List of glycoproteins found on different herpes virions and their putative function.
Conservation | Name | HHV-1 | Varicella | HCMV | HHV6 | EBV | KSHV | Function |
---|---|---|---|---|---|---|---|---|
All | gB | UL27 | ORF31 | UL55 | U39 | BALF4 | ORF8 | - |
All | gH | UL22 | ORF37 | UL75 | U48 | BXLF2 | ORF22 | Fusion |
All | gL | UL1 | ORF60 | UL115 | U82 | BKRF2 | ORF47 | Fusion (gH chaperone) |
All | gM | UL10 | ORF50 | UL100 | U72 | BBRF3 | ORF39 | |
All | gN | UL49.5 | ORF 9a | UL73 | U46 | BLRF1 | ORF53 | |
Alpha | gK | UL53 | ORF5 | x | x | x | x | Essential for infection of neuronal axons |
Alpha | gE | US8 | ORF64 | x | x | x | x | gE/gI is important for anterograde axonal transport |
Alpha | gI | US7 | ORF67 | x | x | x | x | gE/gI is important for anterograde axonal transport |
Alpha | gC | UL44 | ORF14 | x | x | x | x | Skin-tropic factor |
Alpha | gD | US6 | x | x | x | x | x | |
Beta | gO | x | x | UL74 | U47 | x | x | gH/gL chaperone |
Beta | UL128 | x | x | UL128 | x | x | x | Tropism/infect epithelial cells but not fibroblasts |
Beta | UL130 | x | x | UL130 | x | x | x | Tropism/infect epithelial cells but not fibroblasts |
Beta | UL131A | x | x | UL131A | x | x | x | Tropism/infect epithelial cells but not fibroblasts |
Beta | gQ1 | x | x | x | U100 | x | x | Tropism /requires for use of CD46 |
Beta | gQ2 | x | x | x | U100 | x | x | Tropism /requires for use of CD46 |
Gamma | gp350 | x | x | x | x | BLLF1 | x | Tropism/ B-Lymphocytes (CR2-binding) |
Gamma | gp42 | x | x | x | x | BZLF2 | x | Tropism/ B-Lymphocytes (CR2-binding) |
Gamma | BMRF2 | x | x | x | x | BMRF2 | x | Tropism/Epithelial cells (b1 integrin) RGD motif |
Gamma | gK8.1A | x | x | x | x | x | gK8.1A | Tropism?/Heparan sulfate binding |
Gamma | gK8.1B | x | x | x | x | x | gK8.1B | Tropism?/Heparan sulfate binding |