Related to: Hepatitis delta
Location: Host cell nucleus.
Transcription events: The editing of HDV RNA consists of the replacement of one single nucleotide (A to I) that occurs post-transcriptionally on HDV antigenomic RNA . This modification results in a transcriptional readthrough and production of the large delta antigen HDAg-L, since a tryptophan replaces an amber (STOP) codon in the sequence. Cellular double-stranded RNA adenosine deaminase 1 (ADAR1) carries out this change in the antigenomic RNA , and it requires the secondary structure of HDV antigenome. The edited antigenomic RNA is not infectious.
Renxiang Chen, Sarah D Linnstaedt, John L Casey
Viruses January 2010; 2: 131-146
J L Casey, J L Gerin
J. Virol. December 1995; 69: 7593-7600
John L Casey
Curr. Top. Microbiol. Immunol. 2012; 353: 123-143
|Genus||Virus||Number of substitutions||Protein||%||Sequence||Position||Reference|
|Deltavirus||Hepatitis delta virus||1 A to G||SHDAg / LHDAg||-||CCAUAGGAU||1016-1006 (antigenomic)|