Aviadenovirus

VIRION

Non-enveloped capsid with a pseudo T=25 icosahedral symmetry. The capsid diameter is about 90 nm. The capsid shell consists of 720 hexon subunits arranged as 240 trimers and 12 vertex penton capsomers each with a fiber protruding from the surface.

GENOME

Non-segmented, linear double-stranded DNA of 35-36kb encoding about 40 proteins. The genome has terminally redundant sequences which have inverted terminal repetitions (ITR). The terminal protein (TP) is covalently attached to each end of the genome.

GENE EXPRESSION

Transcription is nuclear, in two phases; early (replication), late (virion assembly). All genes are transcribed by host RNA pol II except virus-associated (VA) gene(s) of some fowl adenoviruses transcribed by RNA pol III. Genes transcribed by RNA pol II give rise to multiple mRNA that are produced by alternative splicing and use of different poly(A) sites.

REPLICATION

NUCLEUS

  1. Attachment of the viral fiber glycoproteins to host receptors mediates endocytosis of the virus into the host cell and fiber shedding.
  2. Disruption of the endosome by lytic protein VI releases the viral capsid in the cytosol.
  3. Viral penetration into host nucleus.
  4. Transcription of early genes (E genes) by host RNA pol II, replication of the DNA genome by DNA strand displacement in the nucleus.
  5. Transcription of late genes (L genes) by host RNA pol II, mostly encoding for structural proteins.
  6. Assembly of new virions in the nucleus.
  7. Virions are released by lysis of the cell.

Matching UniProtKB/Swiss-Prot entries

42 entries grouped by protein (browse by keywords)

All proteins are shown (view only 38 complete proteome entries)

1 entry

Pre-hexon-linking protein IIIa (Capsid vertex-specific component IIIa) (CVSC) (Protein IIIa) (pIIIa)

CAP3_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Pre-protein VI (pVI)

CAP6_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Pre-hexon-linking protein VIII (Pre-protein VIII) (pVIII)

CAP8_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Hexon protein (CP-H) (Protein II)

CAPSH_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

2 entries

Penton protein (CP-P) (Penton base protein) (Protein III)

Select_allDeselect_all
CAPSP_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain
CAPSP_ADEGX
Fowl adenovirus C serotype 10 (strain SA2) (FAdV-10) (Fowl adenovirus 10)

1 entry

DNA-binding protein (DBP) (Early 2A protein) (Early E2A DNA-binding protein)

DNB2_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

DNA polymerase (EC 2.7.7.7)

DPOL_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

2 entries

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

Select_allDeselect_all
DUT_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain
DUT_ADEG8
Avian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)

1 entry

Protein GAM-1 (Gallus-anti morte protein) (Gam1)

GAM1_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Late L2 mu core protein (Protein X) (pX) (pMu)

L2MU_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Pre-histone-like nucleoprotein (Pre-core protein VII) (pVII)

NP_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Packaging protein 1 (Packaging protein IVa2)

PKG1_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Packaging protein 3 (L1-52/55 kDa protein) (Packaging protein 52K)

PKG3_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

2 entries

Protease (EC 3.4.22.39) (Adenain) (Adenovirus protease) (AVP) (Adenovirus proteinase) (Endoprotease)

Select_allDeselect_all
PRO_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain
PRO_ADEG8
Avian adenovirus 8 (strain ATCC A-2A) (FAdV-8) (Fowl adenovirus 8)

2 entries

Shutoff protein (100 kDa protein) (p100K) (100K-chaperone protein) (L4-100K) (Shutoff protein 100K)

Select_allDeselect_all
SHUT_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain
SHUT_ADEGX
Fowl adenovirus C serotype 10 (strain SA2) (FAdV-10) (Fowl adenovirus 10)

1 entry

Fiber protein 1

SPIK1_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Fiber protein 2

SPIK2_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Preterminal protein (pTP) (Bellett protein) (Precursor terminal protein)

TERM_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Putative Ig-like domain-containing protein ORF10

YO10_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF11

YO11_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF12

YO12_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF13

YO13_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF14

YO14_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF15

YO15_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF16

YO16_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF17

YO17_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF18

YO18_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF19

YO19_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF2

YO2_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF20

YO20_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF21

YO21_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF22

YO22_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF3

YO3_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF4

YO4_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF5

YO5_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF6

YO6_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF7

YO7_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain

1 entry

Uncharacterized protein ORF9

YO9_ADEG1
Fowl adenovirus A serotype 1 (strain CELO / Phelps) (FAdV-1) (Avian adenovirus gal1 (strain Phelps)) reference strain