SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically
Proven Protease Inhibitor.
Hoffmann M, Kleine-Weber H, Schroeder S, Kr?ger N, Herrler T, Erichsen S,
Schiergens TS, Herrler G, Wu NH, Nitsche A, M?ller MA, Drosten C, P?hlmann S.
Cell. 2020 Apr 16;181(2):271-280
A potential role for integrins in host cell entry by SARS-CoV-2.
Sigrist CJ, Bridge A, Le Mercier P.
Antiviral Res. 2020 May;177:104759
A potential role for integrins in host cell entry by SARS-CoV-2.
Sigrist CJ, Bridge A, Le Mercier P.
Antiviral Res. 2020 May;177:104759
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E.
Antiviral Res. 2020 Apr;176:104742
Severe Acute Respiratory Syndrome Coronavirus ORF7a Inhibits Bone Marrow Stromal Antigen 2 Virion Tethering through a Novel Mechanism of Glycosylation Interference.
Taylor JK, Coleman CM, Postel S, Sisk JM, Bernbaum JG, Venkataraman T, Sundberg EJ, Frieman MB.
J Virol. 2015 Dec;89(23):11820-33
SARS-CoV accessory protein 7a directly interacts with human LFA-1.
H?nel K, Willbold D.
Biol Chem. 2007 Dec;388(12):1325-32.
Severe acute respiratory syndrome coronavirus protein 7a interacts with hSGT.
Fielding BC, Gunalan V, Tan TH, Chou CF, Shen S, Khan S, Lim SG, Hong W, Tan YJ.
Biochem Biophys Res Commun. 2006 May 19;343(4):1201-8
The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis.
Teoh KT, Siu YL, Chan WL, Schl?ter MA, Liu CJ, Peiris JS, Bruzzone R, Margolis B, Nal B.
Mol Biol Cell. 2010 Nov 15;21(22):3838-52
Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling.
Zhao X, Nicholls JM, Chen YG.
J Biol Chem. 2008 Feb 8;283(6):3272-80
Severe acute respiratory syndrome coronavirus nonstructural protein 2 interacts with a host protein complex involved in mitochondrial biogenesis and intracellular signaling.
Cornillez-Ty CT, Liao L, Yates JR 3rd, Kuhn P, Buchmeier MJ.
J Virol. 2009 Oct;83(19):10314-8
The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.
Xu L, Khadijah S, Fang S, Wang L, Tay FP, Liu DX.
J Virol. 2010 Sep;84(17):8571-83.
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membrane.
Frieman M, Yount B, Heise M, Kopecky-Bromberg SA, Palese P, Baric RS.
J Virol. 2007 Sep;81(18):9812-24
Virus-host interactome and proteomic survey of PMBCs from COVID-19 patients reveal potential virulence factors influencing SARS-CoV-2 pathogenesis
Jingjiao Li, Mingquan Guo, Xiaoxu Tian, Chengrong Liu, Xin Wang, Xing Yang, Ping Wu, Zixuan Xiao, Yafei Qu, Yue Yin, Joyce Fu, Zhaoqin Zhu, Zhenshan Liu, Chao Peng, Tongyu Zhu, Qiming Liang
Med (N Y) 2020 Jul 21.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, H?ttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Naing ZZC, Pulido EH, Shi Y, Barrio-Hernandez I, Memon D, Petsalaki E, Dunham A, Marrero MC, Burke D, Koh C, Vallet T, Silvas JA, Azumaya CM, Billesb?lle C, Brilot AF, Campbell MG, Diallo A, Dickinson MS, Diwanji D, Herrera N, Hoppe N, Kratochvil HT, Liu Y, Merz GE, Moritz M, Nguyen HC, Nowotny C, Puchades C, Rizo AN, Schulze-Gahmen U, Smith AM, Sun M, Young ID, Zhao J, Asarnow D, Biel J, Bowen A, Braxton JR, Chen J, Chio CM, Chio US, Deshpande I, Doan L, Faust B, Flores S, Jin M, Kim K, Lam VL, Li F, Li J, Li YL, Li Y, Liu X, Lo M, Lopez KE, Melo AA, Moss FR 3rd, Nguyen P, Paulino J, Pawar KI, Peters JK, Pospiech TH Jr, Safari M, Sangwan S, Schaefer K, Thomas PV, Thwin AC, Trenker R, Tse E, Tsui TKM, Wang F, Whitis N, Yu Z, Zhang K, Zhang Y, Zhou F, Saltzberg D; QCRG Structural Biology Consortium, Hodder AJ, Shun-Shion AS, Williams DM, White KM, Rosales R, Kehrer T, Miorin L, Moreno E, Patel AH, Rihn S, Khalid MM, Vallejo-Gracia A, Fozouni P, Simoneau CR, Roth TL, Wu D, Karim MA, Ghoussaini M, Dunham I, Berardi F, Weigang S, Chazal M, Park J, Logue J, McGrath M, Weston S, Haupt R, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Dorward M, Johnson C, Wilkinson SG, Geyer A, Giesel DM, Baillie C, Raggett S, Leech H, Toth R, Goodman N, Keough KC, Lind AL; Zoonomia Consortium, Klesh RJ, Hemphill KR, Carlson-Stevermer J, Oki J, Holden K, Maures T, Pollard KS, Sali A, Agard DA, Cheng Y, Fraser JS, Frost A, Jura N, Kortemme T, Manglik A, Southworth DR, Stroud RM, Alessi DR, Davies P, Frieman MB, Ideker T, Abate C, Jouvenet N, Kochs G, Shoichet B, Ott M, Palmarini M, Shokat KM, Garc?a-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ.
Science 2020 Oct 15
Neuropilin-1 facilitates SARS-CoV-2 cell entry and provides a possible pathway into the central nervous system
Ludovico Cantuti-Castelvetri, Ravi Ojha, Liliana D. Pedro, Minou Djannatian, Jonas Franz, Suvi Kuivanen, Katri Kallio, Tu?berk Kaya, Maria Anastasina, Teemu Smura, Lev Levanov, Leonora Szirovicza, Allan Tobi, Hannimari Kallio-Kokko, Pamela ?sterlund, Merja Joensuu, Fr?d?ric A. Meunier, Sarah Butcher, Martin Sebastian Winkler, Brit Mollenhauer, Ari Helenius, Ozgun Gokce, Tambet Teesalu, Jussi Hepojoki, Olli Vapalahti, Christine Stadelmann, Giuseppe Balistreri, Mikael Simons
SARS-CoV-2 invades host cells via a novel route: CD147-spike protein
Ke Wang, Wei Chen, Yu-Sen Zhou, Jian-Qi Lian, Zheng Zhang, Peng Du, Li Gong, Yang Zhang, Hong-Yong Cui, Jie-Jie Geng, Bin Wang, Xiu-Xuan Sun, Chun-Fu Wang, Xu Yang, Peng Lin, Yong-Qiang Deng, Ding Wei, Xiang-Min Yang, Yu-Meng Zhu, Kui Zhang, Zhao-Hui Zheng, Jin-Lin Miao, Ting Guo, Ying Shi, Jun Zhang, Ling Fu, Qing-Yi Wang, Huijie Bian, Ping Zhu, Zhi-Nan Chen
The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection
Brandon Beddingfield, Naoki Iwanaga, Wenshu Zheng, Chad J Roy, Tony Y Hu, Jay Kolls, Gregory Bix
JACC Basic Transl Sci. 2020 Oct 16.
Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
Thoms M, Buschauer R, Ameismeier M, et al.
Science. 2020;eabc8665.
Neuropilin-1 is a host factor for SARS-CoV-2 infection
Daly JL, Simonetti B, Klein K, Chen KE, Williamson MK, Ant?n-Pl?garo C, Shoemark DK, Sim?n-Gracia L, Bauer M, Hollandi R, Greber UF, Horvath P, Sessions RB, Helenius A, Hiscox JA, Teesalu T, Matthews DA, Davidson AD, Collins BM, Cullen PJ, Yamauchi
Science 2020 Nov 13;370(6518):861-865.
Effective Inhibition of SARS-CoV-2 Entry by Heparin and Enoxaparin Derivatives
Ritesh Tandon, Joshua S Sharp, Fuming Zhang, Vitor H Pomin , Nicole M Ashpole, Dipanwita Mitra, Martin G McCandless, Weihua Jin, Hao Liu, Poonam Sharma, Robert J Linhardt
J Virol
. 2021 Jan 13;95(3)
Multilevel proteomics reveals host perturbations by SARS-CoV-2 and SARS-CoV
Alexey Stukalov, Virginie Girault, Vincent Grass, Ozge Karayel, Valter Bergant, Christian Urban, Darya A Haas, Yiqi Huang, Lila Oubraham, Anqi Wang, M Sabri Hamad, Antonio Piras, Fynn M Hansen, Maria C Tanzer, Igor Paron, Luca Zinzula, Thomas Enghleitner, Maria Reinecke, Teresa M Lavacca, Rosina Ehmann, Roman W?lfel, J?rg Jores, Bernhard Kuster, Ulrike Protzer, Roland Rad, John Ziebuhr, Volker Thiel, Pietro Scaturro , Matthias Mann, Andreas Pichlmair
Nature
. 2021 Apr 12.
ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation
Guangyan Miao, Hongyu Zhao, Yan Li, Mingming Ji, Yong Chen, Yi Shi, Yuhai Bi, Peihui Wang, Hong Zhang
Dev Cell. 2021 Feb 22;56(4):427-442
SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70
Jiang H.W., Zhang H.N., Meng Q.F., Xie J., Li Y., Chen H., Zheng Y.X., Wang X.N., Qi H., Zhang J., Wang P.H., Han Z.G., Tao S.C.
Cell Mol Immunol 17:998-1000(2020)
No evidence for basigin/CD147 as a direct SARS-CoV-2 spike binding receptor
Jarrod Shilts, Thomas W M Crozier, Edward J D Greenwood, Paul J Lehner, Gavin J Wright
Sci Rep. 2021 Jan 11;11(1):413
