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Inhibition of host MHC class I molecule presentation by virus (kw:KW-1115)

After successful loading with antigenic peptide and survival of the ER quality control, the MHC class I molecules must go on to the plasma membrane in order to be reconized by cytotoxic lymphocytes.

K3 K5 us11 us2 mK3 m06 nef U21 ORF66

Many viruses "intercept" the loaded MHC class I molecules and either retain it in the endoplasmic reticulum or target it to degradation in order to avoid presentation of the peptides at the cell surface. US2 and US11 of HCMV and mK3 form mouse herpesvirus 68 target human MHC class I molecules for degradation through the ERAD pathway. Other viral proteins including U21 from HHV-7 and m06 from MCMV mediate targeting of MHC molecules to the lysosomes and subsequent degradation. VZV ORF66 downregulates MHC I expression by impairing the transport of MHC I molecules from the Golgi compartment to the cell surface.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
MHC escape Inhibition of proteasome processing
Inhibition of host MHC class I
Inhibition of host MHC class II
Inhibition of host TAP
Inhibition of host tapasin
Links Uniprot Keyword: KW-1115
GO ontology: GO:0046776
Virus -HIV
(Retroviridae ,Lentivirus)
-Human cytomegalovirus (HHV-5)
(Herpesviridae ,Cytomegalovirus)
-Mouse herpesvirus 68
(Herpesviridae ,Rhadinovirus)
-HHV-7
(Herpesviridae ,Roseolovirus)
-Varicella Zoster virus
(Herpesviridae ,Varicellovirus)
-Mouse cytomegalovirus
(Herpesviridae ,Cytomegalovirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

60 entries grouped by strain

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

BILF1_EBVB9 G-protein coupled receptor BILF1 (GPCR BILF1)

pdb 7JHJ

1 entry

Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain

P12I_HTL1C Accessory protein p12I

1 entry

Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1) reference strain

P12I_HTL1A Accessory protein p12I

1 entry

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

US11_HCMVA Unique short US11 glycoprotein (Protein HXLF1) (gpUS11)

pdb 8FRT; 8FU4

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

US11_HCMVM Membrane glycoprotein US11

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

NEF_HV1MA Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3W0W; 3WL9

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1) reference strain

NEF_HV1U4 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) reference strain

NEF_HV1A2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3RBB; 3REA; 3REB; 4ORZ; 4U1K; 4U1L; 4U1M; 4U1N; 4U5W; 5XOV; 6B72; 7D7S; 8F2P

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain

NEF_HV1BR Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1AVV; 1AVZ; 1EFN; 4D8D; 6URI

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

NEF_HV1H2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3RL2; 4NEE; 4WU5; 4WU7; 5HGA; 5HGB; 5HGD; 5HGH; 7K80; 7K81; 7YG3; 8GVB; 8GVG; 8GVI; 9BL9; 9BLA

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain

NEF_HV1MN Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1) reference strain

NEF_HV1RH Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1) reference strain

NEF_HV1B9 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1) reference strain

NEF_HV192 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain

NEF_HV1ET Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain

NEF_HV1EL Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1) reference strain

NEF_HV193 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain

NEF_HV1VI Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain

NEF_HV190 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain

NEF_HV1YF Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain

NEF_HV1AN Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3WLB

1 entry

Human papillomavirus type 16 reference strain

VE5_HPV16 Probable protein E5

1 entry

Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

MIR1_MHV68 E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.36) (MK3) (Modulator of immune recognition 1 homolog) ...

1 entry

Myxoma virus (strain Lausanne) (MYXV) reference strain

LAP_MYXVL E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

LAP_RFVKA E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) reference strain

NS7A_SARS2 ORF7a protein (ORF7a) (Accessory protein 7a) (Protein U122) (Protein X4)

pdb 6W37; 7CI3

1 entry

Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVCZ Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVEK Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVMB Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

US03_VZVD Serine/threonine-protein kinase US3 homolog (Protein kinase ORF66) (EC 2.7.11.1)

1 entry

Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

LAP_YMTV5 E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate Z321) (HIV-1)

NEF_HV1ZH Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)

NEF_HV1B1 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1ZEC; 3TB8

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)

NEF_HV1B8 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)

NEF_HV1BN Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

NEF_HV1H3 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)

NEF_HV1JR Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)

NEF_HV1LW Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 2NEF

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)

NEF_HV1OY Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)

NEF_HV112 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1QA4; 1QA5; 1ZEC

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)

NEF_HV1SC Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)

NEF_HV1S1 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)

NEF_HV1S3 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)

NEF_HV1Y2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)

NEF_HV1ND Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)

NEF_HV1Z6 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1QVO

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)

NEF_HV1MP Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)

NEF_HV1M2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)

NEF_HV19N Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)

NEF_HV1SE Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)

NEF_HV1V9 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)

NEF_HV1S9 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)

NEF_HV1S2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)

NEF_HV196 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)

NEF_HV197 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)

NEF_HV1YB Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)

NEF_HV1MV Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Lumpy skin disease virus (LSDV)

LAP_LSDV E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Swinepox virus (strain Kasza) (SWPV)

LAP_SWPVK E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...

1 entry

Yaba-like disease virus (YLDV)

LAP_YLDV E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...