Cucumovirus

VIRION

Non-enveloped, spherical virion about 29nm in diameter with T=3 icosahedral symmetry, composed of 180 coat proteins: 12 pentamers and 20 hexamers.

GENOME

Segmented, tripartite linear ssRNA(+) genome composed of RNA1, RNA2, RNA3. Each genomic segment has a 3' tRNA-like structure and a 5’cap.

GENE EXPRESSION

Genomic RNA serves as messenger RNAs. RNA1 and RNA2 encode respectively proteins 1a and 2a, both involved in genome replication and internal transcription of sgRNA4 from the minus-strand copy of RNA3. RNA3 and sgRNA4 are translated respectively into movement and capsid proteins. ORF2b encodes a viral suppressor of RNA silencing (VSR) and is expressed probably as a subgenomic RNA (sgRNA4A).

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the host cell.
  2. Uncoating, and release of the viral genomic RNA into the cytoplasm.
  3. Expression of protein 1a and 2a to produce replication proteins.
  4. Replication occurs in viral factories made of membrane vesicles derived from the ER (spherules). A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Subgenomic RNA4 is translated producing capsid proteins.
  7. Assembly of new virus particles.
  8. Viral movement protein triggers the formation of tubular structures that mediate virion cell-to-cell transfer via a tubule-guided mechanism.

Host-virus interaction

Suppression of RNA silencing

Cucumovirus protein 2b acts as a suppressor of RNA silencing .

Matching UniProtKB/Swiss-Prot entries

74 entries grouped by strain (browse by keywords)

All proteins are shown (view only 15 complete proteome entries)

5 entries

Cucumber mosaic virus (strain FNY) (CMV) reference strain

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1A_CMVFN Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC ...
2B_CMVFN Suppressor of silencing 2b (Protein 2b)
CAPSD_CMVFN Capsid protein (CP) (Coat protein)
MVP_CMVFN Movement protein (MP) (Protein 3A)
RDRP_CMVFN RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

5 entries

Cucumber mosaic virus (strain Q) (CMV) reference strain

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1A_CMVQ Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC ...
2B_CMVQ Suppressor of silencing 2b (Protein 2b)
CAPSD_CMVQ Capsid protein (CP) (Coat protein)
MVP_CMVQ Movement protein (MP) (Protein 3A)
RDRP_CMVQ RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

5 entries

Tomato aspermy virus (TAV) reference strain

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1A_TAV Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC ...
2B_TAV Suppressor of silencing 2b (Protein 2b)
CAPSD_TAV Capsid protein (CP) (Coat protein)
MVP_TAV Movement protein (MP) (Protein 3A)
RDRP_TAV RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

4 entries

Cucumber mosaic virus (strain Ixora) (CMV)

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1A_CMVIX Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC ...
CAPSD_CMVIX Capsid protein (CP) (Coat protein)
MVP_CMVIX Movement protein (MP) (Protein 3A)
RDRP_CMVIX RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

4 entries

Cucumber mosaic virus (strain NT9) (CMV)

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1A_CMVNT Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC ...
CAPSD_CMVNT Capsid protein (CP) (Coat protein)
MVP_CMVNT Movement protein (MP) (Protein 3A)
RDRP_CMVNT RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

4 entries

Cucumber mosaic virus (strain Y) (CMV)

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1A_CMVY Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC ...
CAPSD_CMVY Capsid protein (CP) (Coat protein)
MVP_CMVY Movement protein (MP) (Protein 3A)
RDRP_CMVY RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

4 entries

Peanut stunt virus (strain J) (PSV)

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1A_PSVJ Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC ...
CAPSD_PSVJ Capsid protein (CP) (Coat protein)
MVP_PSVJ Movement protein (MP) (Protein 3A)
RDRP_PSVJ RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

3 entries

Cucumber mosaic virus (strain As) (CMV)

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CAPSD_CMVAS Capsid protein (CP) (Coat protein)
MVP_CMVAS Movement protein (MP) (Protein 3A)
RDRP_CMVAS RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

3 entries

Cucumber mosaic virus (strain Iizuka) (CMV)

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1A_CMVII Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC ...
CAPSD_CMVII Capsid protein (CP) (Coat protein)
RDRP_CMVII RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

3 entries

Cucumber mosaic virus (strain Kor) (CMV)

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CAPSD_CMVKO Capsid protein (CP) (Coat protein)
MVP_CMVKO Movement protein (MP) (Protein 3A)
RDRP_CMVKO RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

3 entries

Cucumber mosaic virus (strain O) (CMV)

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1A_CMVO Replication protein 1a [Includes: ATP-dependent helicase (EC 3.6.4.-); Methyltransferase (EC ...
CAPSD_CMVO Capsid protein (CP) (Coat protein)
MVP_CMVO Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain C7-2) (CMV)

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CAPSD_CMVC7 Capsid protein (CP) (Coat protein)
MVP_CMVC7 Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain CS) (CMV)

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CAPSD_CMVCS Capsid protein (CP) (Coat protein)
MVP_CMVCS Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain FT) (CMV)

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CAPSD_CMVFT Capsid protein (CP) (Coat protein)
MVP_CMVFT Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain Kin) (CMV)

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CAPSD_CMVKI Capsid protein (CP) (Coat protein)
MVP_CMVKI Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain M) (CMV)

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CAPSD_CMVM Capsid protein (CP) (Coat protein)
MVP_CMVM Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain M48) (CMV)

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CAPSD_CMVM4 Capsid protein (CP) (Coat protein)
MVP_CMVM4 Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain N) (CMV)

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CAPSD_CMVN Capsid protein (CP) (Coat protein)
MVP_CMVN Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain Pepo) (CMV)

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CAPSD_CMVPE Capsid protein (CP) (Coat protein)
MVP_CMVPE Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain S) (CMV)

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CAPSD_CMVS Capsid protein (CP) (Coat protein)
MVP_CMVS Movement protein (MP) (Protein 3A)

2 entries

Cucumber mosaic virus (strain Trk7) (CMV)

Select_allDeselect_all
CAPSD_CMVTR Capsid protein (CP) (Coat protein)
MVP_CMVTR Movement protein (MP) (Protein 3A)

1 entry

Cucumber mosaic virus (strain B) (CMV)

RDRP_CMVB RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

1 entry

Cucumber mosaic virus (strain Banana) (CMV)

CAPSD_CMVBA Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain C) (CMV)

CAPSD_CMVC Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain DKRD) (CMV)

CAPSD_CMVDK Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain E5) (CMV)

CAPSD_CMVE5 Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain FC) (CMV)

CAPSD_CMVFC Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain I17F) (CMV)

CAPSD_CMVI1 Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain K) (CMV)

RDRP_CMVK RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

1 entry

Cucumber mosaic virus (strain MB-8) (CMV)

RDRP_CMVMB RNA-directed RNA polymerase 2a (protein 2a) (EC 2.7.7.48)

1 entry

Cucumber mosaic virus (strain P6) (CMV)

CAPSD_CMVP6 Capsid protein (CP) (Coat protein)

1 entry

Cucumber mosaic virus (strain WL) (CMV)

CAPSD_CMVWL Capsid protein (CP) (Coat protein)