Orthobunyavirus

Molecular biology

VIRION

Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

Segmented Negative-stranded RNA linear genome, L segment is about 6.9kb, M segment about 4.5kb and S segment about 1kb.
Encodes for six proteins.

GENE EXPRESSION

Transcription starts by viral RNA dependent RNA polymerase (L) binding to a promoter on each encapsidated segment, and is terminated by a strong hairpin sequence at the end of each gene. mRNAs are capped by L protein during synthesis using cap snatching ., but are not polyadenylated.

S segment encodes for NSs protein by leaky scanning. M segment encodes for a polyprotein which is cleaved by host protease into Gn, NSm and Gc proteins.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Host-virus interaction

Inhibition of host transcription initiation

The Bunyamwera virus (BUNV) NSs protein plays a role in the inhibition of host RNA polymerase II

Matching UniProtKB/Swiss-Prot entries

26 entries grouped by strain (browse by keywords)

All proteins are shown (view only 8 complete proteome entries)

4 entries

Bunyamwera virus (BUNV) reference strain

Select_allDeselect_all
GP_BUNYW Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NCAP_BUNYW Nucleoprotein (Nucleocapsid protein) (Protein N)
L_BUNYW RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NSS_BUNYW Non-structural protein NS-S

4 entries

Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain

Select_allDeselect_all
GP_BUNL8 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NCAP_BUNL8 Nucleoprotein (Nucleocapsid protein) (Protein N)
L_BUNL8 RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NSS_BUNL8 Non-structural protein NS-S

4 entries

Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

Select_allDeselect_all
GP_SBVBH Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NCAP_SBVBH Nucleoprotein (Nucleocapsid protein) (Protein N)
L_SBVBH RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NSS_SBVBH Non-structural protein NS-S

3 entries

Bunyavirus germiston

Select_allDeselect_all
GP_BUNGE Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NCAP_BUNGE Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNGE Non-structural protein NS-S

3 entries

Bunyavirus snowshoe hare

Select_allDeselect_all
GP_BUNSH Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NCAP_BUNSH Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNSH Non-structural protein NS-S

3 entries

Maguari virus

Select_allDeselect_all
NCAP_MAGV Nucleoprotein (Nucleocapsid protein) (Protein N)
Y9KD_MAGV Putative uncharacterized 9.3 kDa protein
NSS_MAGV Non-structural protein NS-S

2 entries

Aino virus

Select_allDeselect_all
NCAP_AINOV Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_AINOV Non-structural protein NS-S

2 entries

Bunyavirus La Crosse

Select_allDeselect_all
NCAP_BUNLC Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNLC Non-structural protein NS-S

1 entry

Bunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)

GP_BUNL7 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...