Betapapillomavirus

VIRION

Non-enveloped. Small, icosahedral, about 60 nm in size. A single molecule of circular dsDNA is contained within the T=7 icosahedral capsid, which is composed of 72 pentamers.

GENOME

Circular dsDNA, about 8 kb in size, associated with cellular histones.
On rare non-specific recombination, the viral genome can be integrated in host chromosome. This inactivates the integrated virus but can gives the host cell a replicative advantage sometimes leading to malignant tumours.

GENE EXPRESSION

Only one strand of the genome is transcribed and yield two classes of proteins expressed by alternative splicing:
a) Early Proteins: non-structural regulatory proteins (E1-E7).
b) Late Proteins: the structural proteins L1 and L2.

REPLICATION

NUCLEAR

Replication is divided in two distinct steps that are linked to the differentiation state of the host epithelial cell:

a) The plasmid replication takes place in the basal squamous epithelial cells. It corresponds to viral DNA replication in synchrony with the host cell chromosome in order to ensures an average of one viral genome per basal cell.

  1. Attachment of the viral proteins to host receptors mediates endocytosis into vesicles in the basal squamous epithelial cell.
  2. Transport to the nucleus and uncoating of the viral DNA.
  3. Early-region transcription and translation of the early proteins.
  4. Steady-state viral DNA nuclear replication. Requires the origin of DNA replication in cis and the viral E1 and E2 proteins in trans.

b) The vegetative replication, which occurs in differentiated keratinocytes. In these cells, which no longer undergo cellular DNA synthesis, there is a burst of viral DNA synthesis with active production of virions.

  1. Vegetative viral DNA synthesis.
  2. Transcription of the late region.
  3. Capsid proteins L1 and L2 synthesis.
  4. Nuclear capsid assembly and release of viruses.

Matching UniProtKB/Swiss-Prot entries

128 entries grouped by strain (browse by keywords)

All proteins are shown (view only 127 complete proteome entries)

8 entries

Human papillomavirus type 5 reference strain

Select_allDeselect_all
VE6_HPV05 Protein E6
VE2_HPV05 Regulatory protein E2
VE8E2_HPV05 Protein E8^E2C
VL2_HPV05 Minor capsid protein L2
VE4_HPV05 Protein E4
VE7_HPV05 Protein E7
VE1_HPV05 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VL1_HPV05 Major capsid protein L1

6 entries

Human papillomavirus type 22 reference strain

Select_allDeselect_all
VE1_HPV22 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VL1_HPV22 Major capsid protein L1
VE7_HPV22 Protein E7
VL2_HPV22 Minor capsid protein L2
VE6_HPV22 Protein E6
VE2_HPV22 Regulatory protein E2

6 entries

Human papillomavirus type 25 reference strain

Select_allDeselect_all
VL1_HPV25 Major capsid protein L1
VE1_HPV25 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE2_HPV25 Regulatory protein E2
VE6_HPV25 Protein E6
VE7_HPV25 Protein E7
VL2_HPV25 Minor capsid protein L2

6 entries

Human papillomavirus type 38 reference strain

Select_allDeselect_all
VE6_HPV38 Protein E6
VE1_HPV38 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE2_HPV38 Regulatory protein E2
VL1_HPV38 Major capsid protein L1
VL2_HPV38 Minor capsid protein L2
VE7_HPV38 Protein E7

9 entries

Human papillomavirus type 5b

Select_allDeselect_all
VE1_HPV5B Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE7_HPV5B Protein E7
VL1_HPV5B Major capsid protein L1
VE5_HPV5B Probable protein E5
VE4_HPV5B Protein E4
VE6_HPV5B Protein E6
VE2_HPV5B Regulatory protein E2
VL2_HPV5B Minor capsid protein L2
VL3_HPV5B Probable protein L3

8 entries

Human papillomavirus type 47

Select_allDeselect_all
VE8E2_HPV47 Protein E8^E2C
VE6_HPV47 Protein E6
VE4_HPV47 Protein E4
VL1_HPV47 Major capsid protein L1
VE2_HPV47 Regulatory protein E2
VL2_HPV47 Minor capsid protein L2
VE1_HPV47 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE7_HPV47 Protein E7

8 entries

Human papillomavirus type 8

Select_allDeselect_all
VE1_HPV08 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE2_HPV08 Regulatory protein E2
VE7_HPV08 Protein E7
VE8E2_HPV08 Protein E8^E2C
VL1_HPV08 Major capsid protein L1
VE4_HPV08 Protein E4
VE6_HPV08 Protein E6
VL2_HPV08 Minor capsid protein L2

6 entries

Human papillomavirus type 12

Select_allDeselect_all
VE1_HPV12 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE7_HPV12 Protein E7
VL2_HPV12 Minor capsid protein L2
VE2_HPV12 Regulatory protein E2
VE6_HPV12 Protein E6
VL1_HPV12 Major capsid protein L1

6 entries

Human papillomavirus type 15

Select_allDeselect_all
VE2_HPV15 Regulatory protein E2
VE7_HPV15 Protein E7
VL1_HPV15 Major capsid protein L1
VE1_HPV15 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE6_HPV15 Protein E6
VL2_HPV15 Minor capsid protein L2

6 entries

Human papillomavirus type 17

Select_allDeselect_all
VL1_HPV17 Major capsid protein L1
VL2_HPV17 Minor capsid protein L2
VE6_HPV17 Protein E6
VE2_HPV17 Regulatory protein E2
VE7_HPV17 Protein E7
VE1_HPV17 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)

6 entries

Human papillomavirus type 19

Select_allDeselect_all
VE1_HPV19 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE6_HPV19 Protein E6
VL1_HPV19 Major capsid protein L1
VE2_HPV19 Regulatory protein E2
VE7_HPV19 Protein E7
VL2_HPV19 Minor capsid protein L2

6 entries

Human papillomavirus type 20

Select_allDeselect_all
VE1_HPV20 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE7_HPV20 Protein E7
VL1_HPV20 Major capsid protein L1
VL2_HPV20 Minor capsid protein L2
VE2_HPV20 Regulatory protein E2
VE6_HPV20 Protein E6

6 entries

Human papillomavirus type 21

Select_allDeselect_all
VL2_HPV21 Minor capsid protein L2
VE2_HPV21 Regulatory protein E2
VE1_HPV21 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE7_HPV21 Protein E7
VE6_HPV21 Protein E6
VL1_HPV21 Major capsid protein L1

6 entries

Human papillomavirus type 23

Select_allDeselect_all
VE1_HPV23 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE7_HPV23 Protein E7
VE2_HPV23 Regulatory protein E2
VL2_HPV23 Minor capsid protein L2
VE6_HPV23 Protein E6
VL1_HPV23 Major capsid protein L1

6 entries

Human papillomavirus type 24

Select_allDeselect_all
VE2_HPV24 Regulatory protein E2
VE7_HPV24 Protein E7
VL1_HPV24 Major capsid protein L1
VE1_HPV24 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE6_HPV24 Protein E6
VL2_HPV24 Minor capsid protein L2

6 entries

Human papillomavirus type 36

Select_allDeselect_all
VL2_HPV36 Minor capsid protein L2
VE7_HPV36 Protein E7
VL1_HPV36 Major capsid protein L1
VE1_HPV36 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE6_HPV36 Protein E6
VE2_HPV36 Regulatory protein E2

6 entries

Human papillomavirus type 49

Select_allDeselect_all
VE1_HPV49 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VL2_HPV49 Minor capsid protein L2
VE6_HPV49 Protein E6
VE7_HPV49 Protein E7
VL1_HPV49 Major capsid protein L1
VE2_HPV49 Regulatory protein E2

6 entries

Human papillomavirus type 9

Select_allDeselect_all
VL1_HPV09 Major capsid protein L1
VL2_HPV09 Minor capsid protein L2
VE2_HPV09 Regulatory protein E2
VE1_HPV09 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE7_HPV09 Protein E7
VE6_HPV09 Protein E6

5 entries

Human papillomavirus type 14

Select_allDeselect_all
VE1_HPV14 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VE2_HPV14 Regulatory protein E2
VE6_HPV14 Protein E6
VL1_HPV14 Major capsid protein L1
VL2_HPV14 Minor capsid protein L2

5 entries

Human papillomavirus type 37

Select_allDeselect_all
VE2_HPV37 Regulatory protein E2
VE7_HPV37 Protein E7
VE1_HPV37 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)
VL1_HPV37 Major capsid protein L1
VL2_HPV37 Minor capsid protein L2

1 entry

Human papillomavirus type RTRX7

VE1_HPVR7 Replication protein E1 (EC 3.6.4.12) (ATP-dependent helicase E1)