Yatapoxvirus

VIRION

Enveloped, brick-shaped about 300x250x200nm in size. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome about 145kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities. h4. GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachement of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).

Host-virus interaction

Adaptive immune response inhibition

The poxviral E3 ubiquitin-protein ligase LAP promotes ubiquitination and subsequent degradation of host MHC-I and CD4 molecules.

Matching UniProtKB/Swiss-Prot entries

19 entries grouped by strain (browse by keywords)

11 entries

Yaba monkey tumor virus (strain VR587) (YMTV) reference strain

Select_allDeselect_all
A18_YMTV5 Transcript termination protein A18 (EC 3.6.4.-)
A28_YMTV5 Envelope protein A28 homolog (Protein 118)
DUT_YMTV5 Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)
KITH_YMTV5 Thymidine kinase (EC 2.7.1.21)
ETF1_YMTV5 Early transcription factor 70 kDa subunit (EC 3.6.4.-) (ATP-dependent helicase VETFS) (VETF small ...
ETF2_YMTV5 Early transcription factor 82 kDa subunit (ETF large subunit)
LAP_YMTV5 E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
MCES_YMTV5 mRNA-capping enzyme small subunit (mRNA (guanine-N(7)-)-methyltransferase) (EC 2.1.1.56) (mRNA cap ...
PAP1_YMTV5 Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
NTP1_YMTV5 Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH ...
VHR2_YMTV5 Probable host range protein 2

8 entries

Yaba-like disease virus (YLDV)

Select_allDeselect_all
A18_YLDV Transcript termination protein A18 (EC 3.6.4.-)
A28_YLDV Envelope protein A28 homolog (Protein 118)
LAP_YLDV E3 ubiquitin-protein ligase LAP (EC 2.3.2.27) (Leukemia associated protein) (LAP) (RING-type E3 ...
PAP1_YLDV Poly(A) polymerase catalytic subunit (EC 2.7.7.19) (Poly(A) polymerase large subunit) (PAP-L)
MP44_YLDV Probable metalloendopeptidase G1-type (EC 3.4.24.-)
RIR2_YLDV Ribonucleoside-diphosphate reductase small chain (EC 1.17.4.1) (Ribonucleotide reductase small ...
RP07_YLDV DNA-directed RNA polymerase 7 kDa subunit (EC 2.7.7.6)
VHR2_YLDV Probable host range protein 2