ID NS6_SARS2 Reviewed; 61 AA. AC P0DTC6; DT 22-APR-2020, integrated into UniProtKB/Swiss-Prot. DT 22-APR-2020, sequence version 1. DT 22-APR-2020, entry version 1. DE RecName: Full=Non-structural protein 6; DE Short=ns6; DE AltName: Full=Accessory protein 6; DE AltName: Full=Protein X3; GN ORFNames=6; OS Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). OC Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae; OC Orthocoronavirinae; Betacoronavirus; unclassified Betacoronavirus. OX NCBI_TaxID=2697049; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX PubMed=32015508; DOI=10.1038/s41586-020-2008-3; RA Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W., RA Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y., RA Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.; RT "A new coronavirus associated with human respiratory disease in China."; RL Nature 579:265-269(2020). CC -!- FUNCTION: Could be a determinant of virus virulence, since, when CC expressed in an otherwise attenuated JHM strain of murine coronavirus, CC it can dramatically increase the lethality of the latter. Seems to CC stimulate cellular DNA synthesis in vitro. CC {ECO:0000250|UniProtKB:P59634}. CC -!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane CC {ECO:0000250|UniProtKB:P59634}. Host Golgi apparatus membrane CC {ECO:0000250|UniProtKB:P59634}. CC -!- SIMILARITY: Belongs to the coronaviruses accessory protein 6 family. CC {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MN908947; QHD43420.1; -; Genomic_RNA. DR Proteomes; UP000464024; Genome. DR InterPro; IPR022736; SARS_NS6. DR Pfam; PF12133; Sars6; 1. PE 3: Inferred from homology; KW Host endoplasmic reticulum; Host Golgi apparatus; Host membrane; Membrane; KW Reference proteome; Virulence. FT CHAIN 1..61 FT /note="Non-structural protein 6" FT /id="PRO_0000449653" SQ SEQUENCE 61 AA; 7273 MW; B21BD303F59A1D0A CRC64; MFHLVDFQVT IAEILLIIMR TFKVSIWNLD YIINLIIKNL SKSLTENKYS QLDEEQPMEI D //