Birnaviridae

VIRION

Non enveloped, single-shelled T=13 icosahedral symmetry capsid of about 70 nm in diameter, composed of 260 trimers of VP2 that form spikes projecting radially from the capsid. The peptides derived from pre-VP2 C-terminal cleavages remain associated within virion. VP3 forms a ribonucleoprotein complex with the genomic RNA. Minor amounts of VP1 are also incorporated in the virion.

GENOME

Segmented linear dsRNA genome: 2 segments (A,B) encode for 5-6 proteins. VP1 is found in a free form and covalently attached at the 5' genomic RNA end (VPg). Segments size is about 2.3-3 kb. Genome total size is about 6 kb.

GENE EXPRESSION

Genomic segment A encodes for a structural polyprotein which is matured in cis by VP4. It also encodes an alternative ORF translated possibly by leaky scanning (VP5).
Genomic segment B encodes for VP1.

REPLICATION

CYTOPLASMIC

  1. Virus penetrates into the cytoplasm.
  2. Transcription of the dsRNA genome by viral polymerase occurs inside the virion, so that dsRNA is never exposed to the cytoplasm. This plus-strand transcript is used as template for translation.
  3. (+)RNAs are encapsidated in virion particle, inside which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  4. Mature virions are released by budding.

Host-virus interaction

Host transcription modulation

NF-kappaB 21272652 19576240

Apoptosis modulation

21304825 18471101 21304825 20131002

Matching UniProtKB/Swiss-Prot entries

32 entries grouped by strain (browse by keywords)

All proteins are shown (view only 17 complete proteome entries)

3 entries

Avian infectious bursal disease virus (isolate Chicken/UK/UK661/1989) (IBDV) (Gumboro disease virus) reference strain

Select_allDeselect_all
RDRP_IBDVU RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
POLS_IBDVU Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...
VP5_IBDVU Protein VP5

3 entries

Blotched snakehead virus (BSNV) (Channa lucius virus) reference strain

Select_allDeselect_all
RDRP_BSNV RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
POLS_BSNV Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...
VP5_BSNV Protein VP5

3 entries

Drosophila x virus (isolate Chung/1996) (DXV) reference strain

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RDRP_DXV96 RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
POLS_DXV96 Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (pre-VP2); Capsid protein VP2; ...
VP5_DXV96 Protein VP5

3 entries

Infectious pancreatic necrosis virus (strain Jasper) (IPNV) reference strain

Select_allDeselect_all
RDRP_IPNVJ RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
POLS_IPNVJ Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...
VP5_IPNVJ Protein VP5

3 entries

Avian infectious bursal disease virus (strain Chicken/Cuba/Soroa/1998) (IBDV) (Gumboro disease virus)

Select_allDeselect_all
RDRP_IBDVB RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
POLS_IBDVB Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...
VP5_IBDVB Protein VP5

3 entries

Infectious pancreatic necrosis virus (strain Sp) (IPNV)

Select_allDeselect_all
RDRP_IPNVS RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
POLS_IPNVS Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...
VP5_IPNVS Protein VP5

2 entries

Avian infectious bursal disease virus (IBDV) (Gumboro disease virus)

Select_allDeselect_all
RDRP_IBDV RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
POLS_IBDV Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...

2 entries

Avian infectious bursal disease virus (strain 52/70) (IBDV) (Gumboro disease virus)

Select_allDeselect_all
POLS_IBDV5 Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...
VP5_IBDV5 Protein VP5

2 entries

Avian infectious bursal disease virus (strain Australian 002-73) (IBDV) (Gumboro disease virus)

Select_allDeselect_all
RDRP_IBDVA RNA-directed RNA polymerase (RDRP) (EC 2.7.7.48) (Protein VP1)
POLS_IBDVA Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...

2 entries

Avian infectious bursal disease virus (strain Cu-1) (IBDV) (Gumboro disease virus)

Select_allDeselect_all
POLS_IBDVC Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...
VP5_IBDVC Protein VP5

2 entries

Avian infectious bursal disease virus (strain STC) (IBDV) (Gumboro disease virus)

Select_allDeselect_all
POLS_IBDVS Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...
VP5_IBDVS Protein VP5

2 entries

Infectious pancreatic necrosis virus (strain N1) (IPNV)

Select_allDeselect_all
POLS_IPNVN Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...
VP5_IPNVN Protein VP5

1 entry

Avian infectious bursal disease virus (strain E) (IBDV) (Gumboro disease virus)

POLS_IBDVE Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...

1 entry

Avian infectious bursal disease virus (strain OH) (IBDV) (Gumboro disease virus)

POLS_IBDVO Structural polyprotein (PP) [Cleaved into: Precursor of VP2 (Pre-VP2); Capsid protein VP2; ...