Orthohantavirus

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins. Some hantaviruses also encode a NSs protein on their S segment.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching . Transcription is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped by L protein during synthesis. Puumala virus expressed an additional NSs by leaky scanning in the NS gene.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Matching UniProtKB/Swiss-Prot entries

28 entries grouped by strain (browse by keywords)

All proteins are shown (view only 11 complete proteome entries)

3 entries

Hantaan virus (strain 76-118) (Korean hemorrhagic fever virus) reference strain

Select_allDeselect_all
GP_HANTV Envelopment polyprotein (Glycoprotein precursor) (M polyprotein) [Cleaved into: Glycoprotein N (Gn) ...
L_HANTV RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_HANTV Nucleoprotein (Nucleocapsid protein) (Protein N)

4 entries

Puumala virus (strain Bank vole/Russia/CG1820/1984)

Select_allDeselect_all
GP_PUUMG Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
L_PUUMG RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_PUUMG Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_PUUMG Non-structural protein NS-S (NSs)

4 entries

Puumala virus (strain Sotkamo/V-2969/81)

Select_allDeselect_all
GP_PUUMS Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
L_PUUMS RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_PUUMS Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_PUUMS Non-structural protein NS-S (NSs)

2 entries

Prospect Hill virus (PHV)

Select_allDeselect_all
GP_PHV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_PHV Nucleoprotein (Nucleocapsid protein) (Protein N)

2 entries

Puumala virus (strain K27)

Select_allDeselect_all
GP_PUUMK Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_PUUMK Nucleoprotein (Nucleocapsid protein) (Protein N)

2 entries

Puumala virus (strain P360)

Select_allDeselect_all
GP_PUUMP Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_PUUMP Nucleoprotein (Nucleocapsid protein) (Protein N)

2 entries

Seoul virus (strain 80-39)

Select_allDeselect_all
GP_SEOU8 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
L_SEOU8 RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...

2 entries

Seoul virus (strain SR-11) (Sapporo rat virus)

Select_allDeselect_all
GP_SEOUS Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...
NCAP_SEOUS Nucleoprotein (Nucleocapsid protein) (Protein N)

1 entry

Hantaan virus (strain B-1) (Korean hemorrhagic fever virus)

GP_HANTB Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Hantaan virus (strain Hojo) (Hojo virus) (Korean hemorrhagic fever virus)

GP_HANTH Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Hantaan virus (strain Lee) (Lee virus) (Korean hemorrhagic fever virus)

GP_HANTL Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

New York virus (NYV)

GP_NYV Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...

1 entry

Puumala virus (strain Evo/12CG/93)

NCAP_PUUME Nucleoprotein (Nucleocapsid protein) (Protein N)

1 entry

Puumala virus (strain Udmurtia/894CG/91)

NCAP_PUUMU Nucleoprotein (Nucleocapsid protein) (Protein N)

1 entry

Seoul virus (strain R22)

GP_SEOUR Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G1); ...