Avihepadnavirus

VIRION

Enveloped, spherical. Diameter from about 42nm. Icosahedric capsid with a T=4 symmetry.

GENOME

Partially dsDNA circular genome, about 3.2 kb in size. Encodes for 7 proteins. h4. GENE EXPRESSION

REPLICATION

NUCLEO-CYTOPLASMIC

  1. Virus attaches to host receptors through major surface antigen and enters the cell by an unknown mechanism.
  2. Relaxed circular DNA (RC-DNA) and capsid are transported via microtubules to the nucleus where DNA is released through the nuclear pore, and repaired to form covalently closed circular DNA (cccDNA).
  3. Transcription by RNA polymerase II of the pregenomic RNA (pgRNA) and subgenomic mRNAs, inducing synthesis of all the viral proteins.
  4. pgRNA is encapsidated, together with the P protein, and reverse-transcribed inside the nucleocapsid in (-)DNA covalently linked to P protein.
  5. (+)DNA synthesis from the (-)DNA template generates new RC-DNA.
  6. Transport to the nucleus of new RC-DNA leads to cccDNA amplification; alternatively, the RC-DNA containing nucleocapsids are enveloped at the ER, and new virions are released by exocytosis.

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by strain (browse by keywords)

4 entries

Duck hepatitis B virus (isolate Shanghai/DHBVQCA34) (DHBV) reference strain

Select_allDeselect_all
CAPSD_DHBVQ Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_DHBVQ Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_DHBVQ External core antigen (HBeAg) (Precore protein)
HBSAG_DHBVQ Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

4 entries

Duck hepatitis B virus (isolate brown Shanghai duck S5) (DHBV)

Select_allDeselect_all
CAPSD_HPBDB Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HPBDB Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HPBDB Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HPBDB External core antigen (HBeAg) (Precore protein)

4 entries

Duck hepatitis B virus (isolate white Shanghai duck S31) (DHBV)

Select_allDeselect_all
CAPSD_HPBDW Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HPBDW Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_HPBDW Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_HPBDW External core antigen (HBeAg) (Precore protein)

4 entries

Duck hepatitis B virus (strain China) (DHBV)

Select_allDeselect_all
CAPSD_HPBDC Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HPBDC Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HPBDC External core antigen (HBeAg) (Precore protein)
HBSAG_HPBDC Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

4 entries

Duck hepatitis B virus (strain Germany/DHBV-3) (DHBV)

Select_allDeselect_all
CAPSD_DHBV3 Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_DHBV3 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBSAG_DHBV3 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...
HBEAG_DHBV3 External core antigen (HBeAg) (Precore protein)

4 entries

Duck hepatitis B virus (strain United States/DHBV-16) (DHBV)

Select_allDeselect_all
CAPSD_DHBV1 Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_DHBV1 Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_DHBV1 External core antigen (HBeAg) (Precore protein)
HBSAG_DHBV1 Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...

4 entries

Heron hepatitis B virus (HHBV)

Select_allDeselect_all
CAPSD_HHBV Capsid protein (Core antigen) (Core protein) (HBcAg)
DPOL_HHBV Protein P [Includes: DNA-directed DNA polymerase (EC 2.7.7.7); RNA-directed DNA polymerase (EC ...
HBEAG_HHBV External core antigen (HBeAg) (Precore protein)
HBSAG_HHBV Large envelope protein (L glycoprotein) (L-HBsAg) (LHB) (Large S protein) (Large surface protein) ...