Filoviridae

Molecular biology

Filamentous 790 nm long for Marburg virus and 970 nm long for Ebolavirus. Diameter is about 80nm.

GENOME

Negative-stranded RNA linear genome, about 18-19 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.
In Ebolavirus, the primary product of the unedited transcript of GP gene yields a smaller non-structural glycoprotein sGP which is efficiently secreted from infected cells. RNA editing allows expression of full-length GP.

REPLICATION

CYTOPLASMIC

  1. Attachment to host receptors through GP glycoprotein mediates is endocytosed into vesicles in the host cell by apoptotic mimicry
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released into the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane, buds via the host ESCRT complexes from the plasma membrane, releasing the virion.

Host-virus interaction

Inhibition of host Interferon induction

Vp35 protein prevents host interferon induction by inhibiting host TBK1-IKBKE-DDX3 complex

Inhibition of host interferon signaling

Vp24 protein block interferon signaling by preventing STAT1 signaling. May act by binding host karyopherin ? proteins, thereby preventing them from transporting the tyrosine-phosphorylated transcription factor STAT1 to the nucleus. May directly bind to STAT1 to prevent its signaling .

Antigenic subvertion

Small Glycoprotein (sGP) is a secreted truncated version of GP that prevent host antibodies anti-GP to effectively neutralize it .

Matching UniProtKB/Swiss-Prot entries

97 entries grouped by strain (browse by keywords)

All proteins are shown (view only 80 complete proteome entries)

9 entries

Reston ebolavirus (strain Reston-89) (REBOV) (Reston Ebola virus) reference strain

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NCAP_EBORR Nucleoprotein (Nucleocapsid protein) (Protein N)
VP40_EBORR Matrix protein VP40 (Membrane-associated protein VP40)
VGP_EBORR Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VSSGP_EBORR Super small secreted glycoprotein (SsGP)
VP30_EBORR Minor nucleoprotein VP30 (Transcription activator VP30)
VSGP_EBORR Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...
VP24_EBORR Membrane-associated protein VP24
VP35_EBORR Polymerase cofactor VP35
L_EBORR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

9 entries

Zaire ebolavirus (strain Mayinga-76) (ZEBOV) (Zaire Ebola virus) reference strain

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NCAP_EBOZM Nucleoprotein (Nucleocapsid protein) (Protein N)
VP40_EBOZM Matrix protein VP40 (Membrane-associated protein VP40)
VP30_EBOZM Minor nucleoprotein VP30 (Transcription activator VP30)
VGP_EBOZM Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VSSGP_EBOZM Super small secreted glycoprotein (SsGP)
VP35_EBOZM Polymerase cofactor VP35
VSGP_EBOZM Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...
VP24_EBOZM Membrane-associated protein VP24
L_EBOZM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

7 entries

Lake Victoria marburgvirus (strain Musoke-80) (MARV) (Marburg virus (strain Kenya/Musoke/1980)) reference strain

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NCAP_MABVM Nucleoprotein (Nucleocapsid protein) (Protein N)
VGP_MABVM Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP40_MABVM Matrix protein VP40 (Membrane-associated protein VP40)
VP24_MABVM Membrane-associated protein VP24
VP35_MABVM Polymerase cofactor VP35
L_MABVM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
VP30_MABVM Minor nucleoprotein VP30 (Transcription activator VP30)

9 entries

Reston ebolavirus (strain Philippines-96) (REBOV) (Reston Ebola virus)

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NCAP_EBORE Nucleoprotein (Nucleocapsid protein) (Protein N)
VP24_EBORE Membrane-associated protein VP24
VSSGP_EBORE Super small secreted glycoprotein (SsGP)
VP30_EBORE Minor nucleoprotein VP30 (Transcription activator VP30)
VGP_EBORE Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VP40_EBORE Matrix protein VP40 (Membrane-associated protein VP40)
VSGP_EBORE Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...
VP35_EBORE Polymerase cofactor VP35
L_EBORE RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

9 entries

Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)

Select_allDeselect_all
NCAP_EBOSU Nucleoprotein (Nucleocapsid protein) (Protein N)
VSSGP_EBOSU Super small secreted glycoprotein (SsGP)
VP35_EBOSU Polymerase cofactor VP35
VGP_EBOSU Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VP40_EBOSU Matrix protein VP40 (Membrane-associated protein VP40)
VSGP_EBOSU Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...
VP24_EBOSU Membrane-associated protein VP24
VP30_EBOSU Minor nucleoprotein VP30 (Transcription activator VP30)
L_EBOSU RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

9 entries

Zaire ebolavirus (strain Kikwit-95) (ZEBOV) (Zaire Ebola virus)

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NCAP_EBOZ5 Nucleoprotein (Nucleocapsid protein) (Protein N)
VP30_EBOZ5 Minor nucleoprotein VP30 (Transcription activator VP30)
VGP_EBOZ5 Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VP24_EBOZ5 Membrane-associated protein VP24
VP35_EBOZ5 Polymerase cofactor VP35
VP40_EBOZ5 Matrix protein VP40 (Membrane-associated protein VP40)
VSSGP_EBOZ5 Super small secreted glycoprotein (SsGP)
VSGP_EBOZ5 Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...
L_EBOZ5 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

7 entries

Lake Victoria marburgvirus (strain Angola/2005) (MARV)

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NCAP_MABVA Nucleoprotein (Nucleocapsid protein)
VGP_MABVA Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP24_MABVA Membrane-associated protein VP24
VP35_MABVA Polymerase cofactor VP35
VP40_MABVA Matrix protein VP40 (Membrane-associated protein VP40)
VP30_MABVA Minor nucleoprotein VP30 (Transcription activator VP30)
L_MABVA RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

7 entries

Lake Victoria marburgvirus (strain Ozolin-75) (MARV) (Marburg virus (strain South Africa/Ozolin/1975))

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NCAP_MABVO Nucleoprotein (Nucleocapsid protein)
VGP_MABVO Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP35_MABVO Polymerase cofactor VP35
VP40_MABVO Matrix protein VP40 (Membrane-associated protein VP40)
VP24_MABVO Membrane-associated protein VP24
VP30_MABVO Minor nucleoprotein VP30 (Transcription activator VP30)
L_MABVO RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

7 entries

Lake Victoria marburgvirus (strain Popp-67) (MARV) (Marburg virus (strain West Germany/Popp/1967))

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NCAP_MABVP Nucleoprotein (Nucleocapsid protein) (Protein N)
VP24_MABVP Membrane-associated protein VP24
VP30_MABVP Minor nucleoprotein VP30 (Transcription activator VP30)
VGP_MABVP Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP35_MABVP Polymerase cofactor VP35
VP40_MABVP Matrix protein VP40 (Membrane-associated protein VP40)
L_MABVP RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

7 entries

Lake Victoria marburgvirus (strain Ravn-87) (MARV) (Marburg virus (strain Kenya/Ravn/1987))

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NCAP_MABVR Nucleoprotein (Nucleocapsid protein)
VGP_MABVR Envelope glycoprotein (GP1,2) (GP) (Virion spike glycoprotein) [Cleaved into: GP1; GP2]
VP30_MABVR Minor nucleoprotein VP30 (Transcription activator VP30)
VP40_MABVR Matrix protein VP40 (Membrane-associated protein VP40)
VP24_MABVR Membrane-associated protein VP24
VP35_MABVR Polymerase cofactor VP35
L_MABVR RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

5 entries

Zaire ebolavirus (strain Gabon-94) (ZEBOV) (Zaire Ebola virus)

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NCAP_EBOG4 Nucleoprotein (Nucleocapsid protein) (Protein N)
VP40_EBOG4 Matrix protein VP40 (Membrane-associated protein VP40)
VGP_EBOG4 Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VP24_EBOG4 Membrane-associated protein VP24
VSGP_EBOG4 Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...

3 entries

Sudan ebolavirus (strain Boniface-76) (SEBOV) (Sudan Ebola virus)

Select_allDeselect_all
NCAP_EBOSB Nucleoprotein (Nucleocapsid protein) (Protein N)
VGP_EBOSB Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VSGP_EBOSB Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...

3 entries

Sudan ebolavirus (strain Maleo-79) (SEBOV) (Sudan Ebola virus)

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VGP_EBOSM Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VSGP_EBOSM Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...
L_EBOSM RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...

2 entries

Reston ebolavirus (strain Siena/Philippine-92) (REBOV) (Reston Ebola virus)

Select_allDeselect_all
VGP_EBORS Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VSGP_EBORS Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...

2 entries

Tai Forest ebolavirus (strain Cote d'Ivoire-94) (TAFV) (Cote d'Ivoire Ebola virus)

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VSGP_TAFVC Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...
VGP_TAFVC Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]

2 entries

Zaire ebolavirus (strain Eckron-76) (ZEBOV) (Zaire Ebola virus)

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VGP_EBOEC Envelope glycoprotein (GP1,2) (GP) [Cleaved into: GP1; GP2; GP2-delta]
VSGP_EBOEC Pre-small/secreted glycoprotein (pre-sGP) [Cleaved into: Small/secreted glycoprotein (sGP); ...