Assymmetric rolling circle replication
Related to: Pospiviroidae
Location: Host cell nucleus.
Replication events:
Pospoviroids replicate their genome through rolling circle by a host RNA polymerase that generate linear multimers from circular RNA template. The linear multimeric (-) antigenome is directly replicated into multimeric (+) genome. These multimers are subsequently cleaved to unit-length RNAs by host RNAse.
This replication is called "assymmetric replication" since only plus strands are circularized 
Rolling-circle replication of viroids, viroid-like satellite RNAs and hepatitis delta virus: variations on a theme
Ricardo Flores, Douglas Grubb, Amine Elleuch, Mar?a-?ngeles Nohales, Sonia Delgado, Selma Gago
RNA Biol April 2011; 8: 200?206.
Ricardo Flores, Douglas Grubb, Amine Elleuch, Mar?a-?ngeles Nohales, Sonia Delgado, Selma Gago
RNA Biol April 2011; 8: 200?206.