Suppressor of RNA silencing (kw:KW-0941)

RNA-mediated gene silencing (also known as RNA interference, RNAi) is a conserved sequence-specific gene regulation system, which has an essential role in the maintenance of cell genome integrity, and, in higher plants and insects, it also operates as an adaptive inducible antiviral defense mechanism. It consists in sequence-specific recognition and inhibition of target genes expression by endogenous (gene, development, stress response regulation) or virus-derived short silencing RNAs (sRNAs) .

Target genes expression can be inhibited post-translationally (post-transcriptional gene silencing or PTGS): target dsRNAs are recognized by Dicer-like enzymes (DCL) and diced into small interfering RNAs duplexes (siRNA) of about 21- to 24-nt, which interact with Argonaute (AGO) proteins and associated proteins to form RNA-induced complexes (RISCs) to target homologous RNAs for destruction. PTGS can also be performed by endogenous microRNAs (miRNAs). miRNAs differ from siRNAs in that they are encoded by cellular genes and generally base pair imperfectly with homologous RNAs to target them for destruction or inhibit their translation.

Target genes expression can also be inhibited by heavy methylation of concerned DNA loci (transcriptional gene silencing or TGS).

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To counteract host RNAi antiviral defense, viruses from almost all plant virus genera (and also from some animal viruses) encode viral suppressors of RNA silencing (VSRs) which inhibit key steps of cellular RNAi system . They are often multifunctional and play important roles in viral replication, coating, movement, and pathogenesis, in addition to suppressing host RNA silencing-based antiviral immunity.


VSRs suppress RNA silencing pathways mainly:

-through dsRNA binding. Sequestering siRNA duplexes prevents small RNA loading into the AGO effector proteins to assemble the RNA-induced silencing complex (RISC). Sequestering long dsRNA duplexes inhibits siRNA biogenesis.

-by interacting with and inhibiting components of the host RISC machinery.

-by inhibiting enzymes necessary for host cell-mediated DNA methylation.

Family/Genus Virus Viral proteins Reference Mechanism of action
Alphaflexiviridae, Potexvirus Triple gene block protein 1 -
Betaflexiviridae, Carlavirus Potato virus M Triple gene block protein 1, ORF6 Sequesters siRNA duplexes (ORF6)
Betaflexiviridae, Citrivirus Citrus leaf blotch virus Movement protein
Betaflexiviridae, Trichovirus Apple chlorotic leaf spot virus 50 kDa movement protein
Betaflexiviridae, Vitivirus Grapevine virus A ORF5 p10 Sequesters siRNA duplexes
Bromoviridae, Cucumovirus Cucumber mosaic virus Protein 2b sequestering siRNA and long dsRNA
Tomato aspermy virus Protein 2b Sequesters siRNA duplexes
Bromoviridae, Ilarvirus Tobacco streak virus Protein 2b - -
Bunyaviridae, Tospovirus Tomato spotted wilt virus NSs Sequesters both long dsRNA and double-stranded siRNA or miRNA
Closteroviridae, Closterovirus Beet yellows virus P21 Sequesters siRNA duplexes
Citrus tristeza virus p23, capsid protein, p20 -
Closteroviridae, Crinivirus Sweet potato chlorotic stunt virus P22 Sequesters siRNA duplexes
Tomato chlorosis virus P22 Sequesters siRNA duplexes
Dicistroviridae, Cripavirus Drosophila C virus DCV-1A Sequesters long dsRNA and inhibits siRNA biogenesis
Cricket paralysis virus CrPV-1A Interaction with Argonaute 2 and inhibition of RISC
Geminiviridae, Begomovirus Mungbean yellow mosaic virus-Vigna TrAP/AC2 -
Tomato leaf curl Java virus V2 -
Tomato leaf curl China virus V2 ?Sequesters siRNA duplexes
Tomato yellow leaf curl virus C4 -
Luteoviridae , Polerovirus Beet western yellows virus P0 protein Targets AGO1 to degradation
Luteoviridae, Enamovirus Pea enation mosaic virus-1 P0 protein Targets AGO1 to degradation
Nanoviridae , Babuvirus Banana bunchy top virus Clink , MP -
Nodaviridae, Alphanodavirus Flock house virus B2 protein Interaction with Dicer leads to suppression of siRNA biogenesis
Nodaviridae, Alphanodavirus Flock house virus B2 protein Interaction with Dicer leads to suppression of siRNA biogenesis
Nodamura virus B2 protein Interaction with Dicer leads to suppression of siRNA biogenesis
Potyviridae, Potyvirus HC-Pro Prevents accumulation of siRNA
Potyviridae, Ipomovirus Cucumber vein yellowing virus P1b protein Sequesters siRNA duplexes
Potyviridae, Poacevirus Triticum mosaic virus P1 protein -
Potyviridae, Tritimovirus Wheat streak mosaic virus P1 protein -
Reoviridae, Phytoreovirus Rice gall dwarf virus Pns11, Pns12 -
Rice dwarf virus Pns10 -
Reoviridae, Oryzavirus Rice ragged stunt virus Pns6 -
Rice dwarf virus Pns10 -
Secoviridae, Comovirus Cowpea mosaic virus small capsid protein -
Tenuivirus Rice stripe virus NS3 Sequesters siRNA duplexes
Sobemovirus Cocksfoot mottle virus P1
Rice yellow mottle virus P1
Tombusviridae, Tombusvirus Carnation Italian ringspot virus p19 Sequesters siRNA duplexes
Tombusviridae, Aureusvirus Pothos latent virus Protein p14 Sequesters both long dsRNA and double-stranded siRNA
Tombusviridae, Dianthovirus Red clover necrotic mosaic virus MP -
Tombusviridae, Carmovirus Turnip crinkle virus Capsid protein P38 Competes for and inhibits Argonaute 1
Tymoviridae, Tymovirus Turnip yellow mosaic virus p69 -
Virgaviridae, Furovirus Soil-borne wheat mosaic virus P19 -
Virgaviridae, Pecluvirus Peanut clump virus P15 -
Virgaviridae, Hordeivirus Barley stripe mosaic virus Gamma-B -
Virgaviridae, tobamovirus Tobacco mosaic virus Small replicase subunit -
Virgaviridae, Tobravirus Tobacco rattle virus P16 -
Hypovirus Cryphonectria hypovirus 1 P29 -

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

298 entries grouped by protein

4 entries

Suppressor of silencing 2b (Protein 2b)

Select_allDeselect_all
2B_CMVFN
Cucumber mosaic virus (strain FNY) (CMV) reference strain
2B_TAV
Tomato aspermy virus (TAV) reference strain
2B_TOBSV
Tobacco streak virus (strain WC) (TSV) reference strain
2B_CMVQ
Cucumber mosaic virus (strain Q) (CMV)

19 entries

Protein AC4 (Protein AL4)

Select_allDeselect_all
AC4_ABMVW
Abutilon mosaic virus (isolate West India) (AbMV) reference strain
AC4_BCTVC
Beet curly top virus (strain California/Logan) (BCTV) reference strain

Protein C4 (Protein L4)

AC4_BGYMJ
Bean golden yellow mosaic virus (isolate Puerto Rico-Japan) (BGYMV) reference strain
AC4_BGYMV
Bean golden yellow mosaic virus (isolate Puerto Rico) (BGYMV) (Bean golden mosaic virus (isolate Puerto Rico)) reference strain
AC4_ICMV
Indian cassava mosaic virus (ICMV) reference strain
AC4_MYMVV
Mungbean yellow mosaic virus (strain Vigna) (MYMV) reference strain
AC4_PHUV
Pepper huasteco yellow vein virus (PHYVV) (Pepper huasteco virus) reference strain
AC4_SLCV
Squash leaf curl virus (SLCV) reference strain
AC4_TLCVA
Tomato leaf curl virus (strain Australia) (ToLCV) reference strain

Protein C4 (10.9 kDa protein) (Protein L4)

AC4_TPCTV
Tomato pseudo-curly top virus (TPCTV) reference strain

Protein C4 (Protein L4)

AC4_TYCSV
Tomato yellow leaf curl Sardinia virus (TYLCSV) reference strain

Protein C4 (11.1 kDa protein) (Protein L4)

AC4_TYLCC
Tomato yellow leaf curl China virus (TYLCCNV) reference strain

Protein C4 (10.9 kDa protein) (Protein L4)

AC4_TYLCI
Tomato yellow leaf curl virus (strain Israel) (TYLCV) reference strain

Protein C4 (10.9 kDa protein) (Protein L4)

AC4_CALCV
Cabbage leaf curl virus (isolate Jamaica) (CaLCuV)
AC4_CLVK
African cassava mosaic virus (isolate West Kenyan 844) (ACMV) (Cassava latent virus (isolate West Kenyan 844))
AC4_CLVN
African cassava mosaic virus (isolate Nigerian) (ACMV) (Cassava latent virus (isolate Nigerian))
AC4_PYMVV
Potato yellow mosaic virus (isolate Venezuela) (PYMV)
AC4_TYCS1
Tomato yellow leaf curl Sardinia virus (isolate Spain-1) (TYLCSV)

Protein C4 (10.9 kDa protein) (Protein L4)

AC4_TYCS2
Tomato yellow leaf curl Sardinia virus (isolate Spain-2) (TYLCSV)

Protein C4 (10.9 kDa protein) (Protein L4)

10 entries

Protein V2

Select_allDeselect_all
AV2_ICMV
Indian cassava mosaic virus (ICMV) reference strain

Protein AV2

AV2_MYMVV
Mungbean yellow mosaic virus (strain Vigna) (MYMV) reference strain

Protein AV2

AV2_TLCVA
Tomato leaf curl virus (strain Australia) (ToLCV) reference strain
AV2_TYCSV
Tomato yellow leaf curl Sardinia virus (TYLCSV) reference strain
AV2_TYLCC
Tomato yellow leaf curl China virus (TYLCCNV) reference strain
AV2_TYLCI
Tomato yellow leaf curl virus (strain Israel) (TYLCV) reference strain
AV2_CLVK
African cassava mosaic virus (isolate West Kenyan 844) (ACMV) (Cassava latent virus (isolate West Kenyan 844))

Protein AV2

AV2_CLVN
African cassava mosaic virus (isolate Nigerian) (ACMV) (Cassava latent virus (isolate Nigerian))

Uncharacterized 13.1 kDa protein

AV2_TYCS1
Tomato yellow leaf curl Sardinia virus (isolate Spain-1) (TYLCSV)
AV2_TYCS2
Tomato yellow leaf curl Sardinia virus (isolate Spain-2) (TYLCSV)

4 entries

Protein B2

Select_allDeselect_all
B2_NODAM
Nodamura virus (strain Mag115) (NoV) reference strain
B2_BBV
Black beetle virus (BBV)
B2_BOOLV
Boolarra virus (BoV)
B2_FHV
Flock house virus (FHV)

2 entries

Protein C2 (Protein L2)

Select_allDeselect_all
C2_BCTVC
Beet curly top virus (strain California/Logan) (BCTV) reference strain
C2_TPCTV
Tomato pseudo-curly top virus (TPCTV) reference strain

1 entry

Capsid protein (Coat protein) (p38)

CAPSD_TCV
Turnip crinkle virus (TCV) reference strain

1 entry

Cell cycle link protein (Clink)

CLINK_BBTVA
Banana bunchy top virus (isolate Autralia) (BBTV) reference strain

1 entry

Putative movement protein (MP) (Cell-to-cell transport protein)

MOVP_CLBVS
Citrus leaf blotch virus (isolate Nagami kumquat/France/SRA-153/1984) (CLBV) reference strain

4 entries

Movement protein (MP)

Select_allDeselect_all
MP_ACLSP
Apple chlorotic leaf spot virus (isolate plum P863) (ACLSV) reference strain

Putative movement protein (50.8 kDa protein) (ORF2 protein)

MP_CRSVL
Carnation ringspot virus (isolate Lommel) (CRSV) reference strain
MP_RCNMV
Red clover necrotic mosaic virus (RCNMV) reference strain
MP_ACLSA
Apple chlorotic leaf spot virus (isolate apple) (ACLSV)

Putative movement protein (50.4 kDa protein) (ORF2 protein)

30 entries

P3N-PIPO polyprotein

Select_allDeselect_all
MVP_BBTVA
Banana bunchy top virus (isolate Autralia) (BBTV) reference strain

Movement and RNA silencing protein (MP)

MVP_BYDVP
Barley yellow dwarf virus (isolate PAV) (BYDV) reference strain

Movement protein (MP) (17 kDa protein)

MVP_CFMVN
Cocksfoot mottle virus (isolate Dactylis glomerata/Norway/CfMV-NO/1995) (CfMV) reference strain

Movement protein P1 (Cell-to-cell transport protein)

MVP_PVYN
Potato virus Y (strain N) (PVY) reference strain
MVP_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

Movement and RNA silencing protein VP6

MVP_SBMVA
Southern bean mosaic virus (isolate Bean/United States/Arkansas) (SBMV) reference strain

Movement protein P1 (Cell-to-cell transport protein)

MVP_SBMVN
Soybean mosaic virus (strain N) (SMV) reference strain
MVP_SCPMV
Southern cowpea mosaic virus (SCPMV) (Southern bean mosaic virus (strain cowpea)) reference strain

Movement protein P1 (Cell-to-cell transport protein)

MVP_TUMVJ
Turnip mosaic virus (strain Japanese) (TuMV) reference strain
MVP_BCMNN
Bean common mosaic necrosis virus (strain NL-3) (BCMNV) (Bean common mosaic virus serotype A (strain NL-3))
MVP_BTMV
Beet mosaic virus (BtMV)
MVP_BYMV
Bean yellow mosaic virus
MVP_LMV0
Lettuce mosaic virus (strain 0 / isolate French) (LMV)
MVP_LMVE
Lettuce mosaic virus (strain E) (LMV)
MVP_PEMVC
Pepper mottle virus (isolate California) (PeMV) (PepMoV C)
MVP_PEMVM
Peanut mottle virus (strain M)
MVP_PPVD
Plum pox potyvirus (strain D) (PPV)
MVP_PPVNA
Plum pox potyvirus (isolate NAT) (PPV)
MVP_PPVSK
Plum pox potyvirus (strain SK 68) (PPV)
MVP_PRSVH
Papaya ringspot virus (strain P / mutant HA)
MVP_PSBMV
Pea seed-borne mosaic virus (strain DPD1)
MVP_PVMA
Potato virus A (PVA)
MVP_PVYHU
Potato virus Y (strain Hungarian) (PVY)
MVP_SBMVG
Soybean mosaic virus (strain G2) (SMV)
MVP_TEV
Tobacco etch virus (TEV)
MVP_TUMVQ
Turnip mosaic virus (strain Quebec) (TuMV)
MVP_TVMV
Tobacco vein mottling virus (TVMV)
MVP_ZYMVC
Zucchini yellow mosaic virus (strain California) (ZYMV)
MVP_ZYMVR
Zucchini yellow mosaic virus (strain Reunion Island) (ZYMV)
MVP_ZYMVS
Zucchini yellow mosaic virus (strain Singapore) (ZYMV)

2 entries

Non-structural protein NS-S

Select_allDeselect_all
NSS_TSWV1
Tomato spotted wilt virus (strain Brazilian Br-01) (TSWV) reference strain
NSS_TSWVL
Tomato spotted wilt virus (strain Bulgarian L3) (TSWV)

4 entries

Suppressor of silencing P0 (28 kDa protein) (Protein ORF0)

Select_allDeselect_all
P0_PEMVW
Pea enation mosaic virus-1 (strain WSG) (PEMV-1) reference strain

Suppressor of silencing P0 (ORF0 protein)

P0_PLRV1
Potato leafroll virus (strain Potato/Scotland/strain 1/1984) (PLrV) reference strain
P0_TYYVF
Turnip yellows virus (isolate FL-1) (TuYV) (BWYV-FL1) reference strain

Suppressor of silencing P0 (29 kDa protein) (Protein ORF0)

P0_PLRVW
Potato leafroll virus (strain Potato/Netherlands/Wageningen/1989) (PLrV)

1 entry

RNA silencing suppressor p14

P14_POLVP
Pothos latent virus (isolate Pigeonpea/India) (PoLV) reference strain

14 entries

RNA silencing suppressor p19 (19 kDa symptom severity modulator)

Select_allDeselect_all
P19_TBSVC
Tomato bushy stunt virus (strain Cherry) (TBSV) reference strain
P19_AMCV
Artichoke mottled crinkle virus (AMCV)
P19_CIRV
Carnation Italian ringspot virus (CIRV)
P19_CNV
Cucumber necrosis virus (CNV)
P19_CRV
Cymbidium ringspot virus (CymRSV)
P19_HARV
Havel river virus (HaRV)
P19_PENSV
Pelargonium necrotic spot virus (PeNSV)
P19_PLV
Pear latent virus (PeLV)
P19_TBSV8
Tomato bushy stunt virus (strain B8) (TBSV)
P19_TBSVA
Tomato bushy stunt virus (strain A23) (TBSV)
P19_TBSVB
Tomato bushy stunt virus (strain BS-3) (TBSV)
P19_TBSVJ
Tomato bushy stunt virus (strain Ja6) (TBSV)
P19_TBSVK
Tomato bushy stunt virus (strain Ja9) (TBSV)
P19_TBSVT
Tomato bushy stunt virus (strain type) (TBSV)

1 entry

RNA silencing suppressor (21 kDa protein) (p21)

P21_BYVU
Beet yellows virus (isolate Ukraine) (BYV) (Sugar beet yellows virus) reference strain

1 entry

Early 35 kDa protein (Apoptosis-preventing protein) (p35)

P35_NPVAC
Autographa californica nuclear polyhedrosis virus (AcMNPV) reference strain

3 entries

69 kDa protein (p69)

Select_allDeselect_all
P69_TYMV
Turnip yellow mosaic virus reference strain
P69_TYMVA
Turnip yellow mosaic virus (isolate Australia)
P69_TYMVC
Turnip yellow mosaic virus (isolate TYMC)

7 entries

RNA2 polyprotein (119kDa protein) (Genome polyprotein M)

Select_allDeselect_all
POL2_CPMVS
Cowpea mosaic virus (strain SB) (CPMV) reference strain

RNA2 polyprotein (Genome polyprotein M) (M RNA polyprotein) (Middle component RNA polyprotein) (P2)

POL2_APMV
Andean potato mottle virus (APMV)

RNA2 polyprotein (Genome polyprotein M) (M RNA polyprotein) (Middle component RNA polyprotein) (P2)

POL2_BBWV2
Broad bean wilt virus 2 (BBWV-2)
POL2_BPMV
Bean-pod mottle virus (strain Kentucky G7) (BPMV)

RNA2 polyprotein (Genome polyprotein M) (M RNA polyprotein) (Middle component RNA polyprotein) (P2)

POL2_CPSMV
Cowpea severe mosaic virus (strain DG) (CPSMV)

RNA2 polyprotein (Genome polyprotein M) (M RNA polyprotein) (Middle component RNA polyprotein) (P2)

POL2_RCMV
Red clover mottle virus (RCMV)

RNA2 polyprotein (Genome polyprotein M) (M RNA polyprotein) (Middle component RNA polyprotein) (P2)

POL2_SQMVM
Squash mosaic virus (strain melon) (SqMV)

RNA2 polyprotein (Genome polyprotein M) (M RNA polyprotein) (Middle component RNA polyprotein) (P2)

2 entries

Polyprotein p69 (ORFA polyprotein)

Select_allDeselect_all
POLA_CHPVE
Cryphonectria hypovirus 1 (strain EP713) (CHV-1/EP713) (Chestnut blight fungus hypovirulence-associated virus) reference strain
POLA_CHPVU
Cryphonectria hypovirus 1 (strain Euro7) (CHV-1/Euro7) (Chestnut blight fungus hypovirulence-associated virus)

85 entries

Genome polyprotein

Select_allDeselect_all
POLG_BSTV1
Brome streak virus (strain 11-Cal) (BStV) (Brome streak mosaic rymovirus) reference strain
POLG_BVY3
Blackberry virus Y (isolate Blackberry plant/USA:Arkansas/C3ARK/2005) (BVY) reference strain
POLG_DEN1W
Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain
POLG_PVYN
Potato virus Y (strain N) (PVY) reference strain
POLG_RGMVD
Ryegrass mosaic virus (isolate Denmark/Danish) (RGMV) reference strain
POLG_SBMVN
Soybean mosaic virus (strain N) (SMV) reference strain
POLG_SPMMV
Sweet potato mild mottle virus (isolate Salazar) (SPMMV) reference strain
POLG_TRMVU
Triticum mosaic virus (isolate Triticum aestivum/United States/U06-123/2006) (TriMV) reference strain
POLG_TUMVJ
Turnip mosaic virus (strain Japanese) (TuMV) reference strain
POLG_YEFV1
Yellow fever virus (strain 17D vaccine) (YFV) reference strain
POLG_ALKV
Alkhumra hemorrhagic fever virus (ALKV) (Alkhurma hemorrhagic fever virus)
POLG_BANV
Banzi virus (BANV)
POLG_BCMNN
Bean common mosaic necrosis virus (strain NL-3) (BCMNV) (Bean common mosaic virus serotype A (strain NL-3))
POLG_BTMV
Beet mosaic virus (BtMV)
POLG_BUSV
Bussuquara virus (BUSV)
POLG_BYMV
Bean yellow mosaic virus
POLG_DEN1S
Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)
POLG_DEN26
Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)
POLG_DEN27
Dengue virus type 2 (strain 16681-PDK53) (DENV-2)
POLG_DEN28
Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)
POLG_DEN2J
Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)
POLG_DEN2N
Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)
POLG_DEN2P
Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)
POLG_DEN2Q
Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)
POLG_DEN3C
Dengue virus type 3 (strain China/80-2/1980) (DENV-3)
POLG_DEN3I
Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)
POLG_DEN3M
Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)
POLG_DEN3P
Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)
POLG_DEN3S
Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)
POLG_DEN4D
Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)
POLG_DEN4H
Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)
POLG_DEN4P
Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)
POLG_DEN4S
Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)
POLG_DEN4T
Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)
POLG_EHV
Edge Hill virus (EHV)
POLG_ILHV
Ilheus virus (ILHV)
POLG_JAEV1
Japanese encephalitis virus (strain SA-14) (JEV)
POLG_JAEV5
Japanese encephalitis virus (strain SA(v)) (JEV)
POLG_JAEVJ
Japanese encephalitis virus (strain Jaoars982) (JEV)
POLG_JAEVM
Japanese encephalitis virus (strain M28) (JEV)
POLG_KFDV
Kyasanur forest disease virus (KFDV)
POLG_KOKV
Kokobera virus (KOKV)
POLG_KUNJM
Kunjin virus (strain MRM61C)
POLG_LANVT
Langat virus (strain TP21)
POLG_LIV
Louping ill virus (Li)
POLG_LMV0
Lettuce mosaic virus (strain 0 / isolate French) (LMV)
POLG_LMVE
Lettuce mosaic virus (strain E) (LMV)
POLG_MVEV5
Murray valley encephalitis virus (strain MVE-1-51) (MVEV)
POLG_OHFV
Omsk hemorrhagic fever virus (OHFV)
POLG_PEMVC
Pepper mottle virus (isolate California) (PeMV) (PepMoV C)
POLG_PEMVM
Peanut mottle virus (strain M)
POLG_POWVL
Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)
POLG_PPVD
Plum pox potyvirus (strain D) (PPV)
POLG_PPVNA
Plum pox potyvirus (isolate NAT) (PPV)
POLG_PPVRA
Plum pox potyvirus (strain Rankovic) (PPV)
POLG_PPVSK
Plum pox potyvirus (strain SK 68) (PPV)
POLG_PRSVH
Papaya ringspot virus (strain P / mutant HA)
POLG_PSBMV
Pea seed-borne mosaic virus (strain DPD1)
POLG_PVMA
Potato virus A (PVA)
POLG_PVYHU
Potato virus Y (strain Hungarian) (PVY)
POLG_ROCV
Rocio virus (ROCV)
POLG_SBMVG
Soybean mosaic virus (strain G2) (SMV)
POLG_TBEVH
Tick-borne encephalitis virus (strain Hypr) (TBEV)
POLG_TBEVS
Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)
POLG_TBEVW
Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)
POLG_TEV
Tobacco etch virus (TEV)
POLG_TUMVQ
Turnip mosaic virus (strain Quebec) (TuMV)
POLG_TVMV
Tobacco vein mottling virus (TVMV)
POLG_USUV
Usutu virus (USUV)
POLG_WNV
West Nile virus (WNV)
POLG_WNV9
West Nile virus (strain NY-99) (WNV) (West Nile virus (strain NY-1999))
POLG_WSLV
Wesselsbron virus (WSLV)
POLG_YEFVA
Yellow fever virus (strain Ghana/Asibi/1927) (YFV)
POLG_YEFVC
Yellow fever virus (isolate Ivory Coast/1999) (YFV)
POLG_YEFVE
Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)
POLG_YEFVF
Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)
POLG_YEFVI
Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)
POLG_YEFVN
Yellow fever virus (isolate Angola/14FA/1971) (YFV)
POLG_YEFVT
Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)
POLG_YEFVU
Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)
POLG_ZIKVF
Zika virus (isolate ZIKV/Human/French Polynesia/10087PF/2013) (ZIKV)
POLG_ZYMVC
Zucchini yellow mosaic virus (strain California) (ZYMV)
POLG_ZYMVR
Zucchini yellow mosaic virus (strain Reunion Island) (ZYMV)
POLG_ZYMVS
Zucchini yellow mosaic virus (strain Singapore) (ZYMV)

2 entries

Replicase polyprotein

Select_allDeselect_all
POLN_CRPVC
Cricket paralysis virus (isolate Teleogryllus commodus/Australia/CrPVVIC/1968) (CrPV) reference strain
POLN_DCVEB
Drosophila C virus (strain EB) (DCV)

21 entries

Replicase large subunit (EC 2.1.1.-) (EC 2.7.7.-) (EC 2.7.7.48) (EC 3.6.4.13) (183 kDa protein) (RNA-directed RNA polymerase)

Select_allDeselect_all
RDRP_CGMVS
Cucumber green mottle mosaic virus (strain watermelon SH) (CGMMV) reference strain

Replicase large subunit (EC 2.7.7.48) (186 kDa protein)

RDRP_RCNMV
Red clover necrotic mosaic virus (RCNMV) reference strain

RNA-directed RNA polymerase (EC 2.7.7.48) (Protein p88)

RDRP_SHMV
Sunn-hemp mosaic virus (SHMV) (TMV strain cowpea) reference strain
RDRP_TMV
Tobacco mosaic virus (strain vulgare) (TMV) (Tobacco mosaic virus (strain U1)) reference strain
RDRP_TVCV
Turnip vein-clearing virus (TVCV) reference strain
RDRP_YOMV
Youcai mosaic virus (YoMV) reference strain

Replicase large subunit (EC 2.7.7.48) (182 kDa protein)

RDRP_ORSVC
Odontoglossum ringspot virus (isolate Korean Cy) (ORSV-Cy)
RDRP_ORSVS
Odontoglossum ringspot virus (isolate Singapore 1) (ORSV)
RDRP_PMMVJ
Pepper mild mottle virus (strain Japan) (PMMV-J)
RDRP_PMMVS
Pepper mild mottle virus (strain Spain) (PMMV-S)
RDRP_TBRFV
Tomato brown rugose fruit virus (isolate TOBRFV/Tomato/Jordan/Tom1-Jo/2015) (ToBRFV)
RDRP_TMGMV
Tobacco mild green mosaic virus (TMGMV) (TMV strain U2)
RDRP_TMOB
Tobamovirus Ob
RDRP_TMVB
Tobacco mosaic virus (strain B935A) (TMV)
RDRP_TMVKR
Tobacco mosaic virus (strain Korean NC 82) (TMV)
RDRP_TMVOM
Tobacco mosaic virus (strain OM) (TMV)
RDRP_TMVRA
Tobacco mosaic virus (strain Rakkyo) (TMV-R)
RDRP_TOMK1
Tomato mosaic virus (strain Kazakh K1) (ToMV) (TMV strain K1)
RDRP_TOMK2
Tomato mosaic virus (strain Kazakh K2) (ToMV) (TMV strain K2)
RDRP_TOML
Tomato mosaic virus (strain L) (ToMV) (TMV strain tomato)
RDRP_TOMS1
Tomato mosaic virus (strain S-1) (ToMV)

21 entries

Movement and silencing protein TGBp1 (25 kDa protein) (Silencing suppressor P25) (Triple gene block 1 protein) (TGBp1)

Select_allDeselect_all
TGB1_ASPVP
Apple stem pitting virus (isolate PA66) (ASPV) reference strain
TGB1_FXMV
Foxtail mosaic virus reference strain
TGB1_ICRSV
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV) reference strain
TGB1_LOLV
Lolium latent virus (isolate Lolium/USA/US1/-) (LoLV) reference strain
TGB1_NMV
Narcissus mosaic virus (NMV) reference strain
TGB1_P1AMV
Plantago asiatica mosaic potexvirus (P1AMV) reference strain
TGB1_PMV
Papaya mosaic potexvirus (PMV) reference strain
TGB1_PVMR
Potato virus M (strain Russian) (PVM) reference strain
TGB1_PVXX3
Potato virus X (strain X3) (PVX) reference strain
TGB1_SHVX
Shallot virus X (ShVX) reference strain
TGB1_SMYEA
Strawberry mild yellow edge-associated virus (SMYEaV) reference strain
TGB1_WCMVM
White clover mosaic virus (strain M) (WCMV) reference strain
TGB1_CVB
Chrysanthemum virus B (CVB)
TGB1_LSV
Lily symptomless virus (LSV)
TGB1_LVX
Lily virus X
TGB1_POPMV
Poplar mosaic virus (isolate ATCC Pv275) (PMV)
TGB1_PVSP
Potato virus S (strain Peruvian)
TGB1_PVX
Potato virus X (PVX)
TGB1_PVXCP
Potato virus X (strain CP) (PVX)
TGB1_PVXHB
Potato virus X (strain HB) (PVX)
TGB1_WCMVO
White clover mosaic virus (strain O) (WCMV)

19 entries

Transcriptional activator protein (TrAP) (Protein AC2) (Protein AL2)

Select_allDeselect_all
TRAP_ABMVW
Abutilon mosaic virus (isolate West India) (AbMV) reference strain
TRAP_BGYMJ
Bean golden yellow mosaic virus (isolate Puerto Rico-Japan) (BGYMV) reference strain

Transcriptional activator protein (TrAP) (19.6 kDa protein) (Protein AC2) (Protein AL2)

TRAP_BGYMV
Bean golden yellow mosaic virus (isolate Puerto Rico) (BGYMV) (Bean golden mosaic virus (isolate Puerto Rico)) reference strain

Transcriptional activator protein (TrAP) (19.6 kDa protein) (Protein AC2) (Protein AL2)

TRAP_ICMV
Indian cassava mosaic virus (ICMV) reference strain
TRAP_MYMVV
Mungbean yellow mosaic virus (strain Vigna) (MYMV) reference strain
TRAP_PHUV
Pepper huasteco yellow vein virus (PHYVV) (Pepper huasteco virus) reference strain
TRAP_SLCV
Squash leaf curl virus (SLCV) reference strain
TRAP_TLCVA
Tomato leaf curl virus (strain Australia) (ToLCV) reference strain

Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)

TRAP_TYCSV
Tomato yellow leaf curl Sardinia virus (TYLCSV) reference strain

Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)

TRAP_TYLCC
Tomato yellow leaf curl China virus (TYLCCNV) reference strain

Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)

TRAP_TYLCI
Tomato yellow leaf curl virus (strain Israel) (TYLCV) reference strain

Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)

TRAP_CALCV
Cabbage leaf curl virus (isolate Jamaica) (CaLCuV)
TRAP_CLVK
African cassava mosaic virus (isolate West Kenyan 844) (ACMV) (Cassava latent virus (isolate West Kenyan 844))

Transcriptional activator protein (TrAP) (15.2 kDa protein) (Protein AC2) (Protein AL2)

TRAP_CLVN
African cassava mosaic virus (isolate Nigerian) (ACMV) (Cassava latent virus (isolate Nigerian))

Transcriptional activator protein (TrAP) (15.2 kDa protein) (Protein AC2) (Protein AL2)

TRAP_PYMVV
Potato yellow mosaic virus (isolate Venezuela) (PYMV)
TRAP_TGMVY
Tomato golden mosaic virus (strain Yellow vein) (TGMV)
TRAP_TMOV
Tomato mottle virus (isolate Florida) (ToMoV)
TRAP_TYCS1
Tomato yellow leaf curl Sardinia virus (isolate Spain-1) (TYLCSV)

Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)

TRAP_TYCS2
Tomato yellow leaf curl Sardinia virus (isolate Spain-2) (TYLCSV)

Transcriptional activator protein (TrAP) (Protein C2) (Protein L2)

5 entries

Transcriptional activator VP30 (EbolaVP30) (eVP30) (Minor nucleoprotein VP30)

Select_allDeselect_all
VP30_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

Transcriptional activator VP30 (Ebola VP30) (eVP30) (Minor nucleoprotein VP30)

VP30_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP30_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
VP30_EBOSU
Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus)
VP30_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)

5 entries

Polymerase cofactor VP35

Select_allDeselect_all
VP35_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

Polymerase cofactor VP35 (Ebola VP35) (eVP35)

VP35_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP35_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
VP35_EBOSU
Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus)
VP35_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)

Polymerase cofactor VP35 (Ebola VP35) (eVP35)

6 entries

Matrix protein VP40 (Ebola VP40) (eVP40) (Membrane-associated protein VP40)

Select_allDeselect_all
VP40_EBOZM
Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain
VP40_EBOG4
Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)
VP40_EBORE
Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)
VP40_EBORR
Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus)
VP40_EBOSU
Sudan ebolavirus (strain Human/Uganda/Gulu/2000) (SEBOV) (Sudan Ebola virus)
VP40_EBOZ5
Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)

23 entries

Suppressor of RNA silencing p3 (Protein NS3) (Protein p3)

Select_allDeselect_all
VSR_BNYVS
Beet necrotic yellow vein virus (isolate Japan/S) (BNYVV) reference strain

Probable suppressor of RNA silencing (14kD cysteine rich protein) (P14)

VSR_BSMV
Barley stripe mosaic virus (BSMV) reference strain

Suppressor of RNA silencing (Gamma-B protein) (Gammab protein)

VSR_GVAIS
Grapevine virus A (isolate Is 151) (GVA) reference strain

RNA silencing suppressor

VSR_PCV87
Peanut clump virus (isolate 87/TGTA2) (PCV) reference strain

Suppressor of RNA silencing (15kD cysteine rich protein) (P15)

VSR_PNLV
Poinsettia latent virus (isolate Euphorbia pulcherrima/Germany/Siepen/2005) (PnLV) (Poinsettia cryptic virus) reference strain

Putative suppressor of silencing

VSR_PVMR
Potato virus M (strain Russian) (PVM) reference strain

RNA silencing suppressor (10.7 kDa protein) (Putative nucleic acid-binding protein)

VSR_RGDV
Rice gall dwarf virus (RGDV) reference strain

Suppressor of RNA-mediated gene silencing (Non-structural protein 11) (Pns11)

VSR_RSVT
Rice stripe virus (isolate T) (RSV) reference strain
VSR_SBWMN
Soil-borne wheat mosaic virus (strain United States/Nebraska/1981) (SBWMV) reference strain

Suppressor of RNA silencing (19kD cysteine rich protein) (P19)

VSR_TRVPP
Tobacco rattle virus (isolate PpK20) (TRV) reference strain

Suppressor of RNA silencing (16kD cysteine rich protein) (P16)

VSR_CLV
Carnation latent virus (CLV)

RNA silencing suppressor (11.6 kDa protein) (Putative nucleic acid-binding protein)

VSR_CVB
Chrysanthemum virus B (CVB)

RNA silencing suppressor (12.6 kDa protein) (Putative nucleic acid-binding protein)

VSR_HELVS
Helenium virus S (HelVS)

RNA silencing suppressor (12.6 kDa protein) (Putative nucleic acid-binding protein)

VSR_LSV
Lily symptomless virus (LSV)

RNA silencing suppressor (16 kDa protein) (ORF6 protein) (Putative nucleic acid-binding protein)

VSR_MSTV
Maize stripe virus (MStV)
VSR_POPMV
Poplar mosaic virus (isolate ATCC Pv275) (PMV)

RNA silencing suppressor (14 kDa protein) (Putative nucleic acid-binding protein)

VSR_PVMG
Potato virus M (strain German) (PVM)

RNA silencing suppressor (12 kDa protein) (Cysteine-rich protein) (CRP) (Nucleic acid-binding regulatory protein) (PR12)

VSR_PVSP
Potato virus S (strain Peruvian)

RNA silencing suppressor (10.7 kDa protein) (Putative nucleic acid-binding protein)

VSR_RDVA
Rice dwarf virus (isolate Akita) (RDV)

Suppressor of RNA-mediated gene silencing (Non-structural protein 10) (Pns10)

VSR_RDVO
Rice dwarf virus (isolate O) (RDV)

Suppressor of RNA-mediated gene silencing (Non-structural protein 10) (Pns10)

VSR_RHBVC
Rice hoja blanca virus (strain cr) (RHBV) (Rice hoja blanca virus (strain Costa Rica))
VSR_RSVM
Rice stripe virus (isolate M) (RSV)
VSR_WTV
Wound tumor virus (WTV)

Suppressor of RNA-mediated gene silencing (Non-structural protein 10) (Pns10)