SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically
Proven Protease Inhibitor.
Hoffmann M, Kleine-Weber H, Schroeder S, Kr?ger N, Herrler T, Erichsen S,
Schiergens TS, Herrler G, Wu NH, Nitsche A, M?ller MA, Drosten C, P?hlmann S.
Cell. 2020 Apr 16;181(2):271-280
A potential role for integrins in host cell entry by SARS-CoV-2.
Sigrist CJ, Bridge A, Le Mercier P.
Antiviral Res. 2020 May;177:104759
A potential role for integrins in host cell entry by SARS-CoV-2.
Sigrist CJ, Bridge A, Le Mercier P.
Antiviral Res. 2020 May;177:104759
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E.
Antiviral Res. 2020 Apr;176:104742
Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.
Taylor JK, Coleman CM, Postel S, Sisk JM, Bernbaum JG, Venkataraman T, Sundberg EJ, Frieman MB.
J Virol. 2015 Dec;89(23):11820-33
SARS-CoV accessory protein 7a directly interacts with human LFA-1.
H?nel K, Willbold D.
Biol Chem. 2007 Dec;388(12):1325-32.
Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT.
Fielding BC, Gunalan V, Tan TH, Chou CF, Shen S, Khan S, Lim SG, Hong W, Tan YJ.
Biochem Biophys Res Commun. 2006 May 19;343(4):1201-8
The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis.
Teoh KT, Siu YL, Chan WL, Schl?ter MA, Liu CJ, Peiris JS, Bruzzone R, Margolis B, Nal B.
Mol Biol Cell. 2010 Nov 15;21(22):3838-52
Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling.
Zhao X, Nicholls JM, Chen YG.
J Biol Chem. 2008 Feb 8;283(6):3272-80
Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.
Cornillez-Ty CT, Liao L, Yates JR 3rd, Kuhn P, Buchmeier MJ.
J Virol. 2009 Oct;83(19):10314-8
The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.
Xu L, Khadijah S, Fang S, Wang L, Tay FP, Liu DX.
J Virol. 2010 Sep;84(17):8571-83.
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.
Frieman M, Yount B, Heise M, Kopecky-Bromberg SA, Palese P, Baric RS.
J Virol. 2007 Sep;81(18):9812-24
Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Chengrong Liu, Xin Wang, Xing Yang, Ping Wu, Zixuan Xiao, Yafei Qu, Yue Yin, Joyce Fu, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu, Qiming Liang
Med (N Y) 2020 Jul 21.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, H?ttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesb?lle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR 3rd, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH Jr, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D; QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL; Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, Garc?a-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ.
Science 2020 Oct 15
Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system
Ludovico Cantuti-Castelvetri, Ravi Ojha, Liliana D. Pedro, Minou Djannatian, Jonas Franz, Suvi Kuivanen, Katri Kallio, Tu?berk Kaya, Maria Anastasina, Teemu Smura, Lev Levanov, Leonora Szirovicza, Allan Tobi, Hannimari Kallio-Kokko, Pamela ?sterlund, Merja Joensuu, Fr?d?ric A. Meunier, Sarah Butcher, Martin Sebastian Winkler, Brit Mollenhauer, Ari Helenius, Ozgun Gokce, Tambet Teesalu, Jussi Hepojoki, Olli Vapalahti, Christine Stadelmann, Giuseppe Balistreri, Mikael Simons
SARS-CoV-2 invades host cells via a novel route: CD147-spike protein
Ke Wang, Wei Chen, Yu-Sen Zhou, Jian-Qi Lian, Zheng Zhang, Peng Du, Li Gong, Yang Zhang, Hong-Yong Cui, Jie-Jie Geng, Bin Wang, Xiu-Xuan Sun, Chun-Fu Wang, Xu Yang, Peng Lin, Yong-Qiang Deng, Ding Wei, Xiang-Min Yang, Yu-Meng Zhu, Kui Zhang, Zhao-Hui Zheng, Jin-Lin Miao, Ting Guo, Ying Shi, Jun Zhang, Ling Fu, Qing-Yi Wang, Huijie Bian, Ping Zhu, Zhi-Nan Chen
The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection
Brandon Beddingfield, Naoki Iwanaga, Wenshu Zheng, Chad J Roy, Tony Y Hu, Jay Kolls, Gregory Bix
JACC Basic Transl Sci. 2020 Oct 16.
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
Thoms M, Buschauer R, Ameismeier M, et al.
Science. 2020;eabc8665.
Neuropilin-1 is a host factor for SARS-CoV-2 infection
Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Ant?n-Pl?garo C, Shoemark DK, Sim?n-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi
Science 2020 Nov 13;370(6518):861-865.
Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives
Ritesh Tandon, Joshua S Sharp, Fuming Zhang, Vitor H Pomin , Nicole M Ashpole, Dipanwita Mitra, Martin G McCandless, Weihua Jin, Hao Liu, Poonam Sharma, Robert J Linhardt
J Virol
. 2021 Jan 13;95(3)
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
Alexey Stukalov, Virginie Girault, Vincent Grass, Ozge Karayel, Valter Bergant, Christian Urban, Darya A Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M Sabri Hamad, Antonio Piras, Fynn M Hansen, Maria C Tanzer, Igor Paron, Luca Zinzula, Thomas Enghleitner, Maria Reinecke, Teresa M Lavacca, Rosina Ehmann, Roman W?lfel, J?rg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volker Thiel, Pietro Scaturro , Matthias Mann, Andreas Pichlmair
Nature
. 2021 Apr 12.
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
Guangyan Miao, Hongyu Zhao, Yan Li, Mingming Ji, Yong Chen, Yi Shi, Yuhai Bi, Peihui Wang, Hong Zhang
Dev Cell. 2021 Feb 22;56(4):427-442
SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70
Jiang H.W., Zhang H.N., Meng Q.F., Xie J., Li Y., Chen H., Zheng Y.X., Wang X.N., Qi H., Zhang J., Wang P.H., Han Z.G., Tao S.C.
Cell Mol Immunol 17:998-1000(2020)
No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor
Jarrod Shilts, Thomas W M Crozier, Edward J D Greenwood, Paul J Lehner, Gavin J Wright
Sci Rep. 2021 Jan 11;11(1):413
Interactions of Severe Acute Respiratory Syndrome Coronavirus 2 Protein E With Cell Junctions and Polarity PSD-95/Dlg/ZO-1-Containing Proteins
Yanlei Zhu, Flavio Alvarez, Nicolas Wolff 1 Ariel Mehaly , Sebastien Brul, Benoit Neitthoffer, Sandrine Etienne-Manneville, Ahmed Haouz, Batiste Boda, Celia Caillet-Saguy
Front Microbiol. 2022 Feb 23;13:829094.
LRRC15 mediates an accessory interaction with the SARS-CoV-2 spike protein
Jarrod Shilts,Thomas W. M. Crozier,Ana Teixeira-Silva,Ildar Gabaev,Pehu?n Pereyra Gerber,Edward J. D. Greenwood,Samuel James Watson,Brian M. Ortmann,Christian M. Gawden-Bone,Tekle Pauzaite,Markus Hoffmann,James A. Nathan,Stefan P?hlmann,Nicholas J. Matheson,Paul J. Lehner ,Gavin J. Wright
PLoS Biol. 2023 Feb 3;21(2):e3001959
SARS-CoV-2 impairs interferon production via NSP2-induced repression of mRNA translation
Zhang Xu, Jung-Hyun Choi, David L Dai, Jun Luo, Reese Jalal Ladak, Qian Li, Yimeng Wang, Christine Zhang, Shane Wiebe, Alex C H Liu, Xiaozhuo Ran, Jiaqi Yang, Parisa Naeli, Aitor Garzia, Lele Zhou, Niaz Mahmood, Qiyun Deng, Mohamed Elaish, Rongtuan Lin, Lara K Mahal, Tom C Hobman, Jerry Pelletier, Tommy Alain, Silvia M Vidal, Thomas Duchaine, Mohammad T Mazhab-Jafari, Xiaojuan Mao, Seyed Mehdi Jafarnejad, Nahum Sonenberg
Proc Natl Acad Sci U S A. 2022 Aug 9;119
ORF8 contributes to cytokine storm during SARS-CoV-2 infection by activating IL-17 pathway
Xiaoyuan Lin, Beibei Fu, Songna Yin, Zhifeng Li, Huawen Liu, Haiwei Zhang, Na Xing, Yu Wang, Weiue, Yan Xiong, Shanfu Zhang, Qingting Zhao, Shiyao Xu, Jig Zhang, Peihui Wang, Weiqi Nian, Xingsheng Wang, Haibo Wu
iScience. 2021 Apr 23;24(4):102293.
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-I
Yiwen Zhang, Yingshi Chen, Yuzhuang Li, Feng Huang, Baohong Luo, Yaochang Yuan, Baijin Xia, Xiancai Ma, Tao Yang, Fei Yu, Jun Liu, Bingfeng Liu, Zheng Song, Jingliang Chen, Shumei Yan, Liyang Wu, Ting Pan, Xu Zhang, Rong Li, Wenjing Huang, Xin He, Fei Xiao, Junsong Zhang, Hui Zhang
Proc Natl Acad Sci U S A. 2021 Jun 8;118(23)
SARS-CoV-2 N protein promotes NLRP3 inflammasome activation to induce hyperinflammation
Pan P, Shen M, Yu Z, Ge W, Chen K, Tian M, Xiao F, Wang Z, Wang J, Jia Y, Wang W, Wan P, Zhang J, Chen W, Lei Z, Chen X, Luo Z, Zhang Q, Xu M, Li G, Li Y, Wu J.
Nat Commun. 2021 Aug 2;12(1):4664
SARS-CoV-2 ORF3a induces RETREG1/FAM134B-dependent reticulophagy and triggers sequential ER stress and inflammatory responses during SARS-CoV-2 infection
Xiaolin Zhang, Ziwei Yang, Ting Pan, Xubing Long, Qinqin Sun, Pei-Hui Wang, Xiaojuan Li, Ersheng Kuang
Autophagy. 2022 Nov;18(11):2576-2592.
Evasion of Type I Interferon by SARS-CoV-2
Hongjie Xia, Zengguo Cao, Xuping Xie, Xianwen Zhang, John Yun-Chung Chen, Hualei Wang, Vineet D Menachery, Ricardo Rajsbaum, Pei-Yong Shi
Cell Rep. 2020 Oct 6;33(1):108234.
SARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signaling
Miorin L., Kehrer T., Sanchez-Aparicio M.T., Zhang K., Cohen P., Patel R.S., Cupic A., Makio T., Mei M., Moreno E., Danziger O., White K.M., Rathnasinghe R., Uccellini M., Gao S., Aydillo T., Mena I., Yin X., Martin-Sancho L., Krogan N.J., Chanda S.K., Schotsaert M., Wozniak R.W., Ren Y., Rosenberg B.R., Fontoura B.M.A., Garcia-Sastre A.
Proc Natl Acad Sci U S A. 2020 Nov 10;117(45):28344-28354
- Last updated 16/February/2023.
