Simplexvirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. The capsid consists of 162 capsomers and is surrounded by an amorphous tegument.

GENOME

Monopartite, linear, dsDNA genome of 152 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

All genes are transcribed by the host RNA polymerase II. and most mRNAs are unspliced. There are three temporal classes of genes: immediate-early (alpha), early (beta) and late (gamma). The immediate-early genes are transcribed immediately after infection to take control of cell defense and to activate early genes. These encode the proteins necessary for the viral DNA replication. The late genes mostly encode structural proteins. Latent genes can stop the replicative process at the early step. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral gB, gC, gD and gH proteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Herpes simplex protein US12 binds specifically to transporters associated with antigen processing (TAP), blocking peptide-binding to TAP and subsequent loading of peptides onto MHC class I molecules . Herpes simplex virus 1 glycoprotein B and US3 collaborate to inhibit CD1d antigen presentation and NKT cell function .

Apoptosis modulation

The viral kinase US3 modulates host apoptosis in different ways. It activates host protein kinase A/PKA to block apoptosis. Additionally, it also interacts with programmed cell death protein 4 (PDCD4) and retains it in the nucleus thereby inhibiting host apoptosis .

Autophagy modulation

Herpes simplex virus ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein and thus blocking host autophagy process .

Cell-cycle modulation

The viral proteins ICP27 and vhs act jointly to repress host gene transcription and blocks the cell cycle at the G1 phase . In addition the UL24 protein induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

Herpes simplex virus inhibits the cascade leading to production of interferon-beta by targeting different cellular proteins. ICP34.5 forms a complex with host TBK1 and thus disrupts the interaction of TBK1-containing complexes with IRF3 . Another viral protein, ICP0, prevents IRF3 activation and subsequent induction of IFN-beta expression .

Host splicing inhibition

HSV-1 ICP27 is an alternative splicing regulator of host mRNA. It has been shown to act as a splicing silencer at the 3' splice site of the PML intron 7a .

Matching UniProtKB/Swiss-Prot entries

230 entries grouped by protein (browse by keywords)

All proteins are shown (view only 146 complete proteome entries)

2 entries

Alkaline nuclease (EC 3.1.-.-)

Select_allDeselect_all
AN_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
AN_HHV2
Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2)

2 entries

Cytoplasmic envelopment protein 1

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CEP1_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CEP1_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Cytoplasmic envelopment protein 2

Select_allDeselect_all
CEP2_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CEP2_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

3 entries

Cytoplasmic envelopment protein 3

Select_allDeselect_all
CEP3_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CEP3_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
CEP3_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)

2 entries

Capsid vertex component 1

Select_allDeselect_all
CVC1_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CVC1_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Capsid vertex component 2

Select_allDeselect_all
CVC2_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
CVC2_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

6 entries

Major DNA-binding protein

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DNBI_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
DNBI_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
DNBI_BHV2B
Bovine herpesvirus 2 (strain BMV) (BoHV-2) (Bovine mammillitis virus)
DNBI_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
DNBI_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
DNBI_HHV2
Human herpesvirus 2 (HHV-2) (Human herpes simplex virus 2)

6 entries

DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)

Select_allDeselect_all
DPOL_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
DPOL_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
DPOL_HHV1A
Human herpesvirus 1 (strain Angelotti) (HHV-1) (Human herpes simplex virus 1)
DPOL_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
DPOL_HHV1S
Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus 1)
DPOL_HHV21
Human herpesvirus 2 (strain 186) (HHV-2) (Human herpes simplex virus 2)

2 entries

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

Select_allDeselect_all
DUT_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
DUT_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

5 entries

Envelope protein UL45 (18 kDa protein)

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EV45_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
EV45_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
EV45_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
EV45_HHV1M
Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
EV45_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

10 entries

Envelope glycoprotein B (gB)

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GB_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GB_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GB_BHV2B
Bovine herpesvirus 2 (strain BMV) (BoHV-2) (Bovine mammillitis virus)
GB_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
GB_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GB_HHV1P
Human herpesvirus 1 (strain Patton) (HHV-1) (Human herpes simplex virus 1)
GB_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
GB_HSV2S
Herpes simplex virus type 2 (strain SA8) (Simian agent 8)
GB_HSVA1
Herpesvirus ateles type 1 (strain Lennette)
GB_SHV1
Saimiriine herpesvirus 1 (strain MV-5-4-PSL) (SaHV-1) (Marmoset herpesvirus)

5 entries

Envelope glycoprotein C

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GC_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GC_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GC_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GC_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
GC_HHV2G
Human herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

Envelope glycoprotein C (Glycoprotein F)

9 entries

Envelope glycoprotein D (gD)

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GD_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GD_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GD_CHV1
Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)
GD_HHV1A
Human herpesvirus 1 (strain Angelotti) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1H
Human herpesvirus 1 (strain HZT) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GD_HHV1P
Human herpesvirus 1 (strain Patton) (HHV-1) (Human herpes simplex virus 1)
GD_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

4 entries

Envelope glycoprotein E (gE) (gE-1)

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GE_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GE_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Envelope glycoprotein E (gE) (gE-2)

GE_CHV1
Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)

Envelope glycoprotein E (gE)

GE_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

3 entries

Envelope glycoprotein G (gG) (gG-2)

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GG_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

Envelope glycoprotein G (gG) (gG-1)

GG_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GG_HHV2B
Human herpesvirus 2 (strain B4327UR) (HHV-2) (Human herpes simplex virus 2)

4 entries

Envelope glycoprotein H (gH)

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GH_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GH_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GH_HHV1E
Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)
GH_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

3 entries

Envelope glycoprotein I (gI)

Select_allDeselect_all
GI_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GI_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GI_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

2 entries

Envelope glycoprotein J

Select_allDeselect_all
GJ_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GJ_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

6 entries

Envelope glycoprotein K (Syncytial protein)

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GK_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GK_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GK_HHV19
Human herpesvirus 1 (strain R19) (HHV-1) (Human herpes simplex virus 1)
GK_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
GK_HHV1M
Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)
GK_HHV1R
Human herpesvirus 1 (strain R15) (HHV-1) (Human herpes simplex virus 1)

3 entries

Envelope glycoprotein L (gL)

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GL_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GL_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
GL_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)

2 entries

Envelope glycoprotein M (gM)

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GM_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GM_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Envelope glycoprotein N

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GN_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
GN_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

DNA replication helicase (EC 3.6.4.-)

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HELI_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
HELI_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)

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HEPA_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
HEPA_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (Alpha-0 protein) (Immediate-early protein IE110) (RING-type E3 ubiquitin transferase ICP0) (Trans-acting transcriptional protein ICP0) (VMW110)

Select_allDeselect_all
ICP0_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP0_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

E3 ubiquitin-protein ligase ICP0 (EC 2.3.2.27) (RING-type E3 ubiquitin transferaseICP0) (VMW118 protein)

2 entries

Transcriptional regulator ICP22 (Immediate-early protein IE68) (Infected cell protein 22) (ICP22)

Select_allDeselect_all
ICP22_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP22_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

3 entries

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27) (VMW63)

Select_allDeselect_all
ICP27_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP27_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP27_HHV1E
Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

mRNA export factor (Immediate-early protein IE63) (Infected cell protein 27) (ICP27)

5 entries

Neurovirulence factor ICP34.5 (Infected cell protein 34.5) (protein gamma(1)34.5)

Select_allDeselect_all
ICP34_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP34_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP34_HHV1D
Human herpesvirus 1 (strain CVG-2) (HHV-1) (Human herpes simplex virus 1)
ICP34_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
ICP34_HHV1N
Human herpesvirus 1 (strain MGH-10) (HHV-1) (Human herpes simplex virus 1)

2 entries

Major viral transcription factor ICP4 (Alpha-4 protein) (Infected cell protein 4) (Transcriptional activator IE175)

Select_allDeselect_all
ICP4_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP4_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Major viral transcription factor ICP4 homolog (Alpha-4 protein) (Infected cell protein 4) (Transcriptional activator IE175)

5 entries

ICP47 protein (Immediate-early protein IE12) (Immediate-early-5) (Infected cell protein 47) (US12 protein) (Vmw12)

Select_allDeselect_all
ICP47_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ICP47_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
ICP47_CHV16
Cercopithecine herpesvirus 16 (CeHV-16) (Herpesvirus papio 2)
ICP47_CHV1E
Cercopithecine herpesvirus 1 (strain E2490) (CeHV-1) (Simian herpes B virus)
ICP47_HSV2S
Herpes simplex virus type 2 (strain SA8) (Simian agent 8)

2 entries

Inner tegument protein

Select_allDeselect_all
ITP_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
ITP_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

10 entries

Thymidine kinase (EC 2.7.1.21)

Select_allDeselect_all
KITH_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
KITH_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
KITH_BHV2H
Bovine herpesvirus 2 (strain BHM-1) (BoHV-2) (Bovine mammillitis virus)
KITH_HHV1
Human herpesvirus 1 (HHV-1) (Human herpes simplex virus 1)
KITH_HHV1C
Human herpesvirus 1 (strain CL101) (HHV-1) (Human herpes simplex virus 1)
KITH_HHV1E
Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)
KITH_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
KITH_HHV1S
Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus 1)
KITH_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
KITH_SHV1
Saimiriine herpesvirus 1 (strain MV-5-4-PSL) (SaHV-1) (Marmoset herpesvirus)

1 entry

Latency-related protein 1

LRP1_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

1 entry

Latency-related protein 2

LRP2_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

2 entries

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

Select_allDeselect_all
LTP_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
LTP_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Membrane protein UL43

Select_allDeselect_all
MB43_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
MB43_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Major capsid protein (MCP)

Select_allDeselect_all
MCP_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
MCP_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Nuclear egress protein 1

Select_allDeselect_all
NEC1_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
NEC1_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Nuclear egress protein 2

Select_allDeselect_all
NEC2_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
NEC2_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

4 entries

Nuclear phosphoprotein UL3

Select_allDeselect_all
NP03_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
NP03_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
NP03_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
NP03_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

2 entries

Nuclear protein UL4

Select_allDeselect_all
NP04_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
NP04_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Replication origin-binding protein (OBP) (OriBP)

Select_allDeselect_all
OBP_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
OBP_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

DNA polymerase processivity factor (DNA-binding protein UL42) (Polymerase accessory protein) (PAP)

Select_allDeselect_all
PAP_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
PAP_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Portal protein

Select_allDeselect_all
PORTL_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
PORTL_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

DNA primase (EC 2.7.7.-)

Select_allDeselect_all
PRIM_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
PRIM_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

3 entries

Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

Select_allDeselect_all
RIR1_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
RIR1_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
RIR1_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

4 entries

Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

Select_allDeselect_all
RIR2_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
RIR2_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
RIR2_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
RIR2_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

3 entries

RNA-binding protein (Vmw21)

Select_allDeselect_all
RNB_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
RNB_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

Probable RNA-binding protein

RNB_HHV1M
Human herpesvirus 1 (strain MP) (HHV-1) (Human herpes simplex virus 1)

2 entries

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Virion structural protein UL26)

Select_allDeselect_all
SCAF_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
SCAF_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Small capsomere-interacting protein

Select_allDeselect_all
SCP_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
SCP_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

5 entries

Virion host shutoff protein (Vhs) (EC 3.1.27.-)

Select_allDeselect_all
SHUT_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
SHUT_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
SHUT_HHV1K
Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
SHUT_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)
SHUT_HHV2G
Human herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

3 entries

Tegument protein UL46 (Tegument protein VP11/12)

Select_allDeselect_all
TEG1_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG1_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TEG1_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

2 entries

Tegument protein UL14

Select_allDeselect_all
TEG3_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG3_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

3 entries

Tegument protein UL21

Select_allDeselect_all
TEG4_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG4_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TEG4_HHV1E
Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

3 entries

Tegument protein UL47 (82/81 kDa tegument protein) (VMW82/81) (VP13/14)

Select_allDeselect_all
TEG5_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG5_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TEG5_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

3 entries

Tegument protein UL55

Select_allDeselect_all
TEG6_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG6_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TEG6_HHV1E
Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

2 entries

Tegument protein UL51

Select_allDeselect_all
TEG7_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TEG7_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

5 entries

Tripartite terminase subunit 1

Select_allDeselect_all
TRM1_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRM1_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TRM1_BHV2B
Bovine herpesvirus 2 (strain BMV) (BoHV-2) (Bovine mammillitis virus)
TRM1_HHV1A
Human herpesvirus 1 (strain Angelotti) (HHV-1) (Human herpes simplex virus 1)
TRM1_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

2 entries

Tripartite terminase subunit 2

Select_allDeselect_all
TRM2_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRM2_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

Select_allDeselect_all
TRM3_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRM3_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

4 entries

Triplex capsid protein 1

Select_allDeselect_all
TRX1_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRX1_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
TRX1_HHV14
Human herpesvirus 1 (strain A44) (HHV-1) (Human herpes simplex virus 1)
TRX1_HHV2G
Human herpesvirus 2 (strain G) (HHV-2) (Human herpes simplex virus 2)

2 entries

Triplex capsid protein 2

Select_allDeselect_all
TRX2_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
TRX2_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Serine/threonine-protein kinase UL13 (EC 2.7.11.1)

Select_allDeselect_all
UL13_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain

Serine/threonine-protein kinase UL13 (EC 2.7.11.1) (Virion protein VMW57)

UL13_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Protein UL20

Select_allDeselect_all
UL20_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UL20_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Protein UL24

Select_allDeselect_all
UL24_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UL24_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Packaging protein UL32

Select_allDeselect_all
UL32_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UL32_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

3 entries

Protein UL56

Select_allDeselect_all
UL56_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UL56_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
UL56_HHV1E
Human herpesvirus 1 (strain HFEM) (HHV-1) (Human herpes simplex virus 1)

3 entries

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

Select_allDeselect_all
UNG_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
UNG_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
UNG_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

2 entries

Protein US2

Select_allDeselect_all
US02_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US02_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

2 entries

Serine/threonine-protein kinase US3 (EC 2.7.11.1)

Select_allDeselect_all
US03_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US03_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain

3 entries

Virion protein US10

Select_allDeselect_all
US10_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US10_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
US10_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

3 entries

Protein US8.5

Select_allDeselect_all
US8A_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US8A_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
US8A_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)

US8.5 protein

3 entries

Envelope protein US9 (10 kDa protein)

Select_allDeselect_all
US9_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
US9_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
US9_CHV1
Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)

Envelope protein US9 homolog (10 kDa protein)

1 entry

Envelope glycoprotein J

VGLJ_CHV1
Cercopithecine herpesvirus 1 (CeHV-1) (Simian herpes B virus)

4 entries

Tegument protein VP16 (Alpha trans-inducing protein) (Alpha-TIF) (ICP25) (Vmw65)

Select_allDeselect_all
VP16_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
VP16_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain
VP16_HHV1F
Human herpesvirus 1 (strain F) (HHV-1) (Human herpes simplex virus 1)
VP16_HHV23
Human herpesvirus 2 (strain 333) (HHV-2) (Human herpes simplex virus 2)

2 entries

Tegument protein VP22

Select_allDeselect_all
VP22_HHV11
Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1) reference strain
VP22_HHV2H
Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2) reference strain