Betaentomopoxvirus

VIRION

Enveloped, ovoid virion about 350x250nm in size. Two distinct infectious virus particles exists: the intracellular mature virus (IMV) and the extracellular enveloped virus (EEV).

GENOME

Linear, dsDNA genome about 225kb. The linear genome is flanked by inverted terminal repeat (ITR) sequences which are covalently-closed at their extremities.
Amsacta moorei entomopoxvirus strain Moyer genome
at Poxvirus Bioinformatics Ressource center

GENE EXPRESSION

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral proteins to host glycosaminoglycans (GAGs) mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core into the host cytoplasm.
  3. Early phase: early genes are transcribed in the cytoplasm by viral RNA polymerase. Early expression begins at 30 minutes post-infection.
  4. Core is completely uncoated as early expression ends, viral genome is now free in the cytoplasm.
  5. Intermediate phase: Intermediate genes are expressed, triggering genomic DNA replication at approximately 100 minutes post-infection.
  6. Late phase: Late genes are expressed from 140 min to 48 hours post-infection, producing all structural proteins.
  7. Assembly of progeny virions starts in cytoplasmic viral factories, producing an spherical immature particle. This virus particle matures into brick-shaped intracellular mature virion (IMV).
  8. IMV virion can be released upon cell lysis, or can acquire a second double membrane from trans-Golgi and bud as external enveloped virion (EEV).
  9. Mature virion can be occluded in spheroids comprised of spheroidin protein.

Host-virus interaction

Apoptosis modulation

The Amsacta moorei entomopoxvirus encodes AMV p33, a functional homolog of the baculovirus apoptosis inhibitor p35 . P33 is a direct inhibitor of caspases.

Matching UniProtKB/Swiss-Prot entries

19 entries grouped by protein (browse by keywords)

All proteins are shown (view only 11 complete proteome entries)

1 entry

Envelope protein A28 homolog (Protein G4R)

A28_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

DNA polymerase (EC 2.7.7.7)

DPOL_CBEPV
Choristoneura biennis entomopoxvirus (CbEPV)

1 entry

Core protease I7 homolog (EC 3.4.22.-)

I7_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

3 entries

Thymidine kinase (EC 2.7.1.21)

Select_allDeselect_all
KITH_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain
KITH_CBEPV
Choristoneura biennis entomopoxvirus (CbEPV)
KITH_CFEPV
Choristoneura fumiferana entomopoxvirus (CfEPV)

1 entry

Putative glycylpeptide N-tetradecanoyltransferase (EC 2.3.1.97) (Myristoyl-CoA:protein N-myristoyltransferase) (NMT) (Peptide N-myristoyltransferase)

NMT_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

4 entries

Nucleoside triphosphatase I (EC 3.6.1.15) (NPH-I) (Nucleoside triphosphate phosphohydrolase I) (NPH I)

Select_allDeselect_all
NTP1_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain
NTP1_CBEPV
Choristoneura biennis entomopoxvirus (CbEPV)
NTP1_CFEPV
Choristoneura fumiferana entomopoxvirus (CfEPV)
NTP1_HAEPV
Heliothis armigera entomopoxvirus (HaEPV)

1 entry

Putative tyrosine-protein phosphatase AMV078 (EC 3.1.3.48)

PTPH_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

Spheroidin

SPHR_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

2 entries

Spindolin (Fusolin) (p50)

Select_allDeselect_all
SPIN_CBEPV
Choristoneura biennis entomopoxvirus (CbEPV)

Spindolin (Spheroidin) (p50)

SPIN_HAEPV
Heliothis armigera entomopoxvirus (HaEPV)

1 entry

Uncharacterized protein AMV183/G2R

V183_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

Uncharacterized protein AMV185/G3L

V185_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

Uncharacterized leucine-rich repeat-containing protein AMV014/Q3

Y014_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain

1 entry

Uncharacterized protein AMV017/Q1

YO17_AMEPV
Amsacta moorei entomopoxvirus (AmEPV) reference strain