SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor.
Hoffmann M, Kleine-Weber H, Schroeder S, Kr?ger N, Herrler T, Erichsen S, Schiergens TS, Herrler G, Wu NH, Nitsche A, M?ller MA, Drosten C, P?hlmann S.
Cell. 2020 Apr 16;181(2):271-280
A potential role for integrins in host cell entry by SARS-CoV-2.
Sigrist CJ, Bridge A, Le Mercier P.
Antiviral Res. 2020 May;177:104759
A potential role for integrins in host cell entry by SARS-CoV-2.
Sigrist CJ, Bridge A, Le Mercier P.
Antiviral Res. 2020 May;177:104759
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E.
Antiviral Res. 2020 Apr;176:104742
Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.
Taylor JK, Coleman CM, Postel S, Sisk JM, Bernbaum JG, Venkataraman T, Sundberg EJ, Frieman MB.
J Virol. 2015 Dec;89(23):11820-33
SARS-CoV accessory protein 7a directly interacts with human LFA-1.
H?nel K, Willbold D.
Biol Chem. 2007 Dec;388(12):1325-32.
Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT.
Fielding BC, Gunalan V, Tan TH, Chou CF, Shen S, Khan S, Lim SG, Hong W, Tan YJ.
Biochem Biophys Res Commun. 2006 May 19;343(4):1201-8
The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis.
Teoh KT, Siu YL, Chan WL, Schl?ter MA, Liu CJ, Peiris JS, Bruzzone R, Margolis B, Nal B.
Mol Biol Cell. 2010 Nov 15;21(22):3838-52
Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling.
Zhao X, Nicholls JM, Chen YG.
J Biol Chem. 2008 Feb 8;283(6):3272-80
Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.
Cornillez-Ty CT, Liao L, Yates JR 3rd, Kuhn P, Buchmeier MJ.
J Virol. 2009 Oct;83(19):10314-8
The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.
Xu L, Khadijah S, Fang S, Wang L, Tay FP, Liu DX.
J Virol. 2010 Sep;84(17):8571-83.
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.
Frieman M, Yount B, Heise M, Kopecky-Bromberg SA, Palese P, Baric RS.
J Virol. 2007 Sep;81(18):9812-24
Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Chengrong Liu, Xin Wang, Xing Yang, Ping Wu, Zixuan Xiao, Yafei Qu, Yue Yin, Joyce Fu, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu, Qiming Liang
Biorxiv, April 2, 2020.
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Gordon DE, Jang GM, Bouhaddou M, Xu J, Obernier K, White KM, O’Meara MJ, Rezelj VV, Guo JZ, Swaney DL, Tummino TA, Huettenhain R, Kaake RM, Richards AL, Tutuncuoglu B, Foussard H, Batra J, Haas K, Modak M, Kim M, Haas P, Polacco BJ, Braberg H, Fabius JM, Eckhardt M, Soucheray M, Bennett MJ, Cakir M, McGregor MJ, Li Q, Meyer B, Roesch F, Vallet T, Mac Kain A, Miorin L, Moreno E, Naing ZZC, Zhou Y, Peng S, Shi Y, Zhang Z, Shen W, Kirby IT, Melnyk JE, Chorba JS, Lou K, Dai SA, Barrio-Hernandez I, Memon D, Hernandez-Armenta C, Lyu J, Mathy CJP, Perica T, Pilla KB, Ganesan SJ, Saltzberg DJ, Rakesh R, Liu X, Rosenthal SB, Calviello L, Venkataramanan S, Liboy-Lugo J, Lin Y, Huang XP, Liu Y, Wankowicz SA, Bohn M, Safari M, Ugur FS, Koh C, Savar NS, Tran QD, Shengjuler D, Fletcher SJ, O’Neal MC, Cai Y, Chang JCJ, Broadhurst DJ, Klippsten S, Sharp PP, Wenzell NA, Kuzuoglu D, Wang HY, Trenker R, Young JM, Cavero DA, Hiatt J, Roth TL, Rathore U, Subramanian A, Noack J, Hubert M, Stroud RM, Frankel AD, Rosenberg OS, Verba KA, Agard DA, Ott M, Emerman M, Jura N, von Zastrow M, Verdin E, Ashworth A, Schwartz O, d’Enfert C, Mukherjee S, Jacobson M, Malik HS, Fujimori DG, Ideker T, Craik CS, Floor SN, Fraser JS, Gross JD, Sali A, Roth BL, Ruggero D, Taunton J, Kortemme T, Beltrao P, Vignuzzi M, Garc?a-Sastre A, Shokat KM, Shoichet BK, Krogan NJ.
Nature. 2020 Apr 30.
