Viral budding via the host ESCRT complexes


Many enveloped viruses recruit components of the cellular ESCRT (endosomal sorting complex required for transport) system to mediate host-assisted viral budding .

ESCRT complexes are normally used by the cell for biological functions involving membrane remodeling, such as intraluminal vesicle formation, autophagy or terminal stages of cytokinesis . The ESCRT family consists of ESCRT-0, ESCRT-I, ESCRT-II which are primarily involved in cargo sorting and membrane deformation, and ESCRT-III which cleaves the bud neck from its cytosolic face . In the last step, vps4 disassembles the complex. The budding reaction catalyzed by the ESCRT machinery has reversed topology when compared with most other budding processes in the cell, such as endocytosis and formation of transport vesicles.



Specific motifs in viral proteins called late assembly domains (L-domains) are responsible for recruiting the host ESCRT machinery directly or via ESCRT-associated proteins like ALIX.

- PTAP motif (and PSAP) recruits the ESCRT machinery via Tsg101.

- LYPx n L motif bind the adaptor protein ALIX, which in turn binds and recruits the ESCRT machinery.

- PPxY motif enlists members of the NEDD4 family of ubiquitin ligases through interactions with WW domains, although the precise link between the NEDD4-like proteins and the ESCRT machinery is still unknown.

- A fourth motif encoded by FPIV has been identified in the matrix protein of the paramyxovirus simian virus 5.
Some enveloped viruses however seem to use other mechanisms to bud, as it has been shown for Influenza virus .

Viruses budding through the ESCRT machinery:

Family Virus Viral protein L-domain motif Host ESCRT Budding location ref
Retroviridae HIV-1 P6-gag PTAP TSG101 Cell membrane
LYPx n L ALIX (low affinity) Cell membrane
SIV P6-gag PTAP TSG101 Cell membrane
LYPx n L ALIX Cell membrane
HTLV-1 P19-gag PPxY NEDD4 Cell membrane
PTAP TSG101 (low affinity) Cell membrane
Human spumaretrovirus Gag protein PTAP TSG101 Cell membrane
Moloney murine leukemia virus P12-gag PPxY ITCH Cell membrane
PTAP TSG101 Cell membrane
LYPx n L ALIX Cell membrane
Bovine leukemia virus Gag protein PPxY n L NEDD4 Cell membrane
Rous sarcoma virus Gag protein PPxY NEDD4 Cell membrane
Mason-Pfizer monkey virus Gag protein PSAP TSG101 Cell membrane
PPxY NEDD4 Cell membrane
EIAV P9-gag LYPx n L ALIX Cell membrane
Hepadnaviridae HBV ?Capsid protein ? ALIX Endoplasmic reticulum
Filoviridae Ebolavirus Matrix protein PTAP TSG101 Cell membrane
PPxY NEDD4 Cell membrane
Marburgvirus Matrix protein PPxY NEDD4 Cell membrane
Nucleoprotein PSAP TSG101 Cell membrane
Rhabdoviridae Vesicular stomatitis virus M protein PPxY NEDD4 Cell membrane
?PSAP ? Cell membrane
Rabies virus M protein PPxY ? Cell membrane
Paramyxoviridae Sendai virus M protein YLDL ALIX Cell membrane
Nipah virus M protein YMYL ? Cell membrane
Simian virus 5 M protein FPIV ? Cell membrane
Arenaviridae Lymphocytic choriomeningitis virus Z protein PTAP TSG101 Cell membrane
Lassa virus Z protein PTAP TSG101 Cell membrane
PPxY ? Cell membrane
Bunyaviridae Gn glycoproteins YxxL? ? Golgi
Flaviviridae Hepatitis C virus ?Core protein ? ? Endoplasmic reticulum
Herpesviridae Herpes simplex virus 1 ? ? Vps4 Trans-Golgi
Epstein-Barr virus ? ? ? Trans-Golgi
HCMV ? ? Vps4 Trans-Golgi
Poxviridae Vaccinia virus F13 protein LYPx(n)L ? Cell membrane

Matching UniProtKB/Swiss-Prot entries

207 entries grouped by strain (browse by keywords)

All proteins are shown (view only 137 complete proteome entries)

2 entries

Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain

Select_allDeselect_all
NCAP_MABVM Nucleoprotein (Nucleocapsid protein) (Protein N)
VP40_MABVM Matrix protein VP40 (Membrane-associated protein VP40)

1 entry

Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain

MATRX_ABLVB Matrix protein (Phosphoprotein M2)

1 entry

Chandipura virus (strain I653514) (CHPV) reference strain

MATRX_CHAV Matrix protein

1 entry

Drosophila melanogaster sigma virus (isolate Drosophila/USA/AP30/2005) (DMelSV) reference strain

MATRX_DMSVA Matrix protein

1 entry

European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain

MATRX_EBLV1 Matrix protein

1 entry

European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain

MATRX_EBLV2 Matrix protein

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain

GAG_HV1MA Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain

GAG_HV1B1 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) reference strain

GAG_HV1BR Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain

GAG_HV1H2 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain

GAG_HV1MN Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain

GAG_HV1EL Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain

GAG_HV1VI Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) reference strain

GAG_HV2BE Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human spumaretrovirus (SFVcpz(hu)) (Human foamy virus) reference strain

GAG_FOAMV Gag polyprotein (Pr71Gag) [Cleaved into: Gag protein (p68Gag); p3 (p3Gag)]

1 entry

Lassa virus (strain Mouse/Sierra Leone/Josiah/1976) (LASV) reference strain

Z_LASSJ RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Latino mammarenavirus (isolate Rat/Bolivia/MARU 1924/1965) (LATV) reference strain

Z_LATVB RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Lymphocytic choriomeningitis virus (strain Armstrong) (LCMV) reference strain

Z_LYCVA RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Mokola virus (MOKV) reference strain

MATRX_MOKV Matrix protein (Phosphoprotein M2)

1 entry

Moloney murine leukemia virus (isolate Shinnick) (MoMLV) reference strain

GAG_MLVMS Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Mouse mammary tumor virus (strain C3H) (MMTV) reference strain

GAG_MMTVC Gag polyprotein [Cleaved into: Matrix protein p10; Phosphorylated protein pp21; Protein p3; Protein ...

1 entry

Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

MATRX_NDVB1 Matrix protein

1 entry

Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain

MATRX_PIV5 Matrix protein (Membrane protein)

1 entry

Pirital mammarenavirus (isolate Rat/Venezuela/VAV-488/1995) (PIRV) reference strain

Z_PIRVV RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain

MATRX_RABVP Matrix protein (Phosphoprotein M2)

1 entry

Rabies virus (strain SAD B19) (RABV) reference strain

MATRX_RABVS Matrix protein (Phosphoprotein M2)

1 entry

Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain

VP40_EBORR Matrix protein VP40 (Membrane-associated protein VP40)

1 entry

Sendai virus (strain Ohita) (SeV) reference strain

MATRX_SENDO Matrix protein (M protein)

1 entry

Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

MATRX_SENDZ Matrix protein (M protein)

1 entry

Simian foamy virus (isolate chimpanzee) (SFVcpz) reference strain

GAG_SFVCP Gag polyprotein (Pr71Gag) [Cleaved into: Gag protein (p68Gag); p3 (p3Gag)]

1 entry

Simian foamy virus type 1 (SFVmac) (SFV-1) reference strain

GAG_SFV1 Gag polyprotein (Pr71Gag) [Cleaved into: Gag protein (p68Gag); p3 (p3Gag)]

1 entry

Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

GAG_SIVEK Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

GAG_SIVMB Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); ...

1 entry

Simian immunodeficiency virus (isolate TAN1) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain

GAG_SIVTN Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Tacaribe virus (strain Franze-Fernandez) (TCRV) reference strain

Z_TACVF RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Tamiami mammarenavirus (isolate Rat/United States/W 10777/1964) (TAMV) reference strain

Z_TAMVU RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Tibrogargan virus (strain CS132) (TIBV) reference strain

MATRX_TIBVC Matrix protein

1 entry

Tupaia virus (isolate Tupaia/Thailand/-/1986) (TUPV) reference strain

MATRX_TUPVT Matrix protein

1 entry

Vaccinia virus (strain Copenhagen) (VACV) reference strain

F13_VACCC Envelope protein F13 (37 kDa protein) (Palmitoylated EV membrane protein) (p37K)

1 entry

Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

F13_VACCW Envelope protein F13 (37 kDa protein) (Palmitoylated EV membrane protein) (p37K)

1 entry

Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain

F13_VAR67 Envelope protein F13 (37 kDa protein) (Palmitoylated EV membrane protein) (p37K)

1 entry

Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV) reference strain

MATRX_VSIVG Matrix protein

1 entry

Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain

MATRX_VSIVA Matrix protein

1 entry

Xenotropic MuLV-related virus (isolate VP62) (XMRV) reference strain

GAG_XMRV6 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

VP40_EBOZM Matrix protein VP40 (Membrane-associated protein VP40)

2 entries

Lake Victoria marburgvirus (strain Angola/2005) (MARV)

Select_allDeselect_all
NCAP_MABVA Nucleoprotein (Nucleocapsid protein)
VP40_MABVA Matrix protein VP40 (Membrane-associated protein VP40)

2 entries

Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))

Select_allDeselect_all
NCAP_MABVO Nucleoprotein (Nucleocapsid protein)
VP40_MABVO Matrix protein VP40 (Membrane-associated protein VP40)

2 entries

Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))

Select_allDeselect_all
NCAP_MABVP Nucleoprotein (Nucleocapsid protein) (Protein N)
VP40_MABVP Matrix protein VP40 (Membrane-associated protein VP40)

2 entries

Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

Select_allDeselect_all
NCAP_MABVR Nucleoprotein (Nucleocapsid protein)
VP40_MABVR Matrix protein VP40 (Membrane-associated protein VP40)

1 entry

AKV murine leukemia virus (AKR (endogenous) murine leukemia virus)

GAG_MLVAV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Abelson murine leukemia virus

GAG_MLVAB Gag polyprotein [Cleaved into: Matrix protein p15 (MA); RNA-binding phosphoprotein p12; Capsid ...

1 entry

Allpahuayo mammarenavirus (isolate Rat/Peru/CLHP-2472/1997) (ALLV)

Z_ALLVP RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Aravan virus (ARAV)

MATRX_ARAV Matrix protein (Phosphoprotein M2)

1 entry

Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)

MATRX_ABLVH Matrix protein (Phosphoprotein M2)

1 entry

Avian myelocytomatosis virus HBI

GAG_AVIMD Gag polyprotein [Cleaved into: Matrix protein p19; Core protein p10; Core protein p27]

1 entry

Avian myelocytomatosis virus MC29

GAG_AVIMC Gag polyprotein [Cleaved into: Matrix protein p19; Core protein p10; Core protein p27]

1 entry

Avian sarcoma virus (strain CT10)

GAGC_AVISC P47(GAG-CRK) protein

1 entry

Avian sarcoma virus (strain Y73)

GAG_AVISY Gag polyprotein [Cleaved into: Matrix protein p19; Core protein p10]

1 entry

Baboon endogenous virus (strain M7)

GAG_BAEVM Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Bear Canyon mammarenavirus (isolate Mouse/United States/AV A0070039/2000) (BCNV)

Z_BCNVU RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Bovine immunodeficiency virus (strain R29) (BIV) (Bovine immunodeficiency-like virus)

GAG_BIV29 Gag polyprotein (Pr53Gag) [Cleaved into: Matrix protein p16 (MA); p2L; Capsid protein p26 (CA); p3; ...

1 entry

Bovine leukemia virus (isolate Australian) (BLV)

GAG_BLVAU Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p24 (CA); Core protein p12]

1 entry

Bovine leukemia virus (isolate Japanese BLV-1) (BLV)

GAG_BLVJ Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p24 (CA); Core protein p12]

1 entry

Caprine arthritis encephalitis virus (strain Cork) (CAEV-Co)

GAG_CAEVC Gag polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14]

1 entry

Cas-Br-E murine leukemia virus

GAG_MLVCB Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Chapare mammarenavirus (isolate Human/Bolivia/810419/2003)

Z_CHAVB RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Cupixi mammarenavirus (isolate Rat/Brasil/BeAn 119303/1970) (CPXV)

Z_CPXVB RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Equine infectious anemia virus (isolate 1369) (EIAV)

GAG_EIAV9 Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p26 (CA); p1; Nucleocapsid ...

1 entry

Equine infectious anemia virus (isolate CL22) (EIAV)

GAG_EIAVC Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p26 (CA); p1; Nucleocapsid ...

1 entry

Equine infectious anemia virus (strain Wyoming) (EIAV)

GAG_EIAVY Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p26 (CA); p1; Nucleocapsid ...

1 entry

FBR murine osteosarcoma virus (FBR-MSV) (Finkel-Biskis-Reilly murine osteosarcoma virus)

GAG_MSVFR Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Feline immunodeficiency virus (isolate Petaluma) (FIV)

GAG_FIVPE Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p24 (CA); p1; Nucleocapsid ...

1 entry

Feline immunodeficiency virus (isolate TM2) (FIV)

GAG_FIVT2 Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p24 (CA); p1; Nucleocapsid ...

1 entry

Feline immunodeficiency virus (isolate Wo) (FIV)

GAG_FIVWO Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p24 (CA); p1; Nucleocapsid ...

1 entry

Feline immunodeficiency virus (strain San Diego) (FIV)

GAG_FIVSD Gag polyprotein [Cleaved into: Matrix protein p15 (MA); Capsid protein p24 (CA); p1; Nucleocapsid ...

1 entry

Feline leukemia virus

GAG_FLV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Feline sarcoma virus (strain Gardner-Arnstein) (Ga-FeSV) (Gardner-Arnstein feline leukemia oncovirus B)

GAG_FSVGA Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Feline sarcoma virus (strain McDonough)

GAG_FSVMD Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Feline sarcoma virus (strain Snyder-Theilen)

GAG_FSVST Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Friend murine leukemia virus (isolate 57) (FrMLV)

GAG_MLVF5 Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...

1 entry

Friend murine leukemia virus (isolate FB29) (FrMLV)

GAG_MLVFF Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...

1 entry

Friend murine leukemia virus (isolate PVC-211) (FrMLV)

GAG_MLVFP Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15; RNA-binding phosphoprotein p12 ...

1 entry

Friend spleen focus-forming virus (isolate 502) (FSFFV)

GAG_FRSF5 Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Fujinami sarcoma virus

GAG_FUJSV Gag polyprotein [Cleaved into: Matrix protein p19; p10; Capsid protein p27]

1 entry

Gibbon ape leukemia virus (GALV)

GAG_GALV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Guanarito mammarenavirus (isolate Human/Venezuela/NH-95551/1990) (GTOV)

Z_GTOVV RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Hortulanus murine leukemia virus (HoMuLV) (Mus hortulanus virus)

GAG_MLVHO Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1)

GAG_HV1U4 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)

GAG_HV1A2 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1)

GAG_HV1B5 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate CDC-451) (HIV-1)

GAG_HV1C4 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JH32) (HIV-1)

GAG_HV1J3 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)

GAG_HV1JR Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)

GAG_HV1LW Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)

GAG_HV1N5 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)

GAG_HV1OY Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)

GAG_HV1RH Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)

GAG_HV1Y2 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)

GAG_HV1B9 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)

GAG_HV192 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1)

GAG_HV1ET Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)

GAG_HV1ND Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)

GAG_HV1Z2 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)

GAG_HV193 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)

GAG_HV1MP Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)

GAG_HV1M2 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)

GAG_HV19N Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)

GAG_HV1SE Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1)

GAG_HV190 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)

GAG_HV1V9 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)

GAG_HV1S9 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)

GAG_HV1S2 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)

GAG_HV196 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)

GAG_HV197 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)

GAG_HV1YB Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1)

GAG_HV1YF Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)

GAG_HV1AN Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)

GAG_HV1MV Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2)

GAG_HV2CA Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2)

GAG_HV2D1 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)

GAG_HV2G1 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2)

GAG_HV2KR Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2)

GAG_HV2NZ Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)

GAG_HV2RO Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2)

GAG_HV2SB Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2)

GAG_HV2ST Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2)

GAG_HV2D2 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2)

GAG_HV2EH Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2)

GAG_HV2UC Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Ippy mammarenavirus (isolate Rat/Central African Republic/Dak An B 188 d/1970) (IPPYV)

Z_IPPYV RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Irkut virus (IRKV)

MATRX_IRKV Matrix protein (Phosphoprotein M2)

1 entry

Isfahan virus (ISFV)

MATRX_ISFV Matrix protein

1 entry

Jembrana disease virus (JDV)

GAG_JEMBR Gag polyprotein (Pr53Gag) [Cleaved into: Matrix protein p16 (MA); Capsid protein p26 (CA); ...

1 entry

Junin mammarenavirus (JUNV) (Junn mammarenavirus)

Z_JUNIN RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Khujand virus (KHUV)

MATRX_KHUV Matrix protein (Phosphoprotein M2)

1 entry

Koala retrovirus (KoRV)

GAG_KORV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Lagos bat virus (LBV)

MATRX_LBV Matrix protein

1 entry

Machupo virus (MACV)

Z_MACHU RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Maedi visna virus (strain 1514 / clone LV1-1KS1) (MVV) (Visna lentivirus)

GAG_VILV1 Gag polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14]

1 entry

Maedi visna virus (strain 1514 / clone LV1-1KS2) (MVV) (Visna lentivirus)

GAG_VILV2 Gag polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14]

1 entry

Maedi visna virus (strain 1514) (MVV) (Visna lentivirus)

GAG_VILV Gag polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14]

1 entry

Maedi visna virus (strain KV1772) (MVV) (Visna lentivirus)

GAG_VILVK Gag polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14]

1 entry

Mason-Pfizer monkey virus (MPMV) (Simian Mason-Pfizer virus)

GAG_MPMV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p10; Core phosphoprotein pp24; p12; ...

1 entry

Mobala mammarenavirus (isolate Rat/Central African Republic/Acar 3080/1983) (MOBV)

Z_MOBVC RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Moloney murine sarcoma virus (MoMSV)

GAG_MSVMO Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Moloney murine sarcoma virus (strain ts110) (MoMSV)

GAG_MSVMT Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Mouse mammary tumor virus (strain BR6) (MMTV)

GAG_MMTVB Gag polyprotein [Cleaved into: Matrix protein p10; Phosphorylated protein pp21; Protein p3; Protein ...

1 entry

Murine leukemia virus (strain BM5 eco)

GAG_MLVBM Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Newcastle disease virus (strain Beaudette C/45) (NDV)

MATRX_NDVB Matrix protein

1 entry

Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)

MATRX_NDVA Matrix protein

1 entry

Oliveros mammarenavirus (isolate Mouse/Argentina/RIID 3229/1990) (OLVV)

Z_OLVVA RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Ovine maedi visna related virus (strain South Africa) (SA-OMVV) (Ovine lentivirus)

GAG_OMVVS Gag polyprotein [Cleaved into: Matrix protein p16; Capsid protein p25; Nucleocapsid protein p14]

1 entry

Parana mammarenavirus (isolate Rat/Paraguay/12056/1965) (PARV) (Paran mammarenavirus)

Z_PARVP RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Piry virus (PIRYV)

MATRX_PIRYV Matrix protein

1 entry

Rabies virus (strain CVS-11) (RABV)

MATRX_RABVC Matrix protein (Phosphoprotein M2)

1 entry

Rabies virus (strain China/DRV) (RABV)

MATRX_RABVD Matrix protein (Phosphoprotein M2)

1 entry

Rabies virus (strain China/MRV) (RABV)

MATRX_RABVR Matrix protein (Phosphoprotein M2)

1 entry

Rabies virus (strain ERA) (RABV)

MATRX_RABVE Matrix protein (Phosphoprotein M2)

1 entry

Rabies virus (strain HEP-Flury) (RABV)

MATRX_RABVH Matrix protein (Phosphoprotein M2)

1 entry

Rabies virus (strain India) (RABV)

MATRX_RABVI Matrix protein (Phosphoprotein M2)

1 entry

Rabies virus (strain Nishigahara RCEH) (RABV)

MATRX_RABVN Matrix protein (Phosphoprotein M2)

1 entry

Rabies virus (strain PM1503/AVO1) (RABV)

MATRX_RABVA Matrix protein (Phosphoprotein M2)

1 entry

Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)

MATRX_RABVB Matrix protein (Phosphoprotein M2)

1 entry

Radiation murine leukemia virus

GAG_MLVRD Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)

VP40_EBORE Matrix protein VP40 (Membrane-associated protein VP40)

1 entry

Sabia mammarenavirus (isolate Human/Brasil/SPH114202/1990) (SABV) (Sabi mammarenavirus)

Z_SABVB RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Sendai virus (strain Enders) (SeV)

MATRX_SENDE Matrix protein (M protein)

1 entry

Sendai virus (strain Fushimi) (SeV)

MATRX_SENDF Matrix protein (M protein)

1 entry

Sendai virus (strain Hamamatsu) (SeV)

MATRX_SENDA Matrix protein (M protein)

1 entry

Sendai virus (strain Harris) (SeV)

MATRX_SENDH Matrix protein (M protein)

1 entry

Sheep pulmonary adenomatosis virus (Jaagsiekte sheep retrovirus) (JSRV)

GAG_JSRV Gag polyprotein [Cleaved into: Matrix protein p10; Core protein p18; p12; Capsid protein p27; ...

1 entry

Simian foamy virus type 3 (strain LK3) (SFVagm) (SFV-3)

GAG_SFV3L Gag polyprotein (Pr71Gag) [Cleaved into: Gag protein (p68); p3]

1 entry

Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus)

GAG_SIVCZ Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus (isolate F236/smH4) (SIV-sm) (Simian immunodeficiency virus sooty mangabey monkey)

GAG_SIVS4 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus (isolate GB1) (SIV-mnd) (Simian immunodeficiency virus mandrill)

GAG_SIVGB Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus (isolate K6W) (SIV-mac) (Simian immunodeficiency virus rhesus monkey)

GAG_SIVMK Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus (isolate Mm142-83) (SIV-mac) (Simian immunodeficiency virus rhesus monkey)

GAG_SIVM1 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus (isolate PBj14/BCL-3) (SIV-sm) (Simian immunodeficiency virus sooty mangabey monkey)

GAG_SIVSP Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus (isolate STM) (SIV-mac) (Simian immunodeficiency virus rhesus monkey)

GAG_SIVMS Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus agm.grivet (isolate AGM gr-1) (SIV-agm.gri) (Simian immunodeficiency virus African green monkey grivet)

GAG_SIVG1 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus agm.vervet (isolate AGM TYO-1) (SIV-agm.ver) (Simian immunodeficiency virus African green monkey vervet)

GAG_SIVVT Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus agm.vervet (isolate AGM155) (SIV-agm.ver) (Simian immunodeficiency virus African green monkey vervet)

GAG_SIVV1 Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian immunodeficiency virus agm.vervet (isolate AGM3) (SIV-agm.ver) (Simian immunodeficiency virus African green monkey vervet)

GAG_SIVVG Gag polyprotein (Pr55Gag) [Cleaved into: Matrix protein p17 (MA); Capsid protein p24 (CA); Spacer ...

1 entry

Simian retrovirus SRV-1

GAG_SRV1 Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p10; Core phosphoprotein pp18; p12; ...

1 entry

Simian retrovirus SRV-2

GAG_SRV2 Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p10; Core phosphoprotein pp18; p12; ...

1 entry

Spring viremia of carp virus (Rhabdovirus carpia)

MATRX_SVCV Matrix protein

1 entry

Squirrel monkey retrovirus (SMRV-H) (SMRV-HLB)

GAG_SMRVH Gag polyprotein [Cleaved into: Core protein p19; Core protein p16; Putative nucleocapsid protein ...

1 entry

Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)

VP40_EBOSU Matrix protein VP40 (Membrane-associated protein VP40)

1 entry

Vaccinia virus (strain Ankara) (VACV)

F13_VACCA Envelope protein F13 (37 kDa protein) (Palmitoylated EV membrane protein) (p37K)

1 entry

Vaccinia virus (strain IHD-J) (VACV)

F13_VACCI Envelope protein F13 (37 kDa protein) (Palmitoylated EV membrane protein) (p37K)

1 entry

Vaccinia virus (strain L-IVP) (VACV)

F13_VACCP Envelope protein F13 (37 kDa protein) (Palmitoylated EV membrane protein) (p37K)

1 entry

Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

MATRX_VSIVS Matrix protein

1 entry

Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)

MATRX_VSIVC Matrix protein

1 entry

Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)

MATRX_VSIVN Matrix protein

1 entry

Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV)

MATRX_VSNJO Matrix protein

1 entry

West Caucasian bat virus (WCBV)

MATRX_WCBV Matrix protein (Phosphoprotein M2)

1 entry

Whitewater Arroyo mammarenavirus (isolate Rat/United States/AV 9310135/1995) (WWAV)

Z_WWAVU RING finger protein Z (Protein Z) (Zinc-binding protein)

1 entry

Woolly monkey sarcoma virus (WMSV) (Smian sarcoma-associated virus)

GAG_WMSV Gag polyprotein (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Xenotropic MuLV-related virus (isolate VP35) (XMRV)

GAG_XMRV3 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Xenotropic MuLV-related virus (isolate VP42) (XMRV)

GAG_XMRV4 Gag polyprotein (Pr65gag) (Core polyprotein) [Cleaved into: Matrix protein p15 (MA); RNA-binding ...

1 entry

Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)

VP40_EBOG4 Matrix protein VP40 (Membrane-associated protein VP40)

1 entry

Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)

VP40_EBOZ5 Matrix protein VP40 (Membrane-associated protein VP40)