arboviruses group B

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VIRION

Enveloped, spherical, about 50 nm in diameter. The surface proteins are arranged in an icosahedral-like symmetry. Mature virions contain two virus-encoded membrane proteins (M and E), while immature virions contain a membrane protein precursor.
Source: Zhang et al(Pubmed )

GENOME

Monopartite, linear, ssRNA(+) genome of of 10-11 kb. The genome 5' end has a methylated nucleotide cap for canonical cellular translation. The 3' terminus is not polyadenylated but forms a loop structure. This secondary structure leads to the formation of a subgenomic flavivirus RNA (sfRNA) through genomic RNA degradation by host XRN1. sfRNA is essential for pathogenicity , and may play a role in inhibiting host RIG-I antiviral activity as shown for Dengue virus

GENE EXPRESSION

The virion RNA is infectious and serves as both the genome and the viral messenger RNA. The whole genome is translated in a polyprotein, which is processed co- and post-translationally by host and viral proteases.

REPLICATION

  1. Attachement of the viral envelope protein E to host receptors mediates internalization into the host cell by clathrin-mediated endocytosis, or by apoptotic mimicry
  2. Fusion of virus membrane with host endosomal membrane. RNA genome is released into the cytoplasm.
  3. The positive-sense genomic ssRNA is translated into a polyprotein, which is cleaved into all structural and non structural proteins (to yield the replication proteins).
  4. Replication takes place at the surface of endoplasmic reticulum in cytoplasmic viral factories. A dsRNA genome is synthesized from the genomic ssRNA(+).
  5. The dsRNA genome is transcribed/replicated thereby providing viral mRNAs/new ssRNA(+) genomes.
  6. Virus assembly occurs at the endoplasmic reticulum. The virion buds at the endoplasmic reticulum and is transported to the Golgi apparatus.
  7. The prM protein is cleaved in the Golgi, thereby maturing the virion which is fusion competent.
  8. Release of new virions by exocytosis.

Host-virus interaction

Adaptive immune response inhibition

Dengue NS1 protein inhibits host complement by binding C4 and reducing C4b deposition and C3 convertase activity. Through this mechanism, NS1 protects DENV from complement-dependent neutralization in solution .

Apoptosis modulation

Flaviviruses NS3 induces apoptosis through host caspases activation .

Autophagy modulation

Flaviviruses NS4A and NS4B induces autophagy signaling .

Innate immune response inhibition

Dengue virus blocks STAT2 .

Matching UniProtKB/Swiss-Prot entries

43 entries grouped by strain (browse by keywords)

1 entry

Dengue virus type 1 (strain Nauru/West Pac/1974) (DENV-1) reference strain

POLG_DEN1W Genome polyprotein [Cleaved into: Protein C (Capsid protein) (Core protein); Protein prM (Precursor ...

1 entry

Yellow fever virus (strain 17D vaccine) (YFV) reference strain

POLG_YEFV1 Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Zika virus (strain Mr 766) (ZIKV) reference strain

POLG_ZIKV Genome polyprotein [Cleaved into: Protein C (Capsid protein) (Core protein); Protein prM (Precursor ...

1 entry

Dengue virus type 1 (strain Brazil/97-11/1997) (DENV-1)

POLG_DEN1B Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 1 (strain Singapore/S275/1990) (DENV-1)

POLG_DEN1S Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (isolate Thailand/0168/1979) (DENV-2)

POLG_DEN28 Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain 16681-PDK53) (DENV-2)

POLG_DEN27 Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Jamaica/1409/1983) (DENV-2)

POLG_DEN2J Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Peru/IQT2913/1996) (DENV-2)

POLG_DEN2Q Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Puerto Rico/PR159-S1/1969) (DENV-2)

POLG_DEN2P Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Thailand/16681/1984) (DENV-2)

POLG_DEN26 Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 2 (strain Thailand/NGS-C/1944) (DENV-2)

POLG_DEN2N Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain China/80-2/1980) (DENV-3)

POLG_DEN3C Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain Martinique/1243/1999) (DENV-3)

POLG_DEN3M Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain Philippines/H87/1956) (DENV-3)

POLG_DEN3P Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain Singapore/8120/1995) (DENV-3)

POLG_DEN3I Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 3 (strain Sri Lanka/1266/2000) (DENV-3)

POLG_DEN3S Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Dominica/814669/1981) (DENV-4)

POLG_DEN4D Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Philippines/H241/1956) (DENV-4)

POLG_DEN4P Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Singapore/8976/1995) (DENV-4)

POLG_DEN4S Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Thailand/0348/1991) (DENV-4)

POLG_DEN4T Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Dengue virus type 4 (strain Thailand/0476/1997) (DENV-4)

POLG_DEN4H Genome polyprotein [Cleaved into: Protein C (Core protein); prM; Peptide pr; Small envelope protein ...

1 entry

Japanese encephalitis virus (strain Jaoars982)

POLG_JAEVJ Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Japanese encephalitis virus (strain SA(v))

POLG_JAEV5 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Japanese encephalitis virus (strain SA-14)

POLG_JAEV1 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Kunjin virus (strain MRM61C)

POLG_KUNJM Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Langat virus (strain TP21)

POLG_LANVT Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Louping ill virus (Li)

POLG_LIV Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Mosquito cell fusing agent (CFA flavivirus)

POLG_MCFA Genome polyprotein [Cleaved into: Protein C (Capsid protein) (Core protein); Small envelope protein ...

1 entry

Murray valley encephalitis virus (strain MVE-1-51) (MVEV)

POLG_MVEV5 Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Tick-borne encephalitis virus (strain Hypr) (TBEV)

POLG_TBEVH Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Tick-borne encephalitis virus European subtype (strain Neudoerfl) (NEUV) (Neudoerfl virus)

POLG_TBEVW Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Tick-borne encephalitis virus Far Eastern subtype (strain Sofjin) (SOFV) (Sofjin virus)

POLG_TBEVS Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Tick-borne powassan virus (strain LB) (POWV) (Powassan virus)

POLG_POWVL Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

West Nile virus (WNV)

POLG_WNV Genome polyprotein [Cleaved into: Peptide 2k; Capsid protein C (Core protein); prM; Peptide pr; ...

1 entry

Yellow fever virus (isolate Angola/14FA/1971) (YFV)

POLG_YEFVN Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (isolate Ethiopia/Couma/1961) (YFV)

POLG_YEFVE Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (isolate Ivory Coast/1999) (YFV)

POLG_YEFVC Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (isolate Ivory Coast/85-82H/1982) (YFV)

POLG_YEFVI Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (isolate Uganda/A7094A4/1948) (YFV)

POLG_YEFVU Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (strain French neurotropic vaccine FNV) (YFV)

POLG_YEFVF Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (strain Ghana/Asibi/1927) (YFV)

POLG_YEFVA Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...

1 entry

Yellow fever virus (strain Trinidad/TRINID79A/1979) (YFV)

POLG_YEFVT Genome polyprotein [Cleaved into: Capsid protein C (Core protein); prM; Peptide pr; Small envelope ...