Mastadenovirus

VIRION

Non-enveloped capsid with a pseudo T=25 icosahedral symmetry . The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.


GENOME

Non segmented, linear double-stranded DNA of 35-36kb encoding about 40 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.

GENE EXPRESSION

Transcription is nuclear, in three phases; early, intermediate (replication), and late (virion assembly). All genes are transcribed by host RNA pol II except virus-associated (VA) gene(s) of some primate adenoviruses transcribed by RNA pol III. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.

REPLICATION

NUCLEUS

  1. Attachment of the viral fibers to the host CAR adhesion receptor. Subsequent binding of the penton protein to host integrin entry receptors mediates internalization into the host cell by clathrin-mediated endocytosis of the virus and fiber shedding. Some serotypes also seem to use macropinocytosis.
  2. Disruption of host endosomal membrane by lytic protein VI releases the viral capsid in the cytosol.
  3. Microtubular transport toward nucleus of the viral genome still protected by the core protein VII and a partial capsid mainly composed of hexons and protein IX.
  4. Docking at the NPC and capsid disruption.
  5. Import of the viral genome into host nucleus mediated by core protein VII.
  6. Transcription of early genes (E genes) by host RNA pol II: these proteins optimize the cellular milieu for viral replication, and counteract a variety of antiviral defenses.
  7. Intermediate genes activate replication of the DNA genome by DNA strand displacement in the nucleus.
  8. Expression of L4-22K and L4-33K causes early to late switch. Transcription of late genes (L genes) by host RNA pol II, mostly encoding structural proteins.
  9. Host translation shutoff performed by the viral 100K protein.
  10. Assembly of new virions in the nucleus.
  11. Virions are released by lysis of the cell.
  12. Virion maturation by the viral protease.

Host-virus interaction

Adaptive immune response inhibition

The adenovirus E19 protein downregulates cell-surface expression of MHC-I by binding and retains the heavy chain in ER. E19 binds TAP and acts as a tapasin inhibitor, preventing class I/TAP association .

Apoptosis modulation

Soon after infection, the expression of E1A protein drives the cell cycle into S-phase so that the virus can replicate its genome optimally . However, this arrest leads to the accumulation of host p53 protein and subsequently apoptosis. The apoptosis is then inhibited by different viral proteins including E1B 55K, E4 orf6 or the bcl-2 homolog E1B 19K .

Autophagy modulation

Autophagy is triggered after adenoviral infection and may facilitate viral replication and/or cell lysis. The E1B 19K viral protein interacts with host Beclin 1, removes Bcl-2 (a negative regulator of autophagy) from Beclin-1 and thereby promotes autophagy .

Cell-cycle modulation

The expression of E1A protein drives the cell cycle into S-phase so that the virus can replicate its genome optimally .

Innate immune response inhibition

Adenoviruses do not inhibit the cascade leading to production of interferon-beta directly. However, they evade the host innate immunity by targeting a cellular histone modification. Indeed, the E1A viral protein blocks the IFN-induced H2B mono-ubiquitination and thereby associated ISGs expression .

Matching UniProtKB/Swiss-Prot entries

326 entries grouped by strain (browse by keywords)

All proteins are shown (view only 139 complete proteome entries)

45 entries

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

Select_allDeselect_all
ADP_ADE02 Adenovirus death protein (ADP) (Early-3 11.6 kDa glycoprotein) (E3-11.6K)
CAP3_ADE02 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAPSH_ADE02 Hexon protein (CP-H) (Protein II)
CAP9_ADE02 Hexon-interlacing protein (Protein IX)
CAP6_ADE02 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP8_ADE02 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CAPSP_ADE02 Penton protein (CP-P) (Penton base protein) (Protein III)
COR10_ADE02 Pre-core protein X (pX) (11 kDa core protein) (Protein mu) (pMu) [Cleaved into: Core protein X]
CORE5_ADE02 Core-capsid bridging protein (Core protein V)
DPOL_ADE02 DNA polymerase (EC 2.7.7.7)
DNB2_ADE02 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
E1B55_ADE02 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E3RDA_ADE02 Pre-early 3 receptor internalization and degradation alpha protein (Pre-E3-RID-alpha protein) ...
E312_ADE02 Early E3A 12.5 kDa protein (E3-12,5K)
E3145_ADE02 Early 3 14.7 kDa protein (E3-14.7k)
E4RF1_ADE02 Early 4 ORF1 protein (E4-ORF1) (E4 ORF1 control protein)
E4RF3_ADE02 Early 4 ORF3 protein (E4-ORF3) (E4 ORF3 control protein) (Early 4 11 kDa protein) (E4-11k)
E1BS_ADE02 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K) (E1B-175R)
E4RF4_ADE02 Early 4 ORF4 protein (E4 ORF4) (Early E4 13 kDa protein)
E1A_ADE02 Early E1A protein (Early E1A 32 kDa protein)
E3GL_ADE02 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
E3RDB_ADE02 Early 3 receptor internalization and degradation beta protein (E3 RID-beta protein) (Early E3B 14.5 ...
E4RF5_ADE02 Early 4 ORF6/7 control protein (E4-ORF6/7) (Early E4 17 kDa protein)
E434_ADE02 Early 4 ORF6 protein (E4-ORF6) (Early 4 34 kDa protein) (E4-34k)
E4RF2_ADE02 Early 4 ORF2 protein (E4-ORF2)
LEAD_ADE02 I-leader protein
NP_ADE02 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PKG1_ADE02 Packaging protein 1 (Packaging protein IVa2)
PKG2_ADE02 Packaging protein 2 (Packaging protein 22K) (L4-22K)
PKG3_ADE02 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
PRO_ADE02 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SF33K_ADE02 Protein 33K (L4-33K) (Splicing factor 33K) (Terminase, small subunit)
Y168_ADE02 Uncharacterized protein C-168
Y172_ADE02 Uncharacterized protein D-172
Y215_ADE02 Uncharacterized protein F-215
Y116_ADE02 Uncharacterized 11.6 kDa early protein
Y121_ADE02 Uncharacterized protein F-121
Y137_ADE02 Uncharacterized protein B-137
Y95_ADE02 Uncharacterized protein E-95
SHUT_ADE02 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
SPIKE_ADE02 Fiber protein (SPIKE) (Protein IV)
TERM_ADE02 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
UXP_ADE02 U exon protein (UXP)
Y112_ADE02 Uncharacterized protein F-112
Y115_ADE02 Uncharacterized protein E-115

30 entries

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

Select_allDeselect_all
CAP3_ADE05 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAPSH_ADE05 Hexon protein (CP-H) (Protein II)
CAPSP_ADE05 Penton protein (CP-P) (Penton base protein) (Protein III)
CAP8_ADE05 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CAP6_ADE05 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP9_ADE05 Hexon-interlacing protein (Protein IX)
COR10_ADE05 Pre-core protein X (pX) (11 kDa core protein) (Protein mu) (pMu) [Cleaved into: Core protein X]
CORE5_ADE05 Core-capsid bridging protein (Core protein V)
DPOL_ADE05 DNA polymerase (EC 2.7.7.7)
DNB2_ADE05 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
E1B55_ADE05 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E1BS_ADE05 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E3145_ADE05 Early E3 14.5 kDa protein
E310_ADE05 Early E3B 10.4 kDa protein
E3B14_ADE05 Early E3B 14.6 kDa protein
E3GL_ADE05 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
E1A_ADE05 Early E1A protein (Early E1A 32 kDa protein)
E311_ADE05 Early E3A 10.5 kDa glycoprotein
E312_ADE05 Early E3A 12.5 kDa protein
E411_ADE05 Probable early E4 11 kDa protein
NP_ADE05 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PKG1_ADE05 Packaging protein 1 (Packaging protein IVa2)
PKG3_ADE05 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
PKG2_ADE05 Packaging protein 2 (Packaging protein 22K) (L4-22K)
PRO_ADE05 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SHUT_ADE05 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
SPIKE_ADE05 Fiber protein (SPIKE) (Protein IV)
SF33K_ADE05 Protein 33K (L4-33K) (Splicing factor 33K) (Terminase, small subunit)
TERM_ADE05 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
UXP_ADE05 U exon protein (UXP)

26 entries

Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain

Select_allDeselect_all
CAP6_ADE12 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP3_ADE12 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAP8_ADE12 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CAP9_ADE12 Hexon-interlacing protein (Protein IX)
CAPSH_ADE12 Hexon protein (CP-H) (Protein II)
CAPSP_ADE12 Penton protein (CP-P) (Penton base protein) (Protein III)
CORE5_ADE12 Core-capsid bridging protein (Core protein V)
DNB2_ADE12 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
DNBI_ADE12 Probable DNA-binding protein (Agnoprotein)
E1A_ADE12 Early E1A protein (Early E1A 29.5 kDa protein)
E310_ADE12 Early E3B 10.4 kDa protein
E411_ADE12 Probable early E4 11 kDa protein
DPOL_ADE12 DNA polymerase (EC 2.7.7.7)
E1BS_ADE12 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E312_ADE12 Early E3A 12.1 kDa protein
E3B14_ADE12 Early E3B 12.7 kDa protein
E1B55_ADE12 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E413_ADE12 Probable early E4 13 kDa protein
E434_ADE12 Early E4 34 kDa protein
L2MU_ADE12 Late L2 mu core protein (11 kDa core protein) (Protein X) (pX) (pMu)
PKG3_ADE12 Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
PKG1_ADE12 Packaging protein 1 (Packaging protein IVa2)
PRO_ADE12 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SHUT_ADE12 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
SPIKE_ADE12 Fiber protein (SPIKE) (Protein IV)
TERM_ADE12 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...

3 entries

Bovine adenovirus 2 (BAdV-2) (Mastadenovirus bos2) reference strain

Select_allDeselect_all
CAP8_ADEB2 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
DPOL_ADEB2 DNA polymerase (EC 2.7.7.7)
TERM_ADEB2 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...

3 entries

Bovine adenovirus B serotype 3 (BAdV-3) (Mastadenovirus bos3) reference strain

Select_allDeselect_all
E3145_ADEB3 Early E3 14.5 kDa protein
PRO_ADEB3 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SPIKE_ADEB3 Fiber protein (SPIKE) (Protein IV)

6 entries

Porcine adenovirus A serotype 3 (PAdV-3) (Porcine adenovirus 3) reference strain

Select_allDeselect_all
CAPSP_ADEP3 Penton protein (CP-P) (Penton base protein) (Protein III)
CAPSH_ADEP3 Hexon protein (CP-H) (Protein II)
CAP8_ADEP3 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
PRO_ADEP3 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SHUT_ADEP3 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
SPIKE_ADEP3 Fiber protein (SPIKE) (Protein IV)

1 entry

Human adenovirus D serotype 17 (HAdV-17) (Human adenovirus 17) reference strain

PRO_ADE17 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

1 entry

Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2)

E3CR1_ADE02 Early 3 Conserved Region 1-alpha protein (E3 CR1-alpha) (Early 3 6.7K protein) (E3-6.7k)

1 entry

Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5)

LEAD_ADE05 I-leader protein

25 entries

Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

Select_allDeselect_all
CAP9_ADE07 Hexon-interlacing protein (Protein IX)
CAPSH_ADE07 Hexon protein (CP-H) (Protein II)
DPOL_ADE07 DNA polymerase (EC 2.7.7.7)
DNB2_ADE07 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
DNBI_ADE07 Probable DNA-binding protein (Agnoprotein)
E310_ADE07 Early E3B 10.4 kDa protein
E1B55_ADE07 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E311_ADE07 Early E3 7.7 kDa protein
E1BS_ADE07 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E321_ADE07 Early E3 20.5 kDa glycoprotein
E1B9_ADE07 Early E1B 9 kDa protein
E3145_ADE07 Early E3 15.3 kDa protein
E3B14_ADE07 Early E3B 14.9 kDa protein
E1A_ADE07 Early E1A protein (Early E1A 28 kDa protein)
PKG1_ADE07 Packaging protein 1 (Packaging protein IVa2)
Y190_ADE07 Uncharacterized 19.0 kDa early protein
Y206_ADE07 Uncharacterized 20.6 kDa early protein
Y104_ADE07 Uncharacterized 10.4 kDa early protein
Y97_ADE07 Uncharacterized 9.7 kDa early protein
SPIKE_ADE07 Fiber protein (SPIKE) (Protein IV)
TERM_ADE07 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...
Y145_ADE07 Uncharacterized 14.5 kDa early protein
Y126_ADE07 Uncharacterized 12.6 kDa early protein
Y115_ADE07 Uncharacterized 11.5 kDa early protein
Y113_ADE07 Uncharacterized 11.3 kDa early protein

22 entries

Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))

Select_allDeselect_all
CAP8_ADECC Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CAPSH_ADECC Hexon protein (CP-H) (Protein II)
CAPSP_ADECC Penton protein (CP-P) (Penton base protein) (Protein III)
CAP3_ADECC Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAP6_ADECC Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP9_ADECC Hexon-interlacing protein (Protein IX)
CORE5_ADECC Core-capsid bridging protein (Core protein V)
DNB2_ADECC DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
DPOL_ADECC DNA polymerase (EC 2.7.7.7)
E434_ADECC Early E4 31 kDa protein
E325_ADECC Early E3 25 kDa glycoprotein
E1B55_ADECC E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E1A_ADECC Early E1A protein (Early E1A 25 kDa protein)
E1BS_ADECC E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
L2MU_ADECC Late L2 mu core protein (Protein X) (pX) (pMu)
NP_ADECC Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PKG1_ADECC Packaging protein 1 (Packaging protein IVa2)
PKG3_ADECC Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
PRO_ADECC Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SPIKE_ADECC Fiber protein (SPIKE) (Protein IV)
SHUT_ADECC Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
TERM_ADECC Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...

22 entries

Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))

Select_allDeselect_all
CAP6_ADECR Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP9_ADECR Hexon-interlacing protein (Protein IX)
CAPSP_ADECR Penton protein (CP-P) (Penton base protein) (Protein III)
CAP3_ADECR Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAP8_ADECR Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CAPSH_ADECR Hexon protein (CP-H) (Protein II)
CORE5_ADECR Core-capsid bridging protein (Core protein V)
DNB2_ADECR DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
E1A_ADECR Early E1A protein (Early E1A 20 kDa protein)
E434_ADECR Early E4 31 kDa protein
E1BS_ADECR E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E1B55_ADECR E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E322_ADECR Early E3 22.1 kDa glycoprotein
E313_ADECR Early E3 13.3 kDa protein
L2MU_ADECR Late L2 mu core protein (Protein X) (pX) (pMu)
NP_ADECR Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PKG1_ADECR Packaging protein 1 (Packaging protein IVa2)
PKG3_ADECR Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)
PRO_ADECR Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SHUT_ADECR Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
SPIKE_ADECR Fiber protein (SPIKE) (Protein IV)
TERM_ADECR Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...

20 entries

Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

Select_allDeselect_all
CAP8_ADE40 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CAP9_ADE40 Hexon-interlacing protein (Protein IX)
CAP6_ADE40 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAPSH_ADE40 Hexon protein (CP-H) (Protein II)
CORE5_ADE40 Core-capsid bridging protein (Core protein V)
DPOL_ADE40 DNA polymerase (EC 2.7.7.7)
DNB2_ADE40 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
E1B55_ADE40 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E1BS_ADE40 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E434_ADE40 Early E4 34 kDa protein
E1A_ADE40 Early E1A protein (Early E1A 27 kDa protein)
L2MU_ADE40 Late L2 mu core protein (Protein X) (pX) (pMu)
NP_ADE40 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PKG1_ADE40 Packaging protein 1 (Packaging protein IVa2)
PRO_ADE40 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SF33K_ADE40 Protein 33K (L4-33K) (Splicing factor 33K) (Terminase, small subunit)
SHUT_ADE40 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
SPIK2_ADE40 Fiber protein 2
SPIK1_ADE40 Fiber protein 1 (SPIKE)
TERM_ADE40 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...

18 entries

Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

Select_allDeselect_all
CAPSH_ADE41 Hexon protein (CP-H) (Protein II)
CAP6_ADE41 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAP9_ADE41 Hexon-interlacing protein (Protein IX)
CAP8_ADE41 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
E1A_ADE41 Early E1A protein (Early E1A 27 kDa protein)
DNB2_ADE41 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
E1BS_ADE41 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E1B55_ADE41 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
PRO_ADE41 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SF33K_ADE41 Protein 33K (L4-33K) (Splicing factor 33K) (Terminase, small subunit)
YL12_ADE41 Uncharacterized 8.0 kDa protein in 100 kDa protein region
YL14_ADE41 Uncharacterized 7.3 kDa protein in 100 kDa protein region
YL15_ADE41 Uncharacterized 12.4 kDa protein in 33 kDa protein region
SHUT_ADE41 Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)
SPIK1_ADE41 Fiber protein 1
SPIK2_ADE41 Fiber protein 2
YL11_ADE41 Uncharacterized 16.5 kDa protein in 100 kDa protein region
YL13_ADE41 Uncharacterized 6.9 kDa protein in 100 kDa protein region

17 entries

Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)

Select_allDeselect_all
CAPSP_ADEM1 Penton protein (CP-P) (Penton base protein) (Protein III)
CAP3_ADEM1 Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa) ...
CAP8_ADEM1 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CAP6_ADEM1 Pre-protein VI (pVI) [Cleaved into: Endosome lysis protein; Protease cofactor (pVI-C)]
CAPSH_ADEM1 Hexon protein (CP-H) (Protein II)
CORE5_ADEM1 Core-capsid bridging protein (Core protein V)
E1A_ADEM1 Early E1A 21 kDa protein
E3GL_ADEM1 Early E3 17.7 kDa glycoprotein
E1B55_ADEM1 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E434_ADEM1 Probable early E4 33 kDa protein (ORF A/B protein)
E111_ADEM1 Early E1A 11 kDa protein
E1BS_ADEM1 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
L2MU_ADEM1 Late L2 mu core protein (Protein X) (pX) (pMu)
NP_ADEM1 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PKG1_ADEM1 Packaging protein 1 (Packaging protein IVa2)
PRO_ADEM1 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SPIKE_ADEM1 Fiber protein (SPIKE) (Protein IV)

13 entries

Human adenovirus B serotype 3 (HAdV-3) (Human adenovirus 3)

Select_allDeselect_all
CAP9_ADE03 Hexon-interlacing protein (Protein IX)
CAPSH_ADE03 Hexon protein (CP-H) (Protein II)
E310_ADE03 Early E3B 10.4 kDa protein
E321_ADE03 Early E3 20.5 kDa glycoprotein
E316_ADE03 Early E3 16 kDa glycoprotein
E311_ADE03 Early E3 9.0 kDa glycoprotein
E3145_ADE03 Early E3 15.3 kDa protein
E3GL_ADE03 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (Early E3 19.2 kDa glycoprotein) (GP19K)
E320_ADE03 Early E3 20.1 kDa glycoprotein
E3B14_ADE03 Early E3B 14.5 kDa protein (Early E3B 15.2 kDa glycoprotein)
E312_ADE03 Probable early E3 12.1 kDa glycoprotein
PRO_ADE03 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SPIKE_ADE03 Fiber protein (SPIKE) (Protein IV)

12 entries

Canine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine adenovirus 2 (strain Toronto A 26-61))

Select_allDeselect_all
CAP8_ADECT Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
CAP9_ADECT Hexon-interlacing protein (Protein IX)
DPOL_ADECT DNA polymerase (EC 2.7.7.7)
E313_ADECT Early E3 13.3 kDa protein
E1B55_ADECT E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B-495R)
E434_ADECT Early E4 30 kDa protein
E1BS_ADECT E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E1A_ADECT Early E1A protein (Early E1A 25 kDa protein)
NP_ADECT Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PKG1_ADECT Packaging protein 1 (Packaging protein IVa2)
PRO_ADECT Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SPIKE_ADECT Fiber protein (SPIKE) (Protein IV)

4 entries

Bovine adenovirus 2 (BAdV-2) (Mastadenovirus bos2)

Select_allDeselect_all
CORE5_ADEB2 Core-capsid bridging protein (Core protein V)
L2MU_ADEB2 Late L2 mu core protein (Protein X) (pX) (pMu)
NP_ADEB2 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PRO_ADEB2 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

7 entries

Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

Select_allDeselect_all
DNB2_ADE04 DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)
DPOL_ADE04 DNA polymerase (EC 2.7.7.7)
E1BS_ADE04 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E1A_ADE04 Early E1A protein (Early E1A 28 kDa protein)
NP_ADE04 Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PRO_ADE04 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SPIKE_ADE04 Fiber protein (SPIKE) (Protein IV)

3 entries

Bovine adenovirus B serotype 3 (BAdV-3) (Mastadenovirus bos3)

Select_allDeselect_all
CAPSH_ADEB3 Hexon protein (CP-H) (Protein II)
DPOL_ADEB3 DNA polymerase (EC 2.7.7.7)
TERM_ADEB3 Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein) [Cleaved into: Intermediate ...

5 entries

Canine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 (strain Glaxo))

Select_allDeselect_all
E1BS_ADECG E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E313_ADECG Early E3 13.3 kDa protein
E322_ADECG Early E3 22.2 kDa glycoprotein
E1A_ADECG Early E1A protein (Early E1A 20 kDa protein)
SPIKE_ADECG Fiber protein (SPIKE) (Protein IV)

5 entries

Human adenovirus C serotype 6 (HAdV-6) (Human adenovirus 6)

Select_allDeselect_all
E311_ADE06 Early E3A 11.6 kDa glycoprotein
E3145_ADE06 Early E3B 14 kDa protein
E3B14_ADE06 Early E3B 14.5 kDa protein
E310_ADE06 Early E3B 10.4 kDa protein
E3GL_ADE06 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)

5 entries

Human adenovirus D serotype 9 (HAdV-9) (Human adenovirus 9)

Select_allDeselect_all
CAPSH_ADE09 Hexon protein (CP-H) (Protein II)
E434_ADE09 Early E4 34 kDa protein
E4OR1_ADE09 E4-ORF1 (EC 3.6.1.23) (Early E4 14.0 kDa protein) (ORF1) (Probable dUTPase E4 ORF1)
PRO_ADE09 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)
SPIKE_ADE09 Fiber protein (SPIKE) (Protein IV)

4 entries

Canine adenovirus serotype 1 (strain Utrecht) (CAdV-1) (Canine adenovirus 1 (strain Utrecht))

Select_allDeselect_all
CAP8_ADECU Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...
E313_ADECU Early E3 13.3 kDa protein
NP_ADECU Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII) [Cleaved into: Histone-like ...
PRO_ADECU Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

4 entries

Human adenovirus B serotype 11 (strain BC34) (HAdV-11) (Human adenovirus 11A (strain BC34))

Select_allDeselect_all
E3GL_ADE1A Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
E320_ADE1A Early E3 20.3 kDa glycoprotein
E321_ADE1A Early E3 20.2 kDa glycoprotein
SPIKE_ADE1A Fiber protein (SPIKE) (Protein IV)

4 entries

Human adenovirus B serotype 11 (strain Slobiski) (HAdV-11) (Human adenovirus 11P (strain Slobiski))

Select_allDeselect_all
E321_ADE1P Early E3 20.6 kDa glycoprotein
E320_ADE1P Early E3 20.3 kDa glycoprotein
E3GL_ADE1P Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)
SPIKE_ADE1P Fiber protein (SPIKE) (Protein IV)

4 entries

Human adenovirus B serotype 35 (HAdV-35) (Human adenovirus 35)

Select_allDeselect_all
E306_ADE35 Early E3 6.4 kDa protein
E321_ADE35 Early E3 20.6 kDa glycoprotein
E320_ADE35 Early E3 20.3 kDa glycoprotein
E3GL_ADE35 Early E3 18.5 kDa glycoprotein (E3-19K) (E3gp 19 kDa) (E19) (GP19K)

4 entries

Tree shrew adenovirus serotype 1 (TSAdV-1) (Tupaia adenovirus 1)

Select_allDeselect_all
CAP9_ADET1 Hexon-interlacing protein (Protein IX)
E1BS_ADET1 E1B protein, small T-antigen homolog (E1B 19 kDa protein) (E1B-19K)
E118_ADET1 Early E1A 18 kDa protein
E1B55_ADET1 E1B 55 kDa protein (E1B-55K) (E1B protein, large T-antigen) (E1B protein, large T-antigen homolog) ...

2 entries

Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)

Select_allDeselect_all
E1BS_ADEC2 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)
E1A_ADEC2 Early E1A protein (Early E1A 20 kDa protein)

2 entries

Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)

Select_allDeselect_all
E1A_ADES7 Early E1A protein (Early E1A 28 kDa protein)
E1BS_ADES7 E1B protein, small T-antigen (E1B 19 kDa protein) (E1B-19K)

1 entry

Bovine adenovirus C serotype 10 (BAdV-10) (Mastadenovirus bos10)

PRO_ADEBA Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

1 entry

Equine adenovirus B serotype 2 (EAdV-2) (Equine adenovirus 2)

PRO_ADEE2 Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

1 entry

Human adenovirus A serotype 31 (HAdV-31) (Human adenovirus 31)

SPIKE_ADE31 Fiber protein (SPIKE) (Protein IV)

1 entry

Human adenovirus B serotype 16 (HAdV-16) (Human adenovirus 16)

CAPSH_ADE16 Hexon protein (CP-H) (Protein II)

1 entry

Human adenovirus D serotype 15 (HAdV-15) (Human adenovirus 15)

SPIKE_ADE15 Fiber protein (SPIKE) (Protein IV)

1 entry

Human adenovirus D serotype 15/H9 (HAdV-15/H9) (Human adenovirus 15/H9)

SPIKE_ADE1H Fiber protein (SPIKE) (Protein IV)

1 entry

Human adenovirus D serotype 8 (HAdV-8) (Human adenovirus 8)

SPIKE_ADE08 Fiber protein (SPIKE) (Protein IV)

1 entry

Porcine adenovirus B serotype 4 (PAdV-4) (Porcine adenovirus 4)

CAP8_ADEP4 Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII) [Cleaved into: Hexon-linking protein-N ...