Marburgvirus

Filamentous, greatly variable up to 1400 nm in length. Diameter is about 80nm.

GENOME

Negative-stranded RNA linear genome, about 19 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.

REPLICATION

CYTOPLASMIC

  1. Attachment to host receptors through GP glycoprotein mediates is endocytosed into vesicles in the host cell by apoptotic mimicry.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane, buds via the host ESCRT complexes from the plasma membrane, releasing the virion.

Host-virus interaction

Inhibition of host interferon signaling

Vp40 protein prevents interferon signaling by preventing the tyrosine phosphorylation of JAK1 and subsequent phosphorylation of STAT1 and STAT2. .

Matching UniProtKB/Swiss-Prot entries

35 entries grouped by strain (browse by keywords)

7 entries

Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain

Select_allDeselect_all
VGP_MABVM Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP35_MABVM Polymerase cofactor VP35
VP30_MABVM Minor nucleoprotein VP30 (Transcription activator VP30)
VP24_MABVM Membrane-associated protein VP24
VP40_MABVM Matrix protein VP40 (Membrane-associated protein VP40)
L_MABVM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_MABVM Nucleoprotein (Nucleocapsid protein) (Protein N)

7 entries

Lake Victoria marburgvirus (strain Angola/2005) (MARV)

Select_allDeselect_all
VP35_MABVA Polymerase cofactor VP35
VP40_MABVA Matrix protein VP40 (Membrane-associated protein VP40)
VGP_MABVA Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP30_MABVA Minor nucleoprotein VP30 (Transcription activator VP30)
VP24_MABVA Membrane-associated protein VP24
L_MABVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_MABVA Nucleoprotein (Nucleocapsid protein)

7 entries

Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))

Select_allDeselect_all
VP40_MABVO Matrix protein VP40 (Membrane-associated protein VP40)
VGP_MABVO Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP24_MABVO Membrane-associated protein VP24
VP30_MABVO Minor nucleoprotein VP30 (Transcription activator VP30)
VP35_MABVO Polymerase cofactor VP35
L_MABVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_MABVO Nucleoprotein (Nucleocapsid protein)

7 entries

Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))

Select_allDeselect_all
VP35_MABVP Polymerase cofactor VP35
VGP_MABVP Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP30_MABVP Minor nucleoprotein VP30 (Transcription activator VP30)
VP40_MABVP Matrix protein VP40 (Membrane-associated protein VP40)
VP24_MABVP Membrane-associated protein VP24
L_MABVP RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_MABVP Nucleoprotein (Nucleocapsid protein) (Protein N)

7 entries

Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

Select_allDeselect_all
VP35_MABVR Polymerase cofactor VP35
VGP_MABVR Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP30_MABVR Minor nucleoprotein VP30 (Transcription activator VP30)
VP40_MABVR Matrix protein VP40 (Membrane-associated protein VP40)
VP24_MABVR Membrane-associated protein VP24
L_MABVR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_MABVR Nucleoprotein (Nucleocapsid protein)