Eukaryotic host transcription shutoff by virus

Host RNA polymerase II (RNA pol-II) is the major enzyme responsible for transcription of mRNA from a DNA template strand.

transcription initiation modulation PolII regulation

Some viruses interfere with host RNA pol-II function. They may either mediate its ubiquitination and subsequent proteasomal degradation, or inhibit RNA pol-II phosphorylation thereby lowering its efficiency. They can as well interfere with initiation factors. Inhibiting host transcription eventually leads to shutoff of host proteins expression and gives viruses transcripts a competitive edge for access to the cellular translation machinery. Preventing the expression of host proteins is also a strategy to counteract the antiviral response.

Viruses inhibiting transcription:

Family Virus Viral protein Transcription inhibition strategy references
Herpesviridae HHV-1 ICP22 Counteracts CTD Ser-2 phosphorylation
Bunyaviridae Bunyamwera virus NSs Counteracts CTD Ser-2 phosphorylation
Orthomyxoviridae Influenza virus Polymerase PB1, PB2, PA RNA pol-II ubiquitination and proteasomal degradation
Papillomaviridae, alphapapillomavirus HPV16 E7 Inhibition of TBP
Picornaviridae Poliovirus 3C Cleavage of TBP
Bunyaviridae, Phlebovirus Rift valley fever virus NSs Downregulates TFIIH subunit p62
Herpesviridae Varicella virus IE63 Disruption of the transcriptional pre-initiation complex

Matching UniProtKB/Swiss-Prot entries

334 entries grouped by protein (browse by keywords)

All proteins are shown (view only 212 complete proteome entries)

2 entries

Early E1A protein (Early E1A 32 kDa protein)

Select_allDeselect_all
E1A_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain
E1A_ADE05
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

4 entries

Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

Select_allDeselect_all
ICP22_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP22_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP22_VZVD
Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) reference strain

Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional regulator IE63)

ICP22_VZVO
Varicella-zoster virus (strain Oka vaccine) (HHV-3) (Human herpesvirus 3)

Transcriptional regulator ICP22 homolog (Immediate-early protein 63) (IE63) (Transcriptional transactivator IE63)

6 entries

Non-structural protein NS-S

Select_allDeselect_all
NSS_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
NSS_BUNYW
Bunyamwera virus (BUNV) reference strain
NSS_RVFVZ
Rift valley fever virus (strain ZH-548 M12) (RVFV) reference strain

Non-structural protein S (NSs)

NSS_BUNGE
Bunyavirus germiston
NSS_BUNLC
Bunyavirus La Crosse
NSS_BUNSH
Bunyavirus snowshoe hare

96 entries

Polymerase acidic protein (EC 3.1.-.-) (RNA-directed RNA polymerase subunit P2)

Select_allDeselect_all
PA_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PA_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
PA_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2) reference strain
PA_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7) reference strain
PA_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PA_INBLE
Influenza B virus (strain B/Lee/1940) reference strain
PA_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
PA_I000X
Influenza A virus (strain A/X-31 H3N2)
PA_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PA_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
PA_I01A0
Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
PA_I01A3
Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
PA_I02A0
Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
PA_I02A1
Influenza A virus (strain A/Guinea fowl/Hong Kong/38/2002 H5N1 genotype X0)
PA_I02A2
Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
PA_I02A4
Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
PA_I02A5
Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PA_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PA_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PA_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PA_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
PA_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
PA_I30A0
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
PA_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
PA_I34A0
Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
PA_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
PA_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
PA_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
PA_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PA_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PA_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PA_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
PA_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
PA_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PA_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PA_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
PA_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PA_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PA_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PA_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PA_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PA_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
PA_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PA_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PA_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
PA_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PA_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
PA_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
PA_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
PA_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
PA_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
PA_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
PA_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
PA_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
PA_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
PA_I73A4
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
PA_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PA_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
PA_I75A3
Influenza A virus (strain A/Victoria/3/1975 H3N2)
PA_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
PA_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PA_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
PA_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
PA_I77AD
Influenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)
PA_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
PA_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
PA_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
PA_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
PA_I78A9
Influenza A virus (strain A/Swine/Hong Kong/81/1978 H3N2)
PA_I78AC
Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
PA_I79A1
Influenza A virus (strain A/Pintail/Alberta/119/1979 H4N6)
PA_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PA_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
PA_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PA_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
PA_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
PA_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PA_I82A4
Influenza A virus (strain A/Swine/Hong Kong/126/1982 H3N2)
PA_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
PA_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PA_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PA_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PA_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PA_I85A7
Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
PA_I86A3
Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
PA_I93A0
Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PA_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
PA_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
PA_I97A0
Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
PA_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PA_INBAC
Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])
PA_INBAD
Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])
PA_INBP9
Influenza B virus (strain B/Panama/45/1990)
PA_INBSI
Influenza B virus (strain B/Singapore/222/1979)
PA_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
PA_INCJJ
Influenza C virus (strain C/JJ/1950)

97 entries

Polymerase basic protein 2 (RNA-directed RNA polymerase subunit P3)

Select_allDeselect_all
PB2_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
PB2_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
PB2_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2) reference strain
PB2_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7) reference strain
PB2_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
PB2_INBLE
Influenza B virus (strain B/Lee/1940) reference strain
PB2_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
PB2_I000F
Influenza A virus (strain A/Chicken/Weybridge H7N7) (Influenza A virus (strain A/FPV/Weybridge H7N7))
PB2_I000X
Influenza A virus (strain A/X-31 H3N2)
PB2_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
PB2_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
PB2_I02A0
Influenza A virus (strain A/Chicken/Brescia/1902 H7N7)
PB2_I02A5
Influenza A virus (strain A/Chicken/Hong Kong/96.1/2002 H5N1 genotype Y)
PB2_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
PB2_I02A7
Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
PB2_I03A0
Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
PB2_I03A1
Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
PB2_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
PB2_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
PB2_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
PB2_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
PB2_I30A0
Influenza A virus (strain A/Swine/Iowa/15/1930 H1N1)
PB2_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
PB2_I34A0
Influenza A virus (strain A/Fowl plague virus/Rostock/8/1934 H7N1)
PB2_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
PB2_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
PB2_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
PB2_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
PB2_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
PB2_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
PB2_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
PB2_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
PB2_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
PB2_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
PB2_I56A3
Influenza A virus (strain A/Equine/Prague/1/1956 H7N7)
PB2_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
PB2_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
PB2_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
PB2_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
PB2_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
PB2_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
PB2_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
PB2_I66A0
Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
PB2_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
PB2_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
PB2_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
PB2_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
PB2_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
PB2_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
PB2_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
PB2_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
PB2_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
PB2_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
PB2_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
PB2_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
PB2_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
PB2_I73A4
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
PB2_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
PB2_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
PB2_I75A3
Influenza A virus (strain A/Victoria/3/1975 H3N2)
PB2_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
PB2_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
PB2_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
PB2_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
PB2_I77AC
Influenza A virus (strain A/Swine/Tennessee/24/1977 H1N1)
PB2_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
PB2_I77AG
Influenza A virus (strain A/Budgerigar/Hokkaido/1/1977 H4N6)
PB2_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
PB2_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
PB2_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
PB2_I79A4
Influenza A virus (strain A/Kiev/59/1979 H1N1)
PB2_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
PB2_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
PB2_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
PB2_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
PB2_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
PB2_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
PB2_I82A3
Influenza A virus (strain A/Seal/Massachusetts/133/1982 H4N5)
PB2_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
PB2_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
PB2_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
PB2_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
PB2_I84A4
Influenza A virus (strain A/Gull/Astrakhan/227/1984 H13N6)
PB2_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
PB2_I85A7
Influenza A virus (strain A/Ruddy Turnstone/New Jersey/47/1985 H4N6)
PB2_I86A2
Influenza A virus (strain A/Equine/Kentucky/2/1986 H3N8)
PB2_I88A3
Influenza A virus (strain A/Memphis/8/1988 H3N2)
PB2_I93A0
Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
PB2_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
PB2_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
PB2_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
PB2_INBAC
Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])
PB2_INBAD
Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])
PB2_INBP9
Influenza B virus (strain B/Panama/45/1990)
PB2_INCBE
Influenza C virus (strain C/Berlin/1/1985)
PB2_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
PB2_INCJJ
Influenza C virus (strain C/JJ/1950)

5 entries

Genome polyprotein

Select_allDeselect_all
POLG_POL1S
Poliovirus type 1 (strain Sabin)
POLG_POL2L
Poliovirus type 2 (strain Lansing)
POLG_POL2W
Poliovirus type 2 (strain W-2)
POLG_POL32
Poliovirus type 3 (strain 23127)
POLG_POL3L
Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)

25 entries

Non-structural polyprotein (Polyprotein nsP1234) (P1234)

Select_allDeselect_all
POLN_CHIKS
Chikungunya virus (strain S27-African prototype) (CHIKV) reference strain
POLN_SFV
Semliki forest virus (SFV) reference strain
POLN_SINDV
Sindbis virus (SINV) reference strain
POLN_AURAV
Aura virus (AURAV)
POLN_BFV
Barmah forest virus (BFV)
POLN_CHIK3
Chikungunya virus (strain 37997) (CHIKV)
POLN_EEEV1
Eastern equine encephalitis virus (strain PE-0.0155) (EEEV) (Eastern equine encephalomyelitis virus)
POLN_EEEV8
Eastern equine encephalitis virus (strain PE-3.0815) (EEEV) (Eastern equine encephalomyelitis virus)
POLN_EEEVF
Eastern equine encephalitis virus (strain Florida 91-469) (EEEV) (Eastern equine encephalomyelitis virus)
POLN_EEVV3
Venezuelan equine encephalitis virus (strain 3880) (VEEV)
POLN_EEVVC
Venezuelan equine encephalitis virus (strain CPA201) (VEEV)
POLN_EEVVM
Venezuelan equine encephalitis virus (strain Mena II) (VEEV)
POLN_EEVVP
Venezuelan equine encephalitis virus (strain P676) (VEEV)
POLN_EEVVT
Venezuelan equine encephalitis virus (strain Trinidad donkey) (VEEV)
POLN_GETV
Getah virus (GETV)
POLN_MAYAB
Mayaro virus (strain Brazil) (MAYV)
POLN_ONNVG
O'nyong-nyong virus (strain Gulu) (ONNV)
POLN_ONNVI
O'nyong-nyong virus (strain Igbo Ora) (ONNV) (Igbo Ora virus)
POLN_ONNVS
O'nyong-nyong virus (strain SG650) (ONNV)
POLN_RRVN
Ross river virus (strain NB5092) (RRV)
POLN_SAGV
Sagiyama virus (SAGV)
POLN_SINDO
Sindbis virus subtype Ockelbo (strain Edsbyn 82-5) (OCKV) (Ockelbo virus)
POLN_SLDV
Sleeping disease virus (SDV)
POLN_SPDV
Salmon pancreas disease virus (SPDV)
POLN_WEEV
Western equine encephalitis virus (WEEV)

99 entries

RNA-directed RNA polymerase catalytic subunit (EC 2.7.7.48) (Polymerase basic protein 1) (PB1) (RNA-directed RNA polymerase subunit P1)

Select_allDeselect_all
RDRP_I34A1
Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) reference strain
RDRP_I49A1
Influenza A virus (strain A/Duck/Germany/1949 H10N7) reference strain
RDRP_I57A5
Influenza A virus (strain A/Singapore/1/1957 H2N2) reference strain
RDRP_I80A2
Influenza A virus (strain A/Seal/Massachusetts/1/1980 H7N7) reference strain
RDRP_I96A0
Influenza A virus (strain A/Goose/Guangdong/1/1996 H5N1 genotype Gs/Gd) reference strain
RDRP_INBLE
Influenza B virus (strain B/Lee/1940) reference strain
RDRP_INCAA
Influenza C virus (strain C/Ann Arbor/1/1950) reference strain
RDRP_I000X
Influenza A virus (strain A/X-31 H3N2)
RDRP_I00A0
Influenza A virus (strain A/Duck/Hong Kong/2986.1/2000 H5N1 genotype C)
RDRP_I00A1
Influenza A virus (strain A/New Zealand:South Canterbury/35/2000 H1N1)
RDRP_I01A0
Influenza A virus (strain A/Silky Chicken/Hong Kong/SF189/2001 H5N1 genotype A)
RDRP_I01A3
Influenza A virus (strain A/Chicken/Hong Kong/715.5/2001 H5N1 genotype E)
RDRP_I02A2
Influenza A virus (strain A/Chicken/Hong Kong/31.2/2002 H5N1 genotype X1)
RDRP_I02A3
Influenza A virus (strain A/Chicken/Hong Kong/37.4/2002 H5N1 genotype X2)
RDRP_I02A4
Influenza A virus (strain A/Silky Chicken/Hong Kong/YU100/2002 H5N1 genotype X3)
RDRP_I02A6
Influenza A virus (strain A/Chicken/Hong Kong/YU22/2002 H5N1 genotype Z)
RDRP_I02A7
Influenza A virus (strain A/Teal/China/2978.1/2002 H5N1 genotype W)
RDRP_I03A0
Influenza A virus (strain A/Hong Kong/212/2003 H5N1 genotype Z+)
RDRP_I03A1
Influenza A virus (strain A/Chicken/Shantou/4231/2003 H5N1 genotype V)
RDRP_I05A1
Influenza A virus (strain A/Goose/Guangxi/345/2005 H5N1 genotype G)
RDRP_I06A0
Influenza A virus (strain A/Russia:St.Petersburg/8/2006 H1N1)
RDRP_I07A0
Influenza A virus (strain A/USA:Texas/UR06-0195/2007 H1N1)
RDRP_I18A0
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
RDRP_I33A0
Influenza A virus (strain A/Wilson-Smith/1933 H1N1) (Influenza A virus (strain A/WS/1933 H1N1))
RDRP_I35A3
Influenza A virus (strain A/USA:Phila/1935 H1N1)
RDRP_I36A0
Influenza A virus (strain A/Henry/1936 H1N1)
RDRP_I40A0
Influenza A virus (strain A/Hickox/1940 H1N1)
RDRP_I43A0
Influenza A virus (strain A/USA:Iowa/1943 H1N1)
RDRP_I45A0
Influenza A virus (strain A/USA:Huston/AA/1945 H1N1)
RDRP_I47A0
Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1)
RDRP_I51A0
Influenza A virus (strain A/USA:Albany/12/1951 H1N1)
RDRP_I54A2
Influenza A virus (strain A/Malaysia:Malaya/302/1954 H1N1)
RDRP_I56A0
Influenza A virus (strain A/Beijing/11/1956 H1N1)
RDRP_I56A1
Influenza A virus (strain A/Duck/Czechoslovakia/1956 H4N6)
RDRP_I56A2
Influenza A virus (strain A/Duck/England/1/1956 H11N6)
RDRP_I57A0
Influenza A virus (strain A/Japan/305/1957 H2N2)
RDRP_I57A1
Influenza A virus (strain A/Leningrad/134/1957 H2N2)
RDRP_I57A2
Influenza A virus (strain A/Leningrad/134/17/1957 H2N2)
RDRP_I57A3
Influenza A virus (strain A/Leningrad/134/47/1957 H2N2)
RDRP_I59A0
Influenza A virus (strain A/Chicken/Scotland/1959 H5N1)
RDRP_I60A0
Influenza A virus (strain A/Ann Arbor/6/1960 H2N2)
RDRP_I61A1
Influenza A virus (strain A/Swine/Wisconsin/1/1961 H1N1)
RDRP_I66A0
Influenza A virus (strain A/Turkey/Ontario/7732/1966 H5N9)
RDRP_I66A1
Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2)
RDRP_I67A0
Influenza A virus (strain A/Tokyo/3/1967 H2N2)
RDRP_I67A2
Influenza A virus (strain A/Swine/Wisconsin/1/1967 H1N1)
RDRP_I68A3
Influenza A virus (strain A/Turkey/Ontario/6118/1968 H8N4)
RDRP_I68A4
Influenza A virus (strain A/Hong Kong/1/1968 H3N2)
RDRP_I68A5
Influenza A virus (strain A/Korea/426/1968 H2N2)
RDRP_I68A6
Influenza A virus (strain A/Northern Territory/60/1968 H3N2) (Influenza A virus (strain NT60)) (Influenza A virus (strain A/NT/60/1968 H3N2))
RDRP_I69A0
Influenza A virus (strain A/England/878/1969 H3N2)
RDRP_I70A0
Influenza A virus (strain A/Qu/7/1970 H3N2)
RDRP_I71A1
Influenza A virus (strain A/Memphis/1/1971 H3N2)
RDRP_I72A2
Influenza A virus (strain A/Udorn/307/1972 H3N2)
RDRP_I72A3
Influenza A virus (strain A/Memphis/102/1972 H3N2)
RDRP_I72A4
Influenza A virus (strain A/Memphis/101/1972 H3N2)
RDRP_I73A4
Influenza A virus (strain A/Equine/London/1416/1973 H7N7)
RDRP_I73A5
Influenza A virus (strain A/Port Chalmers/1/1973 H3N2)
RDRP_I73A6
Influenza A virus (strain A/Dunedin/4/1973 H3N2)
RDRP_I75A0
Influenza A virus (strain A/Beijing/39/1975 H3N2)
RDRP_I75A3
Influenza A virus (strain A/Victoria/3/1975 H3N2)
RDRP_I76A6
Influenza A virus (strain A/Memphis/110/1976 H3N2)
RDRP_I77A4
Influenza A virus (strain A/Swine/Colorado/1/1977 H3N2)
RDRP_I77AA
Influenza A virus (strain A/Brazil/11/1978 H1N1)
RDRP_I77AB
Influenza A virus (strain A/USSR/90/1977 H1N1)
RDRP_I77AD
Influenza A virus (strain A/Swine/Tennessee/26/1977 H1N1)
RDRP_I77AF
Influenza A virus (strain A/Gull/Maryland/704/1977 H13N6)
RDRP_I78A3
Influenza A virus (strain A/Mallard/New York/6750/1978 H2N2)
RDRP_I78A7
Influenza A virus (strain A/Memphis/2/1978 H3N2)
RDRP_I78A8
Influenza A virus (strain A/Memphis/18/1978 H3N2)
RDRP_I78AC
Influenza A virus (strain A/Turkey/Minnesota/501/1978 H6N8)
RDRP_I79A4
Influenza A virus (strain A/Kiev/59/1979 H1N1)
RDRP_I79A7
Influenza A virus (strain A/Grey teal/Australia/2/1979 H4N4)
RDRP_I80A4
Influenza A virus (strain A/Memphis/4/1980 H3N2)
RDRP_I80A6
Influenza A virus (strain A/Duck/Hokkaido/8/1980 H3N8)
RDRP_I80A8
Influenza A virus (strain A/Turkey/Minnesota/833/1980 H4N2)
RDRP_I80AA
Influenza A virus (strain A/India/6263/1980 H1N1)
RDRP_I80AD
Influenza A virus (strain A/Gull/Minnesota/945/1980 H13N6)
RDRP_I81A4
Influenza A virus (strain A/Swine/Ontario/2/1981 H1N1)
RDRP_I82A4
Influenza A virus (strain A/Swine/Hong Kong/126/1982 H3N2)
RDRP_I83A1
Influenza A virus (strain A/Chile/1/1983 H1N1)
RDRP_I83A4
Influenza A virus (strain A/Turkey/Ireland/1378/1983 H5N8)
RDRP_I83A5
Influenza A virus (strain A/Chicken/Pennsylvania/1/1983 H5N2)
RDRP_I83A6
Influenza A virus (strain A/Chicken/Pennsylvania/1370/1983 H5N2)
RDRP_I83A8
Influenza A virus (strain A/Hong Kong/5/1983 H3N2)
RDRP_I85A3
Influenza A virus (strain A/Chicken/Victoria/1/1985 H7N7)
RDRP_I86A3
Influenza A virus (strain A/Equine/Tennessee/5/1986 H3N8)
RDRP_I88A3
Influenza A virus (strain A/Memphis/8/1988 H3N2)
RDRP_I88A7
Influenza A virus (strain A/Wisconsin/3523/1988 H1N1)
RDRP_I93A0
Influenza A virus (strain A/Kitakyushu/159/1993 H3N2)
RDRP_I96A2
Influenza A virus (strain A/USA:Memphis/10/1996 H1N1)
RDRP_I96A3
Influenza A virus (strain A/China:Nanchang/11/1996 H1N1)
RDRP_I97A0
Influenza A virus (strain A/Chicken/Hong Kong/220/1997 H5N1 genotype Gs/Gd)
RDRP_I97A1
Influenza A virus (strain A/Hong Kong/156/1997 H5N1 genotype Gs/Gd)
RDRP_INBAC
Influenza B virus (strain B/Ann Arbor/1/1966 [cold-adapted])
RDRP_INBAD
Influenza B virus (strain B/Ann Arbor/1/1966 [wild-type])
RDRP_INBP9
Influenza B virus (strain B/Panama/45/1990)
RDRP_INCJH
Influenza C virus (strain C/Johannesburg/1/1966)
RDRP_INCJJ
Influenza C virus (strain C/JJ/1950)