Lymphocryptovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. There are some non-coding genes.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Epstein-Barr virus protein BNLF2a inhibits host adaptive immune response by interacting with TAP1 and TAP2 and thus preventing TAP-mediated peptide transport and subsequent loading. The glycine-alanine repeat domain (GAr) of Epstein-Barr virus-encoded nuclear antigen 1 (EBNA1) prevents major histocompatibility complex (MHC) class I-restricted presentation of EBNA1 epitopes to cytotoxic T cells.

Apoptosis modulation

Epstein-Barr viral protein BHRF1 is a viral homologue of the Bcl-2 oncogene that is able to protect cells from induced apoptosis. EBNA3C directly interacts with host Gemin3 and thereby blocks p53-mediated apoptosis .

Autophagy modulation

The viral Bcl-2 homolog BHRF1 in addition to prevent host cel death, may also control host autophagy .

Cell-cycle modulation

EBNA3C forms a complex with Cyclin D1 thereby facilitating the G1-S phase transition . Additionally, EBNA2 can affect activities of cell cycle regulators and retards cell cycle progression at G2/M phase. The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. EBV encodes an UL24 homolog termed BXRF1 that should perform this role .

Innate immune response inhibition

EBV inhibits the cascade leading to production of interferon-beta by targeting host IRF3 protein with the BGLF4 protein kinase that directly interacts with and inhibits host IRF3. BRLF1 expression also decreases induction of IFN-beta, and reduces expression of IRF3 and IRF7.

Host splicing inhibition

EBV EB2 modulates the host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

194 entries grouped by protein (browse by keywords)

All proteins are shown (view only 188 complete proteome entries)

3 entries

Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)

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AN_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
AN_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
AN_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

2 entries

Apoptosis regulator BALF1

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BALF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BALF1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Secreted protein BARF1 (33 kDa early protein) (p33)

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BARF1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BARF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BARF1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Protein BDLF2

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BDLF2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BDLF2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BDLF2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

1 entry

Glycoprotein BDLF3

BDLF3_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Uncharacterized protein BFRF2

BFRF2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Uncharacterized protein BHLF1

BHLF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

G-protein coupled receptor BILF1

BILF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Glycoprotein BILF2

BILF2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

3 entries

Tegument protein BKRF4

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BKRF4_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BKRF4_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BKRF4_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Uncharacterized protein BLLF2

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BLLF2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BLLF2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BLLF2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Tegument protein BLRF2

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BLRF2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BLRF2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BLRF2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Protein BMRF2

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BMRF2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BMRF2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BMRF2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Protein BNLF2a

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BNL2A_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BNL2A_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BNL2A_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Uncharacterized protein BNLF2b

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BNL2B_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BNL2B_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BNL2B_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Transcriptional activator BRRF1

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BRRF1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BRRF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BRRF1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Tegument protein BRRF2

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BRRF2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BRRF2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BRRF2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Uncharacterized protein BTRF1

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BTRF1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BTRF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BTRF1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Trans-activator protein BZLF1 (EB1) (Zebra)

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BZLF1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
BZLF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
BZLF1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Cytoplasmic envelopment protein 1

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CEP1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
CEP1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
CEP1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Cytoplasmic envelopment protein 2

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CEP2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
CEP2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
CEP2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

2 entries

Cytoplasmic envelopment protein 3

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CEP3_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
CEP3_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Capsid vertex component 1

CVC1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

3 entries

Capsid vertex component 2

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CVC2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
CVC2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
CVC2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Major DNA-binding protein

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DNBI_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
DNBI_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
DNBI_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

DNA polymerase catalytic subunit (EC 2.7.7.7)

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DPOL_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
DPOL_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
DPOL_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

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DUT_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
DUT_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
DUT_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

DNA polymerase processivity factor BMRF1 (Early antigen protein D) (EA-D) (Polymerase accessory subunit)

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EAD_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EAD_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EAD_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Apoptosis regulator BHRF1 (Early antigen protein R) (EA-R) (Nuclear antigen)

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EAR_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EAR_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EAR_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Epstein-Barr nuclear antigen 1 (EBNA-1) (EBV nuclear antigen 1)

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EBNA1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Epstein-Barr nuclear antigen 2 (EBNA-2) (EBV nuclear antigen 2)

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EBNA2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Epstein-Barr nuclear antigen 3 (EBNA-3) (EBV nuclear antigen 3) (Epstein-Barr nuclear antigen 3A) (EBNA-3A) (EBV nuclear antigen 3A)

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EBNA3_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA3_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA3_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Epstein-Barr nuclear antigen 4 (EBNA-4) (EBV nuclear antigen 4) (Epstein-Barr nuclear antigen 3B) (EBNA-3B) (EBV nuclear antigen 3B)

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EBNA4_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA4_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA4_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Epstein-Barr nuclear antigen leader protein (EBNA-LP) (EBV nuclear antigen leader protein) (Epstein-Barr nuclear antigen 5) (EBNA-5) (EBV nuclear antigen 5)

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EBNA5_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA5_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA5_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Epstein-Barr nuclear antigen 6 (EBNA-6) (EBV nuclear antigen 6) (Epstein-Barr nuclear antigen 3C) (EBNA-3C) (EBV nuclear antigen 3C) (Epstein-Barr nuclear antigen 4B) (EBNA-4B) (EBV nuclear antigen 4B)

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EBNA6_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
EBNA6_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
EBNA6_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Envelope glycoprotein B (gB)

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GB_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GB_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GB_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Envelope glycoprotein H (gH)

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GH_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GH_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GH_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Envelope glycoprotein L (gL)

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GL_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GL_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GL_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Envelope glycoprotein M (gM)

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GM_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GM_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GM_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Envelope glycoprotein N

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GN_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GN_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GN_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Envelope glycoprotein GP350 (Membrane antigen) (MA)

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GP350_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GP350_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GP350_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Glycoprotein 42 (gp42)

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GP42_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
GP42_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
GP42_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

1 entry

DNA replication helicase (EC 3.6.4.-)

HELI_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

3 entries

mRNA export factor ICP27 homolog (Mta) (ORF57 protein homolog) (Protein SM)

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ICP27_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
ICP27_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
ICP27_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Viral interleukin-10 homolog (vIL-10) (20 kDa protein) (Protein BCRF1)

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IL10H_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
IL10H_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
IL10H_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Inner tegument protein

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ITP_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
ITP_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
ITP_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Thymidine kinase (EC 2.7.1.21)

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KITH_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
KITH_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
KITH_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Serine/threonine-protein kinase BGLF4 (EC 2.7.11.1)

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KR2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
KR2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
KR2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Uncharacterized LF1 protein

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LF1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LF1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LF1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Protein LF2

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LF2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LF2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LF2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

2 entries

Uncharacterized protein LF3

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LF3_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LF3_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

5 entries

Latent membrane protein 1 (LMP-1) (Protein p63)

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LMP1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LMP1_EBVC
Epstein-Barr virus (strain Cao) (HHV-4) (Human herpesvirus 4)
LMP1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
LMP1_EBVR
Epstein-Barr virus (strain Raji) (HHV-4) (Human herpesvirus 4)

3 entries

Latent membrane protein 2 (Terminal protein)

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LMP2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LMP2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LMP2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

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LTP_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
LTP_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
LTP_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Major capsid protein (MCP)

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MCP_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
MCP_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
MCP_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Major tegument protein (MTP) (Protein p140)

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MTP_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
MTP_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
MTP_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

2 entries

Nuclear egress protein 1

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NEC1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
NEC1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Nuclear egress protein 2

NEC2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

3 entries

Portal protein

Select_allDeselect_all
PORTL_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
PORTL_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
PORTL_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

1 entry

DNA primase (EC 2.7.7.-)

PRIM_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

3 entries

Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

Select_allDeselect_all
RIR1_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
RIR1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
RIR1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

Select_allDeselect_all
RIR2_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
RIR2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
RIR2_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

2 entries

Uncharacterized protein RPMS1

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RPMS1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
RPMS1_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Replication and transcription activator (Rta) (Immediate-early protein Rta)

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RTA_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
RTA_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
RTA_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

3 entries

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR) (Protein EC-RF3/EC-RF3A) (Virion structural protein BVRF2)

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SCAF_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
SCAF_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
SCAF_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

1 entry

Small capsomere-interacting protein

SCP_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

3 entries

Tegument protein UL51 homolog

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TEG7_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
TEG7_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
TEG7_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

1 entry

Tripartite terminase subunit 1

TRM1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

3 entries

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

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TRM3_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
TRM3_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain
TRM3_EBVG
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)

1 entry

Triplex capsid protein 1

TRX1_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Triplex capsid protein 2

TRX2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Protein UL24 homolog

UL24_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Packaging protein UL32 homolog

UL32_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

TBP-like protein BcRF1

UL87_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

2 entries

Uncharacterized protein BDLF4

Select_allDeselect_all
UL92_EBVA8
Epstein-Barr virus (strain AG876) (HHV-4) (Human herpesvirus 4) reference strain
UL92_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Protein BGLF3

UL95_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

UNG_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) reference strain

1 entry

Envelope glycoprotein GP340 (Membrane antigen) (MA)

VGP3_EBVP3
Epstein-Barr virus (strain P3HR-1) (HHV-4) (Human herpesvirus 4)

1 entry

Uncharacterized protein BBLF2

YBL2_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)

1 entry

Uncharacterized protein EC-RF4

YEC4_EBVB9
Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4)