TWIV:This Week in Virology is a weekly podcast animated by professors Vincent Racaniello and Dick Despommier from the Columbia University, USA.

Virology and Bioinformatics from
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure Curated by Dr. Chris Upton
30,000 years old and still infectious March 2014

A new virus has been isolated in a 30,000-year-old ice core harvested from permafrost in Siberia, Russia. The Pithovirus infects amoeba’s and has a unique virion structure.

Amoeba’s giant viruses March 2014

A recent discovered amoeba’s Pandora virus has a huge genome compared to other known viruses. This fact may be related to amoebas having the biggest genome of all living cells. Their genome size would reach up to 670,000,000,000bp, that is more than 200 times the human genome size. In this context it is not surprising that amoeba’s nucleo cytoplasmic large DNA viruses like pandora virus can reach 2,470,000bp, which is about six times more than the biggest vertebrate virus, canarypoxvirus 359,000bp. A new page describes the Pandoravirus.

ViralZone update January 2014
- Viral molecular biology section has been completed, for example with: leaky scanning, subgenomic transcription, viroid and hepatitis delta replication, virus genome evolution, fungal virus cell to cell movement ...
- A user pointed out the ICTV code of Virus Classification rules for orthography, and we are updating the 640 pages of ViralZone to follow the rule:

3.36 In formal taxonomic usage, the accepted names of virus Orders, Families, Subfamilies, and Genera are printed in italics and the first letters of the names are capitalized.

E-learning course(2) December 2013

A self-learning module for students has been developed in collaboration with FAO and IAEA about BLAST and multiple sequence alignment.

Host-virus interaction September 2013
The Host-virus interactions menu has been updated to reflect organism specific antiviral activity. By default the page displays vertebrate host-virus interactions, and gives access to invertebrate host-virus interactions, and Plant host-virus interactions. Bacterias host-virus interactions pages are under construction.

poliovirus replication cycle Juin 2013
The replication cycle of poliovirus is annotated and linked to virus ontology.

>>News archive

Publication: ViralZone: a knowledge resource to understand virus diversity. Hulo C, de Castro E, Masson P, Bougueleret L, Bairoch A, Xenarios I, Le Mercier P. Nucleic Acids Res. 2011 Jan;39(Database issue):D576-82.

ViralZone current statistics
March, 2014
470 Virus description pages:
  • 93 Families
  • 373 Genera
  • 9 individual Species

177 Viral molecular biology pages

Linking to:

  • 401 reference strains
  • 16,424 manually reviewed proteins
  • 1,930,916 unreviewed viral proteins

ViralZone picture copyright
All pictures in ViralZone are copyright of the SIB Swiss Institute of Bioinformatics. Permission is granted to use the pictures in academic thesis or non-commercial powerpoint presentations, provided the source is acknowledged
Swiss Institute of Bioinformatics
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