Ranavirus

VIRION

Polyhedral virions 120-350 nm in diameter. The capsid displays an icosahedral symmetry T=133 or 147, with an internal lipid membrane. Virions are either externally enveloped or not depending whether they budded from the cell membrane, or were arranged in paracrystaline array in the host cell cytoplasm and were released by lysis.

GENOME

Linear, dsDNA genome of 150-170 kb. The genome contains terminal and redundant sequences and is circularly permuted. Encodes for about 100 proteins.
Approximately 25% of the cytosine residues of the genome are methylated by a virus encoded DNA methyltransferase. However, there is at least one ranavirus, Singapore grouper iridovirus (SGIV), that lacks the DNA methyltransferase gene and cannot methylate its DNA.

GENE EXPRESSION

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Attachement of the viral proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the DNA core into the host cytoplasm.
  3. Viral DNA is transported to the cell nucleus where host macromolecular synthesis is rapidly shutdown. Transcription is initiated by virally modified host RNA polymerase II.
  4. Parental DNA is used to produce genome and greater than genome length DNA.
  5. Progeny DNA is transported into cytoplasmic viral factories where large concatamers of viral DNA are formed by recombination. Transcription of very late transcripts may also take place in the cytoplasm.
  6. Assembly of new virions in the cytoplasm.
  7. Virions exit the cell by budding or cell lysis.

Host-virus interaction

Apoptosis modulation

The grouper iridovirus (GIV) contains an antiapoptotic B-cell lymphoma (Bcl)-2-like gene that inhibits host apoptosis.

Matching UniProtKB/Swiss-Prot entries

99 entries grouped by strain (browse by keywords)

All proteins are shown (view only 98 complete proteome entries)

98 entries

Frog virus 3 (isolate Goorha) (FV-3) reference strain

Select_allDeselect_all
DPOL_FRG3G Putative DNA polymerase 060R (EC 2.7.7.7)
ICP18_FRG3G Immediate-early protein ICP-18
ICP46_FRG3G Immediate-early protein ICP-46
MCP_FRG3G Major capsid protein (MCP) (P50)
045L_FRG3G Uncharacterized protein 045L
047L_FRG3G Uncharacterized protein 047L
049L_FRG3G Putative SAP domain-containing protein 049L
088R_FRG3G Putative FAD-linked sulfhydryl oxidase 088R (EC 1.8.3.2)
010R_FRG3G Uncharacterized protein 010R
057R_FRG3G Putative phosphotransferase 057R
070R_FRG3G Uncharacterized protein 070R
074L_FRG3G Uncharacterized protein 074L
DUT_FRG3G Putative deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23)
DNK_FRG3G Putative deoxynucleoside kinase (EC 2.7.1.-)
042L_FRG3G Uncharacterized protein 042L
046L_FRG3G Uncharacterized protein 046L
048L_FRG3G Uncharacterized protein 048L
002L_FRG3G Uncharacterized protein 002L
005R_FRG3G Uncharacterized protein 005R
092R_FRG3G Uncharacterized protein 092R
007R_FRG3G Uncharacterized protein 007R
013R_FRG3G Uncharacterized protein 013R
017L_FRG3G Uncharacterized protein 017L
018L_FRG3G Uncharacterized protein 018L
096R_FRG3G Uncharacterized protein 096R
097R_FRG3G Uncharacterized protein 097R
098R_FRG3G Uncharacterized protein 098R
055R_FRG3G Uncharacterized protein 055R
024R_FRG3G Uncharacterized protein 024R
028R_FRG3G Uncharacterized protein 028R
065L_FRG3G Putative collagen-like domain-containing protein 065L
068R_FRG3G Putative uncharacterized protein 068R
032R_FRG3G Uncharacterized protein 032R
036L_FRG3G Uncharacterized protein 036L
006R_FRG3G Uncharacterized protein 006R
093L_FRG3G Uncharacterized protein 093L
051R_FRG3G Uncharacterized protein 051R
052L_FRG3G Uncharacterized protein 052L
053R_FRG3G Putative myristoylated protein 053R
011R_FRG3G Uncharacterized protein 011R
014R_FRG3G Uncharacterized protein 014R
056R_FRG3G Uncharacterized protein 056R
020R_FRG3G Uncharacterized protein 020R
059L_FRG3G Uncharacterized protein 059L
023R_FRG3G Uncharacterized protein 023R
033R_FRG3G Transmembrane protein 033R
071R_FRG3G Uncharacterized protein 071R
076R_FRG3G Uncharacterized protein 076R
078L_FRG3G Uncharacterized protein 078L
064R_FRG3G Caspase recruitment domain-containing protein 064R
029L_FRG3G Uncharacterized protein 029L
066L_FRG3G Uncharacterized protein 066L
069R_FRG3G Transmembrane protein 069R
031R_FRG3G Uncharacterized protein 031R
035L_FRG3G Uncharacterized protein 035L
079R_FRG3G Uncharacterized protein 079R
043R_FRG3G Uncharacterized protein 043R
001R_FRG3G Putative transcription factor 001R
081R_FRG3G Putative transcription elongation factor S-II-like protein 81R
086L_FRG3G Uncharacterized protein 086L
087L_FRG3G Uncharacterized protein 087L
003R_FRG3G Uncharacterized protein 3R
089R_FRG3G Uncharacterized protein 89R
094L_FRG3G Uncharacterized protein 094L
054L_FRG3G Uncharacterized protein 054L
095R_FRG3G Putative RAD2-like endonuclease 095R (EC 3.1.-.-)
015R_FRG3G Uncharacterized protein 015R
019R_FRG3G Putative serine/threonine-protein kinase 019R (EC 2.7.11.1)
021L_FRG3G Uncharacterized protein 021L
058R_FRG3G Uncharacterized protein 058R
027R_FRG3G Uncharacterized protein 027R
030R_FRG3G Uncharacterized protein 030R
037R_FRG3G uncharacterized protein 037R
075L_FRG3G Uncharacterized protein 075L
044R_FRG3G Uncharacterized protein 044R
084R_FRG3G Uncharacterized protein 084R
004R_FRG3G Uncharacterized protein 004R
050L_FRG3G Uncharacterized protein 050L
009L_FRG3G Putative helicase 009L (EC 3.6.4.-)
012L_FRG3G Uncharacterized protein 012L
055L_FRG3G Putative helicase 055L (EC 3.6.4.-)
061L_FRG3G Uncharacterized protein 061L
034R_FRG3G Uncharacterized protein 034R
072L_FRG3G Uncharacterized protein 072L
073L_FRG3G Uncharacterized protein 073L
039R_FRG3G Uncharacterized protein 039R
040R_FRG3G Uncharacterized protein 040R
041R_FRG3G Uncharacterized protein 041R
077L_FRG3G LCDV1 orf2-like protein
O22R_FRG3G Putative helicase 022R (EC 3.6.4.-)
RPB1_FRG3G Putative DNA-directed RNA polymerase 008R (EC 2.7.7.6)
RIR1_FRG3G Putative ribonucleoside-diphosphate reductase large subunit (EC 1.17.4.1) (Ribonucleotide reductase ...
RPB2_FRG3G Putative DNA-directed RNA polymerase II subunit RPB2 homolog (EC 2.7.7.6)
RNC_FRG3G Putative ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III)
RIR2_FRG3G Putative ribonucleoside-diphosphate reductase small subunit 067L (EC 1.17.4.1)
DNMT_FRG3G Putative DNA (cytosine-5)-methyltransferase (EC 2.1.1.37)
VP31_FRG3G Early 31 kDa protein (P31K)
VINT_FRG3G Integrase homolog

1 entry

Rana tigrina ranavirus

MCP_RTRV Major capsid protein (MCP) (P50)