Alefpapillomavirus (taxid:2169650)



Non-enveloped. Small, icosahedral, about 60 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.



Circular dsDNA, about 5.7 kb in size, associated with cellular histones.


Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing :
a) Early Proteins: non-structural regulatory proteins (E1-E2), and possibls 0RF1-3.
b) Late Proteins: the structural proteins L1 and L2.



Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into the host cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Viral genome replication.
  5. Transcription of the late region.
  6. Capsid proteins L1 and L2 synthesis.
  7. Nuclear capsid assembly and release of viruses.
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Sparus aurata papillomavirus 1 taxid:1885928

Protein ModelArchive
E1 ma-jd-viral-57623
E2 ma-jd-viral-61039
L2 ma-jd-viral-65408
Major capsid protein L1 ma-jd-viral-67343
Major capsid protein L1 ma-jd-viral-63243
SORF1 ma-jd-viral-31873
SORF2 ma-jd-viral-59014
SORF3 ma-jd-viral-55027
Uncharacterized protein ma-jd-viral-42254