Inhibition of host STAT1 by virus

The signal transducer and activator of transcription STAT1(M97935:9606) protein is a cytoplasmic latent transcription factor that becomes activated by various extracellular stimuli, including cytokines and growth factors that bind to specific cell surface receptors. The activation of STAT1(M97935:9606) in IFN-γ and IFN-α/β signaling pathways is largely mediated by phosphorylation of conserved tyrosine and serine residues in the C-terminal region. While IFN-γ induces STAT1(M97935:9606) homodimerization, IFN-α/β mainly stimulates heterodimerization of STAT1(M97935:9606) and STAT2(M97934:9606), both leading to STAT1(M97935:9606) activation and nuclear localization.

INFRA1 INFRA2 INFRG1 INFRG2 JAK1 JAK1 TYK2 JAK2 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT1 STAT2 STAT2 STAT2 STAT2 IRF9 IRF9 IRF9 e1a P vh1 V C

Many viruses modulate the interferon mediated response by acting on STAT1(M97935:9606) using different strategies. The V(P11207) protein of simian virus 5 inhibits interferon signalling by targeting STAT1(M97935:9606) for proteasome-mediated degradation. Sendai virus C protein also physically associates with STAT1(M97935:9606) and send it to degradation. Vaccinia VH1(Q80HW5) phosphatase instead reverses STAT1(M97935:9606) activation by interacting with and dephosphorylating STAT1(M97935:9606).

Matching UniProtKB/Swiss-Prot entries

110 entries grouped by protein (browse by keywords)

All proteins are shown (view only 78 complete proteome entries)

13 entries

Protein C

Select_allDeselect_all
C_PI3B
Bovine parainfluenza 3 virus (BPIV-3) reference strain
C_SENDO
Sendai virus (strain Ohita) (SeV) reference strain

Protein C'

C_SENDZ
Sendai virus (strain Z) (SeV) (Sendai virus (strain HVJ)) reference strain

Protein C'

C_PI1HB
Human parainfluenza 1 virus (strain C35) (HPIV-1)
C_PI1HC
Human parainfluenza 1 virus (strain C39) (HPIV-1)
C_PI1HD
Human parainfluenza 1 virus (strain CI-5/73) (HPIV-1)
C_PI1HE
Human parainfluenza 1 virus (strain CI-14/83) (HPIV-1)
C_PI3H4
Human parainfluenza 3 virus (strain Wash/47885/57) (HPIV-3) (Human parainfluenza 3 virus (strain NIH 47885))

Protein C (VP18 protein)

C_SEND6
Sendai virus (strain 6/94) (SeV)

Protein C'

C_SENDA
Sendai virus (strain Hamamatsu) (SeV)

Protein C'

C_SENDF
Sendai virus (strain Fushimi) (SeV)

Protein C'

C_SENDH
Sendai virus (strain Harris) (SeV)

Protein C'

C_SENDN
Sendai virus (strain Nagoya) (SeV)

Protein C'

6 entries

Dual specificity protein phosphatase H1 (EC 3.1.3.-) (EC 3.1.3.48) (Late protein H1)

Select_allDeselect_all
DUSP_FOWPN
Fowlpox virus (strain NVSL) (FPV) reference strain

Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

DUSP_MYXVL
Myxoma virus (strain Lausanne) (MYXV) reference strain

Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

DUSP_VACCC
Vaccinia virus (strain Copenhagen) (VACV) reference strain
DUSP_VACCW
Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain WR)) reference strain
DUSP_VAR67
Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus) reference strain
DUSP_RACVI
Raccoon poxvirus (RCN)

Probable dual specificity protein phosphatase H1 homolog (EC 3.1.3.-) (EC 3.1.3.48)

14 entries

Early E1A protein (Early E1A 20 kDa protein)

Select_allDeselect_all
E1A_ADE02
Human adenovirus C serotype 2 (HAdV-2) (Human adenovirus 2) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE05
Human adenovirus C serotype 5 (HAdV-5) (Human adenovirus 5) reference strain

Early E1A protein (Early E1A 32 kDa protein)

E1A_ADE12
Human adenovirus A serotype 12 (HAdV-12) (Human adenovirus 12) reference strain

Early E1A protein (Early E1A 29.5 kDa protein)

E1A_ADE04
Human adenovirus E serotype 4 (HAdV-4) (Human adenovirus 4)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE07
Human adenovirus B serotype 7 (HAdV-7) (Human adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

E1A_ADE40
Human adenovirus F serotype 40 (HAdV-40) (Human adenovirus 40)

Early E1A protein (Early E1A 27 kDa protein)

E1A_ADE41
Human adenovirus F serotype 41 (HAdV-41) (Human adenovirus 41)

Early E1A protein (Early E1A 27 kDa protein)

E1A_ADEC2
Canine adenovirus serotype 2 (CAdV-2) (Canine adenovirus 2)
E1A_ADECC
Canine adenovirus serotype 1 (strain CLL) (CAdV-1) (Canine adenovirus 1 (strain CLL))

Early E1A protein (Early E1A 25 kDa protein)

E1A_ADECG
Canine adenovirus serotype 1 (strain Glaxo) (CAdV-1) (Canine adenovirus 1 (strain Glaxo))
E1A_ADECR
Canine adenovirus serotype 1 (strain RI261) (CAdV-1) (Canine adenovirus 1 (strain RI261))
E1A_ADECT
Canine adenovirus serotype 2 (strain Toronto A 26-61) (CAdV-2) (Canine adenovirus 2 (strain Toronto A 26-61))

Early E1A protein (Early E1A 25 kDa protein)

E1A_ADEM1
Murine adenovirus A serotype 1 (MAdV-1) (Murine adenovirus 1)

Early E1A 21 kDa protein

E1A_ADES7
Simian adenovirus serotype 7 (SAdV-7) (Simian adenovirus 7)

Early E1A protein (Early E1A 28 kDa protein)

23 entries

Phosphoprotein (Protein P) (Protein M1)

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PHOSP_ABLVB
Australian bat lyssavirus (isolate Bat/AUS/1996) (ABLV) reference strain
PHOSP_EBLV1
European bat lyssavirus 1 (strain Bat/Germany/RV9/1968) (EBLV1) reference strain
PHOSP_EBLV2
European bat lyssavirus 2 (strain Human/Scotland/RV1333/2002) (EBLV2) reference strain
PHOSP_MOKV
Mokola virus (MOKV) reference strain
PHOSP_RABVP
Rabies virus (strain Pasteur vaccins / PV) (RABV) reference strain
PHOSP_ABLVH
Australian bat lyssavirus (isolate Human/AUS/1998) (ABLV)
PHOSP_ARAV
Aravan virus (ARAV)
PHOSP_DUVV
Duvenhage virus (DUVV)
PHOSP_IRKV
Irkut virus (IRKV)
PHOSP_KHUV
Khujand virus (KHUV)
PHOSP_LBV
Lagos bat virus (LBV)
PHOSP_RABVA
Rabies virus (strain PM1503/AVO1) (RABV)
PHOSP_RABVB
Rabies virus (strain silver-haired bat-associated) (RABV) (SHBRV)
PHOSP_RABVC
Rabies virus (strain CVS-11) (RABV)
PHOSP_RABVD
Rabies virus (strain China/DRV) (RABV)
PHOSP_RABVE
Rabies virus (strain ERA) (RABV)
PHOSP_RABVH
Rabies virus (strain HEP-Flury) (RABV)
PHOSP_RABVI
Rabies virus (strain India) (RABV)
PHOSP_RABVM
Rabies virus (strain PM) (RABV)
PHOSP_RABVN
Rabies virus (strain Nishigahara RCEH) (RABV)
PHOSP_RABVR
Rabies virus (strain China/MRV) (RABV)
PHOSP_RABVS
Rabies virus (strain SAD B19) (RABV)
PHOSP_WCBV
West Caucasian bat virus (WCBV)

35 entries

Genome polyprotein

Select_allDeselect_all
POLG_HCVH
Hepatitis C virus genotype 1a (isolate H) (HCV) reference strain
POLG_HCV1
Hepatitis C virus genotype 1a (isolate 1) (HCV)
POLG_HCV6A
Hepatitis C virus genotype 6a (isolate 6a33) (HCV)
POLG_HCVBB
Hepatitis C virus genotype 2c (isolate BEBE1) (HCV)
POLG_HCVCO
Hepatitis C virus genotype 1b (isolate Con1) (HCV)
POLG_HCVED
Hepatitis C virus genotype 4a (isolate ED43) (HCV)
POLG_HCVEU
Hepatitis C virus genotype 6a (isolate EUHK2) (HCV)
POLG_HCVEV
Hepatitis C virus genotype 5a (isolate EUH1480) (HCV)
POLG_HCVH9
Hepatitis C virus genotype 1c (isolate HC-G9) (HCV)
POLG_HCVIN
Hepatitis C virus genotype 1c (isolate India) (HCV)
POLG_HCVJ1
Hepatitis C virus genotype 1b (isolate HC-J1) (HCV)
POLG_HCVJ4
Hepatitis C virus genotype 1b (strain HC-J4) (HCV)
POLG_HCVJ6
Hepatitis C virus genotype 2a (isolate HC-J6) (HCV)
POLG_HCVJ8
Hepatitis C virus genotype 2b (isolate HC-J8) (HCV)
POLG_HCVJA
Hepatitis C virus genotype 1b (isolate Japanese) (HCV)
POLG_HCVJF
Hepatitis C virus genotype 2a (isolate JFH-1) (HCV)
POLG_HCVJK
Hepatitis C virus genotype 3k (isolate JK049) (HCV)
POLG_HCVJL
Hepatitis C virus genotype 6g (isolate JK046) (HCV)
POLG_HCVJP
Hepatitis C virus genotype 2b (isolate JPUT971017) (HCV)
POLG_HCVJT
Hepatitis C virus genotype 1b (isolate HC-JT) (HCV)
POLG_HCVK3
Hepatitis C virus genotype 3a (isolate k3a) (HCV)
POLG_HCVNZ
Hepatitis C virus genotype 3a (isolate NZL1) (HCV)
POLG_HCVR6
Hepatitis C virus genotype 1b (isolate HCR6) (HCV)
POLG_HCVSA
Hepatitis C virus genotype 5a (isolate SA13) (HCV)
POLG_HCVT5
Hepatitis C virus genotype 6b (isolate Th580) (HCV)
POLG_HCVTR
Hepatitis C virus genotype 3b (isolate Tr-Kj) (HCV)
POLG_HCVTW
Hepatitis C virus genotype 1b (isolate Taiwan) (HCV)
POLG_HCVVA
Hepatitis C virus genotype 2k (isolate VAT96) (HCV)
POLG_HCVVN
Hepatitis C virus genotype 6d (isolate VN235) (HCV)
POLG_HCVVO
Hepatitis C virus genotype 6k (isolate VN405) (HCV)
POLG_HCVVP
Hepatitis C virus genotype 6h (isolate VN004) (HCV)
POLG_JAEV1
Japanese encephalitis virus (strain SA-14)
POLG_JAEV5
Japanese encephalitis virus (strain SA(v))
POLG_JAEVJ
Japanese encephalitis virus (strain Jaoars982)

5 entries

Replicase polyprotein 1ab (ORF1ab polyprotein)

Select_allDeselect_all
RPOA_PRRSB
Porcine reproductive and respiratory syndrome virus (strain HB-1) (PRRSV) reference strain
RPOA_PRRSL
Porcine reproductive and respiratory syndrome virus (strain Lelystad) (PRRSV) reference strain
RPOA_PRRS1
Porcine reproductive and respiratory syndrome virus (strain 16244B) (PRRSV)
RPOA_PRRSR
Porcine reproductive and respiratory syndrome virus (strain VR-2332) (PRRSV)
RPOA_PRRSS
Porcine reproductive and respiratory syndrome virus (isolate Pig/United States/SD 01-08/2001) (PRRSV)

14 entries

Non-structural protein V

Select_allDeselect_all
V_HENDH
Hendra virus (isolate Horse/Autralia/Hendra/1994) reference strain
V_MUMPM
Mumps virus (strain Miyahara vaccine) (MuV) reference strain

Non-structural protein V (Non-structural protein NS1)

V_PIV5
Parainfluenza virus 5 (strain W3) (PIV5) (Simian virus 5) reference strain
V_SV41
Simian virus 41 (SV41) reference strain
V_MEASA
Measles virus (strain Edmonston-AIK-C vaccine) (MeV) (Subacute sclerose panencephalitis virus)
V_MEASE
Measles virus (strain Edmonston) (MeV) (Subacute sclerose panencephalitis virus)
V_MUMP1
Mumps virus (strain SBL-1) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPE
Mumps virus (strain Enders) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_MUMPS
Mumps virus (strain SBL) (MuV)

Non-structural protein V (Non-structural protein NS1)

V_NIPAV
Nipah virus
V_PHODV
Phocine distemper virus (PDV)
V_PI4HA
Human parainfluenza 4a virus (strain Toshiba) (HPIV-4a)
V_PI4HB
Human parainfluenza 4b virus (strain 68-333) (HPIV-4b)
V_RINDK
Rinderpest virus (strain Kabete O) (RDV)