ID NS7A_SARS2 Reviewed; 121 AA. AC P0DTC7; DT 22-APR-2020, integrated into UniProtKB/Swiss-Prot. DT 22-APR-2020, sequence version 1. DT 22-APR-2020, entry version 1. DE RecName: Full=Protein 7a; DE AltName: Full=Accessory protein 7a; DE AltName: Full=Protein U122; DE AltName: Full=Protein X4; DE Flags: Precursor; GN ORFNames=7a; OS Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). OC Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae; OC Orthocoronavirinae; Betacoronavirus; unclassified Betacoronavirus. OX NCBI_TaxID=2697049; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX PubMed=32015508; DOI=10.1038/s41586-020-2008-3; RA Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W., RA Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y., RA Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.; RT "A new coronavirus associated with human respiratory disease in China."; RL Nature 579:265-269(2020). CC -!- FUNCTION: Non-structural protein which is dispensable for virus CC replication in cell culture. {ECO:0000250|UniProtKB:P59635}. CC -!- SUBUNIT: Interacts with the spike glycoprotein, M protein, E protein CC and the accessory protein 3a. Interacts with human SGT. CC {ECO:0000250|UniProtKB:P59635}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000250|UniProtKB:P59635}. Host CC endoplasmic reticulum membrane {ECO:0000250|UniProtKB:P59635}; Single- CC pass membrane protein {ECO:0000250|UniProtKB:P59635}. Host endoplasmic CC reticulum-Golgi intermediate compartment membrane CC {ECO:0000250|UniProtKB:P59635}; Single-pass type I membrane protein CC {ECO:0000250|UniProtKB:P59635}. Host Golgi apparatus membrane CC {ECO:0000250|UniProtKB:P59635}; Single-pass membrane protein CC {ECO:0000250|UniProtKB:P59635}. CC -!- DOMAIN: The di-lysine motif confers endoplasmic reticulum localization CC for type I membrane proteins. {ECO:0000250|UniProtKB:P59635}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MN908947; QHD43421.1; -; Genomic_RNA. DR Proteomes; UP000464024; Genome. DR Gene3D; 2.60.40.1550; -; 1. DR InterPro; IPR014888; SARS_X4. DR InterPro; IPR036495; SARS_X4_sf. DR Pfam; PF08779; SARS_X4; 1. DR SUPFAM; SSF117066; SSF117066; 1. DR PROSITE; PS51919; X4E; 1. PE 3: Inferred from homology; KW Disulfide bond; G0/G1 host cell cycle checkpoint dysregulation by virus; KW Host endoplasmic reticulum; Host Golgi apparatus; Host membrane; KW Host-virus interaction; Membrane; Modulation of host cell cycle by virus; KW Reference proteome; Signal; Transmembrane; Transmembrane helix; Virion. FT SIGNAL 1..15 FT /evidence="ECO:0000255" FT CHAIN 16..121 FT /note="Protein 7a" FT /evidence="ECO:0000255" FT /id="PRO_0000449654" FT TRANSMEM 96..116 FT /note="Helical" FT /evidence="ECO:0000255" FT DOMAIN 16..81 FT /note="X4e" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01267" FT MOTIF 117..121 FT /note="Di-lysine motif" FT /evidence="ECO:0000250|UniProtKB:P59635" FT DISULFID 23..58 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01267" FT DISULFID 35..67 FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01267" SQ SEQUENCE 121 AA; 13744 MW; 891E7EAB9E8A5BA9 CRC64; MKIILFLALI TLATCELYHY QECVRGTTVL LKEPCSSGTY EGNSPFHPLA DNKFALTCFS TQFAFACPDG VKHVYQLRAR SVSPKLFIRQ EEVQELYSPI FLIVAAIVFI TLCFTLKRKT E //