Gyrovirus

VIRION

Non-enveloped, round, T=1 icosahedral symmetry, about 25 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentamers.

GENOME

Monopartite, circular, ssDNA genome of about 2300 bp.
The genome is replicated through double-stranded intermediates. A replication Rep-like protein would initiates rolling circle replication.

GENE EXPRESSION

One mRNA is transcribed by cellular RNA polymerase II and encodes for three proteins: VP1, VP2 and VP3 probably through leaky scanning mechanism.

REPLICATION

NUCLEAR

  1. Virus penetrates into the host cell.
  2. Uncoating, the viral ssDNA genome penetrates into the nucleus.
  3. Viral ssDNA is converted into dsDNA with the participation of cellular factors. dsDNA transcription gives rise to viral mRNAs.
  4. Viral mRNAs are translated to produce viral proteins.
  5. Replication may be mediated by a Rep protein, and would occur by rolling circle replication producing ssDNA genomes.
  6. These newly synthesized ssDNA can either
    a) be converted to dsDNA and serve as a template for transcription/replication
    b) be encapsidated by capsid protein and form virions released by cell lysis.

Host-virus interaction

Apoptosis modulation

Chicken anemia virus VP3 protein induces apoptosis observed in CAV infection. Virus-induced apoptosis accounts for the severe depletion of cortical thymocytes and erythroblastoid cells in the bone marrow .

Matching UniProtKB/Swiss-Prot entries

16 entries grouped by protein (browse by keywords)

All proteins are shown (view only 15 complete proteome entries)

6 entries

Capsid protein (CA1) (Coat protein)

Select_allDeselect_all
CAPSD_CAVC1
Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) reference strain
CAPSD_CAV26
Chicken anemia virus (isolate USA 26p4) (CAV)
CAPSD_CAV82
Chicken anemia virus (isolate Japan 82-2) (CAV)
CAPSD_CAVAU
Chicken anemia virus (isolate Australia) (CAV)
CAPSD_CAVCA
Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
CAPSD_CAVCI
Chicken anemia virus (isolate USA CIA-1) (CAV)

5 entries

Dual specificity protein phosphatase VP2 (EC 3.1.3.16) (EC 3.1.3.48)

Select_allDeselect_all
VP2_CAVC1
Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) reference strain
VP2_CAV26
Chicken anemia virus (isolate USA 26p4) (CAV)
VP2_CAV82
Chicken anemia virus (isolate Japan 82-2) (CAV)
VP2_CAVCA
Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
VP2_CAVCI
Chicken anemia virus (isolate USA CIA-1) (CAV)

5 entries

Apoptin

Select_allDeselect_all
VP3_CAVC1
Chicken anemia virus (isolate Germany Cuxhaven-1) (CAV) reference strain
VP3_CAV26
Chicken anemia virus (isolate USA 26p4) (CAV)
VP3_CAV82
Chicken anemia virus (isolate Japan 82-2) (CAV)
VP3_CAVCA
Chicken anemia virus (isolate Australia/CAU269-7/2000) (CAV)
VP3_CAVCI
Chicken anemia virus (isolate USA CIA-1) (CAV)