TWIV:This Week in Virology is a weekly podcast animated by professors Vincent Racaniello and Dick Despommier from the Columbia University, USA.

Virology and Bioinformatics from
Virus and bioinformatics articles with some microbiology and immunology thrown in for good measure Curated by Dr. Chris Upton
Bacterial viruses biology pages June 2014

The bacteriophages (Bacterial viruses) unique molecular biology is now described in 34 molecular virology pages. The content can be accessed by bacterial viruses homepage. One can discover the way M13 uses to enter cell cytoplasm by pilus retraction, the replicative transposition of Mu phage or the evasion of host toxin-antitoxin mechanisms of bacteriophages. Two replication cycles have been added: T7 phage and Mu phage.
The ViralZone team is thankful to Ariane Toussaint for her help.

30,000 years old and still infectious March 2014

A new virus has been isolated in a 30,000-year-old ice core harvested from permafrost in Siberia, Russia. The Pithovirus infects amoeba’s and has a unique virion structure.

Amoeba’s giant viruses March 2014

A recent discovered amoeba’s Pandora virus has a huge genome compared to other known viruses. This fact may be related to amoebas having the biggest genome of all living cells. Their genome size would reach up to 670,000,000,000bp, that is more than 200 times the human genome size. In this context it is not surprising that amoeba’s nucleo cytoplasmic large DNA viruses like pandora virus can reach 2,470,000bp, which is about six times more than the biggest vertebrate virus, canarypoxvirus 359,000bp. A new page describes the Pandoravirus.

ViralZone update January 2014
- Viral molecular biology section has been completed, for example with: leaky scanning, subgenomic transcription, viroid and hepatitis delta replication, virus genome evolution, fungal virus cell to cell movement ...
- A user pointed out the ICTV code of Virus Classification rules for orthography, and we are updating the 640 pages of ViralZone to follow the rule:

3.36 In formal taxonomic usage, the accepted names of virus Orders, Families, Subfamilies, and Genera are printed in italics and the first letters of the names are capitalized.

>>News archive

Publication: ViralZone: a knowledge resource to understand virus diversity. Hulo C, de Castro E, Masson P, Bougueleret L, Bairoch A, Xenarios I, Le Mercier P. Nucleic Acids Res. 2011 Jan;39(Database issue):D576-82.

ViralZone current statistics
June, 2014
470 Virus description pages:
  • 93 Families
  • 373 Genera
  • 9 individual Species

211 Viral molecular biology pages

Linking to:
(UniProt release 2014_06)

  • 401 reference strains
  • 16,479 manually reviewed proteins
  • 2,026,330 unreviewed viral proteins

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