Eukaryotic host translation shutoff by virus

The majority of cellular mRNAs initiate translation! through the recruitment of a multisubunit translation initiation complex termed eIF4F, which consists of the cap-binding protein eIF4E, the RNA helicase eIF4A, and the adaptor protein eIF4G. eIF4G binds poly(A)-binding protein (PABP) to mediate 5' -> 3' communication, probably to promote efficient translation of intact correctly processed mRNAs. eIF4E binding protein 1 (eIF4E-BP1) functions as a translational repressor that limits eIF4E availability and therefore eIF4F complex formation.


Viruses have evolved ways of interacting with the host translational machinery to shutoff host gene expression. This global inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and to evade host immune response .
All the viruses inducing the shutoff of translation are able to continue to translate at least part of their mRNAs using non-canonical translation: IRES, Ribosome shunting, or VPG initiation. For adenoviridae, polyomaviridae and togaviridae the cellular translation shutoff takes place at the late phase of infection and ensures an optimal production of viral structural proteins.
Under stress conditions such as viral infection some cellular translation can continue when the cap-dependent translation initiation is inhibited. Expression of specific cellular proteins seems to occur through cap-independent mechanisms .

Viruses inducing host translation shutoff:

Family Virus Viral protein Shutoff strategy Viral translation ref.
Adenoviridae Adenovirus Shutoff protein 100K Inhibits eIF4G-Mnk1 and prevents EIF4E phosphorylation Ribosome shunting on late mRNAs
Bunyaviridae Bunyamwera virus Nucleoprotein Nuclear retention of PABP Viral mRNAs non polyadenylated
Caliciviridae Norovirus
Feline calicivirus
Protease 3C
Protease
PABP cleavage VPg
Feline calicivirus Protease Cleavage of eIF4G1 and eIF4G2 VPg
Dicistroviridae Cripavirus ? Dissociation of eIF4G and eIF4E IRES
Orthomyxoviridae Influenza virus ? Dephosphorylation of of eIF-4E eIF-4E independent translation of viral mRNAs
Picornaviridae Poliovirus Protease 2A Cleavage of eIF4GI and eIF4GII IRES
Protease 3C Cleavage of eIF5B IRES
Protease 3C PABP cleavage IRES
Rhinovirus Protease 2A Cleavage of eIF4GI and eIF4GII IRES
Coxsackie virus Protease 2A Cleavage of eIF4GI and eIF4GII IRES
Coxsackie virus Protease 2A,3C PABP cleavage IRES
Protease 3C Cleavage of eIF5B IRES
Encephalomyocarditis virus Protein 2A ? IRES
? Dephosphorylation of 4E-BP1 IRES
Foot-and-mouth disease virus Leader protease Cleavage of eIF4GI and eIF4GII IRES
Protease 3C Cleavage of PABP, eIF3a, eIF3b, and eIF4A IRES
Polyomaviridae SV40 Small T antigen Dephosphorylation of 4E-BP1 IRES
Reoviridae Rotavirus NSP3 Interacts with EIF4G and evicts PABP from initiation complexes. Nuclear relocalization of PABP NSP3 replaces PABP and bind the non polyAdenylated viral mRNAs
Rhabdoviridae Vesicular stomatitis virus ? Dephosphorylation of 4E-BP1 classical
Retroviridae HIV-1 Protease Cleavage of eIF4GI and PABP IRES
HTLV-1 Protease Cleavage of eIF4GI IRES
Moloney murine leukemia virus Protease Cleavage of eIF4GI and eIF4GII IRES
Togaviridae Rubella virus Capsid protein PABP sequestration classical
Sindbis virus dsRNA leading to PKR-mediated inhibition of eIF2alpha DLP
Coronaviridae SARS-CoV Nsp1 Binding to host 40S subunit Viral mRNA protected by 5'-end leader sequence
Bat-CoV Nsp1
TGEV Nsp1
Links Uniprot Keyword: KW-1193
GO ontology: GO:0039604

Matching UniProtKB/Swiss-Prot entries

216 entries grouped by protein (browse by keywords)

All proteins are shown (view only 177 complete proteome entries)

1 entry

Protein 169

169_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain

5 entries

Nucleoprotein (Nucleocapsid protein) (Protein N)

Select_allDeselect_all
NCAP_BUNL8
Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain
NCAP_BUNYW
Bunyamwera virus (BUNV) reference strain
NCAP_BUNGE
Bunyavirus germiston
NCAP_BUNLC
Bunyavirus La Crosse
NCAP_BUNSH
Bunyavirus snowshoe hare

23 entries

Non-structural protein 3 (NSP3) (NCVP4) (Non-structural RNA-binding protein 34) (NS34)

Select_allDeselect_all
NSP3_ROTSH
Rotavirus A (isolate RVA/Monkey/South Africa/SA11-H96/1958/G3P5B[2]) (RV-A) (Simian Agent 11 (isolate SI/South Africa/H96/58)) reference strain
NSP3_ROT41
Rotavirus A (isolate RVA/Human/Belgium/B4106/2000/G3P11[14]) (RV-A) (Rotavirus A (isolate B4106))
NSP3_ROTAD
Rotavirus A (strain RVA/Human/United States/D/1974/G1P1A[8]) (RV-A)
NSP3_ROTAM
Rotavirus A (strain RVA/Human/United States/M/1976/G3P[X]) (RV-A)
NSP3_ROTBN
Rotavirus A (strain RVA/Cow/United States/NCDV-Lincoln/1969/G6P6[1]) (RV-A) (Rotavirus A (strain Nebraska calf diarrhea virus))
NSP3_ROTBU
Rotavirus A (strain RVA/Cow/United Kingdom/UK/1975/G6P7[5]) (RV-A)
NSP3_ROTH3
Rotavirus A (strain RVA/Human/Japan/AU-1/1982/G3P3[9]) (RV-A)
NSP3_ROTH6
Rotavirus A (strain RVA/Human/Indonesia/69M/1980/G8P4[10]) (RV-A)
NSP3_ROTH7
Rotavirus A (isolate RVA/Human/United Kingdom/A64/1987/G10P11[14]) (RV-A)
NSP3_ROTHD
Rotavirus A (strain RVA/Human/United States/DS-1/1976/G2P1B[4]) (RV-A) (Rotavirus A (strain DS1))
NSP3_ROTHK
Rotavirus A (strain RVA/Human/Japan/KU/1995/G1P1A[8]) (RV-A)
NSP3_ROTHL
Rotavirus A (strain RVA/Human/Philippines/L26/1987/G12P1B[4]) (RV-A)
NSP3_ROTHP
Rotavirus A (strain RVA/Human/United States/P/1974/G3P1A[8]) (RV-A)
NSP3_ROTHS
Rotavirus A (strain RVA/Human/Japan/S2/1980/G2P1B[4]) (RV-A)
NSP3_ROTHT
Rotavirus A (strain RVA/Human/United Kingdom/ST3/1975/G4P2A[6]) (RV-A) (Rotavirus A (strain St. Thomas 3))
NSP3_ROTHW
Rotavirus A (strain RVA/Human/United States/Wa/1974/G1P1A[8]) (RV-A)
NSP3_ROTP5
Rotavirus A (strain RVA/Pig/United States/OSU/1977/G5P9[7]) (RV-A) (Rotavirus A (strain Ohio State University))
NSP3_ROTRF
Rotavirus A (strain RVA/Cow/France/RF/1975/G6P6[1]) (RV-A)
NSP3_ROTRH
Rotavirus A (strain RVA/Monkey/United States/RRV/1980/G3P5B[3]) (RV-A)
NSP3_ROTS1
Rotavirus A (strain RVA/SA11-Both/G3P5B[2]) (RV-A) (Simian Agent 11 (strain Both))
NSP3_ROTS4
Rotavirus A (strain RVA/SA11-4F/G3P6[1]) (RV-A) (Simian Agent 11 (strain 4F))
NSP3_ROTW3
Rotavirus A (strain RVA/Cow/United States/WC3/1981/G6P7[5]) (RV-A) (Rotavirus (strain Wistar calf 3))
NSP3_ROTWI
Rotavirus A (isolate RVA/Human/United States/WI61/1983/G9P1A[8]) (RV-A)

67 entries

Gag-Pol polyprotein (Pr160Gag-Pol)

Select_allDeselect_all
POL_HTL1C
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HTL32
Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3) reference strain

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HTLV2
Human T-cell leukemia virus 2 (HTLV-2) reference strain

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HV1B1
Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain

pdb 1A9M; 1AJV; 1AJX; 1AXA; 1BQM; 1BQN; 1D4H; 1D4I; 1D4J; 1DLO; 1DW6; 1EBK; 1EBW; 1EBY; 1EBZ; 1EC0; 1EC1; 1EC2; 1EC3; 1EET; 1G35; 1GNM; 1GNN; 1GNO; 1HAR; 1HBV; 1HEF; 1HEG; 1HIH; 1HMV; 1HNI; 1HNV; 1HOS; 1HPS; 1HPZ; 1HQE; 1HQU; 1HRH; 1HTE; 1HTF; 1HTG; 1HVI; 1HVK; 1HVP; 1HVU; 1HYS; 1IKV; 1IKW; 1IKX; 1IKY; 1J5O; 1KJH; 1MER; 1MES; 1MET; 1MEU; 1N5Y; 1N6Q; 1NPA; 1NPV; 1NPW; 1QE1; 1QMC; 1R0A; 1RDH; 1RTD; 1RVL; 1RVM; 1RVN; 1RVO; 1RVP; 1RVQ; 1RVR; 1S6P; 1S6Q; 1S9E; 1S9G; 1SBG; 1SUQ; 1SV5; 1T03; 1T05; 1T7K; 1TV6; 1TVR; 1UWB; 1W5V; 1W5W; 1W5X; 1W5Y; 1YT9; 1ZP8; 1ZPA; 1ZSF; 1ZSR; 2AQU; 2B5J; 2B6A; 2BAN; 2BBB; 2BE2; 2EXF; 2G69; 2HB3; 2HMI; 2HNZ; 2HS1; 2HS2; 2I4D; 2I4U; 2I4V; 2I4W; 2I4X; 2I5J; 2IAJ; 2IC3; 2IDW; 2IEO; 2JZW; 2L45; 2L46; 2L4L; 2UXZ; 2UY0; 2VG5; 2VG6; 2VG7; 2X4U; 2YKM; 2YKN; 2ZD1; 2ZE2; 3AVI; 3BGR; 3DLK; 3GGA; 3GGV; 3GGX; 3HVT; 3IG1; 3IRX; 3IS9; 3ISN; 3ITH; 3JSM; 3JYT; 3K2P; 3K4V; 3KLE; 3KLF; 3KLG; 3KLH; 3KLI; 3NDT; 3NU3; 3NU4; 3NU5; 3NU6; 3NU9; 3NUJ; 3NUO; 3OK9; 3PSU; 3QAA; 3QLH; 3QO9; 3TKG; 3TKW; 3TL9; 3TLH; 3V4I; 3V6D; 3V81; 3ZPS; 3ZPT; 3ZPU; 4COE; 4CP7; 4CPQ; 4CPR; 4CPS; 4CPT; 4CPU; 4CPW; 4CPX; 4DG1; 4G1Q; 4G8G; 4G8I; 4G9D; 4G9F; 4H4M; 4H4O; 4I2P; 4I2Q; 4ICL; 4ID5; 4IDK; 4IFV; 4IFY; 4IG0; 4IG3; 4KFB; 4KKO; 4KO0; 4LSL; 4LSN; 4MFB; 4O44; 4O4G; 4OJR; 4PQU; 4PUO; 4PWD; 4Q0B; 4QAG; 4R5P; 4RW4; 4RW6; 4RW7; 4RW8; 4RW9; 4U8W; 4WE1; 4YE3; 4YHQ; 4ZIP; 4ZLS; 5AGZ; 5AH6; 5AH7; 5AH8; 5AH9; 5AHA; 5AHB; 5AHC; 5BRY; 5BS4; 5C24; 5C25; 5C42; 5CYM; 5CYQ; 5D3G; 5FDL; 5HBM; 5HLF; 5HP1; 5HRO; 5I3U; 5I42; 5J1E; 5JFP; 5JFU; 5JG1; 5T6Z; 5T70; 5TEP; 5TER; 5TW3; 5TXL; 5TXM; 5TXN; 5TXO; 5TXP

POL_HV1EL
Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain
POL_HV1H2
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain
POL_HV1MA
Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1) reference strain
POL_HV1MN
Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1) reference strain
POL_HV1VI
Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1) reference strain
POL_HV2BE
Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2) reference strain
POL_SIVEK
Simian immunodeficiency virus (isolate EK505) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
POL_SIVMB
Simian immunodeficiency virus (isolate MB66) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
POL_SIVTN
Simian immunodeficiency virus (isolate TAN1) (SIV-cpz) (Chimpanzee immunodeficiency virus) reference strain
POL_HTL1A
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HTL1L
Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1)

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HTL3P
Human T-cell leukemia virus 3 (strain Pyl43) (HTLV-3)

Gag-Pro-Pol polyprotein (Pr160Gag-Pro-Pol)

POL_HV190
Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1)
POL_HV192
Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)
POL_HV193
Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)
POL_HV196
Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)
POL_HV197
Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)
POL_HV19N
Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
POL_HV1A2
Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)
POL_HV1AN
Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1)
POL_HV1B5
Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1)
POL_HV1B9
Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)
POL_HV1BR
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
POL_HV1ET
Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1)
POL_HV1JR
Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)
POL_HV1LW
Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)
POL_HV1M2
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)
POL_HV1MP
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)
POL_HV1MV
Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)
POL_HV1N5
Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)
POL_HV1ND
Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)
POL_HV1OY
Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)
POL_HV1RH
Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)
POL_HV1S2
Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)
POL_HV1S9
Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)
POL_HV1SE
Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)
POL_HV1U4
Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1)
POL_HV1V9
Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)
POL_HV1Y2
Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)
POL_HV1YB
Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)
POL_HV1YF
Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1)
POL_HV1Z2
Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)
POL_HV2CA
Human immunodeficiency virus type 2 subtype A (isolate CAM2) (HIV-2)
POL_HV2D1
Human immunodeficiency virus type 2 subtype A (isolate D194) (HIV-2)
POL_HV2D2
Human immunodeficiency virus type 2 subtype B (isolate D205) (HIV-2)
POL_HV2EH
Human immunodeficiency virus type 2 subtype B (isolate EHO) (HIV-2)
POL_HV2G1
Human immunodeficiency virus type 2 subtype A (isolate Ghana-1) (HIV-2)
POL_HV2KR
Human immunodeficiency virus type 2 subtype A (isolate KR) (HIV-2)
POL_HV2NZ
Human immunodeficiency virus type 2 subtype A (isolate NIH-Z) (HIV-2)
POL_HV2RO
Human immunodeficiency virus type 2 subtype A (isolate ROD) (HIV-2)
POL_HV2SB
Human immunodeficiency virus type 2 subtype A (isolate SBLISY) (HIV-2)
POL_HV2ST
Human immunodeficiency virus type 2 subtype A (isolate ST) (HIV-2)
POL_HV2UC
Human immunodeficiency virus type 2 subtype B (isolate UC1) (HIV-2)
POL_SIVCZ
Simian immunodeficiency virus (isolate CPZ GAB1) (SIV-cpz) (Chimpanzee immunodeficiency virus)
POL_SIVG1
Simian immunodeficiency virus agm.grivet (isolate AGM gr-1) (SIV-agm.gri) (Simian immunodeficiency virus African green monkey grivet)
POL_SIVGB
Simian immunodeficiency virus (isolate GB1) (SIV-mnd) (Simian immunodeficiency virus mandrill)
POL_SIVM1
Simian immunodeficiency virus (isolate Mm142-83) (SIV-mac) (Simian immunodeficiency virus rhesus monkey)
POL_SIVMK
Simian immunodeficiency virus (isolate K6W) (SIV-mac) (Simian immunodeficiency virus rhesus monkey)
POL_SIVS4
Simian immunodeficiency virus (isolate F236/smH4) (SIV-sm) (Simian immunodeficiency virus sooty mangabey monkey)
POL_SIVSP
Simian immunodeficiency virus (isolate PBj14/BCL-3) (SIV-sm) (Simian immunodeficiency virus sooty mangabey monkey)
POL_SIVV1
Simian immunodeficiency virus agm.vervet (isolate AGM155) (SIV-agm.ver) (Simian immunodeficiency virus African green monkey vervet)
POL_SIVVG
Simian immunodeficiency virus agm.vervet (isolate AGM3) (SIV-agm.ver) (Simian immunodeficiency virus African green monkey vervet)
POL_SIVVT
Simian immunodeficiency virus agm.vervet (isolate AGM TYO-1) (SIV-agm.ver) (Simian immunodeficiency virus African green monkey vervet)

63 entries

Genome polyprotein

Select_allDeselect_all
POLG_EMCVR
Encephalomyocarditis virus (strain Rueckert) (EMCV) reference strain
POLG_FCVUR
Feline calicivirus (strain Cat/United States/Urbana/1960) (FCV) reference strain
POLG_HAVHM
Human hepatitis A virus genotype IB (isolate HM175) (HHAV) (Human hepatitis A virus (isolate Human/Australia/HM175/1976)) reference strain
POLG_HRV8A
Human rhinovirus A serotype 89 (strain 41467-Gallo) (HRV-89) reference strain
POLG_POL1M
Poliovirus type 1 (strain Mahoney) reference strain
POLG_BOVEV
Bovine enterovirus (strain VG-5-27) (BEV)
POLG_CX16G
Coxsackievirus A16 (strain G-10)
POLG_CX16T
Coxsackievirus A16 (strain Tainan/5079/98)
POLG_CXA21
Coxsackievirus A21 (strain Coe)
POLG_CXA24
Coxsackievirus A24 (strain EH24/70)
POLG_CXA9
Coxsackievirus A9 (strain Griggs)
POLG_CXB1J
Coxsackievirus B1 (strain Japan)
POLG_CXB2O
Coxsackievirus B2 (strain Ohio-1)
POLG_CXB3N
Coxsackievirus B3 (strain Nancy)
POLG_CXB3W
Coxsackievirus B3 (strain Woodruff)
POLG_CXB4E
Coxsackievirus B4 (strain E2)
POLG_CXB4J
Coxsackievirus B4 (strain JVB / Benschoten / New York/51)
POLG_CXB5P
Coxsackievirus B5 (strain Peterborough / 1954/UK/85)
POLG_CXB6S
Coxsackievirus B6 (strain Schmitt)
POLG_EC01F
Echovirus 1 (strain Human/Egypt/Farouk/1951) (E-1)
POLG_EC05N
Echovirus 5 (strain Noyce)
POLG_EC06C
Echovirus 6 (strain Charles)
POLG_EC09B
Echovirus 9 (strain Barty)
POLG_EC09H
Echovirus 9 (strain Hill)
POLG_EC11G
Echovirus 11 (strain Gregory)
POLG_EC12T
Echovirus 12 (strain Travis)
POLG_EC30B
Echovirus 30 (strain Bastianni)
POLG_EMCV
Encephalomyocarditis virus
POLG_EMCVB
Encephalomyocarditis virus (strain emc-b nondiabetogenic)
POLG_EMCVD
Encephalomyocarditis virus (strain emc-d diabetogenic)
POLG_ENMGO
Mengo encephalomyocarditis virus
POLG_FCVC6
Feline calicivirus (strain CFI/68 FIV) (FCV)
POLG_FCVF4
Feline calicivirus (strain Japanese F4) (FCV)
POLG_FCVF9
Feline calicivirus (strain F9) (FCV)
POLG_HAV88
Human hepatitis A virus genotype IIB (isolate SLF88) (HHAV) (Human hepatitis A virus (isolate Human/Sierra Leone/SLF88/1988))
POLG_HAVCF
Human hepatitis A virus genotype IIA (isolate CF-53) (HHAV) (Human hepatitis A virus (isolate Human/France/CF-53/1979))
POLG_HAVGB
Human hepatitis A virus genotype IA (isolate GBM) (HHAV) (Human hepatitis A virus (isolate Human/Germany/GBM/1976))
POLG_HAVH2
Human hepatitis A virus genotype IA (isolate H2) (HHAV) (Human hepatitis A virus (isolate Human/China/H2/1982))
POLG_HAVJ8
Human hepatitis A virus genotype IIIB (isolate HAJ85-1) (HHAV) (Human hepatitis A virus (isolate Human/Japan/HAJ85-1/1985))
POLG_HAVLA
Human hepatitis A virus genotype IA (isolate LA) (HHAV) (Human hepatitis A virus (isolate Human/Northern California/LA/1974))
POLG_HAVMB
Human hepatitis A virus genotype IB (isolate MBB) (HHAV) (Human hepatitis A virus (isolate Human/Northern Africa/MBB/1978))
POLG_HAVNO
Human hepatitis A virus genotype IIIA (isolate NOR-21) (HHAV) (Human hepatitis A virus (isolate Human/Norway/NOR-21/1998))
POLG_HAVS2
Simian hepatitis A virus genotype V (isolate AGM-27) (SHAV) (Simian hepatitis A virus (isolate Cercopithecus/Kenya/AGM-27/1985))
POLG_HE701
Human enterovirus 70 (strain J670/71) (EV 70)
POLG_HE71B
Human enterovirus 71 (strain BrCr) (Ev 71)
POLG_HE71M
Human enterovirus 71 (strain 7423/MS/87) (Ev 71)
POLG_HRV14
Human rhinovirus 14 (HRV-14)
POLG_HRV16
Human rhinovirus 16 (HRV-16)
POLG_HRV1A
Human rhinovirus 1A (HRV-1A)
POLG_HRV1B
Human rhinovirus 1B (HRV-1B)
POLG_HRV2
Human rhinovirus 2 (HRV-2)
POLG_HRV3
Human rhinovirus 3 (HRV-3)
POLG_PEV9U
Porcine enterovirus 9 (strain UKG/410/73)
POLG_POL1S
Poliovirus type 1 (strain Sabin)
POLG_POL2L
Poliovirus type 2 (strain Lansing)
POLG_POL2W
Poliovirus type 2 (strain W-2)
POLG_POL32
Poliovirus type 3 (strain 23127)
POLG_POL3L
Poliovirus type 3 (strains P3/Leon/37 and P3/Leon 12A[1]B)
POLG_SVDVH
Swine vesicular disease virus (strain H/3 '76) (SVDV)
POLG_SVDVU
Swine vesicular disease virus (strain UKG/27/72) (SVDV)
POLG_TMEVB
Theiler's murine encephalomyelitis virus (strain BeAn 8386) (TMEV)
POLG_TMEVD
Theiler's murine encephalomyelitis virus (strain DA) (TMEV)
POLG_TMEVG
Theiler's murine encephalomyelitis virus (strain GDVII) (TMEV)

6 entries

Gag-Pro polyprotein (Pr76Gag-Pro)

Select_allDeselect_all
PRO_HTL1C
Human T-cell leukemia virus 1 (isolate Caribbea HS-35 subtype A) (HTLV-1) reference strain
PRO_HTL32
Human T-cell leukemia virus 3 (strain 2026ND) (HTLV-3) reference strain
PRO_HTLV2
Human T-cell leukemia virus 2 (HTLV-2) reference strain
PRO_HTL1A
Human T-cell leukemia virus 1 (strain Japan ATK-1 subtype A) (HTLV-1)
PRO_HTL1L
Human T-cell leukemia virus 1 (isolate Melanesia mel5 subtype C) (HTLV-1)
PRO_HTL3P
Human T-cell leukemia virus 3 (strain Pyl43) (HTLV-3)

19 entries

Replicase polyprotein 1a (pp1a) (ORF1a polyprotein)

Select_allDeselect_all
R1A_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1A_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1A_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1A_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1A_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1A_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1A_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1A_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1A_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1A_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1A_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1A_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1A_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1A_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1A_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1A_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1A_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1A_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1A_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

20 entries

Replicase polyprotein 1ab (pp1ab) (ORF1ab polyprotein)

Select_allDeselect_all
R1AB_BCHK4
Bat coronavirus HKU4 (BtCoV) (BtCoV/HKU4/2004) reference strain
R1AB_BCHK5
Bat coronavirus HKU5 (BtCoV) (BtCoV/HKU5/2004) reference strain
R1AB_BCHK9
Bat coronavirus HKU9 (BtCoV) (BtCoV/HKU9) reference strain
R1AB_CVEMC
Human coronavirus EMC (isolate United Kingdom/H123990006/2012) (HCoV-EMC) reference strain
R1AB_CVHN1
Human coronavirus HKU1 (isolate N1) (HCoV-HKU1) reference strain
R1AB_CVHOC
Human coronavirus OC43 (HCoV-OC43) reference strain
R1AB_CVHSA
Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus) reference strain
R1AB_CVM2
Murine coronavirus (strain 2) (MHV-2) (Murine hepatitis virus) reference strain
R1AB_CVMA5
Murine coronavirus (strain A59) (MHV-A59) (Murine hepatitis virus) reference strain
R1AB_BC133
Bat coronavirus 133/2005 (BtCoV) (BtCoV/133/2005)
R1AB_BC279
Bat coronavirus 279/2005 (BtCoV) (BtCoV/279/2005)
R1AB_BCHK3
Bat coronavirus HKU3 (BtCoV) (SARS-like coronavirus HKU3)
R1AB_BCRP3
Bat coronavirus Rp3/2004 (BtCoV/Rp3/2004) (SARS-like coronavirus Rp3)
R1AB_CVBEN
Bovine coronavirus (strain 98TXSF-110-ENT) (BCoV-ENT) (BCV)
R1AB_CVBLU
Bovine coronavirus (strain 98TXSF-110-LUN) (BCoV-LUN) (BCV)
R1AB_CVBM
Bovine coronavirus (strain Mebus) (BCoV) (BCV)
R1AB_CVBQ
Bovine coronavirus (strain Quebec) (BCoV) (BCV)
R1AB_CVHN2
Human coronavirus HKU1 (isolate N2) (HCoV-HKU1)
R1AB_CVHN5
Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
R1AB_CVMJH
Murine coronavirus (strain JHM) (MHV-JHM) (Murine hepatitis virus)

11 entries

Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)

Select_allDeselect_all
SHUT_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain
SHUT_ADE05
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain
SHUT_ADE12
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain
SHUT_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain
SHUT_ADEP3
Porcine adenovirus A serotype 3 (PAdV-3) (Porcine adenovirus 3) reference strain
SHUT_ADES1
Snake adenovirus serotype 1 (SnAdV-1) reference strain
SHUT_ADE40
Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)
SHUT_ADE41
Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)
SHUT_ADECC
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))
SHUT_ADECR
Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))
SHUT_ADEGX
Fowl adenovirus C serotype 10 (strain SA2) (FAdV-10) (Fowl adenovirus 10)

1 entry

Small t antigen (ST) (ST-AG)

ST_SV40
Simian virus 40 (SV40) reference strain