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SARS coronavirus 2 interactome

Interaction proteins in these page are those accurately shown to happen and with a function on the viral cycle. Many more interactions have been suggested by large-scale or preliminary experiments and can be found in external resources.

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Host Protein Virus Protein Species Life Cycle Phase Notes Refs.
ACE2 Spike SARS2 Virus entry Main entry receptor
Neuropilin Spike SARS2 Virus entry Secondary entry receptor?
Integrins Spike SARS2 Virus entry Secondary entry receptor?
TMPRSS2 Spike SARS2 Virus entry Cleavage of spike for fusion capacity
Furin Spike SARS2 Virus entry Cleavage of spike for fusion capacity
Heparan sulfate
Spike SARS2 Virus entry Host cell adhesion?
VPS39 ORF3a protein SARS2 Virus budding Facilitates virion egress in lysosomes
TOMM70 ORF9b protein SARS2 Inhibition of host RLR pathway by virus Prevents the activation of IFN upon viral infection
40S ribosome Nsp1 SARS2 Host translation shutoff Inhibits cellular mRNA translation and eventually leads to their degradation. Viral mRNA escape this inhibition because of specific sequence.


By similarity with SARS-2003
Host Protein Virus Protein Species Life Cycle Phase Notes Refs.
Tetherin ORF7a protein SARS1 Virus budding Counteracts antiviral activity of tetherin
ITGAL ORF7a protein SARS1 Virus entry Attachement to leucocytes?
SGTA ORF7a protein SARS1 Virus Exit May play a role in virion assembly
MPP5 Envelope protein (E) SARS1 Virus Exit May play a role in disruption of lung epithelium
SMAd3 Nucleoprotein (N) SARS1 Virus exit May induce myelosuppression
PHB Nsp2 SARS1 Virus replication/transcription May disrupt intracellular host signaling
PHB2 Nsp2 SARS1 Virus replication/transcription May disrupt intracellular host signaling
DDX1 Nsp14 SARS1 Virus replication enhances viral replication
KPNA2 ORF6 protein SARS1 Virus replication/exit
Disrupts interferon signaling by preventing nuclear import of proteins.
Rejected hypothesis
Host Protein Virus Protein Species Life Cycle Phase Notes Refs.
Basigin Spike SARS2 Virus entry Secondary entry receptor?

Interactomes

Coronaviridae interactions network image Large-scale
interactome