Leishmaniavirus (taxid:39755)



Non enveloped, icosahedral virion composed of a single capsid protein (CP), about 33 nm in diameter. The capsid has a T=2* icosahedral symmetry.



Linear dsRNA genome of 5.3 kb. The genome has two large, overlapping ORFs on the positive strand respectively encoding CP and RdRp, and a small 5'-proximal potential ORF.


The dsRNA genome is never completely uncoated, to prevent activation of antiviral state by the cell in response to dsRNA. The viral polymerase synthesizes a mRNA, which is translocated to the cell cytoplasm where it is translated.
Translation is initiated on a unique internal ribosome entry site (IRES) element situated at the 5'-UTR.
L-A virus seems to furnish its transcript with a cap structure derived from host mRNAs by cap snatching . m(7)Gp from the cap donor is transferred to the 5' end of the viral transcript, thus preserving the 5' α-and β-phosphates of the transcript in the triphosphate linkage of the final product. The plus-strand viral transcript directs the translation of the major CP (Gag) and the minor fusion protein CP-RdRP (Gag-Pol) via a -1 ribosomal frameshift.




  1. Virus remains intracellular.
  2. Transcription of the dsRNA genome by viral polymerase occurs inside the virion, so that dsRNA is never exposed to the cytoplasm. This plus-strand transcript is used as template for translation.
  3. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  4. Mature virions may be transmitted to new cells during cell division.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

3 entries grouped by protein

1 entry

Major capsid protein (Major coat protein)

Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1) reference strain

1 entry

Putative ORF1 protein

Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1) reference strain

1 entry

Probable RNA-directed RNA polymerase (EC

Leishmania RNA virus 1 - 1 (isolate Leishmania guyanensis) (LRV-1-1) reference strain
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Leishmania RNA virus 1 - 4 taxid:12530

Protein ModelArchive
Major capsid protein ma-jd-viral-15397
RNA-directed RNA polymerase (EC ma-jd-viral-19849

Leishmania RNA virus 2 - 1 taxid:39116

Protein ModelArchive
Major capsid protein ma-jd-viral-15399
RNA-directed RNA polymerase (EC ma-jd-viral-19838

Leishmania aethiopica RNA virus taxid:1497019

Protein ModelArchive
ORF3 ma-jd-viral-15398
Putative capsid protein ma-jd-viral-15400
RNA-directed RNA polymerase (EC ma-jd-viral-19839