Inhibition of host apoptosis by viral BCL2-like protein

Cellular Bcl-2 family proteins regulate critical steps in programmed cell death pathway by modulating mitochondrial permeability and function. They can be divided on two distinct groups, anti-apoptotic members such as Bcl-2 and Bcl-Xl that prevent cell death and pro-apoptotic elements like Bax and Bak that promote apoptosis.

tnf tnfr tradd fadd casp8 casp8 bax bak vbcl2 vbcl2 apaf1 bcl2 casp3 casp9 casp3 Image Map


Bcl-2 family proteins are also encoded by several large DNA viruses, including all known gamma herpesviruses, adenoviruses, and several other unrelated viruses. Viral Bcl-2 proteins can prevent cell death but often escape cellular regulatory mechanisms that govern their cellular counterparts. Compared to the cellular Bcl-2, viral Bcl-2 members are shorter and are often devoid of a membrane-anchored domain. Even with low level of homology with Bcl-2 such as adenovirus E1B19K, all viral Bcl-2 proteins analyzed so far are able to block apoptosis.

Matching UniProtKB/Swiss-Prot entries

34 entries grouped by strain (browse by keywords)

1 entry

African swine fever virus (isolate Tick/Malawi/Lil 20-1/1983) (ASFV) reference strain

ARBH_ASFM2 Apoptosis regulator Bcl-2 homolog

1 entry

African swine fever virus (isolate Tick/South Africa/Pretoriuskop Pr4/1996) (ASFV) reference strain

ARBH_ASFP4 Apoptosis regulator Bcl-2 homolog

1 entry

African swine fever virus (strain Badajoz 1971 Vero-adapted) (Ba71V) (ASFV) reference strain

ARBH_ASFB7 Apoptosis regulator Bcl-2 homolog

1 entry

Alcelaphine herpesvirus 1 (strain C500) (AlHV-1) (Malignant catarrhal fever virus) reference strain

VGA9_ALHV1 Putative apoptosis regulator A9

1 entry

Canarypox virus (CNPV) reference strain

ARBH_CNPV Apoptosis regulator Bcl-2 homolog (vBcl-2)

1 entry

Deerpox virus (strain Mule deer/United States/W-848-83/1983) (DPV) reference strain

DPV22_DPV83 Apoptosis regulator DPV022

1 entry

Fowlpox virus (strain NVSL) (FPV) reference strain

ARBH_FOWPN Apoptosis regulator Bcl-2 homolog

1 entry

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

E1BS_ADE02 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K) (E1B-175R)

1 entry

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

E1BS_ADE05 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

ARBH_HHV8P Apoptosis regulator Bcl-2 homolog

1 entry

Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

ARBH_MHV68 Apoptosis regulator Bcl-2 homolog (vBcl-2) (Protein M11)

1 entry

Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

VG16_SHV21 Bcl-2-like gene 16 protein

1 entry

Vaccinia virus (strain Ankara) (VACV) reference strain

F1_VACCA Protein F1

1 entry

Vaccinia virus (strain Tian Tan) (VACV) reference strain

F1_VACCT Protein F1

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

F1_VACCW Protein F1

1 entry

African swine fever virus (isolate Pig/Kenya/KEN-50/1950) (ASFV)

ARBH_ASFK5 Apoptosis regulator Bcl-2 homolog

1 entry

African swine fever virus (isolate Warthog/Namibia/Wart80/1980) (ASFV)

ARBH_ASFWA Apoptosis regulator Bcl-2 homolog

1 entry

African swine fever virus (strain E-70 MS44) (ASFV)

ARBH_ASFE4 Apoptosis regulator Bcl-2 homolog (LMH-5W)

1 entry

Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))

E1BS_ADECC E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Canine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 (strain Glaxo))

E1BS_ADECG E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))

E1BS_ADECR E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)

E1BS_ADEC2 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Canine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine adenovirus 2 (strain Toronto A 26-61))

E1BS_ADECT E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

E1BS_ADE12 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

E1BS_ADE07 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

E1BS_ADE04 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

E1BS_ADE40 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

E1BS_ADE41 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)

E1BS_ADEM1 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Rabbitpox virus (strain Utrecht) (RPV)

F1_RABPU Protein F1

1 entry

Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)

E1BS_ADES7 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Tree shrew adenovirus serotype 1 (TSAdV-1) (Tupaia adenovirus 1)

E1BS_ADET1 E1B protein, small T-antigen homolog (E1B 19 kDa protein) (E1B-19K)

1 entry

Vaccinia virus (strain Copenhagen) (VACV)

F1_VACCC Protein F1

1 entry

Variola virus

ARBH_VARV Apoptosis regulator Bcl-2 homolog (vBcl-2) (F1L homolog)