ID NCAP_SARS2 Reviewed; 419 AA. AC P0DTC9; DT 22-APR-2020, integrated into UniProtKB/Swiss-Prot. DT 22-APR-2020, sequence version 1. DT 22-APR-2020, entry version 1. DE RecName: Full=Nucleoprotein {ECO:0000255|HAMAP-Rule:MF_04096}; DE AltName: Full=Nucleocapsid protein {ECO:0000255|HAMAP-Rule:MF_04096}; DE Short=NC {ECO:0000255|HAMAP-Rule:MF_04096}; DE Short=Protein N {ECO:0000255|HAMAP-Rule:MF_04096}; GN Name=N {ECO:0000255|HAMAP-Rule:MF_04096}; OS Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2). OC Viruses; Riboviria; Nidovirales; Cornidovirineae; Coronaviridae; OC Orthocoronavirinae; Betacoronavirus; unclassified Betacoronavirus. OX NCBI_TaxID=2697049; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC RNA]. RX PubMed=32015508; DOI=10.1038/s41586-020-2008-3; RA Wu F., Zhao S., Yu B., Chen Y.-M., Wang W., Song Z.-G., Hu Y., Tao Z.-W., RA Tian J.-H., Pei Y.-Y., Yuan M.-L., Zhang Y.-L., Dai F.-H., Liu Y., RA Wang Q.-M., Zheng J.-J., Xu L., Holmes E.C., Zhang Y.-Z.; RT "A new coronavirus associated with human respiratory disease in China."; RL Nature 579:265-269(2020). CC -!- FUNCTION: Packages the positive strand viral genome RNA into a helical CC ribonucleocapsid (RNP) and plays a fundamental role during virion CC assembly through its interactions with the viral genome and membrane CC protein M. Plays an important role in enhancing the efficiency of CC subgenomic viral RNA transcription as well as viral replication. CC {ECO:0000255|HAMAP-Rule:MF_04096}. CC -!- SUBUNIT: Homooligomer. Both monomeric and oligomeric forms interact CC with RNA. Interacts with protein M. Interacts with NSP3; this CC interaction serves to tether the genome to the newly translated CC replicase-transcriptase complex at a very early stage of infection. CC {ECO:0000255|HAMAP-Rule:MF_04096}. CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000255|HAMAP-Rule:MF_04096}. Host CC endoplasmic reticulum-Golgi intermediate compartment CC {ECO:0000255|HAMAP-Rule:MF_04096}. Host Golgi apparatus CC {ECO:0000255|HAMAP-Rule:MF_04096}. Note=Located inside the virion, CC complexed with the viral RNA. Probably associates with ER-derived CC membranes where it participates in viral RNA synthesis and virus CC budding. {ECO:0000255|HAMAP-Rule:MF_04096}. CC -!- PTM: ADP-ribosylated. The ADP-ribosylation is retained in the virion CC during infection. {ECO:0000255|HAMAP-Rule:MF_04096}. CC -!- PTM: Phosphorylated on serine and threonine residues. CC {ECO:0000255|HAMAP-Rule:MF_04096}. CC -!- SIMILARITY: Belongs to the betacoronavirus nucleocapsid protein family. CC {ECO:0000255|HAMAP-Rule:MF_04096}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; MN908947; QHD43423.2; -; Genomic_RNA. DR Proteomes; UP000464024; Genome. DR GO; GO:0044172; C:host cell endoplasmic reticulum-Golgi intermediate compartment; IEA:UniProtKB-SubCell. DR GO; GO:0044177; C:host cell Golgi apparatus; IEA:UniProtKB-SubCell. DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-UniRule. DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule. DR HAMAP; MF_04096; BETA_CORONA_NCAP; 1. DR InterPro; IPR001218; Corona_nucleocap. DR InterPro; IPR037179; Nucleocapsid_C. DR InterPro; IPR037195; Nucleocapsid_N. DR Pfam; PF00937; Corona_nucleoca; 1. DR PIRSF; PIRSF003888; NCAP_CRV; 1. DR SUPFAM; SSF103068; SSF103068; 1. DR SUPFAM; SSF110304; SSF110304; 1. PE 3: Inferred from homology; KW ADP-ribosylation; Host Golgi apparatus; Phosphoprotein; Reference proteome; KW Ribonucleoprotein; RNA-binding; Transcription; Transcription regulation; KW Viral nucleoprotein; Virion. FT CHAIN 1..419 FT /note="Nucleoprotein" FT /id="PRO_0000449656" FT REGION 41..186 FT /note="RNA-binding" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04096" FT REGION 258..361 FT /note="Dimerization" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04096" FT MOD_RES 176 FT /note="Phosphoserine; by host" FT /evidence="ECO:0000255|HAMAP-Rule:MF_04096" SQ SEQUENCE 419 AA; 45626 MW; 56688DB785414E81 CRC64; MSDNGPQNQR NAPRITFGGP SDSTGSNQNG ERSGARSKQR RPQGLPNNTA SWFTALTQHG KEDLKFPRGQ GVPINTNSSP DDQIGYYRRA TRRIRGGDGK MKDLSPRWYF YYLGTGPEAG LPYGANKDGI IWVATEGALN TPKDHIGTRN PANNAAIVLQ LPQGTTLPKG FYAEGSRGGS QASSRSSSRS RNSSRNSTPG SSRGTSPARM AGNGGDAALA LLLLDRLNQL ESKMSGKGQQ QQGQTVTKKS AAEASKKPRQ KRTATKAYNV TQAFGRRGPE QTQGNFGDQE LIRQGTDYKH WPQIAQFAPS ASAFFGMSRI GMEVTPSGTW LTYTGAIKLD DKDPNFKDQV ILLNKHIDAY KTFPPTEPKK DKKKKADETQ ALPQRQKKQQ TVTLLPAADL DDFSKQLQQS MSSADSTQA //