Phenuiviridae (taxid:1980418)

VIRION

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Enveloped, spherical. Diameter from 80 to 120nm. Glycoproteins at the surface of the envelope are arranged on an icosahedral lattice, with T=12 symmetry.

GENOME

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Segmented Negative-stranded RNA linear genome, L segment is about 6.4kb, M segment about 3.2kb and S segment about 1.7kb.
Encodes for six proteins.

GENE EXPRESSION

Transcription starts by viral RNA dependent RNA polymerase (L) binding to a promoter on each encapsidated segment, and is terminated by a strong hairpin sequence at the end of each gene. These are capped by L protein during synthesis using cap snatching , but are not polyadenylated.
S segment uses ambisense strategy to encode for several proteins: both genomic and antigenomic RNA are transcribed. The hairpin sequence is a stop polymerase signal which prevents ambisense transcription from producing dsRNA. M segment encodes for several polyproteins by leaky scanning, which are cleaved by host protease into Nsm-GN, Nsm, NSm',Gn and Gc proteins.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Host-virus interaction

Inhibition of host transcription initiation

The Rift valley fever virus NSs protein instead plays a role in the inhibition of the host transcription initiation by acting on host TFIIH.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

47 entries grouped by strain

7 entries

Rice stripe virus (isolate T) (RSV) reference strain

Select_allDeselect_all
L_RSVT RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
VSR_RSVT Suppressor of RNA silencing p3 (Protein NS3) (Protein p3)
NCAP_RSVT Nucleoprotein (Coat protein) (CP) (Nucleocapsid protein) (Protein N) (Protein pc3)
MVP_RSVT Movement protein (Non-structural protein 4) (NS4) (Protein pc4)
NCP_RSVT Major non-capsid protein (NCP) (20.5 kDa protein) (Protein p4) (Stripe disease-specific protein) ...
GLYC_RSVT Putative envelope glycoprotein (GP) (Protein pc2) [Cleaved into: Putative glycoprotein G1; Putative ...
P2_RSVT Protein p2

4 entries

Rift valley fever virus (strain ZH-548 M12) (RVFV) reference strain

Select_allDeselect_all
GP_RVFVZ Envelopment polyprotein (M polyprotein) [Cleaved into: NSm-Gn protein (p78); Glycoprotein N (Gn) ...
NSS_RVFVZ Non-structural protein S (NSs)
L_RVFVZ RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_RVFVZ Nucleoprotein (Nucleocapsid protein) (Protein N)

4 entries

Uukuniemi virus (strain S23) (UUKV) reference strain

Select_allDeselect_all
GP_UUKS Envelopment polyprotein (M polyprotein) (p110) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
L_UUKS RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_UUKS Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_UUKS Non-structural protein NS-S (NSs)

1 entry

Dabie bandavirus (Severe fever with thrombocytopenia virus) (Huaiyangshan banyangvirus) reference strain

L_SFTS RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...

3 entries

Heartland virus (HTRV) reference strain

Select_allDeselect_all
L_HTRV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
GP_HTRV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NSS_HTRV Non-structural protein NS-S (NSs)

3 entries

SFTS phlebovirus (isolate SFTSV/Human/China/HB29/2010) (Severe fever with thrombocytopenia virus) reference strain

Select_allDeselect_all
GP_SFTSV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NSS_SFTSV Non-structural protein NS-S (NSs)
NCAP_SFTSV Nucleoprotein (Nucleocapsid protein) (Protein N)

1 entry

Bhanja virus (BHAV) reference strain

GP_BHAV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

5 entries

Maize stripe virus (MStV)

Select_allDeselect_all
NCAP_MSTV Nucleoprotein (Coat protein) (CP) (Nucleocapsid protein) (Protein N) (Protein pc3)
VSR_MSTV Suppressor of RNA silencing p3 (Protein NS3) (Protein p3)
MVP_MSTV Movement protein (Non-structural protein 4) (NS4) (Protein pc4)
NCP_MSTV Major non-capsid protein (NCP) (Protein p4) (Stripe disease-specific protein) (Protein S)
VNS5_MSTV Non-structural protein NS5

4 entries

Rice stripe virus (isolate M) (RSV)

Select_allDeselect_all
MVP_RSVM Movement protein (Non-structural protein 4) (NS4) (Protein pc4)
NCAP_RSVM Nucleoprotein (Coat protein) (CP) (Nucleocapsid protein) (Protein N) (Protein pc3)
NCP_RSVM Major non-capsid protein (NCP) (20.5 kDa protein) (Protein p4) (Stripe disease-specific protein) ...
VSR_RSVM Suppressor of RNA silencing p3 (Protein NS3) (Protein p3)

2 entries

Dabie bandavirus (Severe fever with thrombocytopenia virus) (Huaiyangshan banyangvirus)

Select_allDeselect_all
GP_SFTS Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_SFTS Nucleoprotein (Nucleocapsid protein) (Protein N)

3 entries

Punta toro phlebovirus

Select_allDeselect_all
GP_PTPV Envelopment polyprotein (M polyprotein) [Cleaved into: NSm-Gn protein; Glycoprotein N (Gn) ...
NCAP_PTPV Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_PTPV Non-structural protein NS-S

3 entries

Rift valley fever virus (RVFV)

Select_allDeselect_all
L_RVFV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_RVFV Nucleoprotein (Nucleocapsid protein) (Protein N)
GP_RVFV Envelopment polyprotein (M polyprotein) [Cleaved into: NSm-Gn protein; Glycoprotein N (Gn) ...

3 entries

Toscana virus (Tos)

Select_allDeselect_all
L_TOSV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_TOSV Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_TOSV Non-structural protein NS-S (NSs)

2 entries

Sandfly fever sicilian virus (SFS)

Select_allDeselect_all
NCAP_SFSV Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_SFSV Non-structural protein NS-S

1 entry

Rice hoja blanca virus (strain cr) (RHBV) (Rice hoja blanca virus (strain Costa Rica))

VSR_RHBVC Suppressor of RNA silencing p3 (Protein NS3) (Protein p3)

1 entry

Wheat yellow head virus (WYHV)

NCAP_WYHV Nucleoprotein (Coat protein) (CP) (Nucleocapsid protein) (Protein N) (Protein pc3)