Hypoviridae

VIRION

No true capsid. The dsRNA genome is encapsulated along with the viral replicase enzyme within host-derived lipid pleomorphic vesicles (50-80nm in diameter).

GENOME

Linear dsRNA genome of 9-13kb, encodes one or two ORFs (ORFB, and eventually ORFA). The 3’end is polyadenylated. The genome only encodes non-structural proteins.
May also contain additional satellite dsRNAs.

GENE EXPRESSION

ORFB (and if present, ORFA) encodes a polyprotein that is proteolytically processed.

REPLICATION

CYTOPLASMIC

Poorly understood. The virus never budds out of its host and probably replicates in lipid pleomorphic vesicles. Transmission dependent on cell to cell cytoplasmic exchange, and hyphal anastomosis.

Matching UniProtKB/Swiss-Prot entries

4 entries grouped by strain (browse by keywords)

2 entries

Cryphonectria hypovirus 1 (strain EP713) (CHV-1/EP713) (Chestnut blight fungus hypovirulence-associated virus) reference strain

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POLB_CHPVE ORFB polyprotein [Cleaved into: Papain-like protease p48 (EC 3.4.22.-); Putative RNA-directed RNA ...
POLA_CHPVE Polyprotein p69 (ORFA polyprotein) [Cleaved into: Papain-like protease p29 (EC 3.4.22.-); p40 ...

2 entries

Cryphonectria hypovirus 1 (strain Euro7) (CHV-1/Euro7) (Chestnut blight fungus hypovirulence-associated virus)

Select_allDeselect_all
POLB_CHPVU ORFB polyprotein [Cleaved into: Papain-like protease p48 (EC 3.4.22.-); Putative RNA-directed RNA ...
POLA_CHPVU Polyprotein p69 (ORFA polyprotein) [Cleaved into: Papain-like protease p29 (EC 3.4.22.-); p40 ...