Epsilontorquevirus (taxid:687335)



Non-enveloped, T=1 icosahedral symmetry, with a diameter of about 30-32nm.


Circular ssDNA genome (-) genome of about 3.8 kb.
The genome is replicated through double-stranded intermediates. It may encode for 4 proteins: ORF1 (Rep protein?), ORF2, ORF3 and ORF4.


The proteins are expressed by alternative splicing of pre-mRNA.



  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. The ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. viral mRNAs are transcribed and translated to produce viral proteins.
  5. Replication may be mediated by a "Rep-like" protein, and would occur by rolling circle producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

4 entries grouped by strain

4 entries

Torque teno tamarin virus (isolate So-TTV2) reference strain

CAPSD_TTVE1 Capsid protein
ORF4_TTVE1 Uncharacterized ORF4 protein
ORF3_TTVE1 Uncharacterized ORF3 protein
ORF2_TTVE1 Uncharacterized ORF2 protein
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Torque teno tamarin virus (isolate So-TTV2) taxid:766186

Protein ModelArchive
Capsid protein ma-jd-viral-04572
Uncharacterized ORF2 protein ma-jd-viral-46204
Uncharacterized ORF3 protein ma-jd-viral-54555
Uncharacterized ORF4 protein ma-jd-viral-60626