Rhadinovirus

VIRION

Enveloped, spherical to pleomorphic, 150-200 nm in diameter, T=16 icosahedral symmetry. Capsid consists of 162 capsomers and is surrounded by an amorphous tegument. Glycoproteins complexes are embedded in the lipid envelope.

GENOME

Monopartite, linear, dsDNA genome of about 180 kb. The genome contains terminal and internal reiterated sequences.

GENE EXPRESSION

Each viral transcript usually encodes a single protein and has a promoter/regulatory sequence, a TATA box, a transcription initiation site, a 5' leader sequence of 30-300 bp (not translated), a 3' untranslated sequence of 10-30 bp, and a poly A signal. There are many gene overlaps. There are only few spliced genes. Some of the expressed ORFs are antisense to each other. Some ORFs can be accessed from more than one promoter. Certain proteins are downregulated translationaly by a leaky scanning from an upstream ORF.

REPLICATION

NUCLEAR

Lytic replication:

  1. Attachment of the viral glycoproteins to host receptors mediates endocytosis of the virus into the host cell.
  2. Fusion with the plasma membrane to release the core and the tegument proteins into the host cytoplasm.
  3. The capsid is transported to the nuclear pore where the viral DNA is released into the nucleus.
  4. Transcription of immediate early genes which promote transcription of early genes and protect the virus against innate host immunity.
  5. Transcription of early viral mRNA by host polymerase II, encoding proteins involved in replication of the viral DNA.
  6. A first round of circular genome amplification occurs by bidirectional replication
  7. Synthesis of linear concatemer copies of viral DNA by rolling circle.
  8. Transcription of late mRNAs by host polymerase II, encoding structural proteins.
  9. Assembly of the virus in nuclear viral factories and budding through the inner lamella of the nuclear membrane which has been modified by the insertion of herpes glycoproteins, throughout the Golgi and final release at the plasma membrane.

Latent replication : replication of circular viral episome in tandem with the host cell DNA using the host cell replication machinery.

Host-virus interaction

Adaptive immune response inhibition

Kaposi proteins MIR1/K3 and MIR2/K5 are E3 ubiquitin ligase which promote the ubiquitination and subsequent degradation of host MHC-I and CD1D molecules, thereby inhibiting the host adaptive immune response.

Apoptosis modulation

Kaposi sarcoma-associated herpesvirus encodes a viral FLICE inhibitory protein (vFLIP) that blocks apoptosis .

Autophagy modulation

The KSHV v-Bcl-2 inhibits host autophagy by interacting with host beclin-1 .

Cell-cycle modulation

KSHV v-cyclin encoded by ORF72, is a cyclin-like protein that shares homology to cellular D-type cyclins. Like human cyclins, v-cyclin interacts with cdk4 and cdk6 to activate these kinases and promote the G1/S phase transition. The conserved UL24 family of human alpha, beta and gamma herpesviruses induces a cell cycle arrest at G2/M transition through inactivation of the host cyclinB/cdc2 complex. EBV encodes an UL24 homolog termed ORF20 that should perform this role .

Innate immune response inhibition

Human herpes virus 8 (HHV-8) has developed unique mechanisms to modulate host immune system by incorporating viral homologs to several cellular regulatory genes into its genome. For instance, vIRF-1 is able to bind to both IRF-3 and IRF-7 and efficiently inhibits the formation of transcriptionally competent IRF-3-CBP/p300 complexes .

Splicing inhibition

KSHV ORF57 modulates the viral and host mRNA expression by exporting unspliced mRNA, thereby inducing alternative splicing .

Matching UniProtKB/Swiss-Prot entries

180 entries grouped by protein (browse by keywords)

All proteins are shown (view only 163 complete proteome entries)

2 entries

Shutoff alkaline exonuclease (SOX) (EC 3.1.-.-)

Select_allDeselect_all
AN_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
AN_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Apoptosis regulator Bcl-2 homolog

ARBH_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

2 entries

Putative transcription activator BRLF1 homolog

Select_allDeselect_all
BRLF1_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Putative transcription activator BRLF1 homolog (Transcription activator EDRF1)

BRLF1_BHV4D
Bovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)

1 entry

Complement control protein homolog (CCPH)

CCPH_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Surface glycoprotein CD59 homolog

CD59_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Cytoplasmic envelopment protein 1

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CEP1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
CEP1_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Cytoplasmic envelopment protein 2

Select_allDeselect_all
CEP2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
CEP2_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Cytoplasmic envelopment protein 3

Select_allDeselect_all
CEP3_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
CEP3_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Cyclin homolog (V-cyclin)

CGH2_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Capsid vertex component 1

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CVC1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
CVC1_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Capsid vertex component 2

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CVC2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
CVC2_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Major DNA-binding protein

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DNBI_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
DNBI_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

DNA polymerase catalytic subunit (EC 2.7.7.7)

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DPOL_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

DNA polymerase catalytic subunit (EC 2.7.7.7) (EC 3.1.26.4)

DPOL_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (EC 3.6.1.23) (dUTP pyrophosphatase)

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DUT_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
DUT_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

4 entries

Viral dihydrofolate reductase (vDHFR) (EC 1.5.1.3)

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DYR_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Putative Dihydrofolate reductase (EC 1.5.1.3)

DYR_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
DYR_SHV24
Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)
DYR_SHV2C
Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

2 entries

Envelope glycoprotein B (gB)

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GB_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
GB_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

4 entries

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (EC 2.4.1.150) (C2GnT-mucin type) (C2GnT-M)

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GCNT3_BHV4
Bovine herpesvirus 4 (BoHV-4) (Movar virus)
GCNT3_BHV4D
Bovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)
GCNT3_BHV4L
Bovine herpesvirus 4 (strain LVR140) (BoHV-4) (Movar virus)
GCNT3_BHV4V
Bovine herpesvirus 4 (strain V. test) (BoHV-4) (Movar virus)

Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (EC 2.4.1.102) (EC 2.4.1.150) (BORFF3-4) (C2GnT-mucin type) (C2GnT-M)

1 entry

Probable ganciclovir kinase (EC 2.7.1.-)

GCVK_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Envelope glycoprotein H (gH)

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GH_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
GH_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Envelope glycoprotein L (gL)

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GL_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
GL_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Envelope glycoprotein M (gM)

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GM_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
GM_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Envelope glycoprotein N

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GN_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
GN_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

DNA replication helicase (EC 3.6.4.-)

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HELI_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
HELI_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

DNA helicase/primase complex-associated protein (HEPA) (Primase-associated factor)

HEPA_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Transcriptional regulator ICP22 homolog (Immediate-early protein)

ICP22_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

mRNA export factor ICP27 homolog (52 kDa immediate-early phosphoprotein) (EB2 protein homolog)

Select_allDeselect_all
ICP27_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

mRNA export factor ICP27 homolog (EB2 protein homolog)

ICP27_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Viral interleukin-17 (vIL-17) (Immediate early gene 13 protein)

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IL17_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
IL17_SHV2C
Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

2 entries

Inner tegument protein

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ITP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
ITP_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Protein K1

K1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein K12

K12_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein K15

K15_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein K4.2

K42_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein K6

K6_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein K7

K7_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein K8.1

K81_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

E3 SUMO-protein ligase K-bZIP (EC 6.3.2.-)

KBZIP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

2 entries

Thymidine kinase (EC 2.7.1.21)

Select_allDeselect_all
KITH_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
KITH_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

3 entries

Large tegument protein deneddylase (EC 3.4.19.12) (EC 3.4.22.-)

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LTP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
LTP_MHV68
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain
LTP_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Major capsid protein (MCP)

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MCP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
MCP_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (IE1B protein) (Modulator of immune recognition 1) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)

Select_allDeselect_all
MIR1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
MIR1_MHV68
Murid herpesvirus 4 (MuHV-4) (Murine gammaherpesvirus 68) reference strain

E3 ubiquitin-protein ligase MIR1 (EC 2.3.2.27) (MK3) (Modulator of immune recognition 1 homolog) (ORF K3) (RING-type E3 ubiquitin transferase MIR1)

1 entry

E3 ubiquitin-protein ligase MIR2 (EC 2.3.2.27) (IE1A protein) (Modulator of immune recognition 2) (ORF K5) (RING-type E3 ubiquitin transferase MIR2)

MIR2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

2 entries

Nuclear egress protein 1

Select_allDeselect_all
NEC1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
NEC1_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Nuclear egress protein 2

Select_allDeselect_all
NEC2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
NEC2_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Protein ORF10

ORF10_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF11

ORF11_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF23

ORF23_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF24

ORF24_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF27

ORF27_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF28

ORF28_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF30

ORF30_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF35

ORF35_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF36 (EC 2.7.-.-)

ORF36_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Complement control protein (KCP)

ORF4_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF45

ORF45_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Tegument protein ORF48

ORF48_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF49

ORF49_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Putative transcription activator ORF50

ORF50_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Tegument protein ORF52

ORF52_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF58

ORF58_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF73

ORF73_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Protein ORF75

ORF75_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

OX-2 membrane glycoprotein homolog (Viral OX2) (vOX2)

OX2V_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

DNA polymerase processivity factor

PAP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

2 entries

Portal protein

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PORTL_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
PORTL_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

DNA primase (EC 2.7.7.-)

Select_allDeselect_all
PRIM_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
PRIM_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Ribonucleoside-diphosphate reductase large subunit (R1) (EC 1.17.4.1) (Ribonucleotide reductase large subunit)

Select_allDeselect_all
RIR1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
RIR1_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Ribonucleoside-diphosphate reductase small subunit (EC 1.17.4.1) (Ribonucleotide reductase small subunit)

Select_allDeselect_all
RIR2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
RIR2_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Capsid scaffolding protein (Capsid protein P40) (Protease precursor) (pPR)

Select_allDeselect_all
SCAF_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
SCAF_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Small capsomere-interacting protein

Select_allDeselect_all
SCP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
SCP_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Saimiri transformation-associated protein (Collagen-like protein) (stpC)

Select_allDeselect_all
STP_SHV24
Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)
STP_SHV2C
Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

2 entries

Gene 55 protein

Select_allDeselect_all
TEG7_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Tegument protein ORF55

TEG7_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Protein tio

TIO_ATHV3
Ateline herpesvirus 3 (AtHV-3) (Herpesvirus ateles)

3 entries

Tyrosine-protein kinase-interacting protein (Tip)

Select_allDeselect_all
TIP_SHV24
Saimiriine herpesvirus 2 (strain 484-77) (SaHV-2) (Herpesvirus saimiri)
TIP_SHV2C
Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)
TIP_SHV48
Saimiriine herpesvirus 2 (strain 484) (SaHV-2) (Herpesvirus saimiri)

Tyrosine protein kinase-interacting protein (Tip) (TipC484)

2 entries

Tripartite terminase subunit 1

Select_allDeselect_all
TRM1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
TRM1_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Tripartite terminase subunit 2

TRM2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

2 entries

Tripartite terminase subunit 3 (EC 3.1.-.-) (Terminase large subunit)

Select_allDeselect_all
TRM3_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
TRM3_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Triplex capsid protein 1

Select_allDeselect_all
TRX1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
TRX1_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Triplex capsid protein 2

Select_allDeselect_all
TRX2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
TRX2_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Transforming protein STP

TSTP_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

3 entries

Thymidylate synthase (TS) (TSase) (EC 2.1.1.45)

Select_allDeselect_all
TYSY_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
TYSY_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain
TYSY_HSVAT
Herpesvirus ateles

2 entries

Protein UL24 homolog

Select_allDeselect_all
UL24_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
UL24_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Packaging protein UL32

Select_allDeselect_all
UL32_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Packaging protein UL32 homolog

UL32_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Protein ORF66

Select_allDeselect_all
UL49_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
UL49_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

Uncharacterized gene 66 protein

2 entries

Gene 18 protein

Select_allDeselect_all
UL79_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Protein UL79 homolog

UL79_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Gene 24 protein

UL87_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 30 protein

UL91_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Gene 31 protein

Select_allDeselect_all
UL92_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Protein ORF31

UL92_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Gene 34 protein

Select_allDeselect_all
UL95_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

Protein UL95 homolog

UL95_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Gene 35 protein

UL96_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

2 entries

Uracil-DNA glycosylase (UDG) (EC 3.2.2.27) (UNG)

Select_allDeselect_all
UNG_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain
UNG_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Protein vCCL3

VCCL3_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

viral cyclin homolog (v-cyclin)

VCYCL_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Viral FLICE protein (vFLIP)

VFLIP_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Uncharacterized gene 5 protein

VG05_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 10 protein

VG10_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 11 protein

VG11_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 12 protein

VG12_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Bcl-2-like gene 16 protein

VG16_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 23 protein

VG23_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 27 protein

VG27_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 28 protein

VG28_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 40 protein

VG40_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 41 protein

VG41_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 45 protein

VG45_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 48 protein

VG48_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 49 protein

VG49_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Gene 51 glycoprotein

VG51_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 52 protein

VG52_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Gene 58 protein

VG58_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Gene 59 protein

VG59_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized gene 71 protein

VG71_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

G-protein coupled receptor homolog ECRF3

VG74_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

viral G-protein coupled receptor (vGPCR) (Protein ORF74)

VGPCR_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Probable E3 ubiquitin-protein ligase IE1 (EC 2.3.2.27) (32.7 kDa immediate early protein IE1) (RING-type E3 ubiquitin transferase IE1)

VIE1_BHV4D
Bovine herpesvirus 4 (strain DN-599) (BoHV-4) (Movar virus)

1 entry

Immediate-early protein IE-G

VIEG_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Viral interleukin-6 homolog (vIL-6)

VIL6_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

VIRF-1

VIRF1_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Viral IRF2-like protein (vIRF-2)

VIRF2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Viral IRF3-like protein (VIRF-3)

VIRF3_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Viral IRF4-like protein (vIRF-4)

VIRF4_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Viral macrophage inflammatory protein 2 (Viral macrophage inflammatory protein II) (vMIP-II) (vMIP-1B)

VMI2_HHV8P
Human herpesvirus 8 type P (isolate GK18) (HHV-8) (Kaposi's sarcoma-associated herpesvirus) reference strain

1 entry

Probable membrane antigen 3 (Tegument protein)

VP03_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Probable membrane antigen 75 (Tegument protein)

VP75_SHV21
Saimiriine herpesvirus 2 (strain 11) (SaHV-2) (Herpesvirus saimiri) reference strain

1 entry

Uncharacterized 9.5 kDa protein in DHFR 3'region (ORF3)

YDH3_SHV2C
Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)

1 entry

Uncharacterized 9.9 kDa protein in DHFR 3'region (ORF4)

YDH4_SHV2C
Saimiriine herpesvirus 2 (strain 488) (SaHV-2) (Herpesvirus saimiri)