Viral penetration via lysis of host organellar membrane


Non-enveloped viruses transfer their genetic material from endosome compartment to cell cytoplasm through membrane permeabilization or lysis.
Lysis occurs when a viral capsid induces rupture of endosomal membrane. This process occurs after capsid protein conformational change triggered by endosomal acidic pH or upon receptor binding. The result is either viral particle escape to the cytoplasm (Adenovirus 2 and 5) or release of viral genome into the cytoplasm (Human rhinovirus)