBVW Probable tyrosine phosphatase protein N1 (PTP-N1) (EC 3.1.3.48)
IKBN1_MDBVW I-Kappa-B like protein N1
PTPJ4_MDBVW Probable tyrosine phosphatase protein J4 (PTP-J4) (EC 3.1.3.48)
PTPJ3_MDBVW Tyrosine phosphatase-like protein J3 (PTP-J3)
PTPJ2_MDBVW Probable tyrosine phosphatase protein J2 (PTP-J2) (EC 3.1.3.48)
IKBJ1_MDBVW I-Kappa-B like protein J1
PTPJ1_MDBVW Tyrosine phosphatase-like protein J1 (PTP-J1)
PTPH5_MDBVW Tyrosine phosphatase-like protein H5 (PTP-H5)
PTPH4_MDBVW Probable tyrosine phosphatase protein H4 (PTP-H4) (EC 3.1.3.48)
IKBH1_MDBVW I-Kappa-B like protein H1
PTPH3_MDBVW Tyrosine phosphatase H3 (PTP-H3) (EC 3.1.3.48)
PTPH1_MDBVW Tyrosine phosphatase-like protein H1 (PTP-H1)
IKBG2_MDBVW I-Kappa-B like protein G2
IKBG1_MDBVW I-Kappa-B like protein G1
PTPD1_MDBVW Truncated tyrosine phosphatase D1 (PTP-D1)
IKBF2_MDBVW I-Kappa-B like protein F2
IKBF1_MDBVW I-Kappa-B like protein F1
IKBC2_MDBVW I-Kappa-B like protein C2
IKBC1_MDBVW I-Kappa-B like protein C1
YB1_MDBVW Putative BEN domain-containing protein B1
EG04B_MDBVW Probable protease inhibitor Egf0.4b
EG04A_MDBVW Probable protease inhibitor Egf0.4a
YI2_MDBVW Uncharacterized protein I2
YL1_MDBVW Uncharacterized protein L1
YN1_MDBVW Uncharacterized protein N1
YM5_MDBVW Uncharacterized protein M5
YM4_MDBVW Uncharacterized protein M4
YM3_MDBVW Uncharacterized protein M3
YM2_MDBVW Uncharacterized protein M2
YM1_MDBVW Uncharacterized protein M1
YK1_MDBVW Uncharacterized protein K1
YG2_MDBVW Uncharacterized protein G2
YG1_MDBVW Uncharacterized protein G1
YD3_MDBVW Uncharacterized protein D3
YD2_MDBVW Uncharacterized protein D2
YF1_MDBVW Uncharacterized protein F1
YC3_MDBVW Uncharacterized protein C3
YE2_MDBVW Uncharacterized protein E2
YE1_MDBVW Uncharacterized protein E1
YA2_MDBVW Uncharacterized protein A2
YA1_MDBVW Uncharacterized protein A1
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Microplitis demolitor bracovirus (isolate Webb) taxid:654919

Protein ModelArchive
I-Kappa-B like protein C1 ma-jd-viral-26021
I-Kappa-B like protein C2 ma-jd-viral-26018
I-Kappa-B like protein F1 ma-jd-viral-26012
I-Kappa-B like protein F2 ma-jd-viral-26017
I-Kappa-B like protein G1 ma-jd-viral-26005
I-Kappa-B like protein G2 ma-jd-viral-26010
I-Kappa-B like protein H1 ma-jd-viral-26007
I-Kappa-B like protein I1 ma-jd-viral-26011
I-Kappa-B like protein J1 ma-jd-viral-26563
I-Kappa-B like protein N1 ma-jd-viral-25878
I-Kappa-B like protein N3 ma-jd-viral-25509
I-kappa-B like protein N2 ma-jd-viral-25510
Major capsid protein ma-jd-viral-47692
Probable tyrosine phosphatase protein H4 (PTP-H4) (EC 3.1.3.48) ma-jd-viral-13338
Probable tyrosine phosphatase protein J2 (PTP-J2) (EC 3.1.3.48) ma-jd-viral-00489
Probable tyrosine phosphatase protein J4 (PTP-J4) (EC 3.1.3.48) ma-jd-viral-00491
Probable tyrosine phosphatase protein N1 (PTP-N1) (EC 3.1.3.48) ma-jd-viral-00512
Putative BEN domain-containing protein B1 ma-jd-viral-64547
Truncated tyrosine phosphatase D1 (PTP-D1) ma-jd-viral-58485
Tyrosine phosphatase H2 (PTP-H2) (EC 3.1.3.48) ma-jd-viral-00499
Tyrosine phosphatase H3 (PTP-H3) (EC 3.1.3.48) ma-jd-viral-00488
Tyrosine phosphatase-like protein H1 (PTP-H1) ma-jd-viral-00486
Tyrosine phosphatase-like protein H5 (PTP-H5) ma-jd-viral-00487
Tyrosine phosphatase-like protein J1 (PTP-J1) ma-jd-viral-00504
Tyrosine phosphatase-like protein J3 (PTP-J3) ma-jd-viral-00490
Tyrosine phosphatase-like protein N2 (PTP-N2) ma-jd-viral-60318
Tyrosine phosphatase-like protein N3 (PTP-N3) ma-jd-viral-00510
Uncharacterized protein C3 ma-jd-viral-00382
Uncharacterized protein D2 ma-jd-viral-55978
Uncharacterized protein D3 ma-jd-viral-62145
Uncharacterized protein E1 ma-jd-viral-57525
Uncharacterized protein E2 ma-jd-viral-00384
Uncharacterized protein F1 ma-jd-viral-00383
Uncharacterized protein G1 ma-jd-viral-57951
Uncharacterized protein G2 ma-jd-viral-60090
Uncharacterized protein I2 ma-jd-viral-00385
Uncharacterized protein K1 ma-jd-viral-00379
Uncharacterized protein L1 ma-jd-viral-41639
Uncharacterized protein M1 ma-jd-viral-40837
Uncharacterized protein M2 ma-jd-viral-00380
Uncharacterized protein M3 ma-jd-viral-00381
Uncharacterized protein M4 ma-jd-viral-35479
Uncharacterized protein M5 ma-jd-viral-35997
Uncharacterized protein N1 ma-jd-viral-46056