Inhibition of host autophagy by virus (kw:KW-1083)

Autophagy is an evolutionary conserved mechanism for the sequestration and subsequent lysosomal degradation of discrete intracellular portions of eukaryotic cells, facilitating the removal of materials not degraded through the ubiquitin-proteasome pathway. In addition, autophagy plays important roles in innate and adaptive immune responses to pathogens.

Several viruses have develop ways to subvert the pathway for their own benefit in order to avoid the immune response or to increase their viral replication. Beclin-1 is an essential autophagy protein and constitutes the major target for manipulation of autophagy by viruses. For example, HHV-1 ICP34.5 binds to Beclin-1 and inhibits autophagosome formation. HIV and Influenza A virus use the same mechanism through Nef and M2 respectively, that also interact with and inhibit host Beclin-1.

Viral molecular biology Virion
Virus entry
Virus latency
Transcription and replication
Host-virus interactions
Virus exit
Autophagy modulation Autophagy activation
Autophagy inhibition
Links Uniprot Keyword: KW-1083
GO ontology: GO:0039521
Virus -Kaposis sarcoma herpes
(Herpesviridae ,Rhadinovirus)
-Human cytomegalovirus
(Herpesviridae ,Cytomegalovirus)
-Herpes virus 1
(Herpesviridae ,Simplexvirus)
-HIV
(Retroviridae ,Lentivirus)
-Influenza A
(Pneumoviridae ,Pneumovirus)

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

175 entries grouped by strain

2 entries

Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

Select_allDeselect_all
RNB_HHV11 Accessory factor US11 (Vmw21)
ICP34_HHV11 Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

2 entries

Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Select_allDeselect_all
ICP34_HHV2H Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)
RNB_HHV2H Probable RNA-binding protein

1 entry

African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain

ARBH_ASFB7 Apoptosis regulator Bcl-2 homolog

pdb 5UA4; 5UA5; 6TZC

1 entry

Barley stripe mosaic virus (BSMV) reference strain

VSR_BSMV Suppressor of RNA silencing (Gamma-B protein) (Gammab protein)

1 entry

Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain

EAR_EBVA8 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)

pdb 2WH6; 4OYD

1 entry

Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

EAR_EBVB9 Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)

pdb 1Q59; 2XPX; 7P33; 7P9W; 8SM5

1 entry

Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5) reference strain

TRS1_HCMVA Protein HHLF1

1 entry

Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5) reference strain

TRS1_HCMVM Protein TRS1

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

NEF_HV1MA Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3W0W; 3WL9

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1) reference strain

NEF_HV1U4 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1) reference strain

NEF_HV1A2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3RBB; 3REA; 3REB; 4ORZ; 4U1K; 4U1L; 4U1M; 4U1N; 4U5W; 5XOV; 6B72; 7D7S; 8F2P

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain

NEF_HV1BR Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1AVV; 1AVZ; 1EFN; 4D8D; 6URI

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

NEF_HV1H2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3RL2; 4NEE; 4WU5; 4WU7; 5HGA; 5HGB; 5HGD; 5HGH; 7K80; 7K81; 7YG3; 8GVB; 8GVG; 8GVI

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1) reference strain

NEF_HV1JR Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain

NEF_HV1MN Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1) reference strain

NEF_HV192 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain

NEF_HV1ET Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain

NEF_HV1EL Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1) reference strain

NEF_HV190 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1) reference strain

NEF_HV1YF Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain

NEF_HV1AN Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 3WLB

1 entry

Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain

M2_I96A0 Matrix protein 2 (Proton channel protein M2)

pdb 6BKK; 6BKL; 6BMZ; 6BOC

1 entry

Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain

M2_I34A1 Matrix protein 2 (Proton channel protein M2)

pdb 5DLM

1 entry

Molluscum contagiosum virus subtype 1 (MOCV) (MCVI) reference strain

CFLA_MCV1 Viral CASP8 and FADD-like apoptosis regulator (v-CFLAR) (Viral FLICE-inhibitory protein) (v-FLIP)

pdb 2BBR; 2BBZ; 2F1S

1 entry

Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

ARBH_MHV68 Apoptosis regulator Bcl-2 homolog (vBcl-2) (Protein M11)

pdb 2ABO; 3BL2; 3DVU; 4MI8

1 entry

Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVCZ Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVEK Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

NEF_SIVMB Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)

ARBH_ASFK5 Apoptosis regulator Bcl-2 homolog

1 entry

Epstein-Barr virus (strain GD1) (HHV-4) (Human gammaherpesvirus 4)

EAR_EBVG Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)

pdb 2V6Q

1 entry

Human herpesvirus 1 (strain CVG-2) (HHV-1) (Human herpes simplex virus 1)

ICP34_HHV1D Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

1 entry

Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

ICP34_HHV1F Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

1 entry

Human herpesvirus 1 (strain MGH-10) (HHV-1) (Human herpes simplex virus 1)

ICP34_HHV1N Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

1 entry

Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

RNB_HHV1M RNA-binding protein (Vmw21)

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate Z321) (HIV-1)

NEF_HV1ZH Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1)

NEF_HV1B1 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1ZEC; 3TB8

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH8) (HIV-1)

NEF_HV1B8 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRVA) (HIV-1)

NEF_HV1BN Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB3) (HIV-1)

NEF_HV1H3 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)

NEF_HV1LW Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 2NEF

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)

NEF_HV1OY Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate PCV12) (HIV-1)

NEF_HV112 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1QA4; 1QA5; 1ZEC

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)

NEF_HV1RH Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SC) (HIV-1)

NEF_HV1SC Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF162) (HIV-1)

NEF_HV1S1 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate SF33) (HIV-1)

NEF_HV1S3 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)

NEF_HV1Y2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)

NEF_HV1B9 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)

NEF_HV1ND Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)

NEF_HV1Z6 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

pdb 1QVO

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)

NEF_HV193 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1)

NEF_HV1VI Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)

NEF_HV1MP Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)

NEF_HV1M2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)

NEF_HV19N Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)

NEF_HV1SE Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)

NEF_HV1V9 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)

NEF_HV1S9 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)

NEF_HV1S2 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)

NEF_HV196 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)

NEF_HV197 Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)

NEF_HV1YB Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)

NEF_HV1MV Protein Nef (3'ORF) (Negative factor) (F-protein) [Cleaved into: C-terminal core protein]

1 entry

Influenza A virus (strain A/Aichi/2/1968 H3N2)

M2_I68A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)

M2_I60A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Bangkok/1/1979 H3N2)

M2_I79A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Beijing/353/1989 H3N2)

M2_I89A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Beijing/39/1975 H3N2)

M2_I75A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Brazil/11/1978 H1N1)

M2_I77AA Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))

M2_I18A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)

M2_I77AG Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)

M2_I02A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)

M2_I97A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)

M2_I02A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)

M2_I02A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)

M2_I01A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)

M2_I02A5 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/FY150/2001 H5N1 genotype D)

M2_I01A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)

M2_I02A6 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Hong Kong/YU562/2001 H5N1 genotype B)

M2_I01A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)

M2_I83A5 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)

M2_I83A6 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)

M2_I59A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)

M2_I03A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)

M2_I85A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chicken/Weybridge H7N7) (Influenza A virus (strain A/FPV/Weybridge H7N7))

M2_I000F Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Chile/1/1983 H1N1)

M2_I83A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)

M2_I96A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)

M2_I56A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Duck/England/1/1956 H11N6)

M2_I56A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Duck/Germany/1949 H10N7)

M2_I49A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)

M2_I80A6 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)

M2_I00A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/England/878/1969 H3N2)

M2_I69A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Equine/Alaska/1/1991 H3N8)

M2_I91A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Equine/Jillin/1/1989 H3N8)

M2_I89A7 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Equine/Kentucky/1/1981)

M2_I81A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Equine/Kentucky/2/1986 H3N8)

M2_I86A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Equine/New Market/1/1977 H7N7)

M2_I77A9 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Equine/New Market/1979 H3N8)

M2_I79A6 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)

M2_I56A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)

M2_I86A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Fort Warren/1/1950 H1N1)

M2_I50A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)

M2_I34A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)

M2_I05A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)

M2_I79A7 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Gull/Maryland/1815/1979 H13N6)

M2_I79A8 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Gull/Maryland/1824/1978 H13N6)

M2_I78AF Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)

M2_I77AF Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Gull/Massachusetts/26/1980 H13N6)

M2_I80AC Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)

M2_I80AD Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Henry/1936 H1N1)

M2_I36A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Hickox/1940 H1N1)

M2_I40A0 Matrix protein 2 (Proton channel protein M2)

pdb 5JOO; 5TTC; 5UM1

1 entry

Influenza A virus (strain A/Hong Kong/1/1968 H3N2)

M2_I68A4 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)

M2_I97A1 Matrix protein 2 (Proton channel protein M2)

pdb 2KAD; 2KQT; 3C9J; 3LBW; 4RWB; 4RWC; 6MPL; 6MPM; 6MPN

1 entry

Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)

M2_I03A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Hong Kong/5/1983 H3N2)

M2_I83A8 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/India/6263/1980 H1N1)

M2_I80AA Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Japan/305/1957 H2N2)

M2_I57A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Korea/426/1968 H2N2)

M2_I68A5 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)

M2_I57A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Leningrad/134/1957 H2N2)

M2_I57A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)

M2_I57A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)

M2_I54A2 Matrix protein 2 (Proton channel protein M2)

pdb 8BDZ; 8BER

1 entry

Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)

M2_I78A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Memphis/1/1971 H3N2)

M2_I71A1 Matrix protein 2 (Proton channel protein M2)

pdb 6OUG

1 entry

Influenza A virus (strain A/Memphis/101/1972 H3N2)

M2_I72A4 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Memphis/102/1972 H3N2)

M2_I72A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Memphis/110/1976 H3N2)

M2_I76A6 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Memphis/18/1978 H3N2)

M2_I78A8 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Memphis/2/1978 H3N2)

M2_I78A7 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Memphis/4/1980 H3N2)

M2_I80A4 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Memphis/8/1988 H3N2)

M2_I88A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))

M2_I68A6 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Philippines/2/1982 H3N2)

M2_I82A9 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)

M2_I73A5 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Qu/7/1970 H3N2)

M2_I70A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)

M2_I06A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7)

M2_I80A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Shearwater/Australia/1972 H6N5)

M2_I72A5 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)

M2_I01A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)

M2_I02A4 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Singapore/1/1957 H2N2)

M2_I57A5 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/29/1937 H1N1)

M2_I37A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)

M2_I77A4 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/Hong Kong/127/1982 H3N2)

M2_I82A7 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)

M2_I30A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/Iowa/17672/1988 H1N1)

M2_I88A5 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/May/1954 H1N1)

M2_I54A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/Netherlands/12/1985 H1N1)

M2_I85A4 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/Ontario/2/1981 H1N1)

M2_I81A4 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)

M2_I77AC Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)

M2_I61A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)

M2_I67A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Tokyo/3/1967 H2N2)

M2_I67A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)

M2_I83A4 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)

M2_I78AC Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)

M2_I80A8 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)

M2_I68A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)

M2_I66A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Turkey/Oregon/1971 H7N3)

M2_I71A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)

M2_I66A1 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/USA:Albany/12/1951 H1N1)

M2_I51A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)

M2_I45A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/USA:Iowa/1943 H1N1)

M2_I43A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)

M2_I96A2 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/USA:Phila/1935 H1N1)

M2_I35A3 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/USSR/90/1977 H1N1)

M2_I77AB Matrix protein 2 (Proton channel protein M2)

pdb 1NYJ; 2H95

1 entry

Influenza A virus (strain A/Udorn/1972 H3N2)

M2_I72A8 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Udorn/307/1972 H3N2)

M2_I72A2 Matrix protein 2 (Proton channel protein M2)

pdb 1MP6; 2KIH; 2KWX; 2L0J; 2N70; 2RLF; 4QK7; 4QKC; 4QKL; 4QKM; 5C02; 8H3C

1 entry

Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))

M2_I33A0 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/Wisconsin/3523/1988 H1N1)

M2_I88A7 Matrix protein 2 (Proton channel protein M2)

1 entry

Influenza A virus (strain A/X-31 H3N2)

M2_I000X Matrix protein 2 (Proton channel protein M2)