Alphapolyomavirus (taxid:1891713)

Alphapolyomavirus is a genus of dsDNA viruses in the family Polyomaviridae that infect mammals. Infections in humans are usually asymptomatic, but in rare cases may be associated with skin cancer, lymphoma or renal disease.

VIRION

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Non-enveloped capsid with a T=7d icosahedral symmetry, about 50 nm in diameter.
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GENOME

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Circular dsDNA about 5 kb in size, associated with cellular histones in a chromatin-like complex. Encodes for 5-6 proteins.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly/exit). 5-6 proteins are expressed from the two pre-MRNA by alternative splicing. All genes are transcribed by host RNA pol II.

REPLICATION

NUCLEAR

  1. Attachement of the viral proteins to host receptors triggers lipid-mediated endocytosis of the virus into the host cell.
  2. Virion transits through endoplasmic reticulum where host protein disulfide isomerases rearrange its capsid structure
  3. Export of misfolded virion to the cytoplasm possibly through host ERAD pathway
  4. Loss of VP1 in the low-calcium conditions of the cytosol
  5. Import of genomic DNA into host nucleus.
  6. Transcription of early genes (LT and sT genes)
  7. Replication of the DNA genome in the nucleus.
  8. Transcription of late genes encoding for structural proteins (VP1, VP2 and VP3).
  9. Assembly of new virions in nuclear viral factories.
  10. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

25 entries grouped by protein

6 entries

Large T antigen (LT) (LT-AG) (EC 3.6.4.-)

Select_allDeselect_all
LT_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
LT_POVM1
Mus musculus polyomavirus 1 (MPyV) reference strain
LT_POVM3
Murine polyomavirus (strain A3) (MPyV) reference strain
LT_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
LT_POVBG
Murine polyomavirus (strain BG) (MPyV)
LT_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)

6 entries

Middle T antigen (MT) (MT-AG)

Select_allDeselect_all
MT_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
MT_POVM1
Mus musculus polyomavirus 1 (MPyV) reference strain
MT_POVM3
Murine polyomavirus (strain A3) (MPyV) reference strain
MT_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
MT_POVBG
Murine polyomavirus (strain BG) (MPyV)
MT_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)

4 entries

Small t antigen (ST) (ST-AG)

Select_allDeselect_all
ST_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
ST_POVM3
Murine polyomavirus (strain A3) (MPyV) reference strain
ST_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
ST_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)

5 entries

Major capsid protein VP1 (Major structural protein VP1)

Select_allDeselect_all
VP1_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
VP1_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1)
VP1_POVM3
Murine polyomavirus (strain A3) (MPyV)
VP1_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)
VP1_POVMP
Murine polyomavirus (strain P16 small-plaque) (MPyV)

Capsid protein VP1

4 entries

Minor capsid protein VP2 (Minor structural protein VP2)

Select_allDeselect_all
VP2_POVHA
Hamster polyomavirus (HaPyV) (Mesocricetus auratus polyomavirus 1) reference strain
VP2_POVM3
Murine polyomavirus (strain A3) (MPyV) reference strain
VP2_POVMA
Murine polyomavirus (strain A2) (MPyV) reference strain
VP2_POVMC
Murine polyomavirus (strain Crawford small-plaque) (MPyV)