Minichromosome synthesis (rcDNA repair)

From rcDNA to cccDNA

The formation of the cccDNA from the rcDNA is incompletely understood, but several steps are essential for the synthesis:
- The removal of the polymerase covalently attached to the 5' end of the negative strand.
- The removal of the primer from the 5' plus strand.
- The removal of the short redundancy region r from the minus strand.
- Fill in gaps in the positive strand
- Fill in gaps at the ends of both strands which must be ligated to yield closed circles (Nassal 2008) Rating=Review



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Minichromosome Minichromosome structure
Minichromosome synthesis
Minichromosome silencing
Minichromosome clearance

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