Viral penetration via lysis of host organellar membrane

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Non-enveloped viruses transfer their genetic material from endosome compartment to cell cytoplasm through membrane permeabilization or lysis.
Lysis occurs when a viral capsid induces rupture of endosomal membrane. This process occurs after capsid protein conformational change triggered by endosomal acidic pH or upon receptor binding. The result is either viral particle escape to the cytoplasm (Adenovirus 2 and 5) or release of viral genome into the cytoplasm (Human rhinovirus)

Matching UniProtKB/Swiss-Prot entries

11 entries grouped by strain (browse by keywords)

1 entry

Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

CAP6_ADEG1 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]

1 entry

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

CAP6_ADE02 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]

1 entry

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

CAP6_ADE05 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]

1 entry

Snake adenovirus serotype 1 (SnAdV-1) reference strain

CAP6_ADES1 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]

1 entry

Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))

CAP6_ADECC Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]

1 entry

Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))

CAP6_ADECR Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]

1 entry

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12)

CAP6_ADE12 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]

1 entry

Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

CAP6_ADE40 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]

1 entry

Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

CAP6_ADE41 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]

1 entry

Human rhinovirus 14 (HRV-14)

POLG_HRV14 Genome polyprotein [Cleaved into: P1; Capsid protein VP0 (VP4-VP2); Capsid protein VP4 (P1A) (Virion ...

1 entry

Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)

CAP6_ADEM1 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]