Roseolovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 200 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Entry into host cell is still unclear and may depend on the host cell type, i.e. endocytosis versus fusion at the plasma membrane.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Occasionally, the viral genome can be integrated in host chromosome thereby creating a latent virus.
  5. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  6. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  7. A first round of circular genome amplification occurs by bidirectional replication
  8. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  9. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  10. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

The HHV-6 U24 protein downregulates the T-cell receptor complex and impairs T-cell activation.

Cell-cycle modulation

The UL24 protein homolog induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex .

Innate immune response inhibition

HHV-6 protein IE1 interferes with the binding of IRF3 to the IFN-beta promoter, reduces levels of dimerized IRF3 and nucleus-translocated IRF3 in response to activation by TBK1. This inhibiton of the pathway through IRF3 subsequenty prevents the expression IFN-beta.

Host splicing inhibition

HHV-6 UL42 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

275 entries grouped by protein (browse by keywords)

All proteins are shown (view only 261 complete proteome entries)

3 entries

Alkaline nuclease (EC 3.1.-.-)

Select_allDeselect_all
AN_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
AN_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
AN_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

1 entry

Protein B1

B1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Protein B2

B2_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Protein B3

B3_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Protein B4

B4_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Protein B5

B5_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Protein B6

B6_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Protein B7

B7_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Protein B8

B8_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Protein B9

B9_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Putative CC-type chemokine U83

Select_allDeselect_all
CCU83_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
CCU83_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

Cytoplasmic envelopment protein 1

Select_allDeselect_all
CEP1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
CEP1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
CEP1_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Cytoplasmic envelopment protein 2

Select_allDeselect_all
CEP2_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
CEP2_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
CEP2_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Cytoplasmic envelopment protein 3

Select_allDeselect_all
CEP3_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
CEP3_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
CEP3_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Capsid vertex component 1

Select_allDeselect_all
CVC1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
CVC1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
CVC1_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Capsid vertex component 2

Select_allDeselect_all
CVC2_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
CVC2_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
CVC2_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Major DNA-binding protein

Select_allDeselect_all
DNBI_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
DNBI_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
DNBI_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

DNA polymerase catalytic subunit (EC 2.7.7.7)

Select_allDeselect_all
DPOL_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
DPOL_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
DPOL_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

2 entries

Uncharacterized protein DR1

Select_allDeselect_all
DR1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
DR1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Uncharacterized protein DR2

DR2_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

2 entries

Uncharacterized protein DR3

Select_allDeselect_all
DR3_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
DR3_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Uncharacterized protein DR4

DR4_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

1 entry

Uncharacterized protein DR5

DR5_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

2 entries

Uncharacterized protein DR6

Select_allDeselect_all
DR6_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
DR6_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Uncharacterized protein DR7

DR7_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

1 entry

Uncharacterized protein DR8

DR8_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

4 entries

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

Select_allDeselect_all
DUT_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
DUT_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
DUT_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
DUT_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

4 entries

Envelope glycoprotein B (gB)

Select_allDeselect_all
GB_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GB_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GB_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
GB_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

3 entries

Probable ganciclovir kinase (EC 2.7.1.-)

Select_allDeselect_all
GCVK_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GCVK_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GCVK_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

4 entries

Envelope glycoprotein H (gH)

Select_allDeselect_all
GH_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GH_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GH_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
GH_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

3 entries

Envelope glycoprotein L (gL)

Select_allDeselect_all
GL_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GL_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GL_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Envelope glycoprotein M (gM)

Select_allDeselect_all
GM_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GM_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GM_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Envelope glycoprotein N

Select_allDeselect_all
GN_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GN_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
GN_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

1 entry

Glycoprotein 105 (gp105)

GP105_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

2 entries

Glycoprotein Q1 (gQ1) (Glycoprotein 105) (gp105) (Glycoprotein Q-80k) (gQ-80k) (HCLF1 protein)

Select_allDeselect_all
GQ1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
GQ1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Glycoprotein Q2 (gQ2)

Select_allDeselect_all
GQ2_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

Glycoprotein Q2 (gQ2) (Glycoprotein Q-37k) (gQ-37k)

GQ2_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

DNA replication helicase (EC 3.6.4.-)

Select_allDeselect_all
HELI_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
HELI_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
HELI_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)

Select_allDeselect_all
HEPA_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
HEPA_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
HEPA_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

mRNA export factor ICP27 homolog

Select_allDeselect_all
ICP27_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
ICP27_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
ICP27_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

1 entry

Immediate-early protein 1 (IE1) (Protein RF2/RF3/RF4) (pRF2/pRF3/pRF4)

IE1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

3 entries

Immediate-early protein 2 (IE2)

Select_allDeselect_all
IE2_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
IE2_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
IE2_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

3 entries

Inner tegument protein

Select_allDeselect_all
ITP_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
ITP_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
ITP_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

1 entry

Uncharacterized protein LJ1

LJ1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

4 entries

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

Select_allDeselect_all
LTP_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
LTP_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
LTP_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
LTP_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

3 entries

Major capsid protein (MCP)

Select_allDeselect_all
MCP_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
MCP_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
MCP_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Nuclear egress protein 1

Select_allDeselect_all
NEC1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
NEC1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
NEC1_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Nuclear egress protein 2

Select_allDeselect_all
NEC2_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
NEC2_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
NEC2_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Replication origin-binding protein (OBP)

Select_allDeselect_all
OBP_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
OBP_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
OBP_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

2 entries

Putative OX-2 membrane glycoprotein homolog (Protein U85)

Select_allDeselect_all
OX2V_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
OX2V_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

Large structural phosphoprotein (100 kDa phosphoprotein) (pp100) (Major antigenic structural protein)

Select_allDeselect_all
P100_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
P100_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
P100_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

Large structural phosphoprotein (100 kDa phosphoprotein) (pp100)

3 entries

Portal protein

Select_allDeselect_all
PORTL_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
PORTL_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
PORTL_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

2 entries

Phosphoprotein 85 (pp85) (Protein U14)

Select_allDeselect_all
PP85_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
PP85_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

DNA primase (EC 2.7.7.-)

Select_allDeselect_all
PRIM_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
PRIM_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
PRIM_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Ribonucleoside-diphosphate reductase large subunit-like protein

Select_allDeselect_all
RIR1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
RIR1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
RIR1_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

1 entry

Protein RJ1 (Protein LT1)

RJ1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

3 entries

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)

Select_allDeselect_all
SCAF_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
SCAF_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
SCAF_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

2 entries

Small capsomere-interacting protein

Select_allDeselect_all
SCP_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
SCP_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

Tegument protein UL51 homolog

Select_allDeselect_all
TEG7_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
TEG7_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
TEG7_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Tripartite terminase subunit 1

Select_allDeselect_all
TRM1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
TRM1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
TRM1_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

2 entries

Tripartite terminase subunit 2

Select_allDeselect_all
TRM2_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
TRM2_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

Select_allDeselect_all
TRM3_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
TRM3_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
TRM3_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Triplex capsid protein 1

Select_allDeselect_all
TRX1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
TRX1_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
TRX1_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

4 entries

Triplex capsid protein 2

Select_allDeselect_all
TRX2_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
TRX2_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
TRX2_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
TRX2_HHV7M
Human herpesvirus 7 (strain MUK) (HHV-7) (Human T lymphotropic virus)

1 entry

Uncharacterized protein U1

U1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

1 entry

Protein U10

U10_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Uncharacterized protein U13

Select_allDeselect_all
U13_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U13_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Protein U15

Select_allDeselect_all
U15_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

Uncharacterized protein U15

U15_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Protein U17/U16

Select_allDeselect_all
U16_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U16_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

3 entries

Protein U17

Select_allDeselect_all
U17_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U17_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
U17_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

2 entries

Putative immediate early glycoprotein (Protein U18)

Select_allDeselect_all
U18_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U18_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Glycoprotein U20

Select_allDeselect_all
U20_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U20_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

4 entries

U21 glycoprotein

Select_allDeselect_all
U21_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

Glycoprotein U21

U21_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
U21_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
U21_HHV7R
Human herpesvirus 7 (strain RK) (HHV-7) (Human T lymphotropic virus)

U21 glycoprotein (gp60)

2 entries

Glycoprotein U22

Select_allDeselect_all
U22_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U22_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U22

2 entries

Glycoprotein U23

Select_allDeselect_all
U23_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U23_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U23

2 entries

Glycoprotein U24

Select_allDeselect_all
U24_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U24_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Protein U24

1 entry

Uncharacterized protein U24A

U24A_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Uncharacterized protein U6

Select_allDeselect_all
U6_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U6_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

1 entry

Uncharacterized protein U61

U61_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

1 entry

Uncharacterized protein U78

U78_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

4 entries

Protein U79

Select_allDeselect_all
U79_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

Protein U79/U80

U79_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
U79_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
U79_HHV6H
Human herpesvirus 6B (strain HST) (HHV-6 variant B) (Human B lymphotropic virus)

Protein U79/U80

1 entry

Uncharacterized protein U88

U88_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

1 entry

Protein U90

U90_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Protein U91

Select_allDeselect_all
U91_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

Uncharacterized protein U91

U91_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Uncharacterized protein U95

Select_allDeselect_all
U95_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
U95_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

4 entries

Protein UL24 homolog

Select_allDeselect_all
UL24_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL24_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL24_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
UL24_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

3 entries

Packaging protein UL32

Select_allDeselect_all
UL32_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL32_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

Packaging protein UL32 homolog

UL32_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

2 entries

G-protein coupled receptor homolog U12

Select_allDeselect_all
UL33_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL33_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

2 entries

Apoptosis inhibitor U19

Select_allDeselect_all
UL38_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL38_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

Protein U33

Select_allDeselect_all
UL49_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL49_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL49_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U52

Select_allDeselect_all
UL79_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL79_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL79_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U58

Select_allDeselect_all
UL87_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL87_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL87_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U59

Select_allDeselect_all
UL88_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL88_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL88_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U62

Select_allDeselect_all
UL91_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL91_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL91_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U63

Select_allDeselect_all
UL92_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL92_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL92_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U67

Select_allDeselect_all
UL95_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL95_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL95_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U68

Select_allDeselect_all
UL96_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UL96_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UL96_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

Select_allDeselect_all
UNG_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
UNG_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
UNG_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

1 entry

Uncharacterized protein U55A

V55A_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

1 entry

Uncharacterized protein U55B

V55B_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

1 entry

G-protein coupled receptor

VGCR_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

DNA polymerase processivity factor (Phosphoprotein P41) (PP41) (Polymerase accessory protein) (PAP)

Select_allDeselect_all
VPAP_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VPAP_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VPAP_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

DNA polymerase processivity factor (Polymerase accessory protein) (PAP)

1 entry

Protein U1

VU1_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain

2 entries

U10 protein

Select_allDeselect_all
VU10_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU10_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

1 entry

Protein U2

VU2_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

Protein U25

Select_allDeselect_all
VU25_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU25_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU25_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

4 entries

Protein U26

Select_allDeselect_all
VU26_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU26_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU26_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain
VU26_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

3 entries

Protein U3

Select_allDeselect_all
VU3_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU3_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU3_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U4

Select_allDeselect_all
VU4_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU4_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU4_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

4 entries

Glycoprotein U47

Select_allDeselect_all
VU47_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU47_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU47_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

Glycoprotein U47 homolog

VU47_HHV6G
Human herpesvirus 6A (strain GS) (HHV-6 variant A) (Human B lymphotropic virus)

2 entries

Protein U5

Select_allDeselect_all
VU5_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU5_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

G-protein coupled receptor homolog U51

Select_allDeselect_all
VU51_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU51_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU51_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U54

Select_allDeselect_all
VU54_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU54_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU54_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

2 entries

Uncharacterized protein U55

Select_allDeselect_all
VU55_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU55_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Protein U7

Select_allDeselect_all
VU7_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU7_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

3 entries

Protein U8

Select_allDeselect_all
VU8_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU8_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU8_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

3 entries

Protein U84

Select_allDeselect_all
VU84_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU84_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain
VU84_HHV7J
Human herpesvirus 7 (strain JI) (HHV-7) (Human T lymphotropic virus) reference strain

2 entries

Protein U9

Select_allDeselect_all
VU9_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU9_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain

2 entries

Protein U94

Select_allDeselect_all
VU94_HHV6U
Human herpesvirus 6A (strain Uganda-1102) (HHV-6 variant A) (Human B lymphotropic virus) reference strain
VU94_HHV6Z
Human herpesvirus 6B (strain Z29) (HHV-6 variant B) (Human B lymphotropic virus) reference strain