Sinsheimervirus (taxid:1910954)



Non-enveloped, round, T=1 icosahedral symmetry, about 30 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentomers. The virion is composed of 60 copies each of the F, G, and J proteins, and 12 copies of the H protein. There are 12 spikes which are each composed of 5 G and one H proteins.



Circular, ssDNA(+) genome of 4.4 to 6.1kb. replication occurs via dsDNA intermediate and rolling circle.


Early and late genes promoters tightly regulate the timing of gene expression, which is crucial for the replication cycle.




  1. The viral particle attaches to host cell by binding host lipopolysaccharides.
  2. The proteins of the capsid perform Injection of the viral DNA through bacterial membranes into cell cytoplasm.
  3. Host polymerase convert the (+)ssDNA viral genome into a covalently closed dsDNA called replicative form DNA I (RF-I).
  4. Early viral genes are transcribed by host RNA polymerase, producing viral replication proteins.
  5. Viral protein A cleaves RF-I(+) DNA strand at the origin of replication and covalently attaches itself to the DNA.
  6. (+)strand replication occurs by rolling circle, which is converted to dsDNA by host polymerase, generating RF-II molecules (amplification of RF-I).
  7. Late viral genes are transcribed by host RNA polymerase.
  8. Procapsid assembly in the cytoplasm.
  9. Viral protein C binds to replication complex, inducing synthesis and packaging of neo-synthesized (+)ssDNA genomes (RF-III) into procapsids.
  10. Procapsids maturation occurs in host cytoplasm
  11. Mature virions are released from the cell by lysis.

Matching UniProtKB/Swiss-Prot entries

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20 entries grouped by strain

10 entries

Enterobacteria phage phiX174 (Isolate Sanger) (Bacteriophage phi-X174) reference strain

REPA_BPPHS Replication-associated protein A (EC 3.1.21.-) (EC (RepA)
SCAFB_BPPHS Internal scaffolding protein B (EC 3.4.-.-) (Scaffolding protein B) (GPB)
LYS_BPPHS Lysis protein E (Protein E) (GPE)
CAPSD_BPPHS Capsid protein F (F protein) (GPF)
G_BPPHS Major spike protein G (G protein) (GPG)
H_BPPHS Minor spike protein H (H protein) (Pilot protein)
SCAFD_BPPHS External scaffolding protein D (Scaffolding protein D) (GPD)
J_BPPHS DNA-binding protein J (J protein) (Small core protein)
C_BPPHS Protein C
K_BPPHS Protein K

10 entries

Enterobacteria phage S13 (Bacteriophage S13)

VGA_BPS13 A' protein (GPA)
SCAFB_BPS13 Internal scaffolding protein B (EC 3.4.-.-) (Scaffolding protein B) (GPB)
LYS_BPS13 Lysis protein (E protein) (GPE)
CAPSD_BPS13 Capsid protein F (F protein) (GPF)
G_BPS13 Major spike protein G (G protein) (GPG)
VGH_BPS13 Minor spike protein (H protein) (Pilot protein)
SCAFD_BPS13 External scaffolding protein D (Scaffolding protein D) (GPD)
VGJ_BPS13 Small core protein (J protein)
VGC_BPS13 C protein
VGK_BPS13 K protein