Vesiculovirus

Molecular biology

VIRION

Enveloped, bullet shaped. 180 nm long and 75 nm wide.

GENOME

Negative-stranded RNA linear genome, about 11 kb in size. Encodes for 5 proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment of the viral G glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription , viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane, releasing new virions.

Host-virus interaction

Host gene expression shutoff

Vesicular stomatitis virus matrix protein blocks nuclear pores, resulting in host mRNA nuclear export inhibiton This shutoff of host gene expression prevents effective antiviral response by the infected cell.

Matching UniProtKB/Swiss-Prot entries

57 entries grouped by strain (browse by keywords)

All proteins are shown (view only 40 complete proteome entries)

6 entries

Vesicular stomatitis Indiana virus (strain San Juan) (VSIV) reference strain

Select_allDeselect_all
C_VSIVA Protein C'
GLYCO_VSIVA Glycoprotein
NCAP_VSIVA Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_VSIVA Matrix protein
L_VSIVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_VSIVA Phosphoprotein (P protein) (Protein M1)

5 entries

Chandipura virus (strain I653514) (CHPV) reference strain

Select_allDeselect_all
GLYCO_CHAV Glycoprotein
NCAP_CHAV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_CHAV Matrix protein
L_CHAV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_CHAV Phosphoprotein (Protein P) (Protein M1)

5 entries

Vesicular stomatitis Indiana virus (strain Glasgow) (VSIV) reference strain

Select_allDeselect_all
C_VSIVG Protein C'
GLYCO_VSIVG Glycoprotein
NCAP_VSIVG Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_VSIVG Matrix protein
PHOSP_VSIVG Phosphoprotein (Protein P) (Protein M1)

6 entries

Vesicular stomatitis Indiana virus (strain 85CLB South America) (VSIV)

Select_allDeselect_all
C_VSIVS Protein C'
GLYCO_VSIVS Glycoprotein
NCAP_VSIVS Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_VSIVS RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_VSIVS Matrix protein
PHOSP_VSIVS Phosphoprotein (Protein P) (NS) (Protein M1)

6 entries

Vesicular stomatitis Indiana virus (strain 94GUB Central America) (VSIV)

Select_allDeselect_all
C_VSIVC Protein C'
GLYCO_VSIVC Glycoprotein
NCAP_VSIVC Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_VSIVC RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_VSIVC Matrix protein
PHOSP_VSIVC Phosphoprotein (Protein P) (NS) (Protein M1)

6 entries

Vesicular stomatitis Indiana virus (strain 98COE North America) (VSIV)

Select_allDeselect_all
C_VSIVN Protein C'
GLYCO_VSIVN Glycoprotein
NCAP_VSIVN Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_VSIVN RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_VSIVN Matrix protein
PHOSP_VSIVN Phosphoprotein (Protein P) (NS) (Protein M1)

6 entries

Vesicular stomatitis New Jersey virus (strain Ogden subtype Concan) (VSNJV)

Select_allDeselect_all
C_VSNJO Protein C'
GLYCO_VSNJO Glycoprotein
NCAP_VSNJO Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_VSNJO Matrix protein
L_VSNJO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_VSNJO Phosphoprotein (P protein) (Protein M1)

5 entries

Isfahan virus (ISFV)

Select_allDeselect_all
GLYCO_ISFV Glycoprotein
NCAP_ISFV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
L_ISFV RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
MATRX_ISFV Matrix protein
PHOSP_ISFV Phosphoprotein (Protein P) (Protein M1)

4 entries

Piry virus (PIRYV)

Select_allDeselect_all
GLYCO_PIRYV Glycoprotein
NCAP_PIRYV Nucleoprotein (NP) (Nucleocapsid protein) (Protein N)
MATRX_PIRYV Matrix protein
PHOSP_PIRYV Phosphoprotein (Protein P) (Protein M1)

3 entries

Vesicular stomatitis Indiana virus (strain Mudd-Summers) (VSIV)

Select_allDeselect_all
C_VSIVM Protein C'
L_VSIVM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
PHOSP_VSIVM Phosphoprotein (Protein P) (Protein M1)

2 entries

Vesicular stomatitis New Jersey virus (strain Missouri subtype Hazelhurst) (VSNJV)

Select_allDeselect_all
C_VSNJM Protein C'
PHOSP_VSNJM Phosphoprotein (Protein P) (Protein M1)

1 entry

Cocal virus (COCV)

GLYCO_COCAV Glycoprotein

1 entry

Vesicular stomatitis Indiana virus (strain Orsay) (VSIV)

GLYCO_VSIVO Glycoprotein

1 entry

Vesicular stomatitis New Jersey virus (strain Hazelhurst subtype Hazelhurst) (VSNJV)

L_VSNJH RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...