Bracovirus

VIRION

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Enveloped, prolate ellipsoid form (ichnovirus) and cylindrical (bracovirus). Depending on the species, a virion contains one or several nucleocapsids.

GENOME

Segmented, circular supercoiled dsDNAs ranging from 2.0-31kb. Each virion contains multiple copies of the genome.

GENE EXPRESSION

REPLICATION

NUCLEAR

a) replicative: occurs in the calyx cells of the ovary.

  1. Excision and circularization of viral DNA in the ovary cells.
  2. Viral DNA synthesis.
  3. Appearance of viral envelopes and nucleocapsids in the nucleus.
  4. Mature virions are released into the lumen of the oviduct probably by lysis (brachovirus) or budding through the cell membrane (ichnovirus).

b) vegetative: occurs in all non-reproductive cells.

The viral genome is transmitted in proviral linear form integrated in the wasp's chromosomes. The virus DNA is replicated, just like any other part of the wasp's genome.

Host-virus interaction

Apoptosis modulation

PTP-H2 triggers mitochondrial membrane depolarization and caspase-dependent apoptosis suggesting that apoptosis is induced through a mitochondria-dependent death pathway.

NF-kappa-B modulation

Polydnavirus Ank proteins bind NF-kappa-B homodimers and inhibit processing of relish/NF-kappa-B p110 subunit .

Innate immune response inhibition

Microplitis demolitor cracovirus PTP-H2 and PTP-H3 are functional tyrosine phosphatases whose expression inhibit phagocytosis . Another protein, Glc1.8 is also involved in suppression of the insect cellular immune response .

Matching UniProtKB/Swiss-Prot entries

52 entries grouped by strain (browse by keywords)

52 entries

Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

Select_allDeselect_all
PTPJ4_MDBVW Probable tyrosine phosphatase protein J4 (PTP-J4) (EC 3.1.3.48)
PTPH4_MDBVW Probable tyrosine phosphatase protein H4 (PTP-H4) (EC 3.1.3.48)
PTPN3_MDBVW Tyrosine phosphatase-like protein N3 (PTP-N3)
PTPH1_MDBVW Tyrosine phosphatase-like protein H1 (PTP-H1)
PTPH2_MDBVW Tyrosine phosphatase H2 (PTP-H2) (EC 3.1.3.48)
PTPN2_MDBVW Tyrosine phosphatase-like protein N2 (PTP-N2)
PTPN1_MDBVW Probable tyrosine phosphatase protein N1 (PTP-N1) (EC 3.1.3.48)
PTPH5_MDBVW Tyrosine phosphatase-like protein H5 (PTP-H5)
YF1_MDBVW Uncharacterized protein F1
YK1_MDBVW Uncharacterized protein K1
YM3_MDBVW Uncharacterized protein M3
YA2_MDBVW Uncharacterized protein A2
YB1_MDBVW Putative BEN domain-containing protein B1
YE2_MDBVW Uncharacterized protein E2
YD3_MDBVW Uncharacterized protein D3
YG2_MDBVW Uncharacterized protein G2
YE1_MDBVW Uncharacterized protein E1
YG1_MDBVW Uncharacterized protein G1
PTPJ1_MDBVW Tyrosine phosphatase-like protein J1 (PTP-J1)
PTPJ3_MDBVW Tyrosine phosphatase-like protein J3 (PTP-J3)
PTPH3_MDBVW Tyrosine phosphatase H3 (PTP-H3) (EC 3.1.3.48)
PTPJ2_MDBVW Probable tyrosine phosphatase protein J2 (PTP-J2) (EC 3.1.3.48)
IKBH1_MDBVW I-Kappa-B like protein H1
YM1_MDBVW Uncharacterized protein M1
YM5_MDBVW Uncharacterized protein M5
YA1_MDBVW Uncharacterized protein A1
YL1_MDBVW Uncharacterized protein L1
YI2_MDBVW Uncharacterized protein I2
YD2_MDBVW Uncharacterized protein D2
YM2_MDBVW Uncharacterized protein M2
PTPD1_MDBVW Truncated tyrosine phosphatase D1 (PTP-D1)
EG15A_MDBVW Protease inhibitor Egf1.5a
IKBC1_MDBVW I-Kappa-B like protein C1
EG10_MDBVW Protease inhibitor Egf1.0
EG15B_MDBVW Protease inhibitor Egf1.5b
GL18B_MDBVW Mucin-like protein Glc1.8b (Glc1.8b)
IKBN3_MDBVW I-Kappa-B like protein N3
IKBJ1_MDBVW I-Kappa-B like protein J1
EG04A_MDBVW Probable protease inhibitor Egf0.4a
IKBC2_MDBVW I-Kappa-B like protein C2
IKBG1_MDBVW I-Kappa-B like protein G1
IKBG2_MDBVW I-Kappa-B like protein G2
GL18A_MDBVW Mucin-like protein Glc1.8a
IKBN1_MDBVW I-Kappa-B like protein N1
EG04B_MDBVW Probable protease inhibitor Egf0.4b
IKBI1_MDBVW I-Kappa-B like protein I1
IKBN2_MDBVW I-kappa-B like protein N2
IKBF1_MDBVW I-Kappa-B like protein F1
IKBF2_MDBVW I-Kappa-B like protein F2
YM4_MDBVW Uncharacterized protein M4
YC3_MDBVW Uncharacterized protein C3
YN1_MDBVW Uncharacterized protein N1