Leporipoxvirus

VIRION

Enveloped, brick-shaped 300x250x200nm. The surface membrane displays surface tubules or surface filaments. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome of 160kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Myxoma virus strain Lausanne genome at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Adaptive immune response inhibition

The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules .

Apoptosis modulation

Myxoma virus M11L inhibits host apoptosis by preventing the conformational activation of host Bax at the mitochondria .

Cell-cycle modulation

The myxomavirus Ankyrin repeat domain-containing protein M-T5 is an adapter of SKP1-containing E3 ubiquitin-protein ligases which mediate the ubiquitination and subsequent proteasomal degradation of host target proteins including CDKN1B. Disappearance of host CDKN1B correlates with cell cycle progression through the G0/G1 checkpoint .

Matching UniProtKB/Swiss-Prot entries

59 entries grouped by strain (browse by keywords)

All proteins are shown (view only 52 complete proteome entries)

27 entries

Rabbit fibroma virus (strain Kasza) (RFV) (Shope fibroma virus (strain Kasza)) reference strain

Select_allDeselect_all
A18_RFVKA Transcript termination protein A18 (EC 3.6.4.-)
A28_RFVKA Envelope protein A28 homolog (Protein Gp116)
B14_RFVKA Protein B14 homolog (Protein T3A)
D3_RFVKA Core protein D3 homolog (27 kDa virion core protein)
D10_RFVKA mRNA-decapping protein D10 (EC 3.1.3.-)
D2_RFVKA Core protein D4
D9_RFVKA mRNA-decapping protein D9 (EC 3.1.3.-)
GRFA_RFVKA Growth factor (Secreted epidermal growth factor-like)
KITH_RFVKA Thymidine kinase (EC 2.7.1.21)
ETF2_RFVKA Early transcription factor 82 kDa subunit (ETF large subunit)
ETF1_RFVKA Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small ...
LAP_RFVKA E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
MCEL_RFVKA mRNA-capping enzyme catalytic subunit (Virus termination factor large subunit) (VTF large subunit) ...
PAP1_RFVKA Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
MP44_RFVKA Probable metalloendopeptidase G1-type (EC 3.4.24.-)
NPH2_RFVKA RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside ...
NTP1_RFVKA Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
VT4_RFVKA T4 protein
RP07_RFVKA DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
TOP1_RFVKA DNA topoisomerase 1 (EC 5.99.1.2) (DNA topoisomerase I)
UNG_RFVKA Uracil-DNA glycosylase (UDG) (EC 3.2.2.27)
VH21_RFVKA Probable host range protein 2-1
VH22_RFVKA Probable host range protein 2-2
VT1_RFVKA Protein T1
VH23_RFVKA Probable host range protein 2-3
VT5_RFVKA Ankyrin repeat protein T5
VT2_RFVKA Tumor necrosis factor soluble receptor (Protein T2)

25 entries

Myxoma virus (strain Lausanne) (MYXV) reference strain

Select_allDeselect_all
A18_MYXVL Transcript termination protein A18 (EC 3.6.4.-)
A28_MYXVL Envelope protein A28 homolog (Protein M116)
DUSP_MYXVL Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)
GRFA_MYXVL Growth factor (Secreted epidermal growth factor-like)
KITH_MYXVL Thymidine kinase (EC 2.7.1.21)
ETF2_MYXVL Early transcription factor 82 kDa subunit (ETF large subunit)
ETF1_MYXVL Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (ETF small ...
LAP_MYXVL E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
MCE_MYXVL Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) polymerase regulatory ...
PAP1_MYXVL Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
MT5_MYXVL Ankyrin repeat domain-containing protein M-T5 (M-T5 protein) (M5)
MP44_MYXVL Probable metalloendopeptidase G1-type (EC 3.4.24.-)
NTP1_MYXVL Nucleoside triphosphatase I (EC 3.6.1.15) (M86L protein) (NPH-I) (Nucleoside triphosphate ...
NPH2_MYXVL RNA helicase NPH-II (EC 3.6.4.13) (Nucleoside triphosphatase II) (NTPase II) (Nucleoside ...
VMF7_MYXVL MF7 protein
RP07_MYXVL DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
RP22_MYXVL DNA-directed RNA polymerase 21 kDa subunit (EC 2.7.7.6)
SPI2_MYXVL Serine proteinase inhibitor 2 (Serp-2) (Serpin-2)
SPI1_MYXVL Serine proteinase inhibitor 1 (Serp-1) (Serpin-1)
VMT8_MYXVL Kelch repeat protein M-T8
VH23_MYXVL Probable host range protein 2-3
VT2_MYXVL Tumor necrosis factor soluble receptor (Protein T2)
VH21_MYXVL Probable host range protein 2-1
VH22_MYXVL Probable host range protein 2-2
VMT9_MYXVL Kelch repeat protein M-T9 (M9-R polypeptide)

7 entries

Myxoma virus (strain Uriarra) (MYXV)

Select_allDeselect_all
A28_MYXVU Envelope protein A28 homolog (MA28)
KITH_MYXVU Thymidine kinase (EC 2.7.1.21)
MCE_MYXVU Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase (EC 2.1.1.57) (Poly(A) polymerase regulatory ...
RP22_MYXVU DNA-directed RNA polymerase 21 kDa subunit (EC 2.7.7.6)
SPI2_MYXVU Serine proteinase inhibitor 2 (Serp-2) (Serpin-2)
VH21_MYXVU Probable host range protein 2-1
VMF7_MYXVU MF7 protein