Parvoviridae

VIRION


Non-enveloped, round, T=1 icosahedral symmetry, 18-26 nm in diameter. The capsid consists of 60 copies of CP protein.

GENOME

Linear, ssDNA genome of about 4 to 6 kb in size.
The genome is replicated through rolling-hairpin mechanism.

GENE EXPRESSION

Host proteins transcribe the genome into mRNAs. Depending on the virus there can be one (Erythrovirus and Iteravirus), two (Densovirus and Brevidensovirus) or three (Dependovirus) promoters for mRNA transcription. Alternative splicing allows expression of both structural and non-structural proteins. Leaky scanning is used as well by densoviruses.

REPLICATION

NUCLEAR

  1. Attachement to host receptors initiates clathrin-mediated endocytosis of the virion into the host cell.
  2. The virion penetrates into the cytoplasm via permeabilization of host endosomal membrane.
  3. Microtubular transport of the virion toward the nucleus.
  4. The viral ssDNA genome penetrates into the nucleus.
  5. The ssDNA is converted into dsDNA by cellular proteins.
  6. dsDNA transcription gives rise to viral mRNAs when host cell enters S phase and translated to produce viral proteins.
  7. Replication occurs through rolling-hairpin mechanism, with NS1 endonuclease binding covalently to the 5' genomic end.
  8. Individual ssDNA genomes are excised from replication concatemers by a process called junction resolution.
  9. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated to form new virions that are released by cell lysis.

Host-virus interaction

Apoptosis modulation

Parvoviruses infection induces host cell death, which is often directly associated with disease outcomes. Apoptosis is the major form of cell death induced by parvovirus infection, mostly associated with caspases activation. However, necrosis, has also been reported during infection of the minute virus of mice, parvovirus H-1 and bovine parvovirus.

Cell-cycle modulation

Many parvoviruses induce G2/M checkpoint arrest.

Matching UniProtKB/Swiss-Prot entries

62 entries grouped by strain (browse by keywords)

All proteins are shown (view only 55 complete proteome entries)

6 entries

Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2) reference strain

Select_allDeselect_all
AAP_AAV2S Assembly activating protein AAP
CAPSD_AAV2S Capsid protein VP1
REP78_AAV2S Protein Rep78
REP52_AAV2S Protein Rep52
REP40_AAV2S Protein Rep40 (EC 3.6.4.12)
REP68_AAV2S Protein Rep68 (EC 3.6.4.12)

5 entries

Human parvovirus B19 (strain HV) (HPV B19) reference strain

Select_allDeselect_all
75K_PAVHV Uncharacterized protein 7.5K (Uncharacterized protein of 7.5 kDa)
11K_PAVHV Host-modulation protein 11K (Host-modulation protein of 11 kDa)
CAPSD_PAVHV Capsid protein VP1
X_PAVHV Uncharacterized protein X
NS1_PAVHV Non-structural protein 1

4 entries

Aleutian mink disease parvovirus (strain G) (ADV) reference strain

Select_allDeselect_all
CAPSD_ADVG Capsid protein VP1
NS2_ADVG Non-structural protein NS2
NS1_ADVG Non-structural protein NS1
NS3_ADVG Non-structural protein NS3

4 entries

Junonia coenia densovirus (isolate pBRJ/1990) (JcDNV) reference strain

Select_allDeselect_all
CAPSD_JDNVP Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)
VNS2_JDNVP Putative non-structural protein NS2 (ORF3)
VNCS_JDNVP Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)
VNS3_JDNVP Putative non-structural protein NS3 (ORF4)

3 entries

Aedes albopictus densovirus (isolate Boublik/1994) (AalDNV) reference strain

Select_allDeselect_all
CAPSD_AADNV Capsid protein VP1/VP2 (Coat protein VP1/VP2)
NS1_AADNV Non-structural protein NS1 (Non-capsid protein NS-1) (NCVP1)
NS2_AADNV Non-structural protein NS2 (Non-capsid protein NS-2) (NCVP2)

3 entries

Bovine parvovirus (isolate pAT153/1986) (BPV) reference strain

Select_allDeselect_all
CAPSD_PAVBP Capsid protein VP1 (Coat protein VP1) [Cleaved into: Capsid protein VP2 (Coat protein VP2)]
VNCS_PAVBP Non-capsid protein NS-1 (Non-structural protein NS1)
VNCN_PAVBP Probable non-capsid protein NP1

3 entries

Murine minute virus (strain MVM prototype) (MVM) (Murine minute virus (strain MVM(p))) reference strain

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CAPSD_MUMIP Capsid protein VP1 (Coat protein VP1)
NS1_MUMIP Non-structural protein NS1
NS2_MUMIP Non-structural protein NS2

4 entries

Diatraea saccharalis densovirus (DsDNV)

Select_allDeselect_all
CAPSD_DSDNV Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)
VNCS_DSDNV Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)
VNS2_DSDNV Non-structural protein NS2
VNS3_DSDNV Non-structural protein NS3

3 entries

Bombyx mori densovirus (BmDNV) (Bombyx densonucleosis virus)

Select_allDeselect_all
VNCS_BMDNV Putative non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)
VNS1_BMDNV Putative non-structural protein (ORF1)
VNS3_BMDNV Putative non-structural protein (ORF3)

2 entries

Aedes densonucleosis virus (strain GKV 002 002) (Aedes densovirus)

Select_allDeselect_all
CAPSD_AEDEV Capsid protein VP1/VP2 (Coat protein VP1/VP2)
VNCS_AEDEV Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

2 entries

Canine parvovirus type 2 (isolate Dog/United States/CPV-N/1978) (CPV-2)

Select_allDeselect_all
CAPSD_PAVCN Capsid protein VP1 (Coat protein VP1)
VNCS_PAVCN Non-capsid protein NS-1 (Non-structural protein NS1)

2 entries

Feline panleukopenia virus (strain 193) (FPV)

Select_allDeselect_all
CAPSD_FPV19 Capsid protein VP1 (Coat protein VP1)
VNCS_FPV19 Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

2 entries

Hamster parvovirus H1

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CAPSD_PAVHH Capsid protein VP1 (Coat protein VP1)
VNCS_PAVHH Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

2 entries

Human parvovirus B19 (isolate AU) (HPV B19)

Select_allDeselect_all
CAPSD_PAVHU Capsid protein VP1 (Coat protein VP1) [Cleaved into: Capsid protein VP2 (Coat protein VP2)]
VNCS_PAVHU Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

2 entries

Mink enteritis virus (strain Abashiri) (MEV)

Select_allDeselect_all
CAPSD_MEVA Capsid protein VP1 (Coat protein VP1) [Cleaved into: Capsid protein VP2 (Coat protein VP2)]
VNCS_MEVA Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

2 entries

Murine minute virus (strain MVMi) (MVM) (Murine parvovirus)

Select_allDeselect_all
CAPSD_MUMIM Capsid protein VP1 (Coat protein VP1)
VNCS_MUMIM Non-capsid protein NS-1 (NCVP1) (Non-structural protein NS1)

2 entries

Parvovirus LuIII

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CAPSD_PAVL3 Capsid protein VP1 (Coat protein VP1)
VNCS_PAVL3 Non-capsid protein NS-1 (Non-structural protein NS1)

2 entries

Porcine parvovirus (strain Kresse) (PPV)

Select_allDeselect_all
CAPSD_PAVPK Capsid protein VP1 (Coat protein VP1)
VNCS_PAVPK Non-capsid protein NS-1 (Non-structural protein NS1)

2 entries

Porcine parvovirus (strain NADL-2) (PPV)

Select_allDeselect_all
CAPSD_PAVPN Capsid protein VP1 (Coat protein VP1)
VNCS_PAVPN Non-capsid protein NS-1 (Non-structural protein NS1)

1 entry

Canine parvovirus type 2 (CPV-2)

CAPSD_PAVC Capsid protein VP2 (Coat protein VP2)

1 entry

Canine parvovirus type 2 (isolate Dog/United States/CPV-b/1978) (CPV-2)

CAPSD_PAVCB Capsid protein VP1 (Coat protein VP1)

1 entry

Canine parvovirus type 2 (strain Dog/United States/780929/-) (CPV-2)

CAPSD_PAVC7 Capsid protein VP1 (Coat protein VP1)

1 entry

Canine parvovirustype 2 (isolate Dog/United States/CPV-d/1988) (CPV-2)

CAPSD_PAVCD Capsid protein VP1 (Coat protein VP1)

1 entry

Feline panleukopenia virus (FPV)

CAPSD_FPV Capsid protein VP1 (Coat protein VP1)

1 entry

Galleria mellonella densovirus (GmDNV)

CAPSD_GMDNV Capsid protein VP1 (Coat protein VP1) (Structural protein VP1)

1 entry

Porcine parvovirus (strain 90HS) (PPV)

CAPSD_PAVP9 Capsid protein VP1 (Coat protein VP1)